LOCUS       NM_026538               5503 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus DEAD box helicase 56 (Ddx56), transcript variant 1,
            mRNA.
ACCESSION   NM_026538
VERSION     NM_026538.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5503)
  AUTHORS   Wang,J., Wang,Y., Wang,J., Zhang,S., Yu,Z., Zheng,K., Fu,Z.,
            Wang,C., Huang,W. and Chen,J.
  TITLE     DEAD-box helicase 56 functions as an oncogene promote cell
            proliferation and invasion in gastric cancer via the FOXO1/p21
            Cip1/c-Myc signaling pathway
  JOURNAL   Bioengineered 13 (5), 13970-13985 (2022)
   PUBMED   35723050
  REMARK    GeneRIF: DEAD-box helicase 56 functions as an oncogene promote cell
            proliferation and invasion in gastric cancer via the FOXO1/p21
            Cip1/c-Myc signaling pathway.
REFERENCE   2  (bases 1 to 5503)
  AUTHORS   Wang,J., Liu,J., Ye,M., Liu,F., Wu,S., Huang,J. and Shi,G.
  TITLE     Ddx56 maintains proliferation of mouse embryonic stem cells via
            ribosome assembly and interaction with the Oct4/Sox2 complex
  JOURNAL   Stem Cell Res Ther 11 (1), 314 (2020)
   PUBMED   32703285
  REMARK    GeneRIF: Ddx56 maintains proliferation of mouse embryonic stem
            cells via ribosome assembly and interaction with the Oct4/Sox2
            complex.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5503)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5503)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   5  (bases 1 to 5503)
  AUTHORS   Johnson,R.S., Sheng,M., Greenberg,M.E., Kolodner,R.D.,
            Papaioannou,V.E. and Spiegelman,B.M.
  TITLE     Targeting of nonexpressed genes in embryonic stem cells via
            homologous recombination
  JOURNAL   Science 245 (4923), 1234-1236 (1989)
   PUBMED   2506639
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL607152.21.
            
            On Mar 7, 2023 this sequence version replaced NM_026538.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK169654.1, AK076975.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AL607152.21        74875-74958         c
            85-246              AL607152.21        74633-74794         c
            247-407             AL607152.21        74026-74186         c
            408-578             AL607152.21        73727-73897         c
            579-669             AL607152.21        73531-73621         c
            670-914             AL607152.21        72727-72971         c
            915-1034            AL607152.21        71891-72010         c
            1035-1148           AL607152.21        71339-71452         c
            1149-1243           AL607152.21        71154-71248         c
            1244-1317           AL607152.21        69878-69951         c
            1318-1407           AL607152.21        69672-69761         c
            1408-1513           AL607152.21        68831-68936         c
            1514-1587           AL607152.21        66762-66835         c
            1588-5503           AL607152.21        62558-66473         c
FEATURES             Location/Qualifiers
     source          1..5503
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 3.94 cM"
     gene            1..5503
                     /gene="Ddx56"
                     /gene_synonym="2600001H07Rik; D11Ertd619e; Noh61"
                     /note="DEAD box helicase 56"
                     /db_xref="GeneID:52513"
                     /db_xref="MGI:MGI:1277172"
     exon            1..84
                     /gene="Ddx56"
                     /gene_synonym="2600001H07Rik; D11Ertd619e; Noh61"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1665
                     /gene="Ddx56"
                     /gene_synonym="2600001H07Rik; D11Ertd619e; Noh61"
                     /EC_number="3.6.4.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DEAD-box RNA helicase; DEAD (Asp-Glu-Ala-Asp) box
                     polypeptide 56; nucleolar RNA helicase homolog; probable
                     ATP-dependent RNA helicase DDX56; DEAD box protein 56;
                     ATP-dependent 61 kDa nucleolar RNA helicase"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DDX56
                     isoform 1"
                     /protein_id="NP_080814.1"
                     /db_xref="CCDS:CCDS24414.1"
                     /db_xref="GeneID:52513"
                     /db_xref="MGI:MGI:1277172"
                     /translation="MEDQEALGFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEG
                     KDLLARARTGSGKTAAYAIPMLQSLLHKKATGPVMEQAVRGLVLVPTKELARQAQAMI
                     QQLAAYCARDVRVANVSAAEDSASQRAVLMEKPDVVVGTPSRVLSHLQQNTLKLRDSL
                     ELLVVDEADLLFSFGFEDELKSLLCHLPRIYQAFLMSATFNEDVQTLKELVLHNPVTL
                     KLQESQLPGPDQLQQFQVVCETEEDKFLLLYALLKLSLIRGKALLFVNTLERGYRLRL
                     FLEQFSIPSCVLNGELPLRSRCHIISQFNQGLYDCVIATDAEILGPQVKGKRRGRGSK
                     GNKASDPESGVARGIDFHHVSAVLNFDLPPTAEAYVHRAGRTARANNPGIVLTFVLPA
                     EQPFLGKIEDLLSGEGEAPILLPYQFQMEEIESFRYRCRDAMRSVTKQAIREARLKEI
                     KEELLHSEKLKTYFEDNPRDLQLLRHDLPLHPAVVKPHLGHVPDYLVPAALRGLVHPR
                     KKRRKVPFSRKAKKVKAQNPLRDFKHRGKKPKPAAKPS"
     exon            85..246
                     /gene="Ddx56"
                     /gene_synonym="2600001H07Rik; D11Ertd619e; Noh61"
                     /inference="alignment:Splign:2.1.0"
     exon            247..407
                     /gene="Ddx56"
                     /gene_synonym="2600001H07Rik; D11Ertd619e; Noh61"
                     /inference="alignment:Splign:2.1.0"
     exon            408..578
                     /gene="Ddx56"
                     /gene_synonym="2600001H07Rik; D11Ertd619e; Noh61"
                     /inference="alignment:Splign:2.1.0"
     exon            579..669
                     /gene="Ddx56"
                     /gene_synonym="2600001H07Rik; D11Ertd619e; Noh61"
                     /inference="alignment:Splign:2.1.0"
     exon            670..914
                     /gene="Ddx56"
                     /gene_synonym="2600001H07Rik; D11Ertd619e; Noh61"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1034
                     /gene="Ddx56"
                     /gene_synonym="2600001H07Rik; D11Ertd619e; Noh61"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1148
                     /gene="Ddx56"
                     /gene_synonym="2600001H07Rik; D11Ertd619e; Noh61"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1243
                     /gene="Ddx56"
                     /gene_synonym="2600001H07Rik; D11Ertd619e; Noh61"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1317
                     /gene="Ddx56"
                     /gene_synonym="2600001H07Rik; D11Ertd619e; Noh61"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1407
                     /gene="Ddx56"
                     /gene_synonym="2600001H07Rik; D11Ertd619e; Noh61"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1513
                     /gene="Ddx56"
                     /gene_synonym="2600001H07Rik; D11Ertd619e; Noh61"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1587
                     /gene="Ddx56"
                     /gene_synonym="2600001H07Rik; D11Ertd619e; Noh61"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..5503
                     /gene="Ddx56"
                     /gene_synonym="2600001H07Rik; D11Ertd619e; Noh61"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1843..1848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddx56"
                     /gene_synonym="2600001H07Rik; D11Ertd619e; Noh61"
                     /note="hexamer: AATAAA"
     polyA_site      1882
                     /gene="Ddx56"
                     /gene_synonym="2600001H07Rik; D11Ertd619e; Noh61"
                     /note="major polyA site"
     polyA_site      1927
                     /gene="Ddx56"
                     /gene_synonym="2600001H07Rik; D11Ertd619e; Noh61"
     regulatory      2257..2262
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddx56"
                     /gene_synonym="2600001H07Rik; D11Ertd619e; Noh61"
                     /note="hexamer: AATATA"
     polyA_site      2277
                     /gene="Ddx56"
                     /gene_synonym="2600001H07Rik; D11Ertd619e; Noh61"
     regulatory      5482..5487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddx56"
                     /gene_synonym="2600001H07Rik; D11Ertd619e; Noh61"
                     /note="hexamer: AATACA"
     polyA_site      5503
                     /gene="Ddx56"
                     /gene_synonym="2600001H07Rik; D11Ertd619e; Noh61"
ORIGIN      
        1 gcactgacag cgtggagtca cgccatggag gaccaagaag cgctgggttt tgaacacatg
       61 ggcctggatc cccggctcct gcaggctgtc accgatttgg gctggtcgcg acctacgttg
      121 atccaggaaa aggccattcc tctggcgctg gaggggaagg acctcctggc ccgcgcccgc
      181 acaggctccg ggaagaccgc agcttatgct attccgatgc ttcagtcgct tctccacaag
      241 aaggcgacag gtcctgtaat ggagcaggct gtgagaggcc ttgttcttgt tcctaccaag
      301 gagctggcac ggcaggccca ggccatgatc cagcaactgg ctgcctactg tgctcgggat
      361 gtgcgagtgg ctaacgtctc agctgcagaa gactcagctt ctcagagagc tgtgttgatg
      421 gagaagccag atgtggtggt gggaacccca tcccgagtgt taagccactt gcagcagaac
      481 accttgaaac tccgggactc cctagagctg ctggtggtag atgaagctga ccttcttttt
      541 tcctttggct ttgaggatga actcaagagt cttctctgtc acttgcctcg gatttaccag
      601 gcttttctca tgtcggccac tttcaatgag gatgtacaaa ctctgaagga gctggtactg
      661 cataacccgg ttaccctcaa gttacaggag tcccagctgc cggggccaga ccagctccag
      721 caatttcagg tggtctgtga gacagaagag gacaagttct tgctgctgta tgccctgctc
      781 aagctgtcac tgattcgggg caaagccttg ctctttgtca acactctaga gaggggttac
      841 cggctccgtc ttttcctgga acagttcagc attccttcct gcgtgctcaa cggagaactc
      901 ccactgcgct ccaggtgcca catcatctca cagttcaacc aaggcttgta tgattgcgtc
      961 atagcgacag atgctgaaat cttgggaccc caagtcaaag gcaaacgtcg aggccgcggg
     1021 tccaaaggaa acaaggcctc tgatccagag tcaggtgtgg ctcggggcat agacttccac
     1081 cacgtgtctg cggtcctcaa ttttgacctt cctcccaccg cagaggctta tgtccatcga
     1141 gctggcagga cagctcgagc caacaaccca ggcatagttc tgacctttgt gttgcccgcg
     1201 gaacagcctt tcttgggaaa gattgaggac cttctgagtg gagagggcga ggcccccatc
     1261 ctgcttccat accagttcca gatggaggag attgaaagct ttcgttatcg ctgcagggat
     1321 gccatgcgct cagtgaccaa gcaggccatt cgagaggcga gactgaagga gatcaaggag
     1381 gagcttctgc actcagagaa gctcaagaca tactttgaag acaaccccag agaccttcag
     1441 ctacttcgcc atgatctgcc cttgcacccg gcagtggtga agcctcattt gggccatgtc
     1501 cctgactatt tggttcctgc tgctcttcgt ggccttgtac atcctcgaaa gaaacggaga
     1561 aaggtgccct tctctaggaa ggctaagaag gtgaaggccc agaacccact gcgtgacttt
     1621 aagcacaggg gaaagaaacc taagcccgca gcaaagcctt cttgaggttg cctgagcctg
     1681 aggacactga attgggcatc ctggcctgga tggagtgggc tttctgctct gtttgtgggc
     1741 acattctggt gctcagtgtg tggacagact gtactttgag gaagcagctt tggacacccc
     1801 atctccttgg tactactggg ctgccatttt gtccattagc agaataaaga ttccagctgc
     1861 cccgggctgt gaccctctgg aatgtgggaa aagattgctt tcccaaatct ccggagttga
     1921 cagaaaaggt ggtgttgtct ggctctgctg ctgcctgcct cagttggcaa gccaaggcca
     1981 ggtgtcctgg ttctgccggt ccagtgttgg gctgtgactg acccagagcc ctgtctgtag
     2041 ttcctgcagt tctaccaccc cagatcagca gaccgaagag cttgtgttct tctaagtcag
     2101 ggcattcctg accataagcc cctggatctc cccagcatac gcatgttcac attcagagga
     2161 aaacatcact aagccctggg agccaaggca actagcgtcc ctttttggat gaaagattgt
     2221 gacagtctgt gtgtttgttt cagaagcaca agtggtaata tacggaatgc acacctacaa
     2281 gacccctcct ccatgtccca acctgagcac tggctgcagg gggcttcaga ggaggtgatg
     2341 ctctgcatcc tccctcagca tcctcctacc tgtcctgtat accagttact ctctgcctgg
     2401 ctgcttgtca cttgcttatc aggcatcgga aggccaggct ggggtagaag agaagtcaag
     2461 cctgaagttc agctttggtt ctagtcaggg ggtgtggctg gagggacagg gtgaggcttg
     2521 gggtttctgt gtcttaactc caagggtctc caggacgctg gagtatgtag cctgggaaga
     2581 cggggattgt cagtggtaga tgtattccag agcctcgaag cccacagtgt catgctatcc
     2641 tgtgctcagt tgtagtgaga aaaagatgaa gagtagccct gggggccagg aagatggttt
     2701 gtagataagt gtttgctgtg caagtagtga gggcctgggt gtgcttcctc agcacccatg
     2761 gaaagacaga gtggcagtct gcatctccaa caccgttgtg tgcctttagg cagggaggga
     2821 gtgcaaaagg gcttgctggc taggcagtgt agacaaaaca ggatgctcta ggttcaggga
     2881 aagactggat cctaaaaact aagatggaga gcaacagaga agacccactg tgacctctgc
     2941 atgcagaaca gcatgcatca gcatatgcaa aaacagcaat tcctggcctt tgccgccctg
     3001 ctttgctgac agccctggac agttcggtgg actgaggtgg atgttggtcc atgcctgctg
     3061 ttcctgtggt actgtctgat tctgtcactt tccttaccat ggtgaggaca tgtgccccaa
     3121 accacctagt tgttagggta gttcagtggg gctcagcagg taaaggtgtt tgcctgtaag
     3181 gtgtgtgaac caaggccagt tcttaggacc ctcatggtgg gaggaaagaa gagattctca
     3241 caagttctct gaccacatat ttgcaatggc ttttgtgctc ccatacccca taaataaatt
     3301 caaaagcaat ccagtaaaga tggggtcaca cagcaggtgg ggcgaggtca ggtttggagc
     3361 ctggcctggt cagcagtaca gggctagctg tgtgggttgt tactgcagta gctggcgact
     3421 gttctgggac ctgccgttac tcaggcctac actttgggat gagataactt aggctgtgga
     3481 gaaaatgttc cctgttttct gagtctaagt agggagagta tgcagagctt actaccctta
     3541 agcttgctat tgattcttcg taagtttctc atcatgtacc ccagtcccac ccatctcctt
     3601 gtcaccccga cccttgcagc ctcgtcgtcc cccccccccc aaaaaaaaag aaacaaagca
     3661 tagaaaacat tgagggagct gtaatgtcac agtgcgtccc acggtttacc cctgtccaca
     3721 cgtctgcaat ggtctggtct ggtttaaggc ctctaccttc tgtgacactt tactgagtcc
     3781 ttccagttag cctgtgtgtc atggagatcc tgcagctctg ggtcagcagg gctggccatt
     3841 ttatgagccc tggcagttca caaatgatgt agatttttga ggtgggcccg ggatctgcat
     3901 ggtcctgagc tggctctccc ttatccacac catcagggtg agctctctgg ctctgctcca
     3961 gctaggctgc ccagtgccat catcagtagg aggcagggtc agctctcctg ctctcgtgac
     4021 cttcgagcca gctccactgt gctgcccagt caagacttag cccttccttt ctaaggtgca
     4081 acctgtgagg ggttaggcca actctaccac tctggggctg gttcacgccc caacccccac
     4141 atgccttccc cttcagggcc agctccactg tgctgcccag gcaagaccct gagcctgctc
     4201 tcctgagtgt tgcagctggc aaggggcagg gccatctgtc acagggggct ggcggtggag
     4261 agtggttacc attgctgcga ggaggcatca taaccaaagc aacttactga ggaaagggtt
     4321 tcttttgttc atagttcctt ataaagttca tcatcaaaag cagtgaggac aggaacccga
     4381 gtgcaggagc tgatgcagag gctgtggagg ctgctgctta ctagcttgtc cctatgcatt
     4441 gctcaaactg ctttcttaga gcacccagga ccactggcca gggcctcacc cacagtaggc
     4501 tgggccctcc catatctatc actagataag aaaatgccct ctgattctgt tgttatagct
     4561 cccttttcat ttctgatttt attttttttt attttttaat tttttattag gtatttagct
     4621 catttacatt tccaatgcta taccaaaagt cccccatacc cactcacccc tactccccta
     4681 cccacccact cccccttttt ggccctggcg ttcccctgta ctggggcata taaagtttgc
     4741 gtgtccaatg ggcctctctt tccagtgatg gccgactagg ccatcttttg atacatatgc
     4801 agctagagtc aagagctcca gggtactggt tagttcataa tgttctgatt ttattaatta
     4861 ggatactgtc cctgtgccct ctagtgagtc tggctaaggg tttatctatc ttgttgattt
     4921 tctcaaagaa ccagttccta gtttggttga ttctttgtat agttcttttt gttccacttg
     4981 gttgatttca gtcctgagtt tgattatttc ttgcgtctac tcctcttggg tgaatttgct
     5041 tccttttgtt ctaaagcttt taggtgtgct gtcaagctgc tagtgtgtgc tccagtttct
     5101 ttttggaggc actcagggct atgagttttc ctcttaggac tgctttcatt gtgtcccata
     5161 agtttgggta tgttgtgtct tcatttcatt aaactcttga aagtctttaa ttttatttct
     5221 tctttgaaca aggtatcatt gagtagtgtt gttcagcttc tacatgtatg tgggctttct
     5281 attatttatg ttgttattga agatcagcct tagtctgtgg tgatctgata ggatacatgg
     5341 gattatttca atattttttg tatgtgttga ggcctatttg gtgaccaatt atatggtcaa
     5401 ttttggagaa ggtaccatga ggtgctgaga agaaggtata tccttttgtt ttaggatgaa
     5461 atgttctata gatatctgtt aaatacattt gtttaataac ttc
//
