LOCUS       NM_026172               2829 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus 2,4-dienoyl CoA reductase 1, mitochondrial (Decr1),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_026172
VERSION     NM_026172.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2829)
  AUTHORS   Makela,A.M., Hohtola,E., Miinalainen,I.J., Autio,J.A., Schmitz,W.,
            Niemi,K.J., Hiltunen,J.K. and Autio,K.J.
  TITLE     Mitochondrial 2,4-dienoyl-CoA reductase (Decr) deficiency and
            impairment of thermogenesis in mouse brown adipose tissue
  JOURNAL   Sci Rep 9 (1), 12038 (2019)
   PUBMED   31427678
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2829)
  AUTHORS   Li,J., Deng,S.P., Wei,G. and Yu,P.
  TITLE     CITGeneDB: a comprehensive database of human and mouse genes
            enhancing or suppressing cold-induced thermogenesis validated by
            perturbation experiments in mice
  JOURNAL   Database (Oxford) 2018 (2018)
   PUBMED   29688375
REFERENCE   3  (bases 1 to 2829)
  AUTHORS   Zhou,L., Dai,H., Wu,J., Zhou,M., Yuan,H., Du,J., Yang,L., Wu,X.,
            Xu,H., Hua,Y., Xu,J., Zheng,L. and Shen,B.
  TITLE     Role of FEN1 S187 phosphorylation in counteracting oxygen-induced
            stress and regulating postnatal heart development
  JOURNAL   FASEB J 31 (1), 132-147 (2017)
   PUBMED   27694478
REFERENCE   4  (bases 1 to 2829)
  AUTHORS   Miinalainen,I.J., Schmitz,W., Huotari,A., Autio,K.J., Soininen,R.,
            Ver Loren van Themaat,E., Baes,M., Herzig,K.H., Conzelmann,E. and
            Hiltunen,J.K.
  TITLE     Mitochondrial 2,4-dienoyl-CoA reductase deficiency in mice results
            in severe hypoglycemia with stress intolerance and unimpaired
            ketogenesis
  JOURNAL   PLoS Genet 5 (7), e1000543 (2009)
   PUBMED   19578400
  REMARK    GeneRIF: Fasted Decr(-/-) mice displayed increased serum
            acylcarnitines and unimpaired ketogenesis.
REFERENCE   5  (bases 1 to 2829)
  AUTHORS   Brown,A.C., Olver,W.I., Donnelly,C.J., May,M.E., Naggert,J.K.,
            Shaffer,D.J. and Roopenian,D.C.
  TITLE     Searching QTL by gene expression: analysis of diabesity
  JOURNAL   BMC Genet 6, 12 (2005)
   PUBMED   15760467
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC046972.1.
            
            On May 4, 2018 this sequence version replaced NM_026172.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046972.1, AK146003.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2829              BC046972.1         131-2959
FEATURES             Location/Qualifiers
     source          1..2829
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 6.66 cM"
     gene            1..2829
                     /gene="Decr1"
                     /gene_synonym="1200012F07Rik; Decr; Nadph"
                     /note="2,4-dienoyl CoA reductase 1, mitochondrial"
                     /db_xref="GeneID:67460"
                     /db_xref="MGI:MGI:1914710"
     exon            1..95
                     /gene="Decr1"
                     /gene_synonym="1200012F07Rik; Decr; Nadph"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1034
                     /gene="Decr1"
                     /gene_synonym="1200012F07Rik; Decr; Nadph"
                     /EC_number="1.3.1.124"
                     /note="2,4-dienoyl-CoA reductase, mitochondrial;
                     2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing],
                     mitochondrial"
                     /codon_start=1
                     /product="2,4-dienoyl-CoA reductase
                     [(3E)-enoyl-CoA-producing], mitochondrial precursor"
                     /protein_id="NP_080448.1"
                     /db_xref="CCDS:CCDS17985.1"
                     /db_xref="GeneID:67460"
                     /db_xref="MGI:MGI:1914710"
                     /translation="MALLGRAFFAGVSRLPCDPGPQRFFSFGTKTLYQSKDAPQSKFF
                     QPVLKPMLPPDAFQGKVAFITGGGTGLGKAMTTFLSTLGAQCVIASRNIDVLKATAEE
                     ISSKTGNKVHAIRCDVRDPDMVHNTVLELIKVAGHPDVVINNAAGNFISPSERLTPNG
                     WKTITDIVLNGTAYVTLEIGKQLIKAQKGAAFLAITTIYAESGSGFVMPSSSAKSGVE
                     AMNKSLAAEWGRYGMRFNIIQPGPIKTKGAFSRLDPTGRFEKEMIDRIPCGRLGTMEE
                     LANLATFLCSDYASWINGAVIRFDGGEEVFLSGEFNSLKKVTKEEWDIIEGLIRKTKG
                     S"
     exon            96..298
                     /gene="Decr1"
                     /gene_synonym="1200012F07Rik; Decr; Nadph"
                     /inference="alignment:Splign:2.1.0"
     exon            299..356
                     /gene="Decr1"
                     /gene_synonym="1200012F07Rik; Decr; Nadph"
                     /inference="alignment:Splign:2.1.0"
     exon            357..443
                     /gene="Decr1"
                     /gene_synonym="1200012F07Rik; Decr; Nadph"
                     /inference="alignment:Splign:2.1.0"
     exon            444..591
                     /gene="Decr1"
                     /gene_synonym="1200012F07Rik; Decr; Nadph"
                     /inference="alignment:Splign:2.1.0"
     exon            592..691
                     /gene="Decr1"
                     /gene_synonym="1200012F07Rik; Decr; Nadph"
                     /inference="alignment:Splign:2.1.0"
     exon            692..764
                     /gene="Decr1"
                     /gene_synonym="1200012F07Rik; Decr; Nadph"
                     /inference="alignment:Splign:2.1.0"
     exon            765..911
                     /gene="Decr1"
                     /gene_synonym="1200012F07Rik; Decr; Nadph"
                     /inference="alignment:Splign:2.1.0"
     exon            912..974
                     /gene="Decr1"
                     /gene_synonym="1200012F07Rik; Decr; Nadph"
                     /inference="alignment:Splign:2.1.0"
     exon            975..2829
                     /gene="Decr1"
                     /gene_synonym="1200012F07Rik; Decr; Nadph"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1122..1127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Decr1"
                     /gene_synonym="1200012F07Rik; Decr; Nadph"
                     /note="hexamer: AATAAA"
     polyA_site      1165
                     /gene="Decr1"
                     /gene_synonym="1200012F07Rik; Decr; Nadph"
                     /note="major polyA site"
     regulatory      2806..2811
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Decr1"
                     /gene_synonym="1200012F07Rik; Decr; Nadph"
                     /note="hexamer: ATTAAA"
     polyA_site      2829
                     /gene="Decr1"
                     /gene_synonym="1200012F07Rik; Decr; Nadph"
ORIGIN      
        1 attaaggact gagtcctgct gcagacatgg cgctgctggg ccgtgcgttc tttgctgggg
       61 tgtcccgcct cccctgcgat ccgggtcctc agaggttttt cagctttgga acaaaaacac
      121 tgtatcaaag caaagatgct ccacagtcta aattcttcca gcccgtttta aagcctatgc
      181 taccacctga tgcttttcaa ggaaaagtgg ctttcattac tggaggaggg actggccttg
      241 gcaaggcaat gacaactttc ttgtctaccc tgggtgccca gtgtgtgata gccagcagaa
      301 atattgatgt tttgaaagcg actgcagaag agatttcttc taaaactgga aacaaggttc
      361 atgcgattcg gtgtgatgtt cgagatcctg atatggtaca taacacagtg ctggaactga
      421 tcaaagttgc agggcatccg gatgtggtga taaacaacgc ggcagggaac ttcatttccc
      481 ccagtgagag actgactccc aatggctgga agaccataac tgacatagtt ctcaatggca
      541 cagcctatgt gacactagaa attggaaagc agctaattaa agcacagaaa ggagctgcgt
      601 ttcttgccat cactaccatc tatgctgaga gtggatcagg ctttgtaatg ccaagttctt
      661 cagccaaatc aggcgtggaa gccatgaata agtcacttgc agctgaatgg ggtagatatg
      721 gaatgcgttt caacataatt cagccaggac ctatcaaaac caaaggagcc tttagccgtt
      781 tggacccgac tggaagattt gagaaggaga tgattgacag aatcccctgt ggtcgtctgg
      841 gaactatgga ggaacttgca aatctggcca ctttcctatg cagtgattat gcctcttgga
      901 ttaatggagc agtcattaga tttgacggtg gagaggaagt atttctgtca ggtgaattca
      961 actctctaaa gaaggtcacc aaggaggagt gggatataat cgaagggctc atcaggaaga
     1021 caaaaggctc ctaagatgac cacaacttca tctgtgaaac actaaagtta gggactagag
     1081 tgctacagat ggaccgtggt cttccacttg tcttgggggt taataaattg tttgcttgat
     1141 gatttctgta gttctgagga tcaaacccag agtgtctgct ctgctcattt tctatctctg
     1201 agttgcacct cagccctaaa aaatggtcga tgtttgccac gtgcaaacag tgtgccaggt
     1261 caggggtggc cactctgtat tgaagggtaa attggacagg atatcttttc tttaaaacac
     1321 gtgaaaaaca aaaaggggca aagatttttt tttttctttt tcaaattatt cttgtgttgt
     1381 ttcgcagtag ataaaggtga aagatgcttg ttgctaagcc agttgaactg agttcaatct
     1441 caaggccctg ctctgtaggg tagaaccaac tcttcaaagt gcctgctaca catgcatacc
     1501 ccaccccagc acatgtgtac gtgtgtgtgt gtgtgtgtgt gtgtgtacat aatgtacaca
     1561 caacctcgac catgtatata aatggctcga ttgttttaca ctctctcatt gttctccttt
     1621 ataccctttc ctctcccatg gaaccctttc ttctccctat cagtcttctt gtactttcag
     1681 ggttgcttcc attggcttgg gtgtgaggtc ttttccttca ggacgggggc tgaggcctat
     1741 gacgcccttc ccacagcagc cattctccac ctgtagtgcc tctggttggt gtgttgaaaa
     1801 agctttgata gtactgaaat atgtgtggaa aggtggaaaa tggaaacagg agtaggcttc
     1861 tgtgatctgg tgaaatagaa gaagcttagg agtggaggta acctgtgagg gacacatcac
     1921 accgtgccta tggcatgggg cctagaaatg agaggcgcta tattgagtct cagtatattc
     1981 tgttttcatt tagacttgtg aattatcttc tttgtagctc tgtattaatt cagccttagt
     2041 gtgttaggag attgtatatc atagcagatg ctttattgaa tacagaataa ctgatagtac
     2101 ttggctcttg atactagcta atggaaattt cagagttcta aaataattgt attgaagaca
     2161 ttgggataag tattacatgg gatttagatg ttgggaaagg ggtaatttac attgctttca
     2221 aagttaacaa atatagtaat atgagatagc agtcaaggat ttctgtaagt agagactcat
     2281 gaaggctata aaatattttt gtatcttact aatatatatt ttttatttgg actataatct
     2341 tgcacttttg agaaccaaat aagaaagcca cagtcttaag cctccagagt tagaattgag
     2401 cctgtgcttt tagaaagtcc atttggcttt cagagcaacc tcttacagca tgttcactac
     2461 actgaccgcc accattgtcc tctgtgctat aacaggaagc agtttttatt acctcatgaa
     2521 tagatctatg caagaatgta gagtttctgt ttgttatgtg taagacctgt atggtaactg
     2581 tacattgaca gttaattgtg tcataaatga tgtttgttgt tcagtaaaca caaccacagt
     2641 gccatcgttt gggtttggaa caaggccttt gagagtcact cttgtccact ggactgttct
     2701 aagatgcttt tcccgcacat ccttagtgcc aacaactacc ccacggcttt gcttccttcc
     2761 cctcatcccc atctgctgct ttaaacgtgt caatacatct tcgacattaa aaacttttcg
     2821 gcagttgta
//
