LOCUS       NM_001282055            5715 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus DEAD box helicase 46 (Ddx46), mRNA.
ACCESSION   NM_001282055
VERSION     NM_001282055.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5715)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5715)
  AUTHORS   Zheng,Q., Hou,J., Zhou,Y., Li,Z. and Cao,X.
  TITLE     The RNA helicase DDX46 inhibits innate immunity by entrapping
            m6A-demethylated antiviral transcripts in the nucleus
  JOURNAL   Nat Immunol 18 (10), 1094-1103 (2017)
   PUBMED   28846086
  REMARK    GeneRIF: DDX46 inhibits antiviral innate responses by entrapping
            selected antiviral transcripts in the nucleus by erasing their
            m(6)A modification, a modification normally required for export
            from the nucleus and translation.
            Erratum:[Nat Immunol. 2017 Nov 16;18(12):1361. doi:
            10.1038/ni1217-1361a. PMID: 29144498]
REFERENCE   3  (bases 1 to 5715)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   4  (bases 1 to 5715)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5715)
  AUTHORS   Wong,A.W., Brickey,W.J., Taxman,D.J., van Deventer,H.W., Reed,W.,
            Gao,J.X., Zheng,P., Liu,Y., Li,P., Blum,J.S., McKinnon,K.P. and
            Ting,J.P.
  TITLE     CIITA-regulated plexin-A1 affects T-cell-dendritic cell
            interactions
  JOURNAL   Nat Immunol 4 (9), 891-898 (2003)
   PUBMED   12910265
REFERENCE   6  (bases 1 to 5715)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (bases 1 to 5715)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ170754.1, BC092240.1 and AC126408.6.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849375,
                              SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               CJ170754.1         1-162
            163-3261            BC092240.1         74-3172
            3262-5715           AC126408.6         181357-183810
FEATURES             Location/Qualifiers
     source          1..5715
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 30.06 cM"
     gene            1..5715
                     /gene="Ddx46"
                     /gene_synonym="2200005K02Rik; 8430438J23Rik; mKIAA0801"
                     /note="DEAD box helicase 46"
                     /db_xref="GeneID:212880"
                     /db_xref="MGI:MGI:1920895"
     exon            1..197
                     /gene="Ddx46"
                     /gene_synonym="2200005K02Rik; 8430438J23Rik; mKIAA0801"
                     /inference="alignment:Splign:2.1.0"
     exon            198..386
                     /gene="Ddx46"
                     /gene_synonym="2200005K02Rik; 8430438J23Rik; mKIAA0801"
                     /inference="alignment:Splign:2.1.0"
     exon            387..530
                     /gene="Ddx46"
                     /gene_synonym="2200005K02Rik; 8430438J23Rik; mKIAA0801"
                     /inference="alignment:Splign:2.1.0"
     exon            531..627
                     /gene="Ddx46"
                     /gene_synonym="2200005K02Rik; 8430438J23Rik; mKIAA0801"
                     /inference="alignment:Splign:2.1.0"
     exon            628..793
                     /gene="Ddx46"
                     /gene_synonym="2200005K02Rik; 8430438J23Rik; mKIAA0801"
                     /inference="alignment:Splign:2.1.0"
     exon            794..945
                     /gene="Ddx46"
                     /gene_synonym="2200005K02Rik; 8430438J23Rik; mKIAA0801"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1059
                     /gene="Ddx46"
                     /gene_synonym="2200005K02Rik; 8430438J23Rik; mKIAA0801"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1225
                     /gene="Ddx46"
                     /gene_synonym="2200005K02Rik; 8430438J23Rik; mKIAA0801"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1346
                     /gene="Ddx46"
                     /gene_synonym="2200005K02Rik; 8430438J23Rik; mKIAA0801"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1522
                     /gene="Ddx46"
                     /gene_synonym="2200005K02Rik; 8430438J23Rik; mKIAA0801"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1644
                     /gene="Ddx46"
                     /gene_synonym="2200005K02Rik; 8430438J23Rik; mKIAA0801"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1723
                     /gene="Ddx46"
                     /gene_synonym="2200005K02Rik; 8430438J23Rik; mKIAA0801"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1806
                     /gene="Ddx46"
                     /gene_synonym="2200005K02Rik; 8430438J23Rik; mKIAA0801"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1971
                     /gene="Ddx46"
                     /gene_synonym="2200005K02Rik; 8430438J23Rik; mKIAA0801"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2134
                     /gene="Ddx46"
                     /gene_synonym="2200005K02Rik; 8430438J23Rik; mKIAA0801"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2328
                     /gene="Ddx46"
                     /gene_synonym="2200005K02Rik; 8430438J23Rik; mKIAA0801"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2466
                     /gene="Ddx46"
                     /gene_synonym="2200005K02Rik; 8430438J23Rik; mKIAA0801"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2616
                     /gene="Ddx46"
                     /gene_synonym="2200005K02Rik; 8430438J23Rik; mKIAA0801"
                     /inference="alignment:Splign:2.1.0"
     exon            2617..2793
                     /gene="Ddx46"
                     /gene_synonym="2200005K02Rik; 8430438J23Rik; mKIAA0801"
                     /inference="alignment:Splign:2.1.0"
     exon            2794..3012
                     /gene="Ddx46"
                     /gene_synonym="2200005K02Rik; 8430438J23Rik; mKIAA0801"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3157
                     /gene="Ddx46"
                     /gene_synonym="2200005K02Rik; 8430438J23Rik; mKIAA0801"
                     /inference="alignment:Splign:2.1.0"
     exon            3158..3231
                     /gene="Ddx46"
                     /gene_synonym="2200005K02Rik; 8430438J23Rik; mKIAA0801"
                     /inference="alignment:Splign:2.1.0"
     exon            3232..5715
                     /gene="Ddx46"
                     /gene_synonym="2200005K02Rik; 8430438J23Rik; mKIAA0801"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3542..3547
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddx46"
                     /gene_synonym="2200005K02Rik; 8430438J23Rik; mKIAA0801"
                     /note="hexamer: AATAAA"
     polyA_site      3563
                     /gene="Ddx46"
                     /gene_synonym="2200005K02Rik; 8430438J23Rik; mKIAA0801"
                     /note="major polyA site"
     polyA_site      3712
                     /gene="Ddx46"
                     /gene_synonym="2200005K02Rik; 8430438J23Rik; mKIAA0801"
     regulatory      3777..3782
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddx46"
                     /gene_synonym="2200005K02Rik; 8430438J23Rik; mKIAA0801"
                     /note="hexamer: ATTAAA"
     polyA_site      3801
                     /gene="Ddx46"
                     /gene_synonym="2200005K02Rik; 8430438J23Rik; mKIAA0801"
     regulatory      5685..5690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddx46"
                     /gene_synonym="2200005K02Rik; 8430438J23Rik; mKIAA0801"
                     /note="hexamer: AATAAA"
     polyA_site      5704
                     /gene="Ddx46"
                     /gene_synonym="2200005K02Rik; 8430438J23Rik; mKIAA0801"
ORIGIN      
        1 ggcaccagca catcctgttt tcgttggcca cgctctgatg gcggtcactg ctggagctct
       61 gtccatttcg taggaccggt cctcgctcgg taccgtgaga gcttgctgcc tccctccttt
      121 gtcctcttca taggcctgcg catcgtcccc gagggcgcag gccttctgct ggccggcagc
      181 atgggccggg agtctcgcca ctaccgaaaa cgctcagcat ctcgaggtcg ttctggaagt
      241 cgatcgagga gtcgctcacc ctctgacaaa agaagcaaac gtggggatga cagacgctct
      301 cggagcagag acagagaccg gaggagagag aggtctcgga gtagggacaa gagaagatct
      361 cggtcaaggg acaggaagcg cctgaggcgc tccagaagta gagagcgaga cagaagccga
      421 gagcggagaa gatctcggag cagagataga aggcgctcaa ggagtcgaag ccggggcagg
      481 cggtcccggt cctccagtcc tggcagcaaa accaagaaga ctgagaacag gtctaggtcc
      541 aaagagaaag cagaaggtgg ggacagctcc aaggagaaga aaaaggacaa ggatgacaag
      601 gaggacgaga aagagaagga tgctgggaac tttgaccaga ataaactgga agaagaaatg
      661 agaaaacgga aagaaagagt tgaaaaatgg cgcgaagagc agcgtaagaa ggctatggag
      721 aacataggag agctgaagaa ggagattgag gagatgaagc aggggaagaa gtggagcttg
      781 gaggacgacg acgatgatga agatgatcct gccgaggctg agaaggaagg gactgaaatg
      841 gaggacgagg agctggaccc attagacgcc tacatggaag aagtgaagga agaggtaaaa
      901 aagtttaaca tgaggagcgt gaaaggcggc gcaggaaatg agaagaagtc tgggccaaca
      961 gtcacaaaag ttgtcactgt ggtgaccacc aagaaagcag tagtagacgc ggataagaag
     1021 aagggggaac tcatggagaa tgaccaggac gccatggagt attcctcaga ggaggaggaa
     1081 gttgaccttc aaacggccct cacaggctac cagacaaaac agagaaaact tctagagcca
     1141 gttgatcatg gaaaaattga atatgagcca ttcagaaaaa acttttatgt tgaagttcca
     1201 gaattagcaa aaatgtctca agaagaggtg aatgtgtttc gattggaaat ggagggcatt
     1261 acagttaaag gaaaaggttg cccgaaacca attaaatcat gggtccagtg tggaatttcc
     1321 atgaagatac taaattccct caaaaagcat ggctatgaaa agccaacacc aatccaaact
     1381 caagcgattc ctgctataat gtctggacga gatttgattg gcattgccaa gacaggaagt
     1441 ggaaaaacca ttgcttttct tttgcccatg tttagacaca tcatggatca gaggtcatta
     1501 gaagaaggag agggaccaat agctgtcatc atgactccaa ctcgagagct ggctttacaa
     1561 atcactaaag aatgtaagaa gttttcgaag accttgggac tgagagtggt ctgtgtgtat
     1621 ggagggacag gaatcagcga gcagattgct gagctgaaaa gaggtgctga aattattgtt
     1681 tgcacacctg gtcgaatgat tgacatgtta gcggctaaca gtggtcgggt cacaaatctt
     1741 cgaagagtga catatgttgt tttagatgaa gcagacagaa tgtttgacat gggttttgaa
     1801 ccacaggtca tgcgcattgt ggataacgtt cgtcctgacc gacagacagt tatgttttca
     1861 gccactttcc ctagagctat ggaggctttg gcccgcagga tcctgagcaa acctattgaa
     1921 gtgcaggttg gaggcaggag tgtggtttgc tccgatgtgg aacagcaggt gattgtgatt
     1981 gaagaagaaa agaaattctt gaaattgctg gagcttttag gccattatca ggagtcagga
     2041 tctgtcatta tatttgtgga taagcaggaa cacgcagatg gtcttctgaa ggacttgatg
     2101 agagcatcgt acccttgcat gtctcttcac ggaggtattg atcaatatga cagggacagt
     2161 atcataaatg actttaagaa tggaacctgc aagctcctcg ttgccacatc tgttgcagct
     2221 cgtggtctcg atgtgaaaca tctaattctt gtagtgaatt acagctgccc caatcattat
     2281 gaagattatg tgcacagagc tgggcggact ggaagagcgg gcaacaaggg ttatgcctac
     2341 accttcatca cagaggatca agctcgatat gctggtgaca tcattaaagc tcttgaattg
     2401 tcagggaccg cagtgcctcc tgacctagaa aaactctgga gtgacttcaa agatcaacag
     2461 aaagctgaag gaaaaataat taaaaagagt agtggcttct ctggcaaggg attcaagttt
     2521 gatgaaacag aacaggcttt agccaatgag aggaaaaagc tgcagaaagc tgctcttggc
     2581 ctgcaagatt ctgatgacga ggatgctgca gttgatattg atgaacagat tgaaagcatg
     2641 tttaattcaa agaagagagt aaaggacatg gctgcacccg gcacatccag cgtgcccgcg
     2701 cccactgcag gcaatgctga gaagctagaa atcgccaaga gattggctct cagaatcaac
     2761 gctcagaaga acctgggcat cgagtctcag gtagatgtga tgcagcaggc caccaacgcc
     2821 atcctcagag gtggcactat cctggctccc actgtgtctg cgaaaaccat tgcagagcag
     2881 cttgctgaga agatcaatgc caagctcaac tacgtgcctt tggagaagca ggaggaagag
     2941 agacaggagg gtgggcagag cgagtctttc aagagatacg aggaagaatt agaaattaat
     3001 gacttcccac agactgcgag gtggaaagtc acctcaaagg aagccctgca gaggatcagc
     3061 gagtactctg aggccgccat caccatcagg ggcacctact tccctcccgg caaggagccc
     3121 aaggaaggag agcgcaagat ctacctggcc atcgaaagtg ccaacgagct ggctgtgcag
     3181 aaagcaaagg cagagatcac caggctcata aaagaggaac tgatccgact gcaaaattca
     3241 taccaaccaa ccaacaaagg acgatacaaa gtattataaa catcggagcc actttgtacc
     3301 tttgctgtct gtgacgttta cagtgtattg taaagtaagg cttttaaaat tctgtcttgc
     3361 ttatttttta aatacaagaa accagtgttt gttcaagagg tcgtctgtaa gtactacccc
     3421 atacccatcc aaaaccatct acattagacc tgttttcaga atgtgatgtt cttcaatgta
     3481 aaccttagat accaacactt taaatatctg gaagacattg gaattttgta ctgaatgctg
     3541 taataaagtc tgtcaggcac taagggccac tgacctgtcc tttcagtgga attgtggtgt
     3601 gctcatcacc taagaaaggt aaaaagctct ggtcatagcc tgctgagctt acacctcgca
     3661 gactggagca tgtgagcagg accctagagt gctgtgatgg aagtttacaa aacaggctca
     3721 gagtttttat tttaatttta tctgaaacga gtaatagtca agccctggct tataaaatta
     3781 aacataagta gtataatggg atttctgcat ttctttttta tttcttccta cttttgagaa
     3841 agtcactgtg gggcatgggc tggccttgaa cttgtgatcc tcctccagct gtctctccag
     3901 tgcttggttt tagcacactt ggctctccac gtctttctac tgtgctagtg ttactattta
     3961 aggttttctc tcgcccctgg ttttgcctaa gtgctgactt ctttattgac tcctttagag
     4021 aaagttatta tgaccaatac atactccatg ttaatcctgt ccctcaagtg tttctttagg
     4081 cattgatatt atggtacatt ctctaccata atacttctaa tctgactttc cttcaggatg
     4141 atggagttat gaattttccc ctttattaaa acgaggcaag gtggtgcatg cctgtaatca
     4201 tagcacctag taggcaaggg tagaaagatg atgaatttga agccagtttg gccttatata
     4261 ataaagcctc atgtggaaaa accgtgcagg caaggctgag gatatagttc agtggtaacg
     4321 cacttgctta agtgtgcccc aggtctaata cgagaaaaca aagcattttt gttactactg
     4381 gttgttgggc aggcgaggtg acttggtgga tgtgagtctt gctttcaaac ctgatcactc
     4441 agttcaatat cttggatcca tatagcagaa agtgcaagtt gttctatgat tcgcattact
     4501 gtgcgtgtgt gctctctcat gcacacacag gtgtaaataa atgtagtaaa tcgaaataaa
     4561 gaaattacat caaatactgg tatttacatt tcagaccaca gcatttctta gtaaaatttg
     4621 gtgcacaaag aatcaaaaat tcctctttag agcatttgag gtctaattct gaataattgg
     4681 attacctaaa aagacagaac agttttttag tctcgattta aaccaggtgt ggtggcaccc
     4741 acctgtaatc cagcctttgg gaggcagagg caggatggtc ccttagttca agaccagcct
     4801 gttgtcctct gcatctggtt ttacatagtg agtttcaggc cagccagagc tacagtgaga
     4861 accagtctta taaaaagaga acaagcaaat atatgtgtat atattgttga tttagaggtt
     4921 gattttaagt cagagcatac tagagttgtt aaatactttt aaggcaaggg cagtgacgca
     4981 gaggttagga gcatctgctg ctctttttga agacccaggt tcaggtctca acacccacat
     5041 ggcagcttac agttgtctgt aattccagtg aataagtcta aagaacaata aataataaat
     5101 aaaccagtgt aacatattta aaagccatag tgacagccac ctatcctact tgttaagtgt
     5161 aaggttactt gtactagaaa agtaagaact acttgggaaa tatttttaga tcttcacata
     5221 cccagttact tcacttcaag aaaagagcaa ttacagcagg aggaactaga acatcacact
     5281 ggaatccctg tcaccagcac ttcttccggc cttggtttat ttattgcgtc tcatcgccca
     5341 ggtgtagctt gttaatttca gagtacacag cagccacacc ggtgcagtgg tgctcccgga
     5401 aactccacac cggtgcggtg gtgctcccgg aaactccata ctggtgcagt agtgctccct
     5461 caactccctg gctccctgga gattcagaag ttacatcgta tcacgttttc tgtttgtgta
     5521 tctaagaagc cctgagagca ttttgtccta aaatggaata ttgcccagta tatctgttag
     5581 tgtcaacact gactgatttt taaagtttta atgatgtaca gagtttaatt tgttttttaa
     5641 tgcaatatca atatttcctc aggctctcta taaattcctt acagaataaa gttgattcag
     5701 tcggcattgt ctcag
//
