LOCUS       NM_001167790             411 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus defensin, alpha, 17 (Defa17), mRNA.
ACCESSION   NM_001167790 XM_006544324 XM_980537
VERSION     NM_001167790.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 411)
  AUTHORS   Amid,C., Rehaume,L.M., Brown,K.L., Gilbert,J.G., Dougan,G.,
            Hancock,R.E. and Harrow,J.L.
  TITLE     Manual annotation and analysis of the defensin gene cluster in the
            C57BL/6J mouse reference genome
  JOURNAL   BMC Genomics 10, 606 (2009)
   PUBMED   20003482
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 411)
  AUTHORS   Jia,H.P., Wowk,S.A., Schutte,B.C., Lee,S.K., Vivado,A., Tack,B.F.,
            Bevins,C.L. and McCray,P.B. Jr.
  TITLE     A novel murine beta -defensin expressed in tongue, esophagus, and
            trachea
  JOURNAL   J Biol Chem 275 (43), 33314-33320 (2000)
   PUBMED   10922379
REFERENCE   3  (bases 1 to 411)
  AUTHORS   Ouellette,A.J., Hsieh,M.M., Nosek,M.T., Cano-Gauci,D.F.,
            Huttner,K.M., Buick,R.N. and Selsted,M.E.
  TITLE     Mouse Paneth cell defensins: primary structures and antibacterial
            activities of numerous cryptdin isoforms
  JOURNAL   Infect Immun 62 (11), 5040-5047 (1994)
   PUBMED   7927786
REFERENCE   4  (bases 1 to 411)
  AUTHORS   Mancuso,G., Tomasello,F., Migliardo,M., Delfino,D., Cochran,J.,
            Cook,J.A. and Teti,G.
  TITLE     Beneficial effects of interleukin-6 in neonatal mouse models of
            group B streptococcal disease
  JOURNAL   Infect Immun 62 (11), 4997-5002 (1994)
   PUBMED   7927780
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134533.3.
            
            On or before Apr 11, 2014 this sequence version replaced
            XM_006544324.1, XM_980537.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AA869121.1, AA734252.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               AC134533.3         58218-58423
            207-411             AC134533.3         58983-59187
FEATURES             Location/Qualifiers
     source          1..411
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 10.35 cM"
     gene            1..411
                     /gene="Defa17"
                     /gene_synonym="Cryp17; Defa3; Defcr17; Defcr3"
                     /note="defensin, alpha, 17"
                     /db_xref="GeneID:23855"
                     /db_xref="MGI:MGI:1345152"
     exon            1..206
                     /gene="Defa17"
                     /gene_synonym="Cryp17; Defa3; Defcr17; Defcr3"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..316
                     /gene="Defa17"
                     /gene_synonym="Cryp17; Defa3; Defcr17; Defcr3"
                     /note="defensin-related cryptdin-17; Alpha-defensin 3;
                     alpha-defensin 17; crypt defensin 17; cryptdin 17"
                     /codon_start=1
                     /product="alpha-defensin 17 preproprotein"
                     /protein_id="NP_001161262.1"
                     /db_xref="CCDS:CCDS52513.1"
                     /db_xref="GeneID:23855"
                     /db_xref="MGI:MGI:1345152"
                     /translation="MKTLVLLSALVLLAFQVQADPIQNTDEETKTEEQPGEDDQAVSV
                     SFGDPEGSSLQEESLRDLVCYCRKRGCKRRERMNGTCRKGHLMYTLCCR"
     exon            207..411
                     /gene="Defa17"
                     /gene_synonym="Cryp17; Defa3; Defcr17; Defcr3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      391..396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Defa17"
                     /gene_synonym="Cryp17; Defa3; Defcr17; Defcr3"
                     /note="hexamer: AATAAA"
     polyA_site      411
                     /gene="Defa17"
                     /gene_synonym="Cryp17; Defa3; Defcr17; Defcr3"
                     /note="major polyA site"
ORIGIN      
        1 tcctgctcac caatcctcca ggtgactccc agccatgaag acactagtcc tcctctctgc
       61 cctcgtcctg ctggccttcc aggtccaggc tgatcctatc caaaacacag atgaagagac
      121 taaaactgag gagcagccag gggaagacga ccaggctgtg tctgtctctt ttggagaccc
      181 agaaggctct tctcttcaag aggaatcgtt gagagatctg gtatgctatt gtagaaaaag
      241 aggctgcaaa agaagagaac gcatgaatgg gacctgcaga aagggtcatt taatgtacac
      301 actctgctgt cgctgaacat ggagaccaca gaggacaaga cgaacatgag tactgaggcc
      361 actgatgctg gtgcctgatg accacctcgc aataaattgt tcgcaatatg c
//
