LOCUS       NM_001024225             419 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus defensin, alpha, 24 (Defa24), mRNA.
ACCESSION   NM_001024225
VERSION     NM_001024225.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 419)
  AUTHORS   Shanahan,M.T., Tanabe,H. and Ouellette,A.J.
  TITLE     Strain-specific polymorphisms in Paneth cell alpha-defensins of
            C57BL/6 mice and evidence of vestigial myeloid alpha-defensin
            pseudogenes
  JOURNAL   Infect Immun 79 (1), 459-473 (2011)
   PUBMED   21041494
REFERENCE   2  (bases 1 to 419)
  AUTHORS   Amid,C., Rehaume,L.M., Brown,K.L., Gilbert,J.G., Dougan,G.,
            Hancock,R.E. and Harrow,J.L.
  TITLE     Manual annotation and analysis of the defensin gene cluster in the
            C57BL/6J mouse reference genome
  JOURNAL   BMC Genomics 10, 606 (2009)
   PUBMED   20003482
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 419)
  AUTHORS   Patil,A., Hughes,A.L. and Zhang,G.
  TITLE     Rapid evolution and diversification of mammalian alpha-defensins as
            revealed by comparative analysis of rodent and primate genes
  JOURNAL   Physiol Genomics 20 (1), 1-11 (2004)
   PUBMED   15494476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134533.3 and AY746429.1.
            
            On Apr 14, 2010 this sequence version replaced NM_001024225.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BE135558.1, AA870370.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AC134533.3         136945-136987
            44-325              AY746429.1         1-282
            326-419             AC134533.3         137829-137922
FEATURES             Location/Qualifiers
     source          1..419
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 10.35 cM"
     gene            1..419
                     /gene="Defa24"
                     /gene_synonym="Defcr24"
                     /note="defensin, alpha, 24"
                     /db_xref="GeneID:503491"
                     /db_xref="MGI:MGI:3630383"
     exon            1..215
                     /gene="Defa24"
                     /gene_synonym="Defcr24"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..325
                     /gene="Defa24"
                     /gene_synonym="Defcr24"
                     /note="defensin-related cryptdin-24; alpha-defensin 24"
                     /codon_start=1
                     /product="alpha-defensin 24 precursor"
                     /protein_id="NP_001019396.1"
                     /db_xref="CCDS:CCDS40281.1"
                     /db_xref="GeneID:503491"
                     /db_xref="MGI:MGI:3630383"
                     /translation="MKTLILLSALVLLAFQVQADPIQNTDEETKTEEQPGEEDQAVSV
                     SFGDPEGASLQEESLRDLVCYCRARGCKGRERMNGTCSKGHLLYMLCCR"
     exon            216..419
                     /gene="Defa24"
                     /gene_synonym="Defcr24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      400..405
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Defa24"
                     /gene_synonym="Defcr24"
                     /note="hexamer: AATAAA"
     polyA_site      419
                     /gene="Defa24"
                     /gene_synonym="Defcr24"
                     /note="major polyA site"
ORIGIN      
        1 acactgagct gctactcacc aatcctccag gtgactccca gccatgaaga cactaatcct
       61 cctctctgcc ctcgtcctgc tggccttcca ggtccaggct gatcctatcc aaaatacaga
      121 tgaagagact aaaactgagg agcagccagg ggaagaggac caggctgtgt ctgtctcttt
      181 tggagaccca gaaggcgctt ctcttcaaga ggaatcattg agagatctgg tatgctattg
      241 tagagcaaga ggctgcaaag gaagagaacg catgaatggg acctgcagta agggtcattt
      301 attgtacatg ctctgctgtc gctgaacatg gagaccacag aggacaagat gaccatgagt
      361 actgaggcca ctgatgctgg tgcctgatga ccacttctca ataaattgct tgcaatatg
//
