LOCUS       NM_001414280            3347 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus differentially expressed in FDCP 8 (Def8), transcript
            variant 5, mRNA.
ACCESSION   NM_001414280 XM_036153981
VERSION     NM_001414280.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3347)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3347)
  AUTHORS   Fujiwara,T., Ye,S., Castro-Gomes,T., Winchell,C.G., Andrews,N.W.,
            Voth,D.E., Varughese,K.I., Mackintosh,S.G., Feng,Y., Pavlos,N.,
            Nakamura,T., Manolagas,S.C. and Zhao,H.
  TITLE     PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone
            homeostasis
  JOURNAL   JCI Insight 1 (17), e86330 (2016)
   PUBMED   27777970
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3347)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   4  (bases 1 to 3347)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   5  (bases 1 to 3347)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   6  (bases 1 to 3347)
  AUTHORS   Kremmidiotis,G., Gardner,A.E., Settasatian,C., Savoia,A.,
            Sutherland,G.R. and Callen,D.F.
  TITLE     Molecular and functional analyses of the human and mouse genes
            encoding AFG3L1, a mitochondrial metalloprotease homologous to the
            human spastic paraplegia protein
  JOURNAL   Genomics 76 (1-3), 58-65 (2001)
   PUBMED   11549317
REFERENCE   7  (bases 1 to 3347)
  AUTHORS   Hotfilder,M., Baxendale,S., Cross,M.A. and Sablitzky,F.
  TITLE     Def-2, -3, -6 and -8, novel mouse genes differentially expressed in
            the haemopoietic system
  JOURNAL   Br J Haematol 106 (2), 335-344 (1999)
   PUBMED   10460589
  REMARK    GeneRIF: def8 was first identified in a retroviral gene-trap screen
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122266.2.
            
            On Nov 17, 2022 this sequence version replaced XM_036153981.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422598.832070.1,
                                           SRR13422600.61695.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               AC122266.2         162196-162347
            153-239             AC122266.2         165000-165086
            240-286             AC122266.2         166219-166265
            287-411             AC122266.2         166690-166814
            412-509             AC122266.2         168203-168300
            510-659             AC122266.2         171647-171796
            660-801             AC122266.2         173131-173272
            802-966             AC122266.2         174316-174480
            967-1094            AC122266.2         175308-175435
            1095-1208           AC122266.2         175573-175686
            1209-1289           AC122266.2         177253-177333
            1290-1430           AC122266.2         178419-178559
            1431-1540           AC122266.2         178719-178828
            1541-3347           AC122266.2         180366-182172
FEATURES             Location/Qualifiers
     source          1..3347
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 72.1 cM"
     gene            1..3347
                     /gene="Def8"
                     /gene_synonym="D8Ertd713e; DEF-8"
                     /note="differentially expressed in FDCP 8"
                     /db_xref="GeneID:23854"
                     /db_xref="MGI:MGI:1346331"
     exon            1..152
                     /gene="Def8"
                     /gene_synonym="D8Ertd713e; DEF-8"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..1643
                     /gene="Def8"
                     /gene_synonym="D8Ertd713e; DEF-8"
                     /note="isoform 4 is encoded by transcript variant 5"
                     /codon_start=1
                     /product="differentially expressed in FDCP 8 isoform 4"
                     /protein_id="NP_001401209.1"
                     /db_xref="GeneID:23854"
                     /db_xref="MGI:MGI:1346331"
                     /translation="MKWDIVTLPCLGAGQSGKSRDKSDALLMQGERGTSQVRGQEGRS
                     SSKRWDAMEYDEKLVRFRQAHLNPFNKQLGPRHHEQEPSEKVTSEDTLPELPAGEPEF
                     HYSERMMDLGLSEDHFSRPVGLFLASDVQQLRQAIEECKQVILELPEQSEKQKDAVVR
                     LIHLRLKLQELKDPNEEEPNIRVLLEHRFYKEKSKSVKQTCDKCNTIIWGLIQTWYTC
                     TGCCYRCHSKCLNLISKPCVSSKVSHQAEYELNICPETGLDSQDYRCAECRAPISLRG
                     VPSEARQCDYTGQYYCSHCHWNDLAVIPARVVHNWDFEPRKVSRCSMRYLALMVSRPV
                     LRLREINPLLFNYVEELVEIRKLRQDILLMKPYFITCKEAMEARLLLQLQDRQHFVEN
                     DEMYSIQDLLEVHMGRLSCSLTEIHTLFAKHIKLDCERCQAKGFVCELCKEGDVLFPF
                     DSHTSVCNDCSAVFHRDCYYDNSTTCPKCARLTLRKQSLFQEPGLDMDA"
     exon            153..239
                     /gene="Def8"
                     /gene_synonym="D8Ertd713e; DEF-8"
                     /inference="alignment:Splign:2.1.0"
     exon            240..286
                     /gene="Def8"
                     /gene_synonym="D8Ertd713e; DEF-8"
                     /inference="alignment:Splign:2.1.0"
     exon            287..411
                     /gene="Def8"
                     /gene_synonym="D8Ertd713e; DEF-8"
                     /inference="alignment:Splign:2.1.0"
     exon            412..509
                     /gene="Def8"
                     /gene_synonym="D8Ertd713e; DEF-8"
                     /inference="alignment:Splign:2.1.0"
     exon            510..659
                     /gene="Def8"
                     /gene_synonym="D8Ertd713e; DEF-8"
                     /inference="alignment:Splign:2.1.0"
     exon            660..801
                     /gene="Def8"
                     /gene_synonym="D8Ertd713e; DEF-8"
                     /inference="alignment:Splign:2.1.0"
     exon            802..966
                     /gene="Def8"
                     /gene_synonym="D8Ertd713e; DEF-8"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1094
                     /gene="Def8"
                     /gene_synonym="D8Ertd713e; DEF-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1208
                     /gene="Def8"
                     /gene_synonym="D8Ertd713e; DEF-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1289
                     /gene="Def8"
                     /gene_synonym="D8Ertd713e; DEF-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1430
                     /gene="Def8"
                     /gene_synonym="D8Ertd713e; DEF-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1540
                     /gene="Def8"
                     /gene_synonym="D8Ertd713e; DEF-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..3347
                     /gene="Def8"
                     /gene_synonym="D8Ertd713e; DEF-8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3323..3328
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Def8"
                     /gene_synonym="D8Ertd713e; DEF-8"
                     /note="hexamer: TATAAA"
     polyA_site      3347
                     /gene="Def8"
                     /gene_synonym="D8Ertd713e; DEF-8"
                     /note="major polyA site"
ORIGIN      
        1 agagcttagc gtccacagat gccgaccccc acccccaatc accgggtggc ttcagagcct
       61 gagtatggga ctcccggccc aaggacccgc agggactcgc cttctgctat gttgagcttt
      121 tctgagcctt cggtttcaca actatgaaat gggacatagt cacattacca tgcctaggtg
      181 cagggcagtc tgggaagtca cgtgacaaga gtgatgccct cctcatgcag ggtgaaaggg
      241 gaacatctca agtaagggga caggaaggaa gatccagttc caagaggtgg gatgctatgg
      301 aatatgatga gaagctggtt cggttccggc aggcccacct caaccccttc aacaagcagc
      361 ttggtccgag gcatcatgaa caggaaccca gtgagaaggt cacttctgaa gacactttgc
      421 ctgagctgcc cgctggggag cctgaattcc actactcgga gcgcatgatg gatctcggcc
      481 tgtctgagga ccacttttcc cgccctgtgg gtctcttcct ggcctctgat gtccagcagc
      541 tgcggcaggc catcgaagaa tgcaaacagg tgatcctgga gctgcccgag cagtcagaga
      601 agcagaagga cgctgtggtg cggctgatcc acctccggct gaagctccag gagctgaagg
      661 accccaatga ggaggaaccc aacatccggg ttctcctgga acatcgcttc tacaaggaga
      721 agagcaagag cgttaaacag acctgcgata agtgcaacac catcatctgg gggctcatcc
      781 agacctggta cacctgcaca gggtgttgtt accgctgtca cagcaagtgc ctgaacctca
      841 tctccaaacc atgtgtcagc tccaaggtca gtcaccaggc tgagtatgag ctgaacatct
      901 gccctgagac cgggctggac agccaggact accgctgtgc ggagtgccgt gctcccatct
      961 ctctgagagg tgtgcctagt gaggcccggc agtgtgacta cacgggccaa tactactgca
     1021 gccactgcca ctggaacgac ctggctgtca tccccgcgag agtggtgcac aactgggact
     1081 ttgagccacg caaggtgtcc cgttgcagca tgcgctacct ggcactgatg gtgtctcggc
     1141 cagtgctccg gctccgggag attaaccctt tgctgtttaa ctacgtggaa gagctggtgg
     1201 agatccggaa actgcgccag gacatcctgc tcatgaagcc atacttcatc acctgcaagg
     1261 aggccatgga ggcgcgacta ctgctgcagc tccaagacag acagcatttt gtggagaacg
     1321 atgagatgta ctctatccag gacctcttgg aagtgcacat gggccgcctc agctgctcgc
     1381 tcactgagat ccacacgctc ttcgccaagc acatcaagtt ggactgtgag cggtgccaag
     1441 ccaaggggtt cgtctgtgaa ctctgcaaag aaggggacgt gctcttcccg ttcgacagcc
     1501 acacgtctgt gtgcaatgac tgttcggctg tcttccacag ggactgttac tacgacaact
     1561 cgaccacgtg ccccaagtgt gcccggctca cattgaggaa gcagtcacta ttccaggaac
     1621 ctggcctaga catggatgcc tagaacactg gagaacgcca ggcaccgtat ccacccctcc
     1681 ggctggtgcc tgctggcctt gcccaccaga tgtgcattct actctggaga cgaccccccc
     1741 ccccccagta tatcctccag acctcttcgt ctcgggccag aaggaagtga ctagtggcca
     1801 ccgggactca ttcctcaggt gcttgtggag acttcgagtg tgtatacctg gctgttgatt
     1861 gggtgtgctg ctatcggggg gtcaaaatac tgcctgtgcc ccattgtagg actccttagg
     1921 cagaggagcc tgggtgtgac tctccaggaa ggtgggggag tcgctctctt atggcacaga
     1981 gccctccagg cctttaaaac caatccttct gcaccataga gatggccttg ctcctgtcta
     2041 gtacaccctt acaactggtc agaaacttga gaggccagtc cagtaagacc agaggatgcc
     2101 tcctgactga gttttatctc tgctgaggaa gatttaggtt ctactcagag gcacccaacc
     2161 cttttagcac cttgtctcct gagggacgtc cggttttctc tgactggggc tgttcactac
     2221 tgtgtcccgt ggatcttccc ctgcatcctg agagttgtca tcgtcatcct taatctgtca
     2281 gtcacgtgtg cttccccacc cccctttgta caatagggag ggaaggggtc tgtggaactt
     2341 ctcttggcag atacgcctgc ttctgccaca gcctagtcca ctttatcctg gtgctctgag
     2401 ccgggcagct aggaacccac cctaaagagg cttagcatcc agttccatag gtgggactgt
     2461 gtccggggag gaggttctag gtcaggtgag cctgtcagtt atcattggcc tcggtggcat
     2521 tcgggggatg aagcttttcc acagaggtca ctgtcctgct gacgcagtgc actgcttgaa
     2581 gatgaccagt cgctgggtgt taacgtagga gcctgaggtc aagagctagg aatatttgct
     2641 agacccccag caggaggccc acggcccata caggaaggtc taagttttga aggtgggtgg
     2701 ggcctacacc tttccacctc catgcacaca ccccataaat cctacgatgg aagatgtgtg
     2761 gagacgaggg gaatctcaca ataatgtggc tcctgtcttt cttcctggga ggcaggagtt
     2821 ggttgtgtct gcccctttgc tccttgtctg tgaattgctg ttgacacaca caactagtgg
     2881 gcaaaggcca gggcatgtca caacctggat ttccttcacc tttaatgagg cacaagaagg
     2941 gacttctcaa ctggccagtt gaagcttagc ttactggcgt gtttggggga aggacggaca
     3001 cactgccacc tcctcctcac tgctctttgc catcaggtgg ctttactcat gctgtttttc
     3061 tgtttcagtt ttcccatctg gaaagcattg gggaggggga gttgacctgc ctcagggtga
     3121 aagatcagga gtcctttgag tgtgatgtgg gtcaacaatg ggtccctgtt ccgcttcctc
     3181 tttggcgtta aagagggtct taaaaccaaa tgccatttcc cataccccca aatctgtgtg
     3241 tttcctgcca ttgtatcaca tgtctgtcct gagtccttgg cccttcttga gcctcctgtg
     3301 taatcaacat cacgtttcca actataaatc atagtgtcta aaggaaa
//
