LOCUS       NM_001355677            3680 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Mus musculus DEAD box helicase 5 (Ddx5), transcript variant 3,
            mRNA.
ACCESSION   NM_001355677 XM_006532137
VERSION     NM_001355677.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3680)
  AUTHORS   Wen,C., Cao,L., Wang,S., Xu,W., Yu,Y., Zhao,S., Yang,F., Chen,Z.J.,
            Zhao,S., Yang,Y. and Qin,Y.
  TITLE     MCM8 interacts with DDX5 to promote R-loop resolution
  JOURNAL   EMBO J 43 (14), 3044-3071 (2024)
   PUBMED   38858601
  REMARK    GeneRIF: MCM8 interacts with DDX5 to promote R-loop resolution.
REFERENCE   2  (bases 1 to 3680)
  AUTHORS   Xu,J., Liu,L.Y., Zhi,F.J., Song,Y.J., Zhang,Z.H., Li,B.,
            Zheng,F.Y., Gao,P.C., Zhang,S.Z., Zhang,Y.Y., Zhang,Y., Qiu,Y.,
            Jiang,B., Li,Y.Q., Peng,C. and Chu,Y.F.
  TITLE     DDX5 inhibits inflammation by modulating m6A levels of TLR2/4
            transcripts during bacterial infection
  JOURNAL   EMBO Rep 25 (2), 770-795 (2024)
   PUBMED   38182816
  REMARK    GeneRIF: DDX5 inhibits inflammation by modulating m6A levels of
            TLR2/4 transcripts during bacterial infection.
REFERENCE   3  (bases 1 to 3680)
  AUTHORS   Louis,T.L., Wong,W.H., Yao,P., Kurd,N.S., Tysl,T.,
            Indralingam,C.S., Ma,S., Huang,W.J.M. and Chang,J.T.
  TITLE     Regulation of CD8 T Cell Differentiation by the RNA-Binding Protein
            DDX5
  JOURNAL   J Immunol 211 (2), 241-251 (2023)
   PUBMED   37265401
  REMARK    GeneRIF: Regulation of CD8 T Cell Differentiation by the
            RNA-Binding Protein DDX5.
REFERENCE   4  (bases 1 to 3680)
  AUTHORS   Ma,S., Yang,Q., Chen,N., Zheng,A., Abbasi,N., Wang,G., Patel,P.R.,
            Cho,B.S., Yee,B.A., Zhang,L., Chu,H., Evans,S.M., Yeo,G.W.,
            Zheng,Y. and Huang,W.J.M.
  TITLE     RNA binding protein DDX5 restricts RORgammat+ Treg suppressor
            function to promote intestine inflammation
  JOURNAL   Sci Adv 9 (5), eadd6165 (2023)
   PUBMED   36724232
  REMARK    GeneRIF: RNA binding protein DDX5 restricts RORgammat[+] Treg
            suppressor function to promote intestine inflammation.
REFERENCE   5  (bases 1 to 3680)
  AUTHORS   Takeda,K., Tago,K. and Funakoshi-Tago,M.
  TITLE     The indispensable role of the RNA helicase DDX5 in tumorigenesis
            induced by the myeloproliferative neoplasm-associated JAK2V617F
            mutant
  JOURNAL   Cell Signal 102, 110537 (2023)
   PUBMED   36442590
  REMARK    GeneRIF: The indispensable role of the RNA helicase DDX5 in
            tumorigenesis induced by the myeloproliferative neoplasm-associated
            JAK2V617F mutant.
REFERENCE   6  (bases 1 to 3680)
  AUTHORS   Petry,P., Johnson,K.R., Lemaire,L. and Heinlein,U.A.
  TITLE     Assignment to chromosome 11 of mouse p68 RNA helicase gene (Hlr1)
            and pseudogene (Hlr1-ps1)
  JOURNAL   FEBS Lett 363 (1-2), 25-28 (1995)
   PUBMED   7729546
REFERENCE   7  (bases 1 to 3680)
  AUTHORS   Lemaire,L., Johnson,K.R., Bammer,S., Petry,P., Ruddle,F.H. and
            Heinlein,U.A.
  TITLE     Chromosomal assignment of three novel mouse genes expressed in
            testicular cells
  JOURNAL   Genomics 21 (2), 409-414 (1994)
   PUBMED   8088835
REFERENCE   8  (bases 1 to 3680)
  AUTHORS   Gee,S.L. and Conboy,J.G.
  TITLE     Mouse erythroid cells express multiple putative RNA helicase genes
            exhibiting high sequence conservation from yeast to mammals
  JOURNAL   Gene 140 (2), 171-177 (1994)
   PUBMED   8144024
REFERENCE   9  (bases 1 to 3680)
  AUTHORS   Lemaire,L. and Heinlein,U.A.
  TITLE     High-level expression in male germ cells of murine P68 RNA helicase
            mRNA
  JOURNAL   Life Sci 52 (11), 917-926 (1993)
   PUBMED   8445986
REFERENCE   10 (bases 1 to 3680)
  AUTHORS   Iggo,R., Gough,A., Xu,W., Lane,D.P. and Spurr,N.K.
  TITLE     Chromosome mapping of the human gene encoding the 68-kDa nuclear
            antigen (p68) by using the polymerase chain reaction
  JOURNAL   Proc Natl Acad Sci U S A 86 (16), 6211-6214 (1989)
   PUBMED   2762324
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603664.16 and BC062916.1.
            
            On Sep 23, 2017 this sequence version replaced XM_006532137.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13861890.67165.1,
                                           SRR7652917.1186289.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               AL603664.16        144579-144748       c
            171-357             AL603664.16        143836-144022       c
            358-523             AL603664.16        142472-142637       c
            524-620             AL603664.16        142011-142107       c
            621-754             AL603664.16        141789-141922       c
            755-820             AL603664.16        141630-141695       c
            821-962             AL603664.16        140958-141099       c
            963-1123            AL603664.16        140699-140859       c
            1124-1296           AL603664.16        140443-140615       c
            1297-1407           AL603664.16        139977-140087       c
            1408-1469           AL603664.16        139664-139725       c
            1470-1529           AL603664.16        139522-139581       c
            1530-1754           AL603664.16        138032-138256       c
            1755-3343           AL603664.16        136231-137819       c
            3344-3680           BC062916.1         3194-3530
FEATURES             Location/Qualifiers
     source          1..3680
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 70.01 cM"
     gene            1..3680
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /note="DEAD box helicase 5"
                     /db_xref="GeneID:13207"
                     /db_xref="MGI:MGI:105037"
     exon            1..170
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            171..357
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..2161
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /EC_number="3.6.4.13"
                     /note="DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5;
                     mDEAD1; RNA helicase p68; DEAD box protein 5; DEAD box RNA
                     helicase DEAD1; DEAD
                     (aspartate-glutamate-alanine-aspartate) box polypeptide 5;
                     DEAD (Asp-Glu-Ala-Asp) box polypeptide 5"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DDX5"
                     /protein_id="NP_001342606.1"
                     /db_xref="CCDS:CCDS25562.1"
                     /db_xref="GeneID:13207"
                     /db_xref="MGI:MGI:105037"
                     /translation="MSSYSSDRDRGRDRGFGAPRFGGSRTGPLSGKKFGNPGEKLVKK
                     KWNLDELPKFEKNFYQEHPDLARRTAQEVDTYRRSKEITVRGHNCPKPVLNFYEANFP
                     ANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQP
                     FLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLERGV
                     EICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTL
                     MWSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLME
                     EIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKA
                     PILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNI
                     KQVSDLISVLREANQAINPKLLQLVEDRGSGRSRGRGGMKDDRRDRYSAGKRGGFNTF
                     RDRENYDRGYSNLLKRDFGAKTQNGVYSAANYTNGSFGSNFVSAGIQTSFRTGNPTGT
                     YQNGYDSTQQYGSNVANMHNGMNQQAYAYPATAAAAPMIGYPMPTGYSQ"
     exon            358..523
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            524..620
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            621..754
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            755..820
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            821..962
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1123
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1296
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1407
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1469
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1529
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1754
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..3656
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3634..3639
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /note="hexamer: AATAAA"
     polyA_site      3656
                     /gene="Ddx5"
                     /gene_synonym="2600009A06Rik; G17P1; Hlr1; HUMP68; p68"
                     /note="major polyA site"
ORIGIN      
        1 agcagaggag cacttcctcg cagcacgcgc tgaggcggca gtttgcgggc tccagatacc
       61 attccccgcg gtcaagatcc cgcttacggg ttctcagatc ggcgggcagg gcagccaggt
      121 cacccagcag cccggccgat ctccccgggg gcgttggagc cgcgcttccg ctccggccct
      181 cgacaccacc ggcccctccg ctggtgacgc ccccgcagag gcttcgccgt cgccgaggcc
      241 ttctctccgc gactcgtcgc cgcaggattc tactttcact gggttccgcc cgcacaccgc
      301 caccattgac gccatgtcga gttattctag tgaccgagac cgcggccggg atcgagggtt
      361 tggtgcacct cgatttggag ggagtagaac aggacccctc tctggaaaga agtttggaaa
      421 tcctggggag aaactagtta aaaagaagtg gaatcttgat gagctgccca aatttgagaa
      481 gaatttttat caagaacacc ctgatttggc aaggcgcacc gcacaagagg tagatacata
      541 cagaagaagc aaggaaatta cagttagagg tcacaactgt ccaaaacctg ttctgaattt
      601 ttatgaagca aactttcctg cgaatgtcat ggatgtgatt gcaaggcaga actttactga
      661 acccactgct attcaagctc agggctggcc agttgctctc agtggattgg atatggttgg
      721 agtagctcag actggatctg ggaaaacatt atcttatttg ctgcctgcca ttgtacacat
      781 aaaccaccag ccattcctag agagaggtga tgggcctatt tgcttggtgc tggcaccaac
      841 tcgagaactg gcacagcagg tgcagcaagt ggctgctgaa tattgtcgag cttgtcgctt
      901 gaagtctact tgcatctatg gtggtgctcc caaaggacca cagattcgtg atttggaaag
      961 aggtgtggaa atctgtattg caacacctgg aagactgatt gactttttag agtgtgggaa
     1021 aaccaatctg agaagaacaa cttaccttgt ccttgatgaa gctgatagga tgcttgatat
     1081 gggatttgaa ccccagataa ggaaaattgt ggatcaaata agacctgata ggcaaacact
     1141 aatgtggagt gcaacttggc caaaagaagt aagacagctt gctgaagatt tcctgaaaga
     1201 ctatattcat atcaatattg gtgcactgga actgagtgca aaccataaca ttcttcagat
     1261 tgtggatgta tgtcatgatg tcgaaaagga tgaaaagctt attcgtctga tggaagaaat
     1321 catgagtgag aaggagaata aaactattgt ttttgttgaa accaaaagaa gatgtgatga
     1381 acttaccaga aaaatgagga gagatgggtg gcctgccatg ggcatccatg gtgacaagag
     1441 tcagcaggaa cgtgactggg ttctaaatga attcaaacat ggaaaagctc ctattctgat
     1501 tgctaccgat gtggcctcca gagggctaga tgtggaagat gtgaaatttg tcatcaatta
     1561 tgactaccct aactcctcag aggattatat tcatcgaatt ggaagaactg ctcgcagtac
     1621 caaaacaggc acagcataca ctttctttac acctaataac ataaagcaag tgagcgacct
     1681 tatctctgtg cttcgggaag ctaatcaagc aattaatccc aagttgcttc agttggtcga
     1741 agacagaggt tcaggtcgtt ccaggggtag aggaggcatg aaggacgatc gtcgtgacag
     1801 atactctgca ggcaaaaggg gtggatttaa tacctttaga gacagggaaa actatgacag
     1861 aggctactct aatctgctta agagagattt tggggctaaa actcagaatg gtgtttacag
     1921 tgctgcaaat tacaccaatg ggagctttgg aagtaatttt gtatctgctg gcatacagac
     1981 cagttttagg actggtaatc caacagggac ttaccagaac ggttatgata gcactcagca
     2041 atatggaagt aatgttgcaa atatgcacaa tggtatgaac caacaggcat atgcatatcc
     2101 tgctaccgca gctgctgcgc ctatgattgg ctatcccatg ccaacagggt attctcaata
     2161 agactttaga agtatatgta aatgtctgtt tttcataatt gctctttata ttgtgtgtta
     2221 tcagacaaga tagttattta agaaacatgg gaaatgcaga aatgactgca gtgcagcagt
     2281 aattatggtg cacttttttc gctatttaag ttggatattt ctctacattc ctgaaacaat
     2341 ttttaggttt tttttgtact agaaaatgca ggcagtgttt tcacaaaagt aactgtacag
     2401 tgatttcaaa tacaataaat gaaggcaatg catggccttc caataaaaga tatttgaaga
     2461 ctgaattaag tgaaattgta ctttatttta catatataat gtcatgtaca acttggctta
     2521 gatagtgttt ttggggggga tttttgtttt ggtgtttatt tttacacaag gaaagttgac
     2581 tacttcccat tcctggattt aggagaggaa ctcagaaggc ccttaggatg atctgtttgt
     2641 atgggaagaa gttagagaca atggatttta taattccaga tttattggat aaaagctttg
     2701 tcatttttca gtatcaggga agtaagtcat ttaatagcct attttcctta agagtgaact
     2761 acaggacagt aactatataa atacatgttg atttcttttg caaaacagtt ttaagtaatg
     2821 acatttttgc tttatcaaaa ttttattcca tctcttggtt ttgttgtcaa ctgccgaaat
     2881 gtgcgaagct gaaagactgt tagcccaaga gctgtgtgca ctgtgtcttt agtgcaggat
     2941 taccttgtag gttcctagtc ctcgaggact tgccagagtg cttatagcca cacctggaag
     3001 tcaggaatgt ctccacatta tttcagggga ttttaggggt cttgtaggct agtcacaagg
     3061 aagacgacat aaccaaaagc acagtaaagt tttcgggtta ggttcactat gggcttaaca
     3121 gctagaagga ttggggggaa agctttagat ttaagtagga tcaccagcaa acagctttgt
     3181 ttcagaatgg ctataagtag gtctaaatgt cttcccaaaa aattggtgtg ttttttgccc
     3241 aggacaaaag tcttaaagga agttatttaa ctttttgttt ttaaaatggg cttattgtta
     3301 atgccttatt tataaaatgt taaaacaaaa tagaatgtgc tgggggtggg agctgggcgt
     3361 gttttccagg gctgataaca ttgaaaactg gttcatcctc tagtactgag tggttttcaa
     3421 tggcatggct agtcagattc atgattttta agtataggtg tagattggag catttattac
     3481 atattttact gttcaatgtc ttaatgtgga ccttttattt tgtaaataat tatggaaatg
     3541 attgtggggc ttggaaaaaa ttacctttga agttttaaaa gacagtccac tttttagcat
     3601 gtgtgttgtg tccagcctgt ggttgtctta actaataaat gtgatttttc tccccaaaaa
     3661 aaaaaaaaaa aaaaaaaaaa
//
