LOCUS       NM_001012307             418 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus defensin, alpha, 23 (Defa23), mRNA.
ACCESSION   NM_001012307 XM_001471645
VERSION     NM_001012307.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 418)
  AUTHORS   Amid,C., Rehaume,L.M., Brown,K.L., Gilbert,J.G., Dougan,G.,
            Hancock,R.E. and Harrow,J.L.
  TITLE     Manual annotation and analysis of the defensin gene cluster in the
            C57BL/6J mouse reference genome
  JOURNAL   BMC Genomics 10, 606 (2009)
   PUBMED   20003482
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 418)
  AUTHORS   Patil,A., Hughes,A.L. and Zhang,G.
  TITLE     Rapid evolution and diversification of mammalian alpha-defensins as
            revealed by comparative analysis of rodent and primate genes
  JOURNAL   Physiol Genomics 20 (1), 1-11 (2004)
   PUBMED   15494476
REFERENCE   3  (bases 1 to 418)
  AUTHORS   Ko,M.S., Wang,X., Horton,J.H., Hagen,M.D., Takahashi,N., Maezaki,Y.
            and Nadeau,J.H.
  TITLE     Genetic mapping of 40 cDNA clones on the mouse genome by PCR
  JOURNAL   Mamm Genome 5 (6), 349-355 (1994)
   PUBMED   8043949
REFERENCE   4  (bases 1 to 418)
  AUTHORS   Huttner,K.M., Selsted,M.E. and Ouellette,A.J.
  TITLE     Structure and diversity of the murine cryptdin gene family
  JOURNAL   Genomics 19 (3), 448-453 (1994)
   PUBMED   8188287
  REMARK    Erratum:[Genomics 1995 Feb 10;25(3):762]
REFERENCE   5  (bases 1 to 418)
  AUTHORS   Eisenhauer,P.B., Harwig,S.S. and Lehrer,R.I.
  TITLE     Cryptdins: antimicrobial defensins of the murine small intestine
  JOURNAL   Infect Immun 60 (9), 3556-3565 (1992)
   PUBMED   1500163
REFERENCE   6  (bases 1 to 418)
  AUTHORS   Selsted,M.E., Miller,S.I., Henschen,A.H. and Ouellette,A.J.
  TITLE     Enteric defensins: antibiotic peptide components of intestinal host
            defense
  JOURNAL   J Cell Biol 118 (4), 929-936 (1992)
   PUBMED   1500431
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB584616.1, AY746428.1 and AV052259.1.
            
            On Apr 10, 2010 this sequence version replaced NM_001012307.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BE138051.1, BE135801.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                BB584616.1         2-42
            42-323              AY746428.1         1-282
            324-418             AV052259.1         203-297
FEATURES             Location/Qualifiers
     source          1..418
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 10.35 cM"
     gene            1..418
                     /gene="Defa23"
                     /gene_synonym="Defcr23"
                     /note="defensin, alpha, 23"
                     /db_xref="GeneID:497114"
                     /db_xref="MGI:MGI:3630381"
     exon            1..213
                     /gene="Defa23"
                     /gene_synonym="Defcr23"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..323
                     /gene="Defa23"
                     /gene_synonym="Defcr23"
                     /note="alpha-defensin 23; defensin-related cryptdin-23"
                     /codon_start=1
                     /product="alpha-defensin 23 precursor"
                     /protein_id="NP_001012307.1"
                     /db_xref="CCDS:CCDS40265.1"
                     /db_xref="GeneID:497114"
                     /db_xref="MGI:MGI:3630381"
                     /translation="MKTLVLLSALILLAFQVQADPIQNTDEETKTEEQPGKEDQAVSV
                     SFGDPEGSSLQEESLRDLVCYCRTRGCKRRERMNGTCRKGHLIYTLCCR"
     exon            214..418
                     /gene="Defa23"
                     /gene_synonym="Defcr23"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attgggctcc tgctcaccaa tcctccaggt gactcccagc catgaagaca ctagtcctcc
       61 tctctgccct catcctgctg gccttccagg tccaggctga tcctatccaa aacacagatg
      121 aagagactaa aactgaggag cagccaggga aagaggacca ggctgtgtct gtctcttttg
      181 gagacccaga aggctcttct cttcaagagg aatcgttgag agatctggta tgctattgta
      241 gaacaagagg ctgcaaaaga agagaacgca tgaatgggac ctgcagaaag ggtcatttaa
      301 tatacacgct ctgctgtcgc tgaacatgga gaccacagag gacaagacga gcatgagtac
      361 tgaggccact gatgctggtg cctgatgacc acttctcaat aaattgttcg caatatgc
//
