LOCUS       NM_030096               3180 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus DExD box helicase 52 (Ddx52), mRNA.
ACCESSION   NM_030096
VERSION     NM_030096.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3180)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3180)
  AUTHORS   Mori,A.D., Zhu,Y., Vahora,I., Nieman,B., Koshiba-Takeuchi,K.,
            Davidson,L., Pizard,A., Seidman,J.G., Seidman,C.E., Chen,X.J.,
            Henkelman,R.M. and Bruneau,B.G.
  TITLE     Tbx5-dependent rheostatic control of cardiac gene expression and
            morphogenesis
  JOURNAL   Dev Biol 297 (2), 566-586 (2006)
   PUBMED   16870172
  REMARK    Erratum:[Dev Biol. 2007 Sep 15;309(2):386]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ142321.1, AK166789.1, AK141200.1, AL645615.14 and CN539261.1.
            
            On Sep 1, 2009 this sequence version replaced NM_030096.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029094.1, AK141200.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                CJ142321.1         2-76
            76-1874             AK166789.1         2-1800
            1875-2213           AK141200.1         1850-2188
            2214-2877           AL645615.14        35357-36020
            2878-3180           CN539261.1         16-318
FEATURES             Location/Qualifiers
     source          1..3180
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 51.24 cM"
     gene            1..3180
                     /gene="Ddx52"
                     /gene_synonym="2700029C06Rik; ROK1"
                     /note="DExD box helicase 52"
                     /db_xref="GeneID:78394"
                     /db_xref="MGI:MGI:1925644"
     exon            1..175
                     /gene="Ddx52"
                     /gene_synonym="2700029C06Rik; ROK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1885
                     /gene="Ddx52"
                     /gene_synonym="2700029C06Rik; ROK1"
                     /EC_number="3.6.4.13"
                     /note="DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 52;
                     DEAD box protein 52; DEAD (Asp-Glu-Ala-Asp) box
                     polypeptide 52"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DDX52"
                     /protein_id="NP_084372.2"
                     /db_xref="CCDS:CCDS25180.1"
                     /db_xref="GeneID:78394"
                     /db_xref="MGI:MGI:1925644"
                     /translation="MDSYDLFRRLGAGAKFDVKRFSADATRFQVGKRKFDSESLEVLK
                     GLDFFGNKKSVSDECGALQIHQEPPNEEKTQGVLLERSKEPKKKKRKKMTSEVPAQED
                     FDGGIQWTSSVEAKLQDEKVSGEKKLTSGKLEHLRKEKVNFFRNKHKIHVQGTDLPDP
                     IATFQQLDQEYKINSRLLQNILDAGFQVPTPIQMQAIPVMLHGRELLASAPTGSGKTL
                     AFSIPILMQLKQPTNKGFRALVISPTRELASQIHRELIKISEGTGFRIHMIHKAAIAA
                     KKFGPKSSKKFDILVTTPNRLIYLLKQDPPGIDLTNVEWLVVDESDKLFEDGKTGFRE
                     QLASIFLACTSPKVRRAMFSATFAYDVEQWCKLNLDNVVSVSIGARNSAVETVEQELL
                     FVGSETGKLLAMRELVKKGFKPPVLVFVQSIERAKELFHELIYEGINVDVIHAERTQQ
                     QRDNTVHSFRAGKIWVLICTALLARGIDFKGVNLVINYDFPTSSVEYIHRIGRTGRAG
                     NRGKAVTFFTEDDKPLLRSVANVIQQAGCPVPEYIKGFQKLLSKQKKKMIKKPLERES
                     ICTTPKYFLEQAKQKKVAGQNSKKKETLKEKS"
     exon            176..374
                     /gene="Ddx52"
                     /gene_synonym="2700029C06Rik; ROK1"
                     /inference="alignment:Splign:2.1.0"
     exon            375..508
                     /gene="Ddx52"
                     /gene_synonym="2700029C06Rik; ROK1"
                     /inference="alignment:Splign:2.1.0"
     exon            509..694
                     /gene="Ddx52"
                     /gene_synonym="2700029C06Rik; ROK1"
                     /inference="alignment:Splign:2.1.0"
     exon            695..838
                     /gene="Ddx52"
                     /gene_synonym="2700029C06Rik; ROK1"
                     /inference="alignment:Splign:2.1.0"
     exon            839..950
                     /gene="Ddx52"
                     /gene_synonym="2700029C06Rik; ROK1"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1023
                     /gene="Ddx52"
                     /gene_synonym="2700029C06Rik; ROK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1227
                     /gene="Ddx52"
                     /gene_synonym="2700029C06Rik; ROK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1318
                     /gene="Ddx52"
                     /gene_synonym="2700029C06Rik; ROK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1441
                     /gene="Ddx52"
                     /gene_synonym="2700029C06Rik; ROK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1592
                     /gene="Ddx52"
                     /gene_synonym="2700029C06Rik; ROK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1668
                     /gene="Ddx52"
                     /gene_synonym="2700029C06Rik; ROK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1740
                     /gene="Ddx52"
                     /gene_synonym="2700029C06Rik; ROK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1827
                     /gene="Ddx52"
                     /gene_synonym="2700029C06Rik; ROK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..3166
                     /gene="Ddx52"
                     /gene_synonym="2700029C06Rik; ROK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2240..2245
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddx52"
                     /gene_synonym="2700029C06Rik; ROK1"
                     /note="hexamer: AATAAA"
     polyA_site      2263
                     /gene="Ddx52"
                     /gene_synonym="2700029C06Rik; ROK1"
                     /note="major polyA site"
     regulatory      3136..3141
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddx52"
                     /gene_synonym="2700029C06Rik; ROK1"
                     /note="hexamer: AATAAA"
     polyA_site      3166
                     /gene="Ddx52"
                     /gene_synonym="2700029C06Rik; ROK1"
                     /note="major polyA site"
ORIGIN      
        1 gacttccgct acggcctgtg cggaagcagt cgcggataga aagtggtaaa cgcaggcgcc
       61 gggaggccgt ggggccttct gggtaaagat ggattcctac gacctgtttc gccggcttgg
      121 agccggcgcc aagttcgacg tgaagcgctt ctcagcagac gctactcgat tccaggtagg
      181 aaaaaggaaa ttcgattccg agtctttgga ggtcctgaag ggactagact tcttcggaaa
      241 caagaagtcc gtctcagatg aatgtggagc attgcaaata caccaggagc ccccaaatga
      301 ggagaaaaca caaggggtcc tgttggaaag gagtaaggag cccaagaaga aaaagagaaa
      361 gaagatgact tcagaagttc ctgctcaaga agactttgac ggtggtatcc agtggacatc
      421 ctctgtagaa gcaaagcttc aagatgaaaa agtcagtgga gagaagaagt taacttcagg
      481 aaagttggaa catctcagaa aggaaaaggt caacttcttt cggaacaagc acaagataca
      541 tgtccaagga actgatcttc ctgacccaat tgctacattt cagcaacttg accaggaata
      601 taaaatcaat tctagattgc tccagaatat tctagacgca ggcttccaag tgcccacacc
      661 aattcagatg caagccattc cagttatgct gcatggtcgg gaacttctgg cttctgctcc
      721 aaccggatct gggaagacgt tggcatttag catccccatt ttaatgcagc tgaaacaacc
      781 aacaaataaa ggctttagag ccctggttat atccccaacc cgagaacttg caagccagat
      841 tcacagagaa ttaattaaaa tatctgaggg tacaggattc agaatacata tgatccacaa
      901 agctgcaata gcagctaaga aatttggacc taaatcatct aagaagtttg atatccttgt
      961 gactactcca aatcgactga tctacttgtt gaagcaggat ccaccaggga ttgacctaac
     1021 aaatgtcgag tggctggtag tagatgaatc agacaaactg tttgaagatg gcaaaactgg
     1081 gtttagagag cagctggctt ccattttcct ggcctgcaca tcgcccaagg tcagaagagc
     1141 aatgttcagc gcaacttttg cgtacgacgt tgaacagtgg tgcaagctca acctggacaa
     1201 cgtcgtttcc gtgtccattg gagcaaggaa ttctgcagtc gaaactgttg aacaagagct
     1261 tctctttgtt ggatctgaga ctggaaaact tctggccatg agagaacttg ttaaaaaggg
     1321 tttcaagcca cctgttcttg ttttcgttca gtccattgaa agagctaaag aacttttcca
     1381 tgagctcata tatgaaggta ttaatgtgga tgtcattcat gcagaaagaa cacagcagca
     1441 gcgagataac acagtccaca gcttcagagc aggaaaaatt tgggttctta tttgtacagc
     1501 cttacttgca agagggattg actttaaagg cgtaaacctg gtcatcaatt atgattttcc
     1561 caccagctca gtggagtaca tccataggat aggtcggact ggaagagcag ggaatagggg
     1621 aaaggctgtt acatttttca ctgaagatga taaaccatta ctaagaagtg ttgccaatgt
     1681 tatccagcag gctggttgtc ctgtgcccga atacataaaa ggtttccaga aactactaag
     1741 caaacaaaag aaaaaaatga ttaagaagcc gttggaaagg gagagcattt gtacaactcc
     1801 aaagtacttc ttagagcaag ctaaacagaa aaaggttgct ggccaaaaca gcaagaagaa
     1861 agaaactctc aaagagaaaa gttaaaaaat aaatacctta gaaggcaatc cctgcagtgt
     1921 aacttatgag cctggcatgg attctcatgg agtacttaca accatcttta ccaaacattt
     1981 gaaatccaca aggatatgag aggacagaat ggttctgatg tagtgatgca tcaagcttca
     2041 ctttgtaggt gggatttata caatgaaaat aacaggcatt ggcatttctg cctgaatcca
     2101 gagagatact tcttatagaa gaacaagagc cgatgctaaa ataacaccca agtgtggtga
     2161 actcttaagg attttgccct tcaagtgtga aggaaagtgt gatgcatgct gtggagaggc
     2221 gtctggaaca gaattttaaa ataaaacctt gagtttgagt gcaccatcca cacttgtgtg
     2281 tatggagagc cagcgctgtg tgggatgcaa acaagagcag cagcacaggc cagacacagg
     2341 aaggagccta gcactccctt tagtgtttct ttgtggtagg agccacagta aggaggtccc
     2401 ccatctgtgg ttatccaaat tccagaggat tggaaacttg agcctgttga aattgacctg
     2461 tactgcactg gggaggaagc ttatgcttag ctgtcataat gttgcaactg taaggttatg
     2521 atcagccttt ccctgtctga cttcattctc catcatttaa ccatgttctt tcctgtctct
     2581 ttccaccaag atgactgcct gaaagcagat agcactctat cctatcctga tgaggaagaa
     2641 cattcccgtt acacgataca cctcgtttca ttgtctcaga tgcttatctt tgctgagact
     2701 tgatgggctt cagccaccct ccacagagaa ctgtgatcat ttggaccaag gcagtgcaca
     2761 gtatgcaggt tttccttaat tacctgcttt gtacagtgga ataaaaaagg cttggtacaa
     2821 gttgaagcac ttaagactgg agcctagaat ttctcagggc ctgtgctgcc acaggactac
     2881 aacataagtg actgccagca actgaattaa gcctgtttcc tttactctag gcagttgata
     2941 ctttagtcta aaatcagcac agtagacctc cttttaaatg tgtatttgtt ttgaaaaggg
     3001 atctctgtat cccagactgg cctggaactc acagcaatcc tcctgtttca gcccctttac
     3061 tgctgagaat acagacatga gactgatatt gaatagatgg gataaagatt taaaaaaaaa
     3121 atcaggcttc atttaaataa actgctctag agaataaaaa ctaaaaaaaa aaaaaaaaaa
//
