LOCUS       NM_007840               3520 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Mus musculus DEAD box helicase 5 (Ddx5), mRNA.
ACCESSION   NM_007840
VERSION     NM_007840.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3520)
  AUTHORS   Wen,C., Cao,L., Wang,S., Xu,W., Yu,Y., Zhao,S., Yang,F., Chen,Z.J.,
            Zhao,S., Yang,Y. and Qin,Y.
  TITLE     MCM8 interacts with DDX5 to promote R-loop resolution
  JOURNAL   EMBO J 43 (14), 3044-3071 (2024)
   PUBMED   38858601
  REMARK    GeneRIF: MCM8 interacts with DDX5 to promote R-loop resolution.
REFERENCE   2  (bases 1 to 3520)
  AUTHORS   Xu,J., Liu,L.Y., Zhi,F.J., Song,Y.J., Zhang,Z.H., Li,B.,
            Zheng,F.Y., Gao,P.C., Zhang,S.Z., Zhang,Y.Y., Zhang,Y., Qiu,Y.,
            Jiang,B., Li,Y.Q., Peng,C. and Chu,Y.F.
  TITLE     DDX5 inhibits inflammation by modulating m6A levels of TLR2/4
            transcripts during bacterial infection
  JOURNAL   EMBO Rep 25 (2), 770-795 (2024)
   PUBMED   38182816
  REMARK    GeneRIF: DDX5 inhibits inflammation by modulating m6A levels of
            TLR2/4 transcripts during bacterial infection.
REFERENCE   3  (bases 1 to 3520)
  AUTHORS   Louis,T.L., Wong,W.H., Yao,P., Kurd,N.S., Tysl,T.,
            Indralingam,C.S., Ma,S., Huang,W.J.M. and Chang,J.T.
  TITLE     Regulation of CD8 T Cell Differentiation by the RNA-Binding Protein
            DDX5
  JOURNAL   J Immunol 211 (2), 241-251 (2023)
   PUBMED   37265401
  REMARK    GeneRIF: Regulation of CD8 T Cell Differentiation by the
            RNA-Binding Protein DDX5.
REFERENCE   4  (bases 1 to 3520)
  AUTHORS   Ma,S., Yang,Q., Chen,N., Zheng,A., Abbasi,N., Wang,G., Patel,P.R.,
            Cho,B.S., Yee,B.A., Zhang,L., Chu,H., Evans,S.M., Yeo,G.W.,
            Zheng,Y. and Huang,W.J.M.
  TITLE     RNA binding protein DDX5 restricts RORgammat+ Treg suppressor
            function to promote intestine inflammation
  JOURNAL   Sci Adv 9 (5), eadd6165 (2023)
   PUBMED   36724232
  REMARK    GeneRIF: RNA binding protein DDX5 restricts RORgammat[+] Treg
            suppressor function to promote intestine inflammation.
REFERENCE   5  (bases 1 to 3520)
  AUTHORS   Takeda,K., Tago,K. and Funakoshi-Tago,M.
  TITLE     The indispensable role of the RNA helicase DDX5 in tumorigenesis
            induced by the myeloproliferative neoplasm-associated JAK2V617F
            mutant
  JOURNAL   Cell Signal 102, 110537 (2023)
   PUBMED   36442590
  REMARK    GeneRIF: The indispensable role of the RNA helicase DDX5 in
            tumorigenesis induced by the myeloproliferative neoplasm-associated
            JAK2V617F mutant.
REFERENCE   6  (bases 1 to 3520)
  AUTHORS   Petry,P., Johnson,K.R., Lemaire,L. and Heinlein,U.A.
  TITLE     Assignment to chromosome 11 of mouse p68 RNA helicase gene (Hlr1)
            and pseudogene (Hlr1-ps1)
  JOURNAL   FEBS Lett 363 (1-2), 25-28 (1995)
   PUBMED   7729546
REFERENCE   7  (bases 1 to 3520)
  AUTHORS   Lemaire,L., Johnson,K.R., Bammer,S., Petry,P., Ruddle,F.H. and
            Heinlein,U.A.
  TITLE     Chromosomal assignment of three novel mouse genes expressed in
            testicular cells
  JOURNAL   Genomics 21 (2), 409-414 (1994)
   PUBMED   8088835
REFERENCE   8  (bases 1 to 3520)
  AUTHORS   Gee,S.L. and Conboy,J.G.
  TITLE     Mouse erythroid cells express multiple putative RNA helicase genes
            exhibiting high sequence conservation from yeast to mammals
  JOURNAL   Gene 140 (2), 171-177 (1994)
   PUBMED   8144024
REFERENCE   9  (bases 1 to 3520)
  AUTHORS   Lemaire,L. and Heinlein,U.A.
  TITLE     High-level expression in male germ cells of murine P68 RNA helicase
            mRNA
  JOURNAL   Life Sci 52 (11), 917-926 (1993)
   PUBMED   8445986
REFERENCE   10 (bases 1 to 3520)
  AUTHORS   Iggo,R., Gough,A., Xu,W., Lane,D.P. and Spurr,N.K.
  TITLE     Chromosome mapping of the human gene encoding the 68-kDa nuclear
            antigen (p68) by using the polymerase chain reaction
  JOURNAL   Proc Natl Acad Sci U S A 86 (16), 6211-6214 (1989)
   PUBMED   2762324
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK166045.1.
            
            On Apr 6, 2007 this sequence version replaced NM_007840.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK166045.1, AK135173.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3520              AK166045.1         2-3521
FEATURES             Location/Qualifiers
     source          1..3520
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 70.01 cM"
     gene            1..3520
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /note="DEAD box helicase 5"
                     /db_xref="GeneID:13207"
                     /db_xref="MGI:MGI:105037"
     exon            1..222
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..2026
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /EC_number="3.6.4.13"
                     /note="DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5;
                     mDEAD1; RNA helicase p68; DEAD box protein 5; DEAD box RNA
                     helicase DEAD1; DEAD
                     (aspartate-glutamate-alanine-aspartate) box polypeptide 5;
                     DEAD (Asp-Glu-Ala-Asp) box polypeptide 5"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DDX5"
                     /protein_id="NP_031866.2"
                     /db_xref="CCDS:CCDS25562.1"
                     /db_xref="GeneID:13207"
                     /db_xref="MGI:MGI:105037"
                     /translation="MSSYSSDRDRGRDRGFGAPRFGGSRTGPLSGKKFGNPGEKLVKK
                     KWNLDELPKFEKNFYQEHPDLARRTAQEVDTYRRSKEITVRGHNCPKPVLNFYEANFP
                     ANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQP
                     FLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLERGV
                     EICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTL
                     MWSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLME
                     EIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKA
                     PILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNI
                     KQVSDLISVLREANQAINPKLLQLVEDRGSGRSRGRGGMKDDRRDRYSAGKRGGFNTF
                     RDRENYDRGYSNLLKRDFGAKTQNGVYSAANYTNGSFGSNFVSAGIQTSFRTGNPTGT
                     YQNGYDSTQQYGSNVANMHNGMNQQAYAYPATAAAAPMIGYPMPTGYSQ"
     exon            223..388
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            389..485
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            486..619
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            620..685
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            686..827
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            828..988
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1161
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1272
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1334
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1394
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1619
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..3520
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3520
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /note="putative"
ORIGIN      
        1 acctcattca tttccatcgg tccttgccct cgcagctccg gccctcgaca ccaccggccc
       61 ctccgctggt gacgcccccg cagaggcttc gccgtcgccg aggccttctc tccgcgactc
      121 gtcgccgcag gattctactt tcactgggtt ccgcccgcac accgccacca ttgacgccat
      181 gtcgagttat tctagtgacc gagaccgcgg ccgggatcga gggtttggtg cacctcgatt
      241 tggagggagt agaacaggac ccctctctgg aaagaagttt ggaaatcctg gggagaaact
      301 agttaaaaag aagtggaatc ttgatgagct gcccaaattt gagaagaatt tttatcaaga
      361 acaccctgat ttggcaaggc gcaccgcaca agaggtagat acatacagaa gaagcaagga
      421 aattacagtt agaggtcaca actgtccaaa acctgttctg aatttttatg aagcaaactt
      481 tcctgcgaat gtcatggatg tgattgcaag gcagaacttt actgaaccca ctgctattca
      541 agctcagggc tggccagttg ctctcagtgg attggatatg gttggagtag ctcagactgg
      601 atctgggaaa acattatctt atttgctgcc tgccattgta cacataaacc accagccatt
      661 cctagagaga ggtgatgggc ctatttgctt ggtgctggca ccaactcgag aactggcaca
      721 gcaggtgcag caagtggctg ctgaatattg tcgagcttgt cgcttgaagt ctacttgcat
      781 ctatggtggt gctcccaaag gaccacagat tcgtgatttg gaaagaggtg tggaaatctg
      841 tattgcaaca cctggaagac tgattgactt tttagagtgt gggaaaacca atctgagaag
      901 aacaacttac cttgtccttg atgaagctga taggatgctt gatatgggat ttgaacccca
      961 gataaggaaa attgtggatc aaataagacc tgataggcaa acactaatgt ggagtgcaac
     1021 ttggccaaaa gaagtaagac agcttgctga agatttcctg aaagactata ttcatatcaa
     1081 tattggtgca ctggaactga gtgcaaacca taacattctt cagattgtgg atgtatgtca
     1141 tgatgtcgaa aaggatgaaa agcttattcg tctgatggaa gaaatcatga gtgagaagga
     1201 gaataaaact attgtttttg ttgaaaccaa aagaagatgt gatgaactta ccagaaaaat
     1261 gaggagagat gggtggcctg ccatgggcat ccatggtgac aagagtcagc aggaacgtga
     1321 ctgggttcta aatgaattca aacatggaaa agctcctatt ctgattgcta ccgatgtggc
     1381 ctccagaggg ctagatgtgg aagatgtgaa atttgtcatc aattatgact accctaactc
     1441 ctcagaggat tatattcatc gaattggaag aactgctcgc agtaccaaaa caggcacagc
     1501 atacactttc tttacaccta ataacataaa gcaagtgagc gaccttatct ctgtgcttcg
     1561 ggaagctaat caagcaatta atcccaagtt gcttcagttg gtcgaagaca gaggttcagg
     1621 tcgttccagg ggtagaggag gcatgaagga cgatcgtcgt gacagatact ctgcaggcaa
     1681 aaggggtgga tttaatacct ttagagacag ggaaaactat gacagaggct actctaatct
     1741 gcttaagaga gattttgggg ctaaaactca gaatggtgtt tacagtgctg caaattacac
     1801 caatgggagc tttggaagta attttgtatc tgctggcata cagaccagtt ttaggactgg
     1861 taatccaaca gggacttacc agaacggtta tgatagcact cagcaatatg gaagtaatgt
     1921 tgcaaatatg cacaatggta tgaaccaaca ggcatatgca tatcctgcta ccgcagctgc
     1981 tgcgcctatg attggctatc ccatgccaac agggtattct caataagact ttagaagtat
     2041 atgtaaatgt ctgtttttca taattgctct ttatattgtg tgttatcaga caagatagtt
     2101 atttaagaaa catgggaaat gcagaaatga ctgcagtgca gcagtaatta tggtgcactt
     2161 ttttcgctat ttaagttgga tatttctcta cattcctgaa acaattttta ggtttttttt
     2221 gtactagaaa atgcaggcag tgttttcaca aaagtaactg tacagtgatt tcaaatacaa
     2281 taaatgaagg caatgcatgg ccttccaata aaagatattt gaagactgaa ttaagtgaaa
     2341 ttgtacttta ttttacatat ataatgtcat gtacaacttg gcttagatag tgtttttggg
     2401 ggggattttt gttttggtgt ttatttttac acaaggaaag ttgactactt cccattcctg
     2461 gatttaggag aggaactcag aaggccctta ggatgatctg tttgtatggg aagaagttag
     2521 agacaatgga ttttataatt ccagatttat tggataaaag ctttgtcatt tttcagtatc
     2581 agggaagtaa gtcatttaat agcctatttt ccttaagagt gaactacagg acagtaacta
     2641 tataaataca tgttgatttc ttttgcaaaa cagttttaag taatgacatt tttgctttat
     2701 caaaatttta ttccatctct tggttttgtt gtcaactgcc gaaatgtgcg aagctgaaag
     2761 actgttagcc caagagctgt gtgcactgtg tctttagtgc aggattacct tgtaggttcc
     2821 tagtcctcga ggacttgcca gagtgcttat agccacacct ggaagtcagg aatgtctcca
     2881 cattatttca ggggatttta ggggtcttgt aggctagtca caaggaagac gacataacca
     2941 aaagcacagt aaagttttcg ggttaggttc actatgggct taacagctag aaggattggg
     3001 gggaaagctt tagatttaag taggatcacc agcaaacagc tttgtttcag aatggctata
     3061 agtaggtcta aatgtcttcc caaaaaattg gtgtgttttt tgcccaggac aaaagtctta
     3121 aaggaagtta tttaactttt tgtttttaaa atgggcttat tgttaatgcc ttatttataa
     3181 aatgttaaaa caaaatagaa tgtgctgggg gtgggagctg ggcgtgtttt ccagggctga
     3241 taacattgaa aactggttca tcctctagta ctgagtggtt ttcaatggca tggctagtca
     3301 gattcatgat ttttaagtat aggtgtagat tggagcattt attacatatt ttactgttca
     3361 atgtcttaat gtggaccttt tattttgtaa ataattatgg aaatgattgt ggggcttgga
     3421 aaaaattacc tttgaagttt taaaagacag tccacttttt agcatgtgtg ttgtgtccag
     3481 cctgtggttg tcttaactaa taaatgtgat ttttctcccc
//
