LOCUS       NM_001128609            2733 bp    mRNA    linear   ROD 22-DEC-2022
DEFINITION  Mus musculus death effector domain-containing (Dedd), transcript
            variant 1, mRNA.
ACCESSION   NM_001128609
VERSION     NM_001128609.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2733)
  AUTHORS   Mori M, Kitazume M, Ose R, Kurokawa J, Koga K, Osuga Y, Arai S and
            Miyazaki T.
  TITLE     Death effector domain-containing protein (DEDD) is required for
            uterine decidualization during early pregnancy in mice
  JOURNAL   J Clin Invest 121 (1), 318-327 (2011)
   PUBMED   21135503
  REMARK    GeneRIF: In uteri of Dedd-/- mice, development of the decidual zone
            and the surrounding edema after embryonic implantation was
            defective. This was accompanied by disintegration of implantation
            site structure, leading to embryonic death before placentation.
REFERENCE   2  (bases 1 to 2733)
  AUTHORS   Kurabe N, Mori M, Kurokawa J, Taniguchi K, Aoyama H, Atsuda K,
            Nishijima A, Odawara N, Harada S, Nakashima K, Arai S and Miyazaki
            T.
  TITLE     The death effector domain-containing DEDD forms a complex with Akt
            and Hsp90, and supports their stability
  JOURNAL   Biochem Biophys Res Commun 391 (4), 1708-1713 (2010)
   PUBMED   20043882
  REMARK    GeneRIF: DEDD plays an important role in maintenance of the Akt
            protein level, which in consequence supports the efficient
            incorporation of glucose into skeletal muscles and adipose tissues.
REFERENCE   3  (bases 1 to 2733)
  AUTHORS   Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S,
            Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N,
            Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y,
            Okado H, Hashimoto M and Asahara H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   4  (bases 1 to 2733)
  AUTHORS   Kurabe N, Arai S, Nishijima A, Kubota N, Suizu F, Mori M, Kurokawa
            J, Kondo-Miyazaki M, Ide T, Murakami K, Miyake K, Ueki K, Koga H,
            Yatomi Y, Tashiro F, Noguchi M, Kadowaki T and Miyazaki T.
  TITLE     The death effector domain-containing DEDD supports S6K1 activity
            via preventing Cdk1-dependent inhibitory phosphorylation
  JOURNAL   J Biol Chem 284 (8), 5050-5055 (2009)
   PUBMED   19106089
  REMARK    GeneRIF: The death effector domain-containing DEDD supports S6K1
            activity via preventing Cdk1-dependent inhibitory phosphorylation.
REFERENCE   5  (bases 1 to 2733)
  AUTHORS   Kurabe N, Arai S and Miyazaki T.
  TITLE     [Cell cycle and cell sizing regulation via death effector domain]
  JOURNAL   Seikagaku 81 (1), 24-27 (2009)
   PUBMED   19260450
  REMARK    GeneRIF: It regulates cell cycle and cell sizing. (review)
            Review article
REFERENCE   6  (bases 1 to 2733)
  AUTHORS   Bilger A, Bennett LM, Carabeo RA, Chiaverotti TA, Dvorak C, Liss
            KM, Schadewald SA, Pitot HC and Drinkwater NR.
  TITLE     A potent modifier of liver cancer risk on distal mouse chromosome
            1: linkage analysis and characterization of congenic lines
  JOURNAL   Genetics 167 (2), 859-866 (2004)
   PUBMED   15238534
REFERENCE   7  (bases 1 to 2733)
  AUTHORS   Reed JC, Doctor K, Rojas A, Zapata JM, Stehlik C, Fiorentino L,
            Damiano J, Roth W, Matsuzawa S, Newman R, Takayama S, Marusawa H,
            Xu F, Salvesen G and Godzik A.
  CONSRTM   RIKEN GER Group; GSL Members
  TITLE     Comparative analysis of apoptosis and inflammation genes of mice
            and humans
  JOURNAL   Genome Res 13 (6B), 1376-1388 (2003)
   PUBMED   12819136
REFERENCE   8  (bases 1 to 2733)
  AUTHORS   Alcivar A, Hu S, Tang J and Yang X.
  TITLE     DEDD and DEDD2 associate with caspase-8/10 and signal cell death
  JOURNAL   Oncogene 22 (2), 291-297 (2003)
   PUBMED   12527898
REFERENCE   9  (bases 1 to 2733)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 2733)
  AUTHORS   Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhansel C, Hofmann
            TG, Grummt I, Krammer PH and Peter ME.
  TITLE     DEDD, a novel death effector domain-containing protein, targeted to
            the nucleolus
  JOURNAL   EMBO J 17 (20), 5974-5986 (1998)
   PUBMED   9774341
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM947911.1, AK009728.1 and AC084821.26.
            
            [WARNING] On May 3, 2023 this sequence was replaced by
            NM_001128609.2.
            
            Transcript Variant: This variant (1) is the longer transcript. Both
            variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157609.1, AK157342.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-627               BM947911.1         1-627
            628-1114            AK009728.1         249-735
            1115-2733           AC084821.26        3027-4645           c
FEATURES             Location/Qualifiers
     source          1..2733
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.34 cM"
     gene            1..2733
                     /gene="Dedd"
                     /gene_synonym="CASP8IP1; Dedpro1; DEFT; FLDED1; KE05"
                     /note="death effector domain-containing"
                     /db_xref="GeneID:21945"
                     /db_xref="MGI:MGI:1333874"
     exon            1..382
                     /gene="Dedd"
                     /gene_synonym="CASP8IP1; Dedpro1; DEFT; FLDED1; KE05"
                     /inference="alignment:Splign:2.1.0"
     exon            383..415
                     /gene="Dedd"
                     /gene_synonym="CASP8IP1; Dedpro1; DEFT; FLDED1; KE05"
                     /inference="alignment:Splign:2.1.0"
     exon            416..804
                     /gene="Dedd"
                     /gene_synonym="CASP8IP1; Dedpro1; DEFT; FLDED1; KE05"
                     /inference="alignment:Splign:2.1.0"
     CDS             480..1436
                     /gene="Dedd"
                     /gene_synonym="CASP8IP1; Dedpro1; DEFT; FLDED1; KE05"
                     /note="tumor necrosis factor (ligand) superfamily, member
                     19"
                     /codon_start=1
                     /product="death effector domain-containing protein"
                     /protein_id="NP_001122081.1"
                     /db_xref="CCDS:CCDS15490.1"
                     /db_xref="GeneID:21945"
                     /db_xref="MGI:MGI:1333874"
                     /translation="MAGLKRRASQVWPEERGEQEHGLYSLHRMFDIVGTHLTHRDVRV
                     LSFLFVDVIDDHERGLIRNGRDFLLALERQGRCDESNFRQVLQLLRIITRHDLLPYVT
                     LKKRRAVCPDLVDKYLEETSIRYVTPRALSDPEPRPPQPSKTVPPHYPVVCCPTSGSQ
                     MCSKRPARGRTTLGSQRKRRKSVTPDPKEKQTCDIRLRVRAEYCQHETALQGNVFSNK
                     QDPLERQFERFNQANTILKSRDLGSIICDIKFSELTYLDAFWRDYINGSLLEALKGVF
                     ITDSLKQAVGHEAIKLLVNVDEEDYELGRQKLLRNLMLQALP"
     exon            805..912
                     /gene="Dedd"
                     /gene_synonym="CASP8IP1; Dedpro1; DEFT; FLDED1; KE05"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1059
                     /gene="Dedd"
                     /gene_synonym="CASP8IP1; Dedpro1; DEFT; FLDED1; KE05"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..2733
                     /gene="Dedd"
                     /gene_synonym="CASP8IP1; Dedpro1; DEFT; FLDED1; KE05"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacctccccg ccgccgccgt taggagaacc ctgcgttgcc agcttgcccc taagcaagat
       61 ggctgccagt ctccagcctc tcttgccgac gtgaagctac ccactccccg cttaatgccg
      121 ctgccaggct gccctcacct agtatggctc ctccgctcat gcctcgttat ggtctcgaag
      181 ccgacactaa ccggccaggt tccgggaggc gctgtgcagg atgcagccac ccccgcccgg
      241 ccctcccctc ccccacgccc gcggcggcgg cggcggcggc ggaggcggcg gcggctggag
      301 cccggatgcg gctccgtgag gcgcaggccc cggagagcgg cgcggatgga tccaacatgg
      361 cggcgccgag gctgagccga gagaagagcc ctggggattt aagtttcttg caaagatcac
      421 tggagattgc agctgctgag cagagattct ggaaagcact ctatttctga gcctctagca
      481 tggcgggcct aaagaggcgg gcaagccagg tgtggcccga agagcgtggg gagcaagaac
      541 atgggctcta cagcctccac cgcatgttcg acatcgtggg cacccaccta acacacagag
      601 atgtccgagt gctttccttc ctttttgttg atgttattga tgaccatgaa cgtggactca
      661 tccgaaatgg acgtgacttc ttattggcac tggagcgcca gggccgctgt gacgagagta
      721 actttcgcca ggtgctgcag ctgctgcgca tcatcactcg ccatgacttg ctgccctacg
      781 ttactctcaa gaagagacga gctgtgtgcc ctgatcttgt agacaagtat ctggaggaaa
      841 catcaattcg ctatgtgacc cccagagccc tcagtgaccc agaaccgagg cctccccagc
      901 cctctaaaac agtgcctccc cactatcctg tggtgtgctg ccccacttcg ggttctcaaa
      961 tgtgtagtaa gcggccagcc cgagggagaa ccacacttgg gagccagcga aaacgccgga
     1021 agtcggtgac accagacccg aaggaaaagc agacatgtga tatcaggctc cgagttcggg
     1081 cggaatactg ccagcatgag acggctctgc aaggcaatgt cttctccaat aagcaggacc
     1141 cacttgagcg ccagtttgag cgctttaacc aggccaacac tatcctcaag tcccgggacc
     1201 tgggctccat catctgtgac atcaagttct ctgagctcac ctacctcgac gcattctggc
     1261 gagactacat taatggctca ttattagagg cactgaaagg tgtcttcatc acagactctc
     1321 tcaagcaagc tgtgggccat gaagccatca agctgctggt gaacgtggat gaggaggact
     1381 atgagctggg ccgacagaaa ctcctgagga acttgatgct gcaggcatta ccctgacctt
     1441 tccccttctc acctttctgg ggactgttcg ctccgtcacc tctggagctg acatactgtt
     1501 ctggggtttg ttctctaccc tttccaacca atcacaccgc cttttttttt tttttttttt
     1561 aaaaggaaaa gacaaaggaa ggtggaagtg gtgtccctgc cctccctgca cccatgtgcc
     1621 tgggcttccc cgtttcctgt tgccacttac cctattgtgt gtctacagcc accttaccac
     1681 tgagccgtaa gacaagtgta tagggacagg gtctctggaa cacagccttt gtaagggatt
     1741 gaacactgct ttcaggtgca ttgaggggta atcaatactt atggctttat gagggctctt
     1801 aaattttgtc tgaaaaacca aagggctgtg agtaaaggag ctatgtggaa ggtgggactc
     1861 tgaagtgtat tttggaaatt aattaccacc ttcttccaaa ttatagaatt ttttaaaaac
     1921 agagaagctg tggccctttg cagtctctcc tggccttggt gctgctcctc tctgcctttc
     1981 cttcattcca cagcgggaac tgctgtcgta tggatccctc cttgtccctg tcaaatgttc
     2041 agcaaactta cagaggactg ggccagcctg atcgatcacc ctcccaactg cgatgtgtat
     2101 gtgaacacca gtacacagga cagtggagta gaggctgcta gttggagcac actttctctg
     2161 aagaggagga gggggtgggg ggtatgacat tttccttccc ttttccagtg aaaataactc
     2221 ttaccccacc ccaaggccct ttccctttgc ttccttcttg cttgagagaa agtggggtat
     2281 ttagtatcag ctcctcctgt tcctctgccc tcccttctcc catcctttgg agagcaggac
     2341 tagtacatgc actgagcacc gcactttctt aggtaaggag gcatgtttga ggcaggaggc
     2401 tgaggagtga agtccagtca agcaggtaca attccacctc cccttctagc ccccaaaaga
     2461 catgtccaga cattatgatt attatatttt tttttcaatg ccagtgctgc tcagccctca
     2521 gcataacttc agttttcatg aaataaacag tgactatata aaatcccact tttctgaaac
     2581 tgaaatctga ggtcaggtca aagtctcttc tttcccatgg acttgattaa gcctgtgttc
     2641 cattaagaga ggttaaagtt ctgcaagtga agggaaccgt gcttgtgtcc tgcctacaag
     2701 tcacagtagc atcacctccc agttggctgt gtc
//
