LOCUS       NM_207677               1828 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus death effector domain-containing DNA binding protein 2
            (Dedd2), mRNA.
ACCESSION   NM_207677 XM_001052058 XM_001052059 XM_001052060
VERSION     NM_207677.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1828)
  AUTHORS   Barnhart,B.C., Lee,J.C., Alappat,E.C. and Peter,M.E.
  TITLE     The death effector domain protein family
  JOURNAL   Oncogene 22 (53), 8634-8644 (2003)
   PUBMED   14634625
REFERENCE   2  (bases 1 to 1828)
  AUTHORS   Reed,J.C., Doctor,K., Rojas,A., Zapata,J.M., Stehlik,C.,
            Fiorentino,L., Damiano,J., Roth,W., Matsuzawa,S., Newman,R.,
            Takayama,S., Marusawa,H., Xu,F., Salvesen,G. and Godzik,A.
  CONSRTM   RIKEN GER Group; GSL Members
  TITLE     Comparative analysis of apoptosis and inflammation genes of mice
            and humans
  JOURNAL   Genome Res 13 (6B), 1376-1388 (2003)
   PUBMED   12819136
REFERENCE   3  (bases 1 to 1828)
  AUTHORS   Alcivar,A., Hu,S., Tang,J. and Yang,X.
  TITLE     DEDD and DEDD2 associate with caspase-8/10 and signal cell death
  JOURNAL   Oncogene 22 (2), 291-297 (2003)
   PUBMED   12527898
REFERENCE   4  (bases 1 to 1828)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   5  (bases 1 to 1828)
  AUTHORS   Zhan,Y., Hegde,R., Srinivasula,S.M., Fernandes-Alnemri,T. and
            Alnemri,E.S.
  TITLE     Death effector domain-containing proteins DEDD and FLAME-3 form
            nuclear complexes with the TFIIIC102 subunit of human transcription
            factor IIIC
  JOURNAL   Cell Death Differ 9 (4), 439-447 (2002)
   PUBMED   11965497
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC092250.1.
            
            On Sep 22, 2006 this sequence version replaced NM_207677.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092250.1, SRR7345562.1676239.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1828              BC092250.1         1-1828
FEATURES             Location/Qualifiers
     source          1..1828
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 13.73 cM"
     gene            1..1828
                     /gene="Dedd2"
                     /gene_synonym="2410050E11Rik; FLAME-3"
                     /note="death effector domain-containing DNA binding
                     protein 2"
                     /db_xref="GeneID:67379"
                     /db_xref="MGI:MGI:1914629"
     exon            1..96
                     /gene="Dedd2"
                     /gene_synonym="2410050E11Rik; FLAME-3"
                     /inference="alignment:Splign:2.1.0"
     exon            97..463
                     /gene="Dedd2"
                     /gene_synonym="2410050E11Rik; FLAME-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..1128
                     /gene="Dedd2"
                     /gene_synonym="2410050E11Rik; FLAME-3"
                     /note="DED-containing protein FLAME-3; FADD-like
                     anti-apoptotic molecule 3"
                     /codon_start=1
                     /product="DNA-binding death effector domain-containing
                     protein 2"
                     /protein_id="NP_997560.3"
                     /db_xref="CCDS:CCDS20973.1"
                     /db_xref="GeneID:67379"
                     /db_xref="MGI:MGI:1914629"
                     /translation="MALSGSTPAPSWEEDECLDYYGMLSLHRMFEVVGGQLTECELEL
                     LAFLLDEAPGAPGGLARARSGLELLLELERRGQCDESNLRLLSQLLRVLARHDLLPHL
                     ARKRRRPVSPERYSYGNPSSSSKRTEDSCRRRRQASSSSDSPQSQWDTGSPPTKRQRR
                     SRGRPSSGARQRRRAGLAASQQHQQHQELGRPSSEGKVTCDIRLRVRAEYCEHGPALE
                     QGVASRRPQALARQLDVFGQATAVLRSRDLGSVVCDIKFSELSYLDAFWGDYLSGALL
                     QALRGVFLTEALREAVGREAVRLLVSVDEADYEAGRRRLLLMEEEGGRRGTEAS"
     exon            464..586
                     /gene="Dedd2"
                     /gene_synonym="2410050E11Rik; FLAME-3"
                     /inference="alignment:Splign:2.1.0"
     exon            587..736
                     /gene="Dedd2"
                     /gene_synonym="2410050E11Rik; FLAME-3"
                     /inference="alignment:Splign:2.1.0"
     exon            737..1828
                     /gene="Dedd2"
                     /gene_synonym="2410050E11Rik; FLAME-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1797..1802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dedd2"
                     /gene_synonym="2410050E11Rik; FLAME-3"
                     /note="hexamer: AATAAA"
     polyA_site      1828
                     /gene="Dedd2"
                     /gene_synonym="2410050E11Rik; FLAME-3"
                     /note="major polyA site"
ORIGIN      
        1 agagaaggtg ccagaaagat ccaaaacaag tggctgcggc cgtcgcccag aagtcatcgg
       61 acgctggaat ctggtgagga taagagaggc ctaaaggccc tggttctgag cttgttccgc
      121 acccctcccc tgggaatggc gttgtccggg tcgaccccgg ccccgagctg ggaggaggat
      181 gagtgtttgg attactacgg catgctgtcg cttcaccgta tgttcgaggt agtgggcggg
      241 cagctgaccg agtgcgaact ggagctcctg gccttcctgc tggatgaggc ccccggcgcc
      301 cccggcggcc tggcccgcgc ccgcagcggc ctggagctgc ttctggagct ggaacgccgc
      361 gggcagtgcg acgagagcaa cctgcggctg ctgagccaac tcctgcgcgt gctagcccgt
      421 cacgacctcc tgccacatct ggcgcgcaag cggcgccggc cagtgtcccc tgagcgatac
      481 agctatggca atcccagctc ttcttccaag aggacagagg acagttgccg gcgtcggcga
      541 caggcgagca gttcttcgga ctctcctcag agtcagtggg acacaggctc cccaccaacc
      601 aagcggcagc ggcggagtcg gggccgccct agcagtggtg cccggcagcg gcggagagca
      661 ggccttgcag cctcgcagca gcaccagcag caccaggagt tgggcaggcc ctcctcagaa
      721 ggcaaggtga cctgtgacat ccggctccgg gttcgggcag agtactgcga gcatgggcca
      781 gccttggagc agggtgtggc gtcccggaga cctcaggcgt tggcccggca gctggatgtg
      841 tttggacaag ccactgctgt gctgcggtca agggacctgg gctctgtggt gtgtgacatc
      901 aagttctcag agctgtccta tctggacgcc ttctggggcg actacctgag tggcgccctg
      961 ctgcaggccc ttcggggcgt gttcctgact gaggctttac gggaggccgt gggccgagag
     1021 gctgtccgct tgctggtcag tgtggacgag gctgactatg aggctggccg gcgtcgcctg
     1081 ttgctgatgg aggaggaagg agggcggcgt gggaccgagg cctcctgatc ctggatctgg
     1141 caggactgac cccacctcca agtcttcgag ggccaccaga aagacgacga ccctcttgcc
     1201 cccagacgtc tgacattcag cagcttgagg acggtgtcag ggctgcaggt tccatgatgg
     1261 cctctccgat gatgtgggct ttgaggcata aaccacttcc agctgcttcc atcccgagtt
     1321 ccctgctccc aggtggtttc cctcagcctt gggggcccag gctcacagag ccccgaagca
     1381 gggaggcata accccctgca catcgtgtct ctcactctgg gctgatgctg tctgccccac
     1441 acactttagc ctaagggcta ctctctcagg atctcagatt tactgtcccc atgtgggttt
     1501 cagccacagc agtgggctct ggagctgggg attgctcacc ttgcccattc atctaaccaa
     1561 cctgggctct gcctgccgca catacagata tcccactctc atcaccttcc cctgctccct
     1621 ggagtgagac agacttgcct ttgggccttt taacccagac tatcacacat gggctttgtg
     1681 gccacatcag gtcaagggaa gctgtttcat acagagctag gaccagaacc agccactttc
     1741 tcgtgaaggg aagacgagga cgagggctga tgggaagatg gttcacaaac tgcgccaata
     1801 aaactgccct ggaaagggca caggtggg
//
