LOCUS       NM_183253                419 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus defensin, alpha, 21 (Defa21), mRNA.
ACCESSION   NM_183253 XM_356137
VERSION     NM_183253.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 419)
  AUTHORS   Shanahan,M.T., Tanabe,H. and Ouellette,A.J.
  TITLE     Strain-specific polymorphisms in Paneth cell alpha-defensins of
            C57BL/6 mice and evidence of vestigial myeloid alpha-defensin
            pseudogenes
  JOURNAL   Infect Immun 79 (1), 459-473 (2011)
   PUBMED   21041494
REFERENCE   2  (bases 1 to 419)
  AUTHORS   Amid,C., Rehaume,L.M., Brown,K.L., Gilbert,J.G., Dougan,G.,
            Hancock,R.E. and Harrow,J.L.
  TITLE     Manual annotation and analysis of the defensin gene cluster in the
            C57BL/6J mouse reference genome
  JOURNAL   BMC Genomics 10, 606 (2009)
   PUBMED   20003482
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 419)
  AUTHORS   Gregorieff,A., Stange,D.E., Kujala,P., Begthel,H., van den Born,M.,
            Korving,J., Peters,P.J. and Clevers,H.
  TITLE     The ets-domain transcription factor Spdef promotes maturation of
            goblet and paneth cells in the intestinal epithelium
  JOURNAL   Gastroenterology 137 (4), 1333-45 (2009)
   PUBMED   19549527
REFERENCE   4  (bases 1 to 419)
  AUTHORS   Patil,A., Hughes,A.L. and Zhang,G.
  TITLE     Rapid evolution and diversification of mammalian alpha-defensins as
            revealed by comparative analysis of rodent and primate genes
  JOURNAL   Physiol Genomics 20 (1), 1-11 (2004)
   PUBMED   15494476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161189.12.
            
            On Apr 28, 2009 this sequence version replaced NM_183253.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008266.1, AV070384.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               AC161189.12        52124-52338         c
            216-419             AC161189.12        51366-51569         c
FEATURES             Location/Qualifiers
     source          1..419
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 10.35 cM"
     gene            1..419
                     /gene="Defa21"
                     /gene_synonym="2010016B13Rik; Defcr21"
                     /note="defensin, alpha, 21"
                     /db_xref="GeneID:66298"
                     /db_xref="MGI:MGI:1913548"
     exon            1..215
                     /gene="Defa21"
                     /gene_synonym="2010016B13Rik; Defcr21"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..325
                     /gene="Defa21"
                     /gene_synonym="2010016B13Rik; Defcr21"
                     /note="alpha-defensin 21; defensin-related cryptdin-21"
                     /codon_start=1
                     /product="alpha-defensin 21 precursor"
                     /protein_id="NP_899076.1"
                     /db_xref="CCDS:CCDS40264.1"
                     /db_xref="GeneID:66298"
                     /db_xref="MGI:MGI:1913548"
                     /translation="MKTLVLLSALILLAYQVQTDPIQNTDEETNTEEQPGEDDQAVSV
                     SFGGQEGSALHEKLSRDLICLCRNRRCNRGELFYGTCAGPFLRCCRRRR"
     exon            216..419
                     /gene="Defa21"
                     /gene_synonym="2010016B13Rik; Defcr21"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acattgggct cctgctcacc aatcctccag gtgactccca gccatgaaga cacttgtcct
       61 cctctctgcc ctcatcctgc tggcctacca ggtccagact gatcctatcc aaaacacaga
      121 tgaagagact aatactgagg agcagccagg ggaagatgac caggctgtgt ctgtctcctt
      181 tggaggccaa gaaggatctg ctcttcatga aaaattgtcg agagatctga tctgcctttg
      241 tagaaatcgt cgctgcaata gaggagaact attttatggg acctgcgcag gacctttttt
      301 gcgctgctgc cgccgccgcc gctgagagtg cagatgacaa agatatgaca accatcagct
      361 ctgaggccac tgatgctggg gcctgatgaa cacttctcaa taaattgttt gcaatatgc
//
