LOCUS       NM_016874               2198 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus DEAF1, transcription factor (Deaf1), transcript
            variant 1, mRNA.
ACCESSION   NM_016874 XM_992693
VERSION     NM_016874.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2198)
  AUTHORS   McGee,S.R., Rajamanickam,S., Adhikari,S., Falayi,O.C., Wilson,T.A.,
            Shayota,B.J., Cooley Coleman,J.A., Skinner,C., Caylor,R.C.,
            Stevenson,R.E., Quaio,C.R.A.C., Wilke,B.C., Bain,J.M.,
            Anyane-Yeboa,K., Brown,K., Greally,J.M., Bijlsma,E.K.,
            Ruivenkamp,C.A.L., Politi,K., Arbogast,L.A., Collard,M.W.,
            Huggenvik,J.I., Elsea,S.H. and Jensik,P.J.
  TITLE     Expansion and mechanistic insights into de novo DEAF1 variants in
            DEAF1-associated neurodevelopmental disorders
  JOURNAL   Hum Mol Genet 32 (3), 386-401 (2023)
   PUBMED   35981081
  REMARK    GeneRIF: Expansion and mechanistic insights into de novo DEAF1
            variants in DEAF1-associated neurodevelopmental disorders.
REFERENCE   2  (bases 1 to 2198)
  AUTHORS   McGee,S.R., Rose,G.M. and Jensik,P.J.
  TITLE     Impaired memory and marble burying activity in deformed epidermal
            autoregulatory factor 1 (Deaf1) conditional knockout mice
  JOURNAL   Behav Brain Res 380, 112383 (2020)
   PUBMED   31783086
  REMARK    GeneRIF: Impaired memory and marble burying activity in deformed
            epidermal autoregulatory factor 1 (Deaf1) conditional knockout
            mice.
REFERENCE   3  (bases 1 to 2198)
  AUTHORS   Aldea,D., Kokalari,B., Luckhart,C., Aharoni,A., Albert,P.R. and
            Kamberov,Y.G.
  TITLE     The Transcription Factor Deaf1 Modulates Engrailed-1 Expression to
            Regulate Skin Appendage Fate
  JOURNAL   J Invest Dermatol 139 (11), 2378-2381 (2019)
   PUBMED   31145909
  REMARK    GeneRIF: this study shows that Deaf1 promotes eccrine gland
            formation
REFERENCE   4  (bases 1 to 2198)
  AUTHORS   Philippe,T.J., Vahid-Ansari,F., Donaldson,Z.R., Le Francois,B.,
            Zahrai,A., Turcotte-Cardin,V., Daigle,M., James,J., Hen,R.,
            Merali,Z. and Albert,P.R.
  TITLE     Loss of MeCP2 in adult 5-HT neurons induces 5-HT1A autoreceptors,
            with opposite sex-dependent anxiety and depression phenotypes
  JOURNAL   Sci Rep 8 (1), 5788 (2018)
   PUBMED   29636529
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2198)
  AUTHORS   Luckhart,C., Philippe,T.J., Le Francois,B., Vahid-Ansari,F.,
            Geddes,S.D., Beique,J.C., Lagace,D.C., Daigle,M. and Albert,P.R.
  TITLE     Sex-dependent adaptive changes in serotonin-1A autoreceptor
            function and anxiety in Deaf1-deficient mice
  JOURNAL   Mol Brain 9 (1), 77 (2016)
   PUBMED   27488351
  REMARK    GeneRIF: The sex dependence of Deaf1 function in mice is consistent
            with a greater role for 5-HT1A autoreceptors in sensitivity to
            depression in men.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2198)
  AUTHORS   Yip,L., Su,L., Sheng,D., Chang,P., Atkinson,M., Czesak,M.,
            Albert,P.R., Collier,A.R., Turley,S.J., Fathman,C.G. and
            Creusot,R.J.
  TITLE     Deaf1 isoforms control the expression of genes encoding peripheral
            tissue antigens in the pancreatic lymph nodes during type 1
            diabetes
  JOURNAL   Nat Immunol 10 (9), 1026-1033 (2009)
   PUBMED   19668219
  REMARK    GeneRIF: Lower peripheral tissue antigens (PTA) expression
            resulting from the alternative splicing of DEAF1 may contribute to
            the pathogenesis of type 1 diabetes.
REFERENCE   7  (bases 1 to 2198)
  AUTHORS   Czesak,M., Lemonde,S., Peterson,E.A., Rogaeva,A. and Albert,P.R.
  TITLE     Cell-specific repressor or enhancer activities of Deaf-1 at a
            serotonin 1A receptor gene polymorphism
  JOURNAL   J Neurosci 26 (6), 1864-1871 (2006)
   PUBMED   16467535
REFERENCE   8  (bases 1 to 2198)
  AUTHORS   Sum,E.Y., O'Reilly,L.A., Jonas,N., Lindeman,G.J. and Visvader,J.E.
  TITLE     The LIM domain protein Lmo4 is highly expressed in proliferating
            mouse epithelial tissues
  JOURNAL   J Histochem Cytochem 53 (4), 475-486 (2005)
   PUBMED   15805422
REFERENCE   9  (bases 1 to 2198)
  AUTHORS   Hahm,K., Sum,E.Y., Fujiwara,Y., Lindeman,G.J., Visvader,J.E. and
            Orkin,S.H.
  TITLE     Defective neural tube closure and anteroposterior patterning in
            mice lacking the LIM protein LMO4 or its interacting partner Deaf-1
  JOURNAL   Mol Cell Biol 24 (5), 2074-2082 (2004)
   PUBMED   14966286
  REMARK    GeneRIF: Data indicate an important role for LMO4 and Deaf-1 in
            pathways affecting neural tube closure and skeletal patterning,
            most likely reflecting their presence in a functional complex in
            vivo.
REFERENCE   10 (bases 1 to 2198)
  AUTHORS   Sugihara,T.M., Bach,I., Kioussi,C., Rosenfeld,M.G. and Andersen,B.
  TITLE     Mouse deformed epidermal autoregulatory factor 1 recruits a LIM
            domain factor, LMO-4, and CLIM coregulators
  JOURNAL   Proc Natl Acad Sci U S A 95 (26), 15418-15423 (1998)
   PUBMED   9860983
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ045430.1, AK146546.1 and AI604909.1.
            
            On Aug 16, 2013 this sequence version replaced NM_016874.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146546.1, AF102818.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               CJ045430.1         2-125
            125-2188            AK146546.1         2-2065
            2189-2198           AI604909.1         1-10                c
FEATURES             Location/Qualifiers
     source          1..2198
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 86.61 cM"
     gene            1..2198
                     /gene="Deaf1"
                     /gene_synonym="C230009B13Rik; NUDR"
                     /note="DEAF1, transcription factor"
                     /db_xref="GeneID:54006"
                     /db_xref="MGI:MGI:1858496"
     exon            1..447
                     /gene="Deaf1"
                     /gene_synonym="C230009B13Rik; NUDR"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1856
                     /gene="Deaf1"
                     /gene_synonym="C230009B13Rik; NUDR"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear DEAF-1-related transcriptional regulator; deformed
                     epidermal autoregulatory factor 1 homolog; suppressin"
                     /codon_start=1
                     /product="deformed epidermal autoregulatory factor 1
                     homolog isoform 1"
                     /protein_id="NP_058570.1"
                     /db_xref="CCDS:CCDS40185.1"
                     /db_xref="GeneID:54006"
                     /db_xref="MGI:MGI:1858496"
                     /translation="MEDSDSAAKQLGLAEAAAVAAAAAVAAAAAAAAESEAEEPVLSR
                     DEDSEEDADSEAERETRRVTAVAVMAAESGHMDMGTEALPSPDEAAAAAAAFAEVTTV
                     TVANVGSSADNVFTTSVANAASISGHVLSGRTALQIGDSLNTEKATLIVVHTDGSIVE
                     TTGLKGPAAPLTPGPQSPPTPLAPGQEKGGTKYNWDPSVYDSELPVRCRNISGTLYKS
                     RLGSGGRGRCIKQGENWYSPTEFEAMAGRASSKDWKRSIRYAGRPLQCLIQDGILNPH
                     AASCTCAACCDDMTLSGPVRLFVPYKRRKKENELPTTPVKKDSPKNITLLPATAATTF
                     TVTPSGQITTSGALTFDRASTVEATAVISESPAQGDVFAGATVQEAGVQPPCRVGHPE
                     PHYPGYQDSCQIAPFPEAALPTSHPKIVLTSLPALAVPPSTPTKAVSPTVVSGLEMSE
                     HRSWLYLEEMVNSLLNTAQQLKTLFEQAKQASSCREAAVTQARMQVDTERKEQSCVNC
                     GREAMSECTGCHKVNYCSTFCQRKDWKDHQHVCGQSASVTVQADDVHVEESVIEKVAV
                     "
     exon            448..545
                     /gene="Deaf1"
                     /gene_synonym="C230009B13Rik; NUDR"
                     /inference="alignment:Splign:2.1.0"
     exon            546..675
                     /gene="Deaf1"
                     /gene_synonym="C230009B13Rik; NUDR"
                     /inference="alignment:Splign:2.1.0"
     exon            676..822
                     /gene="Deaf1"
                     /gene_synonym="C230009B13Rik; NUDR"
                     /inference="alignment:Splign:2.1.0"
     exon            823..962
                     /gene="Deaf1"
                     /gene_synonym="C230009B13Rik; NUDR"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1028
                     /gene="Deaf1"
                     /gene_synonym="C230009B13Rik; NUDR"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1155
                     /gene="Deaf1"
                     /gene_synonym="C230009B13Rik; NUDR"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1284
                     /gene="Deaf1"
                     /gene_synonym="C230009B13Rik; NUDR"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1413
                     /gene="Deaf1"
                     /gene_synonym="C230009B13Rik; NUDR"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1661
                     /gene="Deaf1"
                     /gene_synonym="C230009B13Rik; NUDR"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1751
                     /gene="Deaf1"
                     /gene_synonym="C230009B13Rik; NUDR"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..2192
                     /gene="Deaf1"
                     /gene_synonym="C230009B13Rik; NUDR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2155..2160
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Deaf1"
                     /gene_synonym="C230009B13Rik; NUDR"
                     /note="hexamer: AATAAA"
     regulatory      2167..2172
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Deaf1"
                     /gene_synonym="C230009B13Rik; NUDR"
                     /note="hexamer: AATAAA"
     polyA_site      2186
                     /gene="Deaf1"
                     /gene_synonym="C230009B13Rik; NUDR"
                     /note="major polyA site"
     polyA_site      2192
                     /gene="Deaf1"
                     /gene_synonym="C230009B13Rik; NUDR"
ORIGIN      
        1 gggcgtcaga ctgcctcttc ggtcgctgct cgggcggtgg cttcgggcgg cctcggccca
       61 actcgggcgg cctcttcggg ccccgcttcg ggctcggtgc ctggcgcttc gggcggtccc
      121 ggacagcgcc ttcgggcgga ctcggtggag tccgtatgga ggactcggac tcggcggcaa
      181 aacagctggg cctggccgag gcggcagctg tggcggccgc tgccgcggtg gcggcggccg
      241 ccgcggccgc agcggaaagc gaggcggagg agccggtgtt aagcagagac gaggactcgg
      301 aggaggacgc agactccgag gcggagcgcg agacgcggcg ggtcaccgct gtggcggtga
      361 tggcggccga atctgggcac atggatatgg gtaccgaggc tctgcccagc cccgatgagg
      421 ccgccgccgc cgccgccgcc ttcgcagaag tgaccacagt gactgtggcc aacgtggggt
      481 cctctgcaga taacgtcttc acaacatcag tggcaaacgc agcatcgata tcaggacatg
      541 tcctgtctgg taggacagcc ctgcagatcg gtgacagcct gaacactgaa aaagccacac
      601 taatagttgt acacacagat gggagcattg tggagaccac tgggctgaag ggcccagcag
      661 cacctctcac tccaggtccc cagtctcctc ctaccccact ggcacctggc caggagaaag
      721 gtggtaccaa gtacaactgg gacccttcgg tgtatgacag cgagttgcct gtgcgctgtc
      781 ggaacatcag tggcacgctc tacaagagta ggctcggctc aggtggccgg ggccggtgta
      841 tcaagcaggg agaaaactgg tacagcccaa ctgagtttga agctatggca ggaagagcca
      901 gcagcaagga ctggaagaga agcatccgct atgctggcag acccctgcag tgcctcattc
      961 aggatggtat tttgaaccct cacgctgcct cctgtacctg tgccgcctgt tgtgatgaca
     1021 tgactctgag tggccctgtc aggctcttcg tcccttataa aaggcgcaag aaagagaatg
     1081 agctgcccac aactccagtg aagaaggatt cccccaagaa catcaccctg cttcctgcca
     1141 cggcggccac caccttcact gtgacaccct caggacagat cactacctct ggagcactga
     1201 cctttgacag agcatccact gtagaggcca ctgctgtcat ctctgagagc ccagcccaag
     1261 gtgatgtctt tgcaggagcc acagtgcaag aggcaggtgt gcagcctccc tgcagggttg
     1321 gccaccctga accccactac cctggctatc aggacagctg ccagattgcc ccgtttccag
     1381 aagctgcatt gccaacatca caccccaaaa ttgtcctgac atcgctgccc gcattggccg
     1441 tgccaccgtc cacccccacc aaagctgtct ctcccaccgt ggtcagtggg ctggagatgt
     1501 cagaacatcg gagctggctg tacctggaag agatggtcaa ctccctactc aacacagctc
     1561 agcagctgaa gacgctgttt gaacaagcca agcaggcgag ctcttgcagg gaagctgctg
     1621 tgacccaggc gagaatgcag gttgatacag agaggaaaga gcagtcatgt gtcaactgcg
     1681 gccgggaggc catgagtgag tgtaccggct gccacaaggt taactactgc tctacgttct
     1741 gccagcgcaa ggactggaaa gaccatcagc atgtgtgtgg ccagtcagcg tctgtcactg
     1801 tccaggctga tgacgtccat gttgaagaaa gtgtgataga aaaagttgct gtttgagcca
     1861 ggcttctcct tgagctctgc tgtgaagcca tcgcaggctt aggccctctg atgactgtgg
     1921 gggctgctga gaagaggggc catgggaaac ttgccggaca agttattaac agattgtgcc
     1981 cttggaaaca agctccttcc agagaccaag gaacgctggc agctttcaga atggggcact
     2041 ctgctacagc ccagggccct cagcctatca cggtgctctt tcatccctgg atcatgagtg
     2101 tcccactacc cttggggtgc cctatgccac gtgtacatac ctgtcttatc tgttaataaa
     2161 catgtaaata aaactcccac cccatacctg aaaaaaaa
//
