LOCUS       NP_081461                630 aa            linear   ROD 30-APR-2024
DEFINITION  differentially expressed in FDCP 6 [Mus musculus].
ACCESSION   NP_081461
VERSION     NP_081461.2
DBSOURCE    REFSEQ: accession NM_027185.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 630)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 630)
  AUTHORS   Chen,Z., Flores Castro,D., Gupta,S., Phalke,S., Manni,M.,
            Rivera-Correa,J., Jessberger,R., Zaghouani,H., Giannopoulou,E.,
            Pannellini,T. and Pernis,A.B.
  TITLE     Interleukin-13 Receptor alpha1-Mediated Signaling Regulates
            Age-Associated/Autoimmune B Cell Expansion and Lupus Pathogenesis
  JOURNAL   Arthritis Rheumatol 74 (9), 1544-1555 (2022)
   PUBMED   35438841
REFERENCE   3  (residues 1 to 630)
  AUTHORS   Ricker,E., Manni,M., Flores-Castro,D., Jenkins,D., Gupta,S.,
            Rivera-Correa,J., Meng,W., Rosenfeld,A.M., Pannellini,T., Bachu,M.,
            Chinenov,Y., Sculco,P.K., Jessberger,R., Prak,E.T.L. and
            Pernis,A.B.
  TITLE     Altered function and differentiation of age-associated B cells
            contribute to the female bias in lupus mice
  JOURNAL   Nat Commun 12 (1), 4813 (2021)
   PUBMED   34376664
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 630)
  AUTHORS   Deng,Z., Ng,C., Inoue,K., Chen,Z., Xia,Y., Hu,X., Greenblatt,M.,
            Pernis,A. and Zhao,B.
  TITLE     Def6 regulates endogenous type-I interferon responses in
            osteoblasts and suppresses osteogenesis
  JOURNAL   Elife 9, e59659 (2020)
   PUBMED   33373293
  REMARK    GeneRIF: Def6 regulates endogenous type-I interferon responses in
            osteoblasts and suppresses osteogenesis.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 630)
  AUTHORS   Popovic,J., Wellstein,I., Pernis,A., Jessberger,R. and
            Ocana-Morgner,C.
  TITLE     Control of GM-CSF-Dependent Dendritic Cell Differentiation and
            Maturation by DEF6 and SWAP-70
  JOURNAL   J Immunol 205 (5), 1306-1317 (2020)
   PUBMED   32709659
REFERENCE   6  (residues 1 to 630)
  AUTHORS   Samson,T., Will,C., Knoblauch,A., Sharek,L., von der Mark,K.,
            Burridge,K. and Wixler,V.
  TITLE     Def-6, a guanine nucleotide exchange factor for Rac1, interacts
            with the skeletal muscle integrin chain alpha7A and influences
            myoblast differentiation
  JOURNAL   J Biol Chem 282 (21), 15730-15742 (2007)
   PUBMED   17403664
REFERENCE   7  (residues 1 to 630)
  AUTHORS   Fanzo,J.C., Yang,W., Jang,S.Y., Gupta,S., Chen,Q., Siddiq,A.,
            Greenberg,S. and Pernis,A.B.
  TITLE     Loss of IRF-4-binding protein leads to the spontaneous development
            of systemic autoimmunity
  JOURNAL   J Clin Invest 116 (3), 703-714 (2006)
   PUBMED   16470246
REFERENCE   8  (residues 1 to 630)
  AUTHORS   Gupta,S., Lee,A., Hu,C., Fanzo,J., Goldberg,I., Cattoretti,G. and
            Pernis,A.B.
  TITLE     Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly
            expressed in the immune system
  JOURNAL   Hum Immunol 64 (4), 389-401 (2003)
   PUBMED   12651066
REFERENCE   9  (residues 1 to 630)
  AUTHORS   Tanaka,Y., Bi,K., Kitamura,R., Hong,S., Altman,Y., Matsumoto,A.,
            Tabata,H., Lebedeva,S., Bushway,P.J. and Altman,A.
  TITLE     SWAP-70-like adapter of T cells, an adapter protein that regulates
            early TCR-initiated signaling in Th2 lineage cells
  JOURNAL   Immunity 18 (3), 403-414 (2003)
   PUBMED   12648457
  REMARK    GeneRIF: plays a role in Th2 development and/or activation, perhaps
            by interfering with ZAP-70 signaling
REFERENCE   10 (residues 1 to 630)
  AUTHORS   Hotfilder,M., Baxendale,S., Cross,M.A. and Sablitzky,F.
  TITLE     Def-2, -3, -6 and -8, novel mouse genes differentially expressed in
            the haemopoietic system
  JOURNAL   Br J Haematol 106 (2), 335-344 (1999)
   PUBMED   10460589
  REMARK    GeneRIF: def6 was first identified in a retroviral gene-trap screen
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC120500.1 and BE943894.1.
            
            On Aug 5, 2009 this sequence version replaced NP_081461.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC120500.1, AK038050.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..630
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 14.64 cM"
     Protein         1..630
                     /product="differentially expressed in FDCP 6"
                     /note="SWAP-70-like adapter of T-cells; DEF-6;
                     IRF4-binding protein; IRF-4-binding protein"
                     /calculated_mol_wt=73322
     Region          210..319
                     /region_name="PH_SWAP-70"
                     /note="Switch-associated protein-70 Pleckstrin homology
                     (PH) domain; cd13273"
                     /db_xref="CDD:270092"
     Site            210
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4E7; propagated from
                     UniProtKB/Swiss-Prot (Q8C2K1.1)"
     Site            225
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4E7; propagated from
                     UniProtKB/Swiss-Prot (Q8C2K1.1)"
     Region          <296..>536
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          318..341
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C2K1.1)"
     Region          378..418
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C2K1.1)"
     Region          552..630
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C2K1.1)"
     Site            590
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4E7; propagated from
                     UniProtKB/Swiss-Prot (Q8C2K1.1)"
     CDS             1..630
                     /gene="Def6"
                     /gene_synonym="2410003F05Rik; 6430538D02Rik; Ibp; Slat;
                     Slat2; Slat6"
                     /coded_by="NM_027185.3:66..1958"
                     /db_xref="CCDS:CCDS28574.1"
                     /db_xref="GeneID:23853"
                     /db_xref="MGI:MGI:1346328"
ORIGIN      
        1 malrkellks iwyaftaldv eksgkvsksq lkvlshnlyt vlniphdpva leehfrdddd
       61 gpvssqgymp ylnkyildkv eegafvkehf delcwtltak knyradgigs splsnqdafr
      121 lwclfnflse dkyplimvpd eveyllkkll gslslemglg kleellaqda qsaqtavgls
      181 vwqflelfns grclrgvgrd slsmaiqevy qeliqdvlkq gylwkrghlr rnwaerwfql
      241 qpsslcyfgs eeckekrgti pldahccvev lpdregkrcm fcvktasrty emsasdtrqr
      301 qewtaaiqta irlqaegkts lhkdlkqkrr eqreqrerrr aakeeellrl qqlqeekerk
      361 lqelellqea qrqaerllqe eeerrrsqhk elqqalegql reaeqarasm qaemelkkee
      421 aarqrqriae leemqerlqe alqlevkarr deeavrlaqt rlleeeeekl kqlmhlkeeq
      481 eryieraqqe kqelqqemal qsrslqhaqq qleevrqnrq radedveaaq rklrqastnv
      541 khwnvqmnrl mhpiepgdkr pttsssftgf qppplarrds slkrltrwgs qgnrtlsvns
      601 seqkslnggd etpilalasq eekldpapgn
//
