LOCUS       NM_001293783            5994 bp    mRNA    linear   ROD 10-APR-2023
DEFINITION  Mus musculus DExD/H box helicase 60 (Ddx60), mRNA.
ACCESSION   NM_001293783 XM_006509392
VERSION     NM_001293783.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5994)
  AUTHORS   Zhu Y, Zheng C, Zhang R, Yan J, Li M, Ma S, Chen K, Chen L, Liu J,
            Xiu J, Liao W, Bin J, Huang J, Lin H and Liao Y.
  TITLE     Circ-Ddx60 contributes to the antihypertrophic memory of exercise
            hypertrophic preconditioning
  JOURNAL   J Adv Res 46, 113-121 (2023)
   PUBMED   35718079
  REMARK    GeneRIF: Circ-Ddx60 contributes to the antihypertrophic memory of
            exercise hypertrophic preconditioning.
REFERENCE   2  (bases 1 to 5994)
  AUTHORS   Goubau D, van der Veen AG, Chakravarty P, Lin R, Rogers N,
            Rehwinkel J, Deddouche S, Rosewell I, Hiscott J and Reis e Sousa C.
  TITLE     Mouse superkiller-2-like helicase DDX60 is dispensable for type I
            IFN induction and immunity to multiple viruses
  JOURNAL   Eur J Immunol 45 (12), 3386-3403 (2015)
   PUBMED   26457795
  REMARK    GeneRIF: overexpression of DDX60 did not potentiate IFN induction
REFERENCE   3  (bases 1 to 5994)
  AUTHORS   Oshiumi H, Miyashita M, Okamoto M, Morioka Y, Okabe M, Matsumoto M
            and Seya T.
  TITLE     DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral
            Responses, and Its Function Is Attenuated by Virus-Induced EGFR
            Activation
  JOURNAL   Cell Rep 11 (8), 1193-1207 (2015)
   PUBMED   25981042
  REMARK    GeneRIF: Results define DDX60 as a sentinel for cytoplasmic
            antiviral response, which is counteracted by virus-mediated EGF
            receptor activation.
REFERENCE   4  (bases 1 to 5994)
  AUTHORS   Miyashita M, Oshiumi H, Matsumoto M and Seya T.
  TITLE     DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting
            RIG-I-like receptor-mediated signaling
  JOURNAL   Mol Cell Biol 31 (18), 3802-3819 (2011)
   PUBMED   21791617
  REMARK    GeneRIF: DDX60 is a novel antiviral helicase promoting RIG-I-like
            receptor-mediated signaling.
REFERENCE   5  (bases 1 to 5994)
  AUTHORS   Kirchhof P, Kahr PC, Kaese S, Piccini I, Vokshi I, Scheld HH,
            Rotering H, Fortmueller L, Laakmann S, Verheule S, Schotten U,
            Fabritz L and Brown NA.
  TITLE     PITX2c is expressed in the adult left atrium, and reducing Pitx2c
            expression promotes atrial fibrillation inducibility and complex
            changes in gene expression
  JOURNAL   Circ Cardiovasc Genet 4 (2), 123-133 (2011)
   PUBMED   21282332
REFERENCE   6  (bases 1 to 5994)
  AUTHORS   Fujimoto M, Oshima K, Shinkawa T, Wang BB, Inouye S, Hayashida N,
            Takii R and Nakai A.
  TITLE     Analysis of HSF4 binding regions reveals its necessity for gene
            regulation during development and heat shock response in mouse
            lenses
  JOURNAL   J Biol Chem 283 (44), 29961-29970 (2008)
   PUBMED   18755693
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139846.4 and AC144858.3.
            
            [WARNING] On Apr 20, 2023 this sequence was replaced by
            NM_001293783.2.
            
            On Jun 20, 2014 this sequence version replaced XM_006509392.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164133,
                              SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               AC139846.4         175243-175432
            191-298             AC139846.4         187155-187262
            299-365             AC139846.4         187447-187513
            366-555             AC139846.4         187759-187948
            556-897             AC139846.4         189448-189789
            898-1014            AC144858.3         157328-157444       c
            1015-1176           AC144858.3         154323-154484       c
            1177-1335           AC144858.3         152711-152869       c
            1336-1477           AC144858.3         148657-148798       c
            1478-1633           AC144858.3         147026-147181       c
            1634-1739           AC144858.3         145146-145251       c
            1740-1855           AC144858.3         144620-144735       c
            1856-2013           AC144858.3         139555-139712       c
            2014-2266           AC144858.3         133591-133843       c
            2267-2433           AC144858.3         130975-131141       c
            2434-2592           AC144858.3         129103-129261       c
            2593-2742           AC144858.3         127388-127537       c
            2743-2862           AC144858.3         125293-125412       c
            2863-2958           AC144858.3         123944-124039       c
            2959-3074           AC144858.3         120699-120814       c
            3075-3217           AC144858.3         119353-119495       c
            3218-3327           AC144858.3         119107-119216       c
            3328-3432           AC144858.3         115840-115944       c
            3433-3561           AC144858.3         115128-115256       c
            3562-3686           AC144858.3         113362-113486       c
            3687-3845           AC144858.3         108762-108920       c
            3846-3993           AC144858.3         104517-104664       c
            3994-4146           AC144858.3         102593-102745       c
            4147-4251           AC144858.3         93250-93354         c
            4252-4452           AC144858.3         90825-91025         c
            4453-4557           AC144858.3         86051-86155         c
            4558-4699           AC144858.3         85413-85554         c
            4700-4821           AC144858.3         81887-82008         c
            4822-4969           AC144858.3         79999-80146         c
            4970-5112           AC144858.3         78305-78447         c
            5113-5264           AC144858.3         69770-69921         c
            5265-5327           AC144858.3         68192-68254         c
            5328-5994           AC144858.3         65595-66261         c
FEATURES             Location/Qualifiers
     source          1..5994
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8"
     gene            1..5994
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /note="DExD/H box helicase 60"
                     /db_xref="GeneID:234311"
                     /db_xref="MGI:MGI:2384570"
     exon            1..190
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            191..298
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            299..365
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            366..555
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            556..897
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1014
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1176
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1335
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1477
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1633
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1739
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1855
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..2013
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2266
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2433
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2592
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..2742
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            2743..2862
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            2863..2958
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            2959..3074
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            3075..3217
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            3218..3327
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            3328..3432
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            3433..3561
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            3562..3686
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            3687..3845
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            3846..3993
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            3994..4146
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            4147..4251
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            4252..4452
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            4453..4557
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            4558..4699
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            4700..4821
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            4822..4969
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            4970..5112
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            5113..5264
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            5265..5327
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
     exon            5328..5994
                     /gene="Ddx60"
                     /gene_synonym="9830118M07"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttataaaa ggcggcctga gagactcaca agttgccact ttttggagct agcgattggt
       61 cttaggtctc ctgtggtcga ctgtgtgctt gcttgttacc tgcagcgcgg accagcgcgc
      121 tcaatacctg ctgcgcagac cagcggttct ctgcacgtag caggtccagg ttcccggtct
      181 gggcttcccg atacgacatt tcattaataa ggaccattga gaggaaacag agtaaaggat
      241 atttacattt ttaatatttt ccagttcagg ttgaaagcac agatagcagc aagaatggaa
      301 aaaaaataca caggtttttt aaaaataatg tcacatttaa tcttggaaac tatgtcaaag
      361 gctgactact ccagcttatt caatgatttt gttgaatctg agttctttct gattgatggc
      421 gactccttgc tcatcacgtg tgcgtgtgag aggtcactta agccaggaca gagtctccac
      481 ttcttctacc tggttgagcg ctacctgttg gatgttatta gcaaaggagg gcaatttgcc
      541 atagttttct tcaaggatgc tgagtatgca tacttcaatg tccccgaact tctgacactg
      601 agaactgctt taattctgca tcttcagaag aataccactg ttgaagtttg gactaagttt
      661 tctaactgct tgtcagaaga gtggaatatt tgcttgggtc agagttgccc atatttcttg
      721 atactggctg atgaaggcct gaacgacctg cagacacatc ttttcaactt tgtagttatt
      781 caggcctggg cagcaaaggt caatattgtg ctcttctcag gacagacatc tgacatcctt
      841 cgtctttatg catactttat gcaaagctct catggaatgc agatgttctt caaggagaat
      901 aagagaatga tcatgattgt ttacaaaagc ctgattcaac agctggaaaa atacagagat
      961 atggctttag cacatctgtt cggagattta aaattcaatg atatggaaga gaaggtatgt
     1021 gaaactgtat ctctgctgaa acaactctgg ccagaaggat ctgacatccg atgtgtcttt
     1081 tgtgtcacct catgttctct cttcttggaa atgtatcact gctacttaga aagcagagag
     1141 aaaggagcat ctgaggagat gtccaaagtc aaacagaaaa cagataattg cttaaccctg
     1201 aaggacatgg aagacttttg taagctacat tgcctcagtg tggctctttt gctccatgta
     1261 cctctctctc agagagctcg ctcaagattc atcactgcta attggattca ggacctcaag
     1321 actgtcctaa aaatgaaaaa gtggtgcgag tattttatcc taagtaattt ggatatgttt
     1381 gaatcttgga gtctgaattt acttcacctt tctgacttaa gtgatgagcc tttgttgagg
     1441 aatattgctt tttactatga aaatgaaaat aaagaaggcc tggatttgaa tgtgggagat
     1501 gccatcatga acgagtatgt acatctctgg gacactgtgt caaagttggt cagaaagttt
     1561 gatgtgggaa aaccaattcc tttgagaaca acaaaagttc attttcttga aaagacacca
     1621 tcaccaatca aagaaagttc ccaggagatg atgccaaatt taggttttat tccaatgtca
     1681 tgtaatttag ttgatgaatt tactggagac attttgaaag acttgccttt cctaatgagt
     1741 gatgacccca ttgttacgtc actggtaaag cataaggaat ttgatgagct tgtgcactgg
     1801 cactcccaca gacctctcag tgatgattat gacaggacaa aggtgaattc tggagacaga
     1861 agagacccca atcatcttaa aaggttgcag aagtatcata gttttcaacg attttatggg
     1921 gagtcattag aatcagtcac ttcaaagacc atcacaactc aaggtcctaa gccaaagaag
     1981 gattgtatta agtccaagag cacaaaggca catgagacca aggctgaaat aattaaaaga
     2041 gaaaataaga agaggttaat tgctgaggaa gaacaaaaag aagagcaaaa atggaatgcc
     2101 ctgtcatttt ctatcgagga ggaaatgaga aagaatgtag actcaggaat gaagaaactg
     2161 gaagagtttt tgaaatcatg taaaagtcgc tcagtaaaag ctcaggttga aagagttggg
     2221 ttacaggctt gcttgaaagc ctggaaggaa cattgccagg ctgaaggtga aaccacgaaa
     2281 gacttaagca tagctgtcaa tatgatgaag aggatccatt ccttgttgga caaacactct
     2341 gaacttctgc aagaagcaga tcagaaactc atagccagat gtcttaagta tttagggttt
     2401 tgtgagctag cagtttcttt atatccaact caggatgcat cagatggcat aaaaatgaag
     2461 aaaaagaata aatattcagt tgggattggg ccggctcggt tccaactaca atatatgggt
     2521 cattatttaa tacgagaaga aagaaaagac ccagacccca gggtccaaga ttttattcct
     2581 gacacatggc agcgagagct cctggatgtg gtggataact atgagtctgc agtaattgtt
     2641 gccccaacat catctggcaa gacttatgct tcctactatt gcatggaaaa ggtgctgaaa
     2701 gagagcgatg aaggcgtggt tgtgtatgtt gcaccaacaa aggctcttgt taatcaagtg
     2761 gcagcaactg ttgaatatcg ttatgccaaa aatatgccag ctggtgaatc tctttgtggt
     2821 gtttttacca gggattatcg ccatgatgcc ctcaactgtc aggtgcttat aactgttcct
     2881 gcctgctttg aaattctgct actagctcct catcgccaaa attgggtgaa gaggatcaga
     2941 tatgttatat ttgatgaggt ccattgcctt ggtggagaaa ttggagcgga aatctgggag
     3001 catctccttg ttatgatccg atgtcccttt ttggcccttt cagctaccat tagcaaccct
     3061 cagcatctca ccgagtggct tcagtcagta aagcggtact ggaagcaagt agacagtacc
     3121 atggaggaaa gaactgtttc caaaagaact ggtacctccc gtggcagcta ttacaaagat
     3181 caagcgcaag ccagacagtc ctacaaagtt agacttgtgc tctatggaga gagatacaat
     3241 gacctagaga agtatttgtg ttccgtgaga cagggcgatg tttgctttga tcattttcac
     3301 ccctgcgctg cactaaccat agatcacatt gaaaagtatg gatttccttc tgatcttgcc
     3361 ctttcacccc gagaaagcat acagctgtat gacactatgt gccaggtctg gaagagttgg
     3421 ccccaggccc agagcctatg tccagagaac ttcactcaat ttaagaataa aatagtcatt
     3481 aagaagttgg atgctagaaa atatgaagag agcttaaagg aagaattcac gaattgggtt
     3541 aaaaatggga acgaggagga ggccaggatg gtgctgaaga aactgagccc tgattaccat
     3601 gagcactcag ggaggatgct ggatttcttt ccatgtcttg ttgagaagct aaggaaaatg
     3661 gagaagttgc ctgcactatt ctttttattt aagttaaata ttgtagaaga atgtgctgaa
     3721 aatgctttcg aatttctgga gaaaaaacag gaagaaaaaa gacctcccaa agctgacaaa
     3781 gaagctcgta ccacggctaa caaacttcgg aaagttaaaa aatctctgga gaaacaaaag
     3841 acagtagatg aaaagggcca gaaatcttcc agaagattgg atgaaagcgt tatgcatgaa
     3901 acagaacaca attacctcct gcagactctg gagaagaatc tggagattcc caaggactgc
     3961 acatatgcta atcagaaggc aatagatgat cagttattgc agagggtgtt tcaccgggtg
     4021 agattcgaac gtaaaggtga aacactgaag aggttggcag aaaggggcat tggctaccac
     4081 cacagttcca tgagtgccaa agaaaagcag ttggtcgaaa ttctcttcag gaaaggattc
     4141 atcagggtgg tgacagctac tggaacactc gctttgggaa tcaacatgcc ctgtaaatct
     4201 gtggtttttg cacaaaactc agtctatctg gatgctttaa attacagaca gatgtctggt
     4261 cgggctggaa gacgagggca agacctgttg ggtgatgtct acttctttga tattccactg
     4321 cccaaaatag gaaaactcat aaaatccaaa gttcctgaac ttagaggaca gtttcccctc
     4381 agtatttcac tcatcctaag actcatgttg ctggcttcca aggcggatga cctagaggat
     4441 ggcaaggcaa aggcactgtc agtgctgaag cattcattgt tatccttcaa acaaccccga
     4501 gccatagaca tgttaaagct ttacttctta tattctttgc agttcctggt gaaagaggga
     4561 catatagatc aagaaggtaa tcctacaggg tttgctggcc ttgtctccca tttacattac
     4621 cacgaacctt ctaatctcgt gtttgtcagt tttcttgtaa aaggcctttt ccataaactt
     4681 tgtcagccaa caagggaagg cccaaaacgt ttttctgaag atgtaatgga aaagctggtt
     4741 ttggtattgg caaatctttt tggaagaaga tatatcccag ccaagttcta tgaggttaac
     4801 tccaagtttt atcaatcaaa ggtgttcctt gatgaccttc ccgaggactt cagtcacgcc
     4861 ctgcttgagt acaatacgca agtgacagaa gacttcgctt cctttctgct aatggtatcc
     4921 cgattggctg atatgaaaca ggagtatcaa ctctccttgt caaaaatcga gttcacaggt
     4981 aaagaatgtg aagattcgcc acttgtgtct cacttgatga actgcaagga aggaagggtg
     5041 gcggtttcac cctttgtttg tctgtctgga aactttgatg tggatttgct tagtccagga
     5101 gttccaaatc atgtcattct acacacactt ggtatcaatc acacacaagc cccggtgctg
     5161 tggccatacg cattggatag tcaaggaaga aaaattccac ttaatgccta tgcacttgat
     5221 ttctataagc atggatccct tattggatta gtccaggaca ataggataca tccaggggaa
     5281 gcttatagcc tgttgaaaga ttttaatctt atcattaagt ctatcagtgt ctccttgcgt
     5341 gaactgtgtg aaaatgaaga agacaatgtt gttttagcat ttgaacaatt gtctacgtct
     5401 tttcaagaga agtttgaatt agtgtgaaaa gaaaaactat gtaaactgct taaactatca
     5461 ccatagaatc attgtgaatt atatatcttt actcttatgt cttactcaaa caatcataca
     5521 tgatgagatg gaatgaataa gcaaatagag ttgccatcaa acttcttgtg gttgcctcta
     5581 atgtacttgg tggtttctca aaaagttgac aaaaatgctt atatttctaa attattgagg
     5641 attgaaggaa aaaaaataca agaatattac atatatacat ttaaagacag tttttacact
     5701 ccatgagacc caatcaaata ttgcatttta catattttca ctgttagtat gtctaaaact
     5761 acttttgaag atagaaaaaa atgattttag tatcctgaaa gtgtaatata atctatacaa
     5821 tcaacataaa gggatttcac tgcttagata gctagttaat gaaataatac ctcttgatat
     5881 aatatgaaat gtaaaatatg tatattttca ttgaattttt gtgatgcttt taaagaaaac
     5941 atgtagctaa tatttttctt cattttaatt gtatataaat gactgttgaa ataa
//
