LOCUS       NM_027185               2294 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus differentially expressed in FDCP 6 (Def6), mRNA.
ACCESSION   NM_027185
VERSION     NM_027185.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2294)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2294)
  AUTHORS   Chen,Z., Flores Castro,D., Gupta,S., Phalke,S., Manni,M.,
            Rivera-Correa,J., Jessberger,R., Zaghouani,H., Giannopoulou,E.,
            Pannellini,T. and Pernis,A.B.
  TITLE     Interleukin-13 Receptor alpha1-Mediated Signaling Regulates
            Age-Associated/Autoimmune B Cell Expansion and Lupus Pathogenesis
  JOURNAL   Arthritis Rheumatol 74 (9), 1544-1555 (2022)
   PUBMED   35438841
REFERENCE   3  (bases 1 to 2294)
  AUTHORS   Ricker,E., Manni,M., Flores-Castro,D., Jenkins,D., Gupta,S.,
            Rivera-Correa,J., Meng,W., Rosenfeld,A.M., Pannellini,T., Bachu,M.,
            Chinenov,Y., Sculco,P.K., Jessberger,R., Prak,E.T.L. and
            Pernis,A.B.
  TITLE     Altered function and differentiation of age-associated B cells
            contribute to the female bias in lupus mice
  JOURNAL   Nat Commun 12 (1), 4813 (2021)
   PUBMED   34376664
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2294)
  AUTHORS   Deng,Z., Ng,C., Inoue,K., Chen,Z., Xia,Y., Hu,X., Greenblatt,M.,
            Pernis,A. and Zhao,B.
  TITLE     Def6 regulates endogenous type-I interferon responses in
            osteoblasts and suppresses osteogenesis
  JOURNAL   Elife 9, e59659 (2020)
   PUBMED   33373293
  REMARK    GeneRIF: Def6 regulates endogenous type-I interferon responses in
            osteoblasts and suppresses osteogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2294)
  AUTHORS   Popovic,J., Wellstein,I., Pernis,A., Jessberger,R. and
            Ocana-Morgner,C.
  TITLE     Control of GM-CSF-Dependent Dendritic Cell Differentiation and
            Maturation by DEF6 and SWAP-70
  JOURNAL   J Immunol 205 (5), 1306-1317 (2020)
   PUBMED   32709659
REFERENCE   6  (bases 1 to 2294)
  AUTHORS   Samson,T., Will,C., Knoblauch,A., Sharek,L., von der Mark,K.,
            Burridge,K. and Wixler,V.
  TITLE     Def-6, a guanine nucleotide exchange factor for Rac1, interacts
            with the skeletal muscle integrin chain alpha7A and influences
            myoblast differentiation
  JOURNAL   J Biol Chem 282 (21), 15730-15742 (2007)
   PUBMED   17403664
REFERENCE   7  (bases 1 to 2294)
  AUTHORS   Fanzo,J.C., Yang,W., Jang,S.Y., Gupta,S., Chen,Q., Siddiq,A.,
            Greenberg,S. and Pernis,A.B.
  TITLE     Loss of IRF-4-binding protein leads to the spontaneous development
            of systemic autoimmunity
  JOURNAL   J Clin Invest 116 (3), 703-714 (2006)
   PUBMED   16470246
REFERENCE   8  (bases 1 to 2294)
  AUTHORS   Gupta,S., Lee,A., Hu,C., Fanzo,J., Goldberg,I., Cattoretti,G. and
            Pernis,A.B.
  TITLE     Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly
            expressed in the immune system
  JOURNAL   Hum Immunol 64 (4), 389-401 (2003)
   PUBMED   12651066
REFERENCE   9  (bases 1 to 2294)
  AUTHORS   Tanaka,Y., Bi,K., Kitamura,R., Hong,S., Altman,Y., Matsumoto,A.,
            Tabata,H., Lebedeva,S., Bushway,P.J. and Altman,A.
  TITLE     SWAP-70-like adapter of T cells, an adapter protein that regulates
            early TCR-initiated signaling in Th2 lineage cells
  JOURNAL   Immunity 18 (3), 403-414 (2003)
   PUBMED   12648457
  REMARK    GeneRIF: plays a role in Th2 development and/or activation, perhaps
            by interfering with ZAP-70 signaling
REFERENCE   10 (bases 1 to 2294)
  AUTHORS   Hotfilder,M., Baxendale,S., Cross,M.A. and Sablitzky,F.
  TITLE     Def-2, -3, -6 and -8, novel mouse genes differentially expressed in
            the haemopoietic system
  JOURNAL   Br J Haematol 106 (2), 335-344 (1999)
   PUBMED   10460589
  REMARK    GeneRIF: def6 was first identified in a retroviral gene-trap screen
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC120500.1 and BE943894.1.
            
            On Aug 5, 2009 this sequence version replaced NM_027185.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC120500.1, AK038050.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1981              BC120500.1         1-1981
            1982-2294           BE943894.1         1-313               c
FEATURES             Location/Qualifiers
     source          1..2294
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 14.64 cM"
     gene            1..2294
                     /gene="Def6"
                     /gene_synonym="2410003F05Rik; 6430538D02Rik; Ibp; Slat;
                     Slat2; Slat6"
                     /note="differentially expressed in FDCP 6"
                     /db_xref="GeneID:23853"
                     /db_xref="MGI:MGI:1346328"
     exon            1..161
                     /gene="Def6"
                     /gene_synonym="2410003F05Rik; 6430538D02Rik; Ibp; Slat;
                     Slat2; Slat6"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1958
                     /gene="Def6"
                     /gene_synonym="2410003F05Rik; 6430538D02Rik; Ibp; Slat;
                     Slat2; Slat6"
                     /note="SWAP-70-like adapter of T-cells; DEF-6;
                     IRF4-binding protein; IRF-4-binding protein"
                     /codon_start=1
                     /product="differentially expressed in FDCP 6"
                     /protein_id="NP_081461.2"
                     /db_xref="CCDS:CCDS28574.1"
                     /db_xref="GeneID:23853"
                     /db_xref="MGI:MGI:1346328"
                     /translation="MALRKELLKSIWYAFTALDVEKSGKVSKSQLKVLSHNLYTVLNI
                     PHDPVALEEHFRDDDDGPVSSQGYMPYLNKYILDKVEEGAFVKEHFDELCWTLTAKKN
                     YRADGIGSSPLSNQDAFRLWCLFNFLSEDKYPLIMVPDEVEYLLKKLLGSLSLEMGLG
                     KLEELLAQDAQSAQTAVGLSVWQFLELFNSGRCLRGVGRDSLSMAIQEVYQELIQDVL
                     KQGYLWKRGHLRRNWAERWFQLQPSSLCYFGSEECKEKRGTIPLDAHCCVEVLPDREG
                     KRCMFCVKTASRTYEMSASDTRQRQEWTAAIQTAIRLQAEGKTSLHKDLKQKRREQRE
                     QRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHKEL
                     QQALEGQLREAEQARASMQAEMELKKEEAARQRQRIAELEEMQERLQEALQLEVKARR
                     DEEAVRLAQTRLLEEEEEKLKQLMHLKEEQERYIERAQQEKQELQQEMALQSRSLQHA
                     QQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLMHPIEPGDKRPTTSSS
                     FTGFQPPPLARRDSSLKRLTRWGSQGNRTLSVNSSEQKSLNGGDETPILALASQEEKL
                     DPAPGN"
     exon            162..302
                     /gene="Def6"
                     /gene_synonym="2410003F05Rik; 6430538D02Rik; Ibp; Slat;
                     Slat2; Slat6"
                     /inference="alignment:Splign:2.1.0"
     exon            303..488
                     /gene="Def6"
                     /gene_synonym="2410003F05Rik; 6430538D02Rik; Ibp; Slat;
                     Slat2; Slat6"
                     /inference="alignment:Splign:2.1.0"
     exon            489..725
                     /gene="Def6"
                     /gene_synonym="2410003F05Rik; 6430538D02Rik; Ibp; Slat;
                     Slat2; Slat6"
                     /inference="alignment:Splign:2.1.0"
     exon            726..872
                     /gene="Def6"
                     /gene_synonym="2410003F05Rik; 6430538D02Rik; Ibp; Slat;
                     Slat2; Slat6"
                     /inference="alignment:Splign:2.1.0"
     exon            873..981
                     /gene="Def6"
                     /gene_synonym="2410003F05Rik; 6430538D02Rik; Ibp; Slat;
                     Slat2; Slat6"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1280
                     /gene="Def6"
                     /gene_synonym="2410003F05Rik; 6430538D02Rik; Ibp; Slat;
                     Slat2; Slat6"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1447
                     /gene="Def6"
                     /gene_synonym="2410003F05Rik; 6430538D02Rik; Ibp; Slat;
                     Slat2; Slat6"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1646
                     /gene="Def6"
                     /gene_synonym="2410003F05Rik; 6430538D02Rik; Ibp; Slat;
                     Slat2; Slat6"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1737
                     /gene="Def6"
                     /gene_synonym="2410003F05Rik; 6430538D02Rik; Ibp; Slat;
                     Slat2; Slat6"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..2277
                     /gene="Def6"
                     /gene_synonym="2410003F05Rik; 6430538D02Rik; Ibp; Slat;
                     Slat2; Slat6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2251..2256
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Def6"
                     /gene_synonym="2410003F05Rik; 6430538D02Rik; Ibp; Slat;
                     Slat2; Slat6"
                     /note="hexamer: AATAAA"
     polyA_site      2272
                     /gene="Def6"
                     /gene_synonym="2410003F05Rik; 6430538D02Rik; Ibp; Slat;
                     Slat2; Slat6"
                     /note="major polyA site"
ORIGIN      
        1 ttgcatttcc tgaaaccgga tcttggtgtc agagccgccc ctgggccggg gcgggcgcct
       61 cagccatggc cctgcgcaag gagctgctca agtctatctg gtacgccttc actgcactgg
      121 acgtggagaa gagcggcaag gtctccaagt cccaactcaa ggtgctgtcc cacaacctgt
      181 acactgtcct gaacatcccc catgaccccg tggccctgga ggagcacttc cgggatgacg
      241 atgatggccc ggtgtccagt caaggttaca tgccctacct caacaagtac atcctagaca
      301 aggtggagga gggagctttc gttaaggagc acttcgatga gttgtgctgg accctgactg
      361 ccaagaagaa ctacagggca gatggcatcg ggagcagccc actctctaat caggatgctt
      421 tccgtctatg gtgcctcttc aacttcctgt ctgaggacaa gtacccgctg atcatggttc
      481 ccgatgaggt agagtatctg ctgaagaagc tccttggcag cctgagtttg gagatgggcc
      541 tgggcaagct ggaggagctg ctggcccagg acgcccagtc agcccagacc gccgtggggc
      601 tcagcgtctg gcagtttctg gaactcttca actcaggccg ctgccttcgg ggtgtggggc
      661 gcgactccct cagcatggcc atccaagaag tctaccagga gctcatccaa gacgtcctga
      721 agcagggcta tctgtggaag cgagggcacc tgcggaggaa ctgggccgag cgctggttcc
      781 agctgcaacc cagcagcctc tgctactttg ggagtgagga atgcaaggag aaacgaggca
      841 ccattcccct ggatgctcac tgctgtgtgg aggtgcttcc ggaccgcgaa ggaaagcgct
      901 gcatgttttg tgtgaagact gccagccgca cctatgagat gagcgcctca gacacccgcc
      961 agcgccagga gtggacggcc gccatccaga ctgcgatccg gctgcaggcg gaggggaaga
     1021 cgtcgctgca caaggacctg aaacagaagc ggcgggagca gcgggaacag cgcgagcgac
     1081 gccgggcagc caaggaggag gagctgctgc gactgcagca gctgcaggag gagaaggaga
     1141 ggaagctgca agaactggag ctgctgcagg aggctcagcg gcaggccgag cggctgctgc
     1201 aggaagagga ggagcgccgc cgtagccagc acaaggagct gcagcaggct ctggagggcc
     1261 agctgcggga ggcggagcag gcccgggcct ctatgcaggc tgagatggag ctgaagaagg
     1321 aagaggcggc ccggcaacgg cagcgcatcg ctgaactgga ggagatgcag gagcggctgc
     1381 aggaagctct gcaactagag gtgaaagcta ggcgggatga ggaggccgtg cgcctcgccc
     1441 agaccaggct gctggaggag gaggaggaga agctgaagca gctgatgcat ctgaaggagg
     1501 agcaagagcg ctacatcgag cgagcgcagc aggagaagca ggagctccag caggagatgg
     1561 cgctgcagag ccgttccctg cagcacgccc agcagcagct ggaggaagtg cggcagaacc
     1621 ggcagagggc agacgaggac gtggaggctg cccagaggaa gttgcgccag gccagcacca
     1681 acgtgaaaca ctggaatgtc cagatgaaca ggctcatgca tccgatcgag ccaggagata
     1741 agcgacccac caccagcagc tccttcacgg gcttccagcc ccctccgctt gcccgccggg
     1801 actcctctct aaagcgcctg acccgctggg gttcccaagg taacagaacc ctctcagtca
     1861 atagcagcga acagaagtcc ctcaatggtg gagatgagac tcccatccta gctttggcct
     1921 ctcaggaaga aaaactggat ccagcaccag ggaattagct ccgaccaccc ccttgttctt
     1981 ccgatgctgt gtctacggac ttggccacag caggcctgtg ggtgattcct ggtgctacca
     2041 cctgccgacc aaaagccgat caaggattga acttggttgc cattctcagc aggccgagac
     2101 cgtggaggct gtttgagata ttaatacttg agaatatggt tgtgtgcttc agtctcaagg
     2161 atctgggacc agaactggga aagaaaagga atgaccaaga caagatcata cgcccctccc
     2221 tccagaccaa gttatggaga catacttcca aataaaactg ctcacaactg cccactgaaa
     2281 aaaaaaaaaa aaaa
//
