LOCUS       NP_444413                734 aa            linear   ROD 27-APR-2025
DEFINITION  ATP-dependent RNA helicase DDX50 isoform 1 [Mus musculus].
ACCESSION   NP_444413
VERSION     NP_444413.1
DBSOURCE    REFSEQ: accession NM_053183.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 734)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   2  (residues 1 to 734)
  AUTHORS   Valdez,B.C., Yang,H., Hong,E. and Sequitin,A.M.
  TITLE     Genomic structure of newly identified paralogue of RNA helicase
            II/Gu: detection of pseudogenes and multiple alternatively spliced
            mRNAs
  JOURNAL   Gene 284 (1-2), 53-61 (2002)
   PUBMED   11891046
REFERENCE   3  (residues 1 to 734)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121961.2, AK162423.1 and AK041281.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090996.1, AF334104.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..734
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.44 cM"
     Protein         1..734
                     /product="ATP-dependent RNA helicase DDX50 isoform 1"
                     /EC_number="3.6.4.13"
                     /note="ATP-dependent RNA helicase DDX50; gu-beta; DEAD box
                     protein 50; RH-II/Gubeta; DEAD/H (Asp-Glu-Ala-Asp/His) box
                     polypeptide 50; nucleolar protein GU2; DEAD
                     (Asp-Glu-Ala-Asp) box polypeptide 50"
                     /calculated_mol_wt=82045
     Region          1..131
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MJ9.1)"
     Site            41
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BQ39; propagated from
                     UniProtKB/Swiss-Prot (Q99MJ9.1)"
     Site            81
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BQ39; propagated from
                     UniProtKB/Swiss-Prot (Q99MJ9.1)"
     Site            85
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BQ39; propagated from
                     UniProtKB/Swiss-Prot (Q99MJ9.1)"
     Site            113
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9JIK5; propagated from
                     UniProtKB/Swiss-Prot (Q99MJ9.1)"
     Site            119
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9JIK5; propagated from
                     UniProtKB/Swiss-Prot (Q99MJ9.1)"
     Site            120
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9JIK5; propagated from
                     UniProtKB/Swiss-Prot (Q99MJ9.1)"
     Region          134..162
                     /region_name="Q motif"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MJ9.1)"
     Region          136..523
                     /region_name="SrmB"
                     /note="Superfamily II DNA and RNA helicase [Replication,
                     recombination and repair]; COG0513"
                     /db_xref="CDD:440279"
     Site            244
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9NR30; propagated from
                     UniProtKB/Swiss-Prot (Q99MJ9.1)"
     Region          287..290
                     /region_name="DEVD box"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MJ9.1)"
     Site            515
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9NR30; propagated from
                     UniProtKB/Swiss-Prot (Q99MJ9.1)"
     Region          565..656
                     /region_name="GUCT_RHII_Gualpha_beta"
                     /note="RNA-binding GUCT domain found in vertebrate RNA
                     helicase II/Gualpha (RH-II/Gualpha), RNA helicase
                     II/Gubeta (RH-II/Gubeta) and similar proteins; cd12936"
                     /db_xref="CDD:240593"
     Region          664..734
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MJ9.1)"
     CDS             1..734
                     /gene="Ddx50"
                     /gene_synonym="4933429B04Rik; 8430408E17Rik; GU2; RH-II"
                     /coded_by="NM_053183.3:108..2312"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS23892.1"
                     /db_xref="GeneID:94213"
                     /db_xref="MGI:MGI:2182303"
ORIGIN      
        1 mpgkllwgdi meleaplees esqrkerqks drrksrhhse seertetren gvtddldapk
       61 pkkakmrekl ngdtkeglrf sdefspshks rrkdlpngdv deyekrskrv sssenshkss
      121 dkaeetltre qkegafsnfs iseetikllk grgvtylfpi qvktfgpvye gkdliaqart
      181 gtgktfsfai plierlqrnq etikksrspk vlvlaptrel anqvakdfkd itrklsvacf
      241 yggtsyqsqi nqirngidil vgtpgrikdh lqsgrldlsk lrhvvldevd qmldlgfaeq
      301 vediihesyk tdsednpqtl lfsatcpqwv ykvakkymks ryeqvdlvgk mtqkaattve
      361 hlaiqchwsq rpavigdvlq vysgsegrai ifcetkknvt emamnphikq naqclhgdia
      421 qsqreitlkg fregsfkvlv atnvaargld ipevdlviqs sppqdvesyi hrsgrtgrag
      481 rtgicvcfyq prergqlryv eqkagitfkr vgvpstmdlv ksksmdairs lasvsyaavd
      541 ffrpsaqrli eekgavdala aalahisgas sfeprslits dkgfvtmtle speeiqdvsc
      601 awkelnrkls snavshvtrm cllkgnmgvc fdvptseser lqaewhdsdw ilsvpaklpe
      661 ieeyydgnts snprqrsgws ggrsgrsgrs ggrsggrsgr qsrqgsrsgs rqdgrrrsgn
      721 rnrsrsgghk rnfd
//
