LOCUS       NM_134059               2213 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus DEAD box helicase 41 (Ddx41), mRNA.
ACCESSION   NM_134059
VERSION     NM_134059.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2213)
  AUTHORS   Stepanchick,E., Wilson,A., Sulentic,A.M., Choi,K., Hueneman,K.,
            Starczynowski,D.T. and Chlon,T.M.
  TITLE     DDX41 haploinsufficiency causes inefficient hematopoiesis under
            stress and cooperates with p53 mutations to cause hematologic
            malignancy
  JOURNAL   Leukemia 38 (8), 1787-1798 (2024)
   PUBMED   38937548
  REMARK    GeneRIF: DDX41 haploinsufficiency causes inefficient hematopoiesis
            under stress and cooperates with p53 mutations to cause hematologic
            malignancy.
REFERENCE   2  (bases 1 to 2213)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2213)
  AUTHORS   Shinriki,S., Hirayama,M., Nagamachi,A., Yokoyama,A., Kawamura,T.,
            Kanai,A., Kawai,H., Iwakiri,J., Liu,R., Maeshiro,M., Tungalag,S.,
            Tasaki,M., Ueda,M., Tomizawa,K., Kataoka,N., Ideue,T., Suzuki,Y.,
            Asai,K., Tani,T., Inaba,T. and Matsui,H.
  TITLE     DDX41 coordinates RNA splicing and transcriptional elongation to
            prevent DNA replication stress in hematopoietic cells
  JOURNAL   Leukemia 36 (11), 2605-2620 (2022)
   PUBMED   36229594
REFERENCE   4  (bases 1 to 2213)
  AUTHORS   Ma,J., Mahmud,N., Bosland,M.C. and Ross,S.R.
  TITLE     DDX41 is needed for pre- and postnatal hematopoietic stem cell
            differentiation in mice
  JOURNAL   Stem Cell Reports 17 (4), 879-893 (2022)
   PUBMED   35303436
  REMARK    GeneRIF: DDX41 is needed for pre- and postnatal hematopoietic stem
            cell differentiation in mice.
REFERENCE   5  (bases 1 to 2213)
  AUTHORS   Chlon,T.M., Stepanchick,E., Hershberger,C.E., Daniels,N.J.,
            Hueneman,K.M., Kuenzi Davis,A., Choi,K., Zheng,Y., Gurnari,C.,
            Haferlach,T., Padgett,R.A., Maciejewski,J.P. and Starczynowski,D.T.
  TITLE     Germline DDX41 mutations cause ineffective hematopoiesis and
            myelodysplasia
  JOURNAL   Cell Stem Cell 28 (11), 1966-1981 (2021)
   PUBMED   34473945
REFERENCE   6  (bases 1 to 2213)
  AUTHORS   Zhang,Z., Bao,M., Lu,N., Weng,L., Yuan,B. and Liu,Y.J.
  TITLE     The E3 ubiquitin ligase TRIM21 negatively regulates the innate
            immune response to intracellular double-stranded DNA
  JOURNAL   Nat Immunol 14 (2), 172-178 (2013)
   PUBMED   23222971
  REMARK    GeneRIF: TRIM21 is an interferon-inducible E3 ligase that induces
            the Lys48-linked ubiquitination and degradation of DDX41 and
            negatively regulates the innate immune response to intracellular
            double-stranded DNA.
REFERENCE   7  (bases 1 to 2213)
  AUTHORS   Parvatiyar,K., Zhang,Z., Teles,R.M., Ouyang,S., Jiang,Y.,
            Iyer,S.S., Zaver,S.A., Schenk,M., Zeng,S., Zhong,W., Liu,Z.J.,
            Modlin,R.L., Liu,Y.J. and Cheng,G.
  TITLE     The helicase DDX41 recognizes the bacterial secondary messengers
            cyclic di-GMP and cyclic di-AMP to activate a type I interferon
            immune response
  JOURNAL   Nat Immunol 13 (12), 1155-1161 (2012)
   PUBMED   23142775
REFERENCE   8  (bases 1 to 2213)
  AUTHORS   Zhang,Z., Yuan,B., Bao,M., Lu,N., Kim,T. and Liu,Y.J.
  TITLE     The helicase DDX41 senses intracellular DNA mediated by the adaptor
            STING in dendritic cells
  JOURNAL   Nat Immunol 12 (10), 959-965 (2011)
   PUBMED   21892174
  REMARK    GeneRIF: DDX41 is an additional DNA sensor that depends on STING to
            sense pathogenic DNA.
            Erratum:[Nat Immunol. 2012 Feb;13(2):196]
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2213)
  AUTHORS   Nagamori,I., Yomogida,K., Adams,P.D., Sassone-Corsi,P. and
            Nojima,H.
  TITLE     Transcription factors, cAMP-responsive element modulator (CREM) and
            Tisp40, act in concert in postmeiotic transcriptional regulation
  JOURNAL   J Biol Chem 281 (22), 15073-15081 (2006)
   PUBMED   16595651
REFERENCE   10 (bases 1 to 2213)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK013586.1, AK151427.1, CX231996.1, BE864921.1 and CJ303880.1.
            
            On Dec 2, 2009 this sequence version replaced NM_134059.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011308.1, AK156957.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               AK013586.1         2-181
            181-1130            AK151427.1         55-1004
            1131-1590           CX231996.1         324-783
            1591-1813           BE864921.1         382-604
            1814-2017           AK151427.1         1688-1891
            2018-2213           CJ303880.1         189-384
FEATURES             Location/Qualifiers
     source          1..2213
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 30.06 cM"
     gene            1..2213
                     /gene="Ddx41"
                     /gene_synonym="2900024F02Rik; ABS"
                     /note="DEAD box helicase 41"
                     /db_xref="GeneID:72935"
                     /db_xref="MGI:MGI:1920185"
     exon            1..178
                     /gene="Ddx41"
                     /gene_synonym="2900024F02Rik; ABS"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..2020
                     /gene="Ddx41"
                     /gene_synonym="2900024F02Rik; ABS"
                     /EC_number="3.6.4.13"
                     /note="DEAD-box protein abstrakt; DEAD box protein 41;
                     DEAD (Asp-Glu-Ala-Asp) box polypeptide 41"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DDX41"
                     /protein_id="NP_598820.2"
                     /db_xref="CCDS:CCDS26549.1"
                     /db_xref="GeneID:72935"
                     /db_xref="MGI:MGI:1920185"
                     /translation="MEDSEPERKRARADEATAGGSRSEDEDEDDEDYVPYVPLRQRRQ
                     LLLQKLLQRRRKGATEEEQQDSGSEPRGDEDDIPLGPQSNVSLLDQHQHLKEKAEARK
                     ESAKEKQLKEEEKILESVAEGRALMSVKEMAKGITYDDPIKTSWTPPRYVLSMSEERH
                     ERVRKKYHILVEGDGIPPPIKSFKEMKFPAAILRGLKKKGILHPTPIQIQGIPTILSG
                     RDMIGIAFTGSGKTLVFTLPVIMFCLEQEKRLPFSKREGPYGLIICPSRELARQTHGI
                     LEYYCRLLQEDSSPLLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVS
                     LDICRYLALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVK
                     PVTINVGRAGAASLDVIQEVEYVKEEAKMVYLLECLQKTPPPVLIFAEKKADVDAIHE
                     YLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQHVINYD
                     MPEEIENYVHRIGRTGRSGNTGIATTFINKACDESVLMDLKALLLEAKQKVPPVLQVL
                     HCGDESMLDIGGERGCAFCGGLGHRITDCPKLEAMQTKQVSNIGRKDYLAHSSMDF"
     exon            179..289
                     /gene="Ddx41"
                     /gene_synonym="2900024F02Rik; ABS"
                     /inference="alignment:Splign:2.1.0"
     exon            290..449
                     /gene="Ddx41"
                     /gene_synonym="2900024F02Rik; ABS"
                     /inference="alignment:Splign:2.1.0"
     exon            450..524
                     /gene="Ddx41"
                     /gene_synonym="2900024F02Rik; ABS"
                     /inference="alignment:Splign:2.1.0"
     exon            525..585
                     /gene="Ddx41"
                     /gene_synonym="2900024F02Rik; ABS"
                     /inference="alignment:Splign:2.1.0"
     exon            586..722
                     /gene="Ddx41"
                     /gene_synonym="2900024F02Rik; ABS"
                     /inference="alignment:Splign:2.1.0"
     exon            723..795
                     /gene="Ddx41"
                     /gene_synonym="2900024F02Rik; ABS"
                     /inference="alignment:Splign:2.1.0"
     exon            796..949
                     /gene="Ddx41"
                     /gene_synonym="2900024F02Rik; ABS"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1086
                     /gene="Ddx41"
                     /gene_synonym="2900024F02Rik; ABS"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1249
                     /gene="Ddx41"
                     /gene_synonym="2900024F02Rik; ABS"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1381
                     /gene="Ddx41"
                     /gene_synonym="2900024F02Rik; ABS"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1453
                     /gene="Ddx41"
                     /gene_synonym="2900024F02Rik; ABS"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1550
                     /gene="Ddx41"
                     /gene_synonym="2900024F02Rik; ABS"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1700
                     /gene="Ddx41"
                     /gene_synonym="2900024F02Rik; ABS"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1772
                     /gene="Ddx41"
                     /gene_synonym="2900024F02Rik; ABS"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1883
                     /gene="Ddx41"
                     /gene_synonym="2900024F02Rik; ABS"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2205
                     /gene="Ddx41"
                     /gene_synonym="2900024F02Rik; ABS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2174..2179
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddx41"
                     /gene_synonym="2900024F02Rik; ABS"
                     /note="hexamer: ATTAAA"
     polyA_site      2199
                     /gene="Ddx41"
                     /gene_synonym="2900024F02Rik; ABS"
                     /note="major polyA site"
ORIGIN      
        1 aattggctcc gctgcgcgtc cgtaaacgcg ctggaagaag attgtcccgg ttcgcgatcc
       61 ggcgctcacg ccgttgctag gcgaccacag cagtttttcc tatctgattg gagctcagat
      121 gccctggcat tgcgcatgtg tgcagcctaa gatggaggat tcggaaccgg agcggaagcg
      181 ggcacgcgcg gacgaggcga ccgcgggtgg gagccgctcc gaggacgagg atgaggacga
      241 cgaggactac gtaccctatg tgccgttgcg gcagcgccgg cagctactgc tccagaagct
      301 gctgcagcga agacgcaagg gcgctacgga ggaagagcag caggacagtg gcagtgagcc
      361 ccgaggagat gaggacgaca tcccgctggg ccctcagtcc aatgtcagcc tcctggatca
      421 gcaccagcac ctcaaagaga aggctgaagc acgcaaggag tccgccaagg aaaagcaact
      481 gaaggaagaa gaaaagattc tggagagtgt ggctgaaggc cgagccttga tgtcagtgaa
      541 ggaaatggcc aaaggcatca cctatgacga tccaatcaaa actagttgga cacccccgcg
      601 ttatgtcctg agcatgtctg aggagcggca tgagcgagtt cggaagaagt atcacatcct
      661 ggtggagggc gatggtatcc cgccacccat caagagcttc aaggagatga agtttcctgc
      721 agctatcctt cggggcctga aaaaaaaggg catcctccac ccaacaccca ttcagatcca
      781 gggcatccct accattctgt ccggtcggga catgatcggc attgccttca cggggtcagg
      841 caagacactg gtattcactc tgccagtcat catgttctgc ctggaacagg agaagcggtt
      901 gcctttctcc aagcgagagg ggccttatgg gctcatcatc tgcccctcgc gagagctggc
      961 tcggcagacc cacggcatcc tggagtatta ctgccgtctg ctgcaggagg acagctcacc
     1021 cctcctgcgc tgtgccctct gcatcggggg catgtcggtg aaggagcaga tggagaccat
     1081 ccgacatggt gtgcacatga tggtagccac acctggacgc ctcatggatt tgctgcagaa
     1141 gaaaatggtc agcctagaca tctgccgcta cctagccctg gatgaagctg accgcatgat
     1201 tgacatgggc tttgagggtg acattcgtac catcttctcc tacttcaagg gccaacggca
     1261 gactctgctc ttcagtgcca ccatgccgaa gaagattcaa aactttgcca agagtgcctt
     1321 ggtaaagcct gtcaccatca atgtgggtcg tgctggagca gccagccttg atgtcatcca
     1381 ggaggtggag tatgtgaagg aggaagccaa gatggtgtac ttgcttgagt gcctgcagaa
     1441 gacaccccca cctgtgctca tctttgcaga gaagaaagca gatgtggatg ccattcacga
     1501 atacctcctg ctcaagggtg ttgaggctgt agccattcat gggggcaaag accaggaaga
     1561 gcggaccaag gccattgagg cattccggga aggcaagaag gacgtcttag tggccacaga
     1621 tgtggcctct aaaggcctgg actttcctgc catccagcat gtcatcaact atgacatgcc
     1681 tgaagagata gaaaactatg tgcacagaat tggccgcact gggcgttcag gaaacacagg
     1741 catcgctacc accttcatca acaaggcctg cgatgagtca gtgctcatgg acctcaaagc
     1801 cttgttgctg gaggccaagc agaaggtacc acctgttctg caagtgctgc actgtgggga
     1861 cgagtccatg ctggacattg gaggagaacg gggctgtgcc ttctgtggag gccttggcca
     1921 tcggatcact gactgcccca aacttgaagc tatgcagacc aagcaggtca gcaacattgg
     1981 ccgcaaggac tacctggccc acagctccat ggacttctga gccgtctgac ttctctcttc
     2041 tccccaagag tccaatgcta ggacactggc catgtgcaca ccagcactca agacaagaag
     2101 ccagcctccc ggcccagctg gcctgggcag ccccagtgcc ctcagaatta ctatttttgt
     2161 tctcctcccc agcattaaag cacaatccct tttcttggac cagttaaaaa aaa
//
