LOCUS       NM_001195634             424 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus defensin, alpha, 2 (Defa2), mRNA.
ACCESSION   NM_001195634 XM_003945434
VERSION     NM_001195634.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 424)
  AUTHORS   Yu,Y., Zhang,B., Ji,P., Zuo,Z., Huang,Y., Wang,N., Liu,C., Liu,S.J.
            and Zhao,F.
  TITLE     Changes to gut amino acid transporters and microbiome associated
            with increased E/I ratio in Chd8+/- mouse model of ASD-like
            behavior
  JOURNAL   Nat Commun 13 (1), 1151 (2022)
   PUBMED   35241668
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 424)
  AUTHORS   Ji,J., Gu,Z., Li,H., Su,L. and Liu,Z.
  TITLE     Cryptdin-2 predicts intestinal injury during heatstroke in mice
  JOURNAL   Int J Mol Med 41 (1), 137-146 (2018)
   PUBMED   29115396
  REMARK    GeneRIF: Ulinastatin protected the intestines from heat
            stress-induced injury and downregulated the expression of Cry-2,
            which was also correlated with the extent of intestinal injury.
            Therefore, ulinastatin administration may be beneficial for
            patients with heatstroke, and Cry-2 may be a novel predictor of
            heat stress-induced intestinal injury.
REFERENCE   3  (bases 1 to 424)
  AUTHORS   Shanahan,M.T., Tanabe,H. and Ouellette,A.J.
  TITLE     Strain-specific polymorphisms in Paneth cell alpha-defensins of
            C57BL/6 mice and evidence of vestigial myeloid alpha-defensin
            pseudogenes
  JOURNAL   Infect Immun 79 (1), 459-473 (2011)
   PUBMED   21041494
REFERENCE   4  (bases 1 to 424)
  AUTHORS   Kim,B.M., Buchner,G., Miletich,I., Sharpe,P.T. and Shivdasani,R.A.
  TITLE     The stomach mesenchymal transcription factor Barx1 specifies
            gastric epithelial identity through inhibition of transient Wnt
            signaling
  JOURNAL   Dev Cell 8 (4), 611-622 (2005)
   PUBMED   15809042
REFERENCE   5  (bases 1 to 424)
  AUTHORS   Patil,A., Hughes,A.L. and Zhang,G.
  TITLE     Rapid evolution and diversification of mammalian alpha-defensins as
            revealed by comparative analysis of rodent and primate genes
  JOURNAL   Physiol Genomics 20 (1), 1-11 (2004)
   PUBMED   15494476
REFERENCE   6  (bases 1 to 424)
  AUTHORS   Ouellette,A.J., Hsieh,M.M., Nosek,M.T., Cano-Gauci,D.F.,
            Huttner,K.M., Buick,R.N. and Selsted,M.E.
  TITLE     Mouse Paneth cell defensins: primary structures and antibacterial
            activities of numerous cryptdin isoforms
  JOURNAL   Infect Immun 62 (11), 5040-5047 (1994)
   PUBMED   7927786
REFERENCE   7  (bases 1 to 424)
  AUTHORS   O'Brien,E.P., Novak,E.K., Keller,S.A., Poirier,C., Guenet,J.L. and
            Swank,R.T.
  TITLE     Molecular map of chromosome 19 including three genes affecting
            bleeding time: ep, ru, and bm
  JOURNAL   Mamm Genome 5 (6), 356-360 (1994)
   PUBMED   8043950
REFERENCE   8  (bases 1 to 424)
  AUTHORS   Ko,M.S., Wang,X., Horton,J.H., Hagen,M.D., Takahashi,N., Maezaki,Y.
            and Nadeau,J.H.
  TITLE     Genetic mapping of 40 cDNA clones on the mouse genome by PCR
  JOURNAL   Mamm Genome 5 (6), 349-355 (1994)
   PUBMED   8043949
REFERENCE   9  (bases 1 to 424)
  AUTHORS   Eisenhauer,P.B., Harwig,S.S. and Lehrer,R.I.
  TITLE     Cryptdins: antimicrobial defensins of the murine small intestine
  JOURNAL   Infect Immun 60 (9), 3556-3565 (1992)
   PUBMED   1500163
REFERENCE   10 (bases 1 to 424)
  AUTHORS   Selsted,M.E., Miller,S.I., Henschen,A.H. and Ouellette,A.J.
  TITLE     Enteric defensins: antibiotic peptide components of intestinal host
            defense
  JOURNAL   J Cell Biol 118 (4), 929-936 (1992)
   PUBMED   1500431
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK008377.1 and AK008459.1.
            
            On May 5, 2013 this sequence version replaced NM_001195634.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY708358.1, AK008377.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-303               AK008377.1         2-304
            304-424             AK008459.1         307-427
FEATURES             Location/Qualifiers
     source          1..424
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8"
     gene            1..424
                     /gene="Defa2"
                     /gene_synonym="CR2; Defcr-2; Defcr2"
                     /note="defensin, alpha, 2"
                     /db_xref="GeneID:100294660"
                     /db_xref="MGI:MGI:94882"
     exon            1..215
                     /gene="Defa2"
                     /gene_synonym="CR2; Defcr-2; Defcr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..331
                     /gene="Defa2"
                     /gene_synonym="CR2; Defcr-2; Defcr2"
                     /note="alpha-defensin, 2; defensin-related cryptdin-2;
                     cryptdin-1"
                     /codon_start=1
                     /product="alpha-defensin 2 precursor"
                     /protein_id="NP_001182563.2"
                     /db_xref="CCDS:CCDS59740.1"
                     /db_xref="GeneID:100294660"
                     /db_xref="MGI:MGI:94882"
                     /translation="MKTLVLLSALVLLAFQVQADPIQNTDEETNTEEQAGEEDQAVSV
                     SFGDPEGSALHEKSSRDLICYCRKGGCNRGEQVYGTCSGRLLFCCRRRHRH"
     exon            216..424
                     /gene="Defa2"
                     /gene_synonym="CR2; Defcr-2; Defcr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acattgggct cctgctcacc aattctccag gtgactcaca gccatgaaga cacttgtcct
       61 cctctctgcc ctcgtcctgc tggccttcca ggtccaggct gatcctatcc aaaacacaga
      121 tgaggagact aatactgagg agcaggcagg ggaggaggac caggctgtgt ctgtctcctt
      181 tggagaccca gaaggatctg ctcttcatga aaaatcgtcg agagatctga tatgctattg
      241 tagaaaagga ggctgcaata gaggagaaca agtttatggg acctgctcag gacgactttt
      301 gttctgctgc cgccgccgcc accgccactg aacatgcaga tgacagagat atgacaacca
      361 tcagctctga ggctactgat gctggggcct gataaccact tctcaataaa ttgtttgcaa
      421 tatg
//
