LOCUS       NM_027156               4874 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus DEAD box helicase 51 (Ddx51), mRNA.
ACCESSION   NM_027156
VERSION     NM_027156.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4874)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4874)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4874)
  AUTHORS   Srivastava,L., Lapik,Y.R., Wang,M. and Pestov,D.G.
  TITLE     Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S
            rRNA by promoting the release of U8 snoRNA
  JOURNAL   Mol Cell Biol 30 (12), 2947-2956 (2010)
   PUBMED   20404093
  REMARK    GeneRIF: The mammalian DEAD box helicase family member Ddx51 is
            identified as a novel ribosome synthesis factor and an interacting
            partner of the nucleolar GTP-binding protein Nog1.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY010157.1 and BC060646.1.
            
            On May 7, 2009 this sequence version replaced NM_027156.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060646.1, AK141361.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BY010157.1         2-24
            24-4651             BC060646.1         1-4628
            4652-4874           BC060646.1         4630-4852
FEATURES             Location/Qualifiers
     source          1..4874
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 53.69 cM"
     gene            1..4874
                     /gene="Ddx51"
                     /gene_synonym="2310061O04Rik"
                     /note="DEAD box helicase 51"
                     /db_xref="GeneID:69663"
                     /db_xref="MGI:MGI:1916913"
     exon            1..338
                     /gene="Ddx51"
                     /gene_synonym="2310061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1957
                     /gene="Ddx51"
                     /gene_synonym="2310061O04Rik"
                     /EC_number="3.6.4.13"
                     /note="DEAD box protein 51; DEAD (Asp-Glu-Ala-Asp) box
                     polypeptide 51"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase DDX51"
                     /protein_id="NP_081432.2"
                     /db_xref="CCDS:CCDS19528.1"
                     /db_xref="GeneID:69663"
                     /db_xref="MGI:MGI:1916913"
                     /translation="MALFHIARYAGPEAAGQGDTDAEAGSRARVLLERLQNRARERQQ
                     REPELETTGTAGEGEAAAAGKRRRRPRRRRRVSGSATPNSEAPRAKRRKADKDVDAGR
                     GEEAPEELSAGAEDPGANPQEDVQRPPAPGRVLGDFARRKTPKVQPFLPAWLAKPSCV
                     KKSVTEDLTPIEDIPEVHPDLQKQLRANGITSYFPVQAAVIPALLESADHGFLIGRGG
                     YQPSDLCVSAPTGSGKTLAFVIPVVQALLHRVVCHIRALVVLPTKELAQQVSKVFNIY
                     TDTTPLRVALVTGQKSLAKEQESLVQKTADGFRCLADIVVATPGRLVDHIDQTPGFSL
                     QQLRFLIIDEADRMIDSMHQSWLPRVVAAAFYSEGPTGSCALLQRTQPQALTAASTCV
                     PQMPLQKLLFSATLTQDPEKLQRLGLYQPRLFSTRLGQQSPKDTAEVDENSGKYTFPV
                     GLTHHYVPCRLSSKPLIVLHLVLRMSCSRALCFTNSRENSHRLYLLAQAFGGVSVAEF
                     SSRYGPGQRKKILKQFEQGKIQLLISTDATARGIDVQGVELVINYDAPQYLRTYVHRV
                     GRTARAGKTGQAFTLLLKVQERKFLQMVSEAGVPELTHHEIPRKLLQPLVARYETALS
                     QLEKTVKEEQKLKAA"
     exon            339..472
                     /gene="Ddx51"
                     /gene_synonym="2310061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            473..623
                     /gene="Ddx51"
                     /gene_synonym="2310061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            624..769
                     /gene="Ddx51"
                     /gene_synonym="2310061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            770..841
                     /gene="Ddx51"
                     /gene_synonym="2310061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            842..948
                     /gene="Ddx51"
                     /gene_synonym="2310061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1057
                     /gene="Ddx51"
                     /gene_synonym="2310061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1203
                     /gene="Ddx51"
                     /gene_synonym="2310061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1396
                     /gene="Ddx51"
                     /gene_synonym="2310061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1512
                     /gene="Ddx51"
                     /gene_synonym="2310061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1629
                     /gene="Ddx51"
                     /gene_synonym="2310061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1731
                     /gene="Ddx51"
                     /gene_synonym="2310061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1795
                     /gene="Ddx51"
                     /gene_synonym="2310061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1930
                     /gene="Ddx51"
                     /gene_synonym="2310061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..4846
                     /gene="Ddx51"
                     /gene_synonym="2310061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2526..2531
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddx51"
                     /gene_synonym="2310061O04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2548
                     /gene="Ddx51"
                     /gene_synonym="2310061O04Rik"
                     /note="major polyA site"
     regulatory      3199..3204
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddx51"
                     /gene_synonym="2310061O04Rik"
                     /note="hexamer: TATAAA"
     polyA_site      3220
                     /gene="Ddx51"
                     /gene_synonym="2310061O04Rik"
     regulatory      4118..4123
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddx51"
                     /gene_synonym="2310061O04Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      4152
                     /gene="Ddx51"
                     /gene_synonym="2310061O04Rik"
     regulatory      4823..4828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddx51"
                     /gene_synonym="2310061O04Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      4846
                     /gene="Ddx51"
                     /gene_synonym="2310061O04Rik"
ORIGIN      
        1 aaagagcgcc ggagaggaac cgcggcgtgg ggcagctatg gcgctgttcc acatagcgcg
       61 gtacgcgggc ccagaggccg cggggcaggg ggatacggac gcagaggcgg gcagccgggc
      121 tcgagtgctg ctcgagcggc tgcagaacag agcccgtgag cgacagcagc gggagccgga
      181 gctcgagacc acaggaacgg ccggggaagg ggaagcggca gcagcaggca agcggcgacg
      241 gcggccccga cggcggcgtc gggtgagcgg ctcggcgact ccgaactcgg aggctcctag
      301 ggcgaagcgg cggaaagcgg acaaggacgt ggacgcaggg agaggtgagg aggctccgga
      361 ggagctcagt gccggcgcag aggacccggg tgcgaaccct caggaggatg tccagagacc
      421 cccggctcca ggccgggtgc tgggggactt tgcaagaaga aagacgccga aggttcagcc
      481 tttcctgcca gcatggttgg ctaagccaag ctgtgtcaaa aagagtgtca ccgaagatct
      541 cactcccatt gaggacatcc ctgaggttca ccctgacctg cagaagcagt tgagagctaa
      601 tggcatcact tcctactttc cagtccaggc agctgtgatt cccgccctcc tcgaaagtgc
      661 tgaccatggg tttctcatag gcagaggtgg ctaccaacct agtgacctct gcgtctctgc
      721 cccaacgggc agtgggaaaa cactggcctt tgtcatcccc gtggtacagg ccctgttgca
      781 tcgagtggtc tgccacatcc gtgcactggt tgtacttccc actaaggagc tggcccaaca
      841 ggtgagcaaa gtattcaaca tctacacaga caccacgcct ctgagggttg ccttggtgac
      901 tggacagaag tcgctggcta aggagcagga gagtcttgtc cagaagacag cagatggttt
      961 ccgttgcctg gccgacattg tggtggccac acctggccgc ttggtggacc acattgacca
     1021 gactccagga ttcagcctcc agcagctccg cttcctgatc attgatgagg ctgaccggat
     1081 gatagacagc atgcaccagt cctggctgcc acgagtggtg gcggcagcct tctacagtga
     1141 gggccccacg ggttcctgtg ccctgctcca gaggacacag ccccaggctc tgactgctgc
     1201 cagcacctgt gtcccccaga tgcctctgca gaagctactg ttctcagcca cactgaccca
     1261 ggaccccgag aagctgcagc gccttggcct ctaccagcca cggcttttct ccacaaggct
     1321 gggacaacaa agtcctaaag acacagctga ggtggatgaa aactcgggga agtacacctt
     1381 ccccgtgggg ctcacgcatc actatgtgcc gtgtagactc agctcgaagc cactcattgt
     1441 cttacacctg gtcctcagga tgagctgctc aagggctctt tgcttcacca actcccgaga
     1501 aaactcccac aggctgtacc tattagcaca agcttttggg ggtgtgagtg tggctgaatt
     1561 ctcctcccgc tatgggcctg gccaaaggaa gaaaatcttg aagcagtttg aacaaggaaa
     1621 gatccagctc cttatcagca cagatgctac tgctcgaggc attgatgtgc agggtgtgga
     1681 gctggtgatc aactacgatg ccccacaata tctgaggacc tatgtgcaca gggtcgggag
     1741 aacagctcga gccgggaaaa ctggacaggc attcacactt ctcttgaaag tgcaggaaag
     1801 gaagttcctt cagatggtgt cagaagctgg ggtgcctgag ctgacacacc atgagatccc
     1861 caggaagctc ctgcagccgc tggttgctcg ttatgagaca gccttgtctc agttggagaa
     1921 aactgtcaag gaggagcaga aactgaaggc agcctagatg agaacagggc cctggaggga
     1981 agatcgtgcg aacagaagat aagttccttg gggttccagt ggaaacaacc cttctcccca
     2041 gtgccgtggg catctggtcg tcttggttga tgcagcctag atggtggcct cgtcctgaaa
     2101 agtaatggct ctcgggttgg actgctggtg tccagttggt cttgggaaat aagctcaggt
     2161 gaagctgaag gatgccttct ggagtgtgag caaacactat ggtgactgga ctgtggtgat
     2221 caaagtgctt atacgttagc gtctcctgtc tacagagaag ctatggcgag cctgccccag
     2281 gcaagtcact ggagcccaag aacaggttgg cagcagcctt gaagatactt ccttggctac
     2341 tagtcttcaa gattgtactt tataattagc ctcccaccca tttaagttct taaatgatgt
     2401 gagagtcctt ccctgaatat atatagtcaa ggagaattag cgcttacctg tgcttttaag
     2461 aaggcctgtt tttaaaaagt cagtgtatca aaaaagataa acattttcat ttgtattcag
     2521 aaaaaaataa atggatcact tgaacctata caaattcccg atagctccaa cacagccact
     2581 taactactcc tctaacccag aacacctagg cacaggctac gggtactatc ttcaggccct
     2641 tggaacttgg ataaggggaa gcttcccaca gctttaacca ggcctccctc ccttttaaat
     2701 ttcacatata tgagtgttta cctgcatgta tgtctgtata gcatatatgc ctagtgccca
     2761 aggaagccag aagtgtttgt tggatcccct agaactggaa ctacaggcag ttgtaagctg
     2821 gatcctctac aagagcttta attactgagc catctctgtg tccctgtcca agtccttttt
     2881 aaatctgaag ctaccacagc cctggcttcc cttactggtg ccttgttcca gttgccttgg
     2941 ttttgcctct tctgtgacct ttcagaacat gcattgccct agacccaagc tagcatcact
     3001 ttctttctca caggatcaga cccttcccct acacccagag atctcccaaa cactgtctgc
     3061 caagattagg ttagtaagat catgtgctgg ctttctatct gaattggtga tactaaaagg
     3121 gatagatgct aggatagctg actgggtgtt cacagtgtta gaacaagctt aataacttgt
     3181 aattagacca aaccgatata taaagtgcat gaggattgca gttatgaggt ttggttcatg
     3241 tgtgttgggc ccaggaaatg tttttccaaa gcttgtttta aggaaatgcc tgttttctaa
     3301 caaaatctta ggtagagcct aatagtagga ataaagtagg caaagccatt gtgggaggtt
     3361 caagactgac aacagcatca ggcattttgc agaagaggtt aaaactgggg gaatagtttc
     3421 cacagaagca ccgaaacaaa cgtgggctca tgtcaacatt aaccctgcca ggtagaagcc
     3481 actgaagcta ccccacagga ggacacaaga cagtgaaaca tttggagtaa ctcactcatc
     3541 acactatagg gcctgtttgt ttcccaggcc tgtagtggtt accttacagc tttctctgcc
     3601 ctggaccata gctctgtgga atttgcatct gaccctagcc tcttgctgtg tgggaggttg
     3661 ctcactgggg agtagtaccc aaaactgaga gagtcaaagt agccggtgtc attctgattc
     3721 tttttttttt ttaatgttta ttttgtttgc atgtttattt gtgtaccatg tgtttgcagt
     3781 ccattatgga aaccagaaga gggggactga gttacagtca attatgatct accatttagg
     3841 tgctgggaat tgaacctggg tcctttggaa aagcagccag tgttcttaac tgttgagcca
     3901 tctctccagc ccatcattgt gtcccttaaa tcacagcctt tatgggtaaa tactgatctc
     3961 tcacagggta gtcacagttg atttttgaaa acagctggtt tttttaaaaa aatgtttgtt
     4021 tactgagcag ggttctctgc atagcctggc tgttctggaa cttgctctgt agaccagcag
     4081 ccttgaactc tcctgcctct gcctcttgaa tgctgagatt aaaggcctgt gccaccttca
     4141 ctcctagcca gatacagatg gttttaatgt gagttattag agctaggatt ttcacagacc
     4201 aaaactgaaa gatcttgctg atgagaagtc tggtctgaag gtcagacttc cttttgagta
     4261 atcaacattg tgttactaat gctttcagca tttcatacag tgaaatttga tcatattcac
     4321 acacacaccc ttttctccca tatccatcct tactctcacc tccccaccca tctagcccca
     4381 aggttttctg ttgttgttta aacccattga attgatttgt attatggagt gtggttcctg
     4441 ccctgcaatg tggtcagcct actaggggtc acactaccaa agaaaactga gtccctcttt
     4501 cagtagcagt aataacagta gttcctcagc ttatacaggt cttgtgcatg ccatcacagt
     4561 ctctgtgagt tcatatgcct tactgctcta ttgtgtcttg aaagcatttt cccttgaagt
     4621 tatgtactgc ctctggctct taaatttttt tgtaccctct tccttaaaga tccctgagct
     4681 tggacagaga ggtgtgaaat gttccactta gaggtcaaca ctccacacac acactctcac
     4741 tctggacttg ttgagcagct gtcatctgaa agcttttctg atgaaagttg gcagtacacc
     4801 tacctatggg gatagcagtg tcattaaaag tcatttttta ccctgtaaaa aaaaaaaaaa
     4861 aaaaaaaaaa aaaa
//
