LOCUS       NM_012008               4640 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus DEAD box helicase 3, Y-linked (Ddx3y), mRNA.
ACCESSION   NM_012008
VERSION     NM_012008.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4640)
  AUTHORS   Horitani,K., Chavkin,N.W., Arai,Y., Wang,Y., Ogawa,H., Yura,Y.,
            Evans,M.A., Cochran,J.D., Thel,M.C., Polizio,A.H., Sano,M.,
            Miura-Yura,E., Arai,Y., Doviak,H., Arnold,A.P., Gelfand,B.D.,
            Hirschi,K.K., Sano,S. and Walsh,K.
  TITLE     Disruption of the Uty epigenetic regulator locus in hematopoietic
            cells phenocopies the profibrotic attributes of Y chromosome loss
            in heart failure
  JOURNAL   Nat Cardiovasc Res 3 (3), 343-355 (2024)
   PUBMED   39183958
REFERENCE   2  (bases 1 to 4640)
  AUTHORS   Kazi,S., Castaneda,J.M., Savolainen,A., Xu,Y., Liu,N., Qiao,H.,
            Ramirez-Solis,R., Nozawa,K., Yu,Z., Matzuk,M.M. and
            Prunskaite-Hyyrylainen,R.
  TITLE     MRNIP interacts with sex body chromatin to support meiotic
            progression, spermatogenesis, and male fertility in mice
  JOURNAL   FASEB J 36 (9), e22479 (2022)
   PUBMED   35920200
REFERENCE   3  (bases 1 to 4640)
  AUTHORS   Hoye,M.L., Calviello,L., Poff,A.J., Ejimogu,N.E., Newman,C.R.,
            Montgomery,M.D., Ou,J., Floor,S.N. and Silver,D.L.
  TITLE     Aberrant cortical development is driven by impaired cell cycle and
            translational control in a DDX3X syndrome model
  JOURNAL   Elife 11, e78203 (2022)
   PUBMED   35762573
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4640)
  AUTHORS   Hirata,W., Tomoda,T., Yuri,S. and Isotani,A.
  TITLE     Generation of the Y-chromosome linked red fluorescent protein
            transgenic mouse model and sexing at the preimplantation stage
  JOURNAL   Exp Anim 71 (1), 82-89 (2022)
   PUBMED   34544911
REFERENCE   5  (bases 1 to 4640)
  AUTHORS   Deschepper,C.F.
  TITLE     Regulatory effects of the Uty/Ddx3y locus on neighboring chromosome
            Y genes and autosomal mRNA transcripts in adult mouse
            non-reproductive cells
  JOURNAL   Sci Rep 10 (1), 14900 (2020)
   PUBMED   32913328
  REMARK    GeneRIF: Regulatory effects of the Uty/Ddx3y locus on neighboring
            chromosome Y genes and autosomal mRNA transcripts in adult mouse
            non-reproductive cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4640)
  AUTHORS   Xu,J., Burgoyne,P.S. and Arnold,A.P.
  TITLE     Sex differences in sex chromosome gene expression in mouse brain
  JOURNAL   Hum Mol Genet 11 (12), 1409-1419 (2002)
   PUBMED   12023983
REFERENCE   7  (bases 1 to 4640)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 4640)
  AUTHORS   Mazeyrat,S., Saut,N., Grigoriev,V., Mahadevaiah,S.K.,
            Ojarikre,O.A., Rattigan,A., Bishop,C., Eicher,E.M., Mitchell,M.J.
            and Burgoyne,P.S.
  TITLE     A Y-encoded subunit of the translation initiation factor Eif2 is
            essential for mouse spermatogenesis
  JOURNAL   Nat Genet 29 (1), 49-53 (2001)
   PUBMED   11528390
REFERENCE   9  (bases 1 to 4640)
  AUTHORS   Mazeyrat,S., Saut,N., Sargent,C.A., Grimmond,S., Longepied,G.,
            Ehrmann,I.E., Ellis,P.S., Greenfield,A., Affara,N.A. and
            Mitchell,M.J.
  TITLE     The mouse Y chromosome interval necessary for spermatogonial
            proliferation is gene dense with syntenic homology to the human
            AZFa region
  JOURNAL   Hum Mol Genet 7 (11), 1713-1724 (1998)
   PUBMED   9736773
REFERENCE   10 (bases 1 to 4640)
  AUTHORS   Gee,S.L. and Conboy,J.G.
  TITLE     Mouse erythroid cells express multiple putative RNA helicase genes
            exhibiting high sequence conservation from yeast to mammals
  JOURNAL   Gene 140 (2), 171-177 (1994)
   PUBMED   8144024
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD552910.1, AJ007376.1, BC051046.1, AK160604.1, AK162630.1 and
            BB671323.1.
            
            On Aug 12, 2009 this sequence version replaced NM_012008.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ007376.1, BC021453.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849376,
                                           SAMN00849377 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                CD552910.1         1-36
            37-2088             AJ007376.1         4-2055
            2089-3031           BC051046.1         2078-3020
            3032-3577           AK160604.1         1518-2063
            3578-4583           AK162630.1         469-1474
            4584-4640           BB671323.1         350-406
FEATURES             Location/Qualifiers
     source          1..4640
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="Y"
                     /map="Y"
     gene            1..4640
                     /gene="Ddx3y"
                     /gene_synonym="8030469F12Rik; D1Pas1-rs1; Dby"
                     /note="DEAD box helicase 3, Y-linked"
                     /db_xref="GeneID:26900"
                     /db_xref="MGI:MGI:1349406"
     exon            1..135
                     /gene="Ddx3y"
                     /gene_synonym="8030469F12Rik; D1Pas1-rs1; Dby"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..2067
                     /gene="Ddx3y"
                     /gene_synonym="8030469F12Rik; D1Pas1-rs1; Dby"
                     /EC_number="3.6.4.13"
                     /note="mDEAD2; DEAD-box RNA helicase DEAD2; DEAD box
                     protein 3, Y-chromosomal; DEAD
                     (aspartate-glutamate-alanine-aspartate) box polypeptide, Y
                     chromosome; D1Pas1 related sequence 1; DEAD
                     (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase DDX3Y"
                     /protein_id="NP_036138.1"
                     /db_xref="CCDS:CCDS30543.1"
                     /db_xref="GeneID:26900"
                     /db_xref="MGI:MGI:1349406"
                     /translation="MSQVAAESTAGLDQQFVGLDLKSSDNQNGGGNTESKGRYIPPHL
                     RNRETSKGVCDKDSSGWSCSKDKDAYSSFGSRDSRGKPNYFSDRGSGSRGRFDDHGRN
                     DYDGIGGRDRTGFGKFERSGHSRWSDRSDEDDWSKPLPPSERLEQELFSGGNTGINFE
                     KYDDIPVEATGNNCPPHIENFSDIEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRD
                     LMACAQTGSGKTAAFLLPILSQIYTDGPGEALKAMKENGRYGRRKQYPISLVLAPTRE
                     LAVQIYEEARKFSYRSRVRPCVVYGGADTVQQIRDLERGCHLLVATPGRLVDMMERGK
                     IGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLA
                     RDFLDEYIFLAVGRVGSTSENITQKVVWVEELDKRSFLLDLLNATGKDSLTLVFVETK
                     KGADSLENFLFQERYACTSIHGDRSQKDREEALHQFRSGRKPILVATAVAARGLDISN
                     VKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNLNITKDLLDLLVEAKQEV
                     PSWLESMAYEHHYKGSSRGRSKSRFSGGFGARDYRQSSGSANAGFNSNRANSSRSSGS
                     SHNRGFGGGGYGGFYNNDGYGGNYNSQAVDWWGN"
     exon            136..196
                     /gene="Ddx3y"
                     /gene_synonym="8030469F12Rik; D1Pas1-rs1; Dby"
                     /inference="alignment:Splign:2.1.0"
     exon            197..244
                     /gene="Ddx3y"
                     /gene_synonym="8030469F12Rik; D1Pas1-rs1; Dby"
                     /inference="alignment:Splign:2.1.0"
     exon            245..374
                     /gene="Ddx3y"
                     /gene_synonym="8030469F12Rik; D1Pas1-rs1; Dby"
                     /inference="alignment:Splign:2.1.0"
     exon            375..530
                     /gene="Ddx3y"
                     /gene_synonym="8030469F12Rik; D1Pas1-rs1; Dby"
                     /inference="alignment:Splign:2.1.0"
     exon            531..630
                     /gene="Ddx3y"
                     /gene_synonym="8030469F12Rik; D1Pas1-rs1; Dby"
                     /inference="alignment:Splign:2.1.0"
     exon            631..766
                     /gene="Ddx3y"
                     /gene_synonym="8030469F12Rik; D1Pas1-rs1; Dby"
                     /inference="alignment:Splign:2.1.0"
     exon            767..852
                     /gene="Ddx3y"
                     /gene_synonym="8030469F12Rik; D1Pas1-rs1; Dby"
                     /inference="alignment:Splign:2.1.0"
     exon            853..951
                     /gene="Ddx3y"
                     /gene_synonym="8030469F12Rik; D1Pas1-rs1; Dby"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1112
                     /gene="Ddx3y"
                     /gene_synonym="8030469F12Rik; D1Pas1-rs1; Dby"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1257
                     /gene="Ddx3y"
                     /gene_synonym="8030469F12Rik; D1Pas1-rs1; Dby"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1402
                     /gene="Ddx3y"
                     /gene_synonym="8030469F12Rik; D1Pas1-rs1; Dby"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1584
                     /gene="Ddx3y"
                     /gene_synonym="8030469F12Rik; D1Pas1-rs1; Dby"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1702
                     /gene="Ddx3y"
                     /gene_synonym="8030469F12Rik; D1Pas1-rs1; Dby"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1856
                     /gene="Ddx3y"
                     /gene_synonym="8030469F12Rik; D1Pas1-rs1; Dby"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1987
                     /gene="Ddx3y"
                     /gene_synonym="8030469F12Rik; D1Pas1-rs1; Dby"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..4640
                     /gene="Ddx3y"
                     /gene_synonym="8030469F12Rik; D1Pas1-rs1; Dby"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4560..4565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddx3y"
                     /gene_synonym="8030469F12Rik; D1Pas1-rs1; Dby"
                     /note="hexamer: AATAAA"
     polyA_site      4584
                     /gene="Ddx3y"
                     /gene_synonym="8030469F12Rik; D1Pas1-rs1; Dby"
                     /note="major polyA site"
     regulatory      4615..4620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddx3y"
                     /gene_synonym="8030469F12Rik; D1Pas1-rs1; Dby"
                     /note="hexamer: AATAAA"
     polyA_site      4639
                     /gene="Ddx3y"
                     /gene_synonym="8030469F12Rik; D1Pas1-rs1; Dby"
ORIGIN      
        1 ccaaaactgt gtacgtaagc tcttgcgttc accgtgagga aacaggtcta cggtggctgt
       61 tccgtgagaa gttctcaatt tttttcagca atgagtcaag tggcagcgga aagtacggcc
      121 ggcctggacc agcaatttgt tggtcttgac ctgaaatcat cagataatca gaatggagga
      181 ggaaatacag agagcaaagg gcgctatata cctcctcact taaggaacag agaaacatct
      241 aaaggggtct gtgataagga cagttcagga tggagctgta gtaaagataa agatgcctac
      301 agcagttttg gatctcgtga ttccagaggg aagcccaatt atttcagtga tcgtggaagt
      361 ggatccaggg gaaggttcga tgatcatggt cgaaatgact atgatggtat tggtggtcgt
      421 gaccgaactg gatttggcaa atttgaacgg agtggtcata gtcgttggag tgacagatca
      481 gatgaagatg actggtcaaa accacttcca ccaagtgaac gcttagagca agaacttttt
      541 tctggaggaa acacagggat taactttgag aaatatgatg atataccagt agaagcaact
      601 ggaaataatt gtcctcctca cattgaaaat ttcagtgata ttgagatggg agaaattatc
      661 atggggaaca ttgaacttac tcgttacact cgtcctactc cagtgcaaaa acatgctatt
      721 ccaattatta aagaaaaaag ggacttaatg gcttgtgctc aaacagggtc tggaaaaact
      781 gctgcatttc tactacccat tctcagtcag atttatacag atggtccagg agaggctttg
      841 aaggctatga aggaaaatgg aagatatggt cgccgtaaac aatacccaat ctccttggtg
      901 ttagccccaa caagagaatt ggctgtgcag atctatgagg aagccagaaa attttcatac
      961 cgatctagag tccgtccttg tgtagtgtat ggtggtgctg atactgttca gcagattcgg
     1021 gacttagaac gtggatgcca cttgttagtt gccacaccag gacgtctagt ggacatgatg
     1081 gaaagaggaa agattggatt agatttctgc aaatacttag tattggatga agctgatagg
     1141 atgctggata tgggatttga acctcaaata cgtcgtatag ttgagcagga cacaatgcca
     1201 ccaaaggggg ttcgtcacac tatgatgttt agtgctactt ttcctaagga gatacagatg
     1261 cttgctcgtg actttttaga tgaatatatc tttctggctg taggcagagt aggatctact
     1321 tctgagaaca tcacacagaa agtagtatgg gttgaagaac tagacaaacg gtcattttta
     1381 cttgatctct taaatgcaac agggaaggat tcattgactt tagtatttgt ggagactaaa
     1441 aagggtgcag attcgctgga gaacttctta tttcaagaaa gatatgcgtg tactagtatt
     1501 catggagaca gatcacagaa agatcgagag gaggcccttc accagtttcg ctcagggcga
     1561 aagccaattt tagtggctac agctgtggca gcaagaggtc tagacatttc aaatgtgaaa
     1621 catgttatca attttgattt gccaagcgat attgaagaat atgtgcatcg aattggccgc
     1681 acaggacgtg taggaaacct tggacttgcc acctcttttt tcaatgagag gaatttgaac
     1741 atcacaaaag atttgttaga tctccttgtt gaggctaaac aagaagtgcc ttcttggttg
     1801 gaaagtatgg cttatgaaca ccactacaag ggaagtagcc gtggacgttc taaaagcaga
     1861 ttcagtggag gatttggagc cagagactat cgacagagca gtggttctgc aaatgctgga
     1921 tttaatagta accgtgccaa tagcagccga agtagtggta gtagccacaa cagaggattt
     1981 ggtggaggtg gctatggagg tttctacaat aatgatggtt atggaggaaa ttataactcc
     2041 caggcagttg actggtgggg caattgaatt tgtatcatta tttcatacag ctaatatgga
     2101 aaccacatgt aacttagcca gactgtattg tgtagcttca agaacttgca gtacattacc
     2161 agctgtgatt cttctaaaag ttcatgagag ctcaaagtca caagaaatta agcaacaacc
     2221 tgtagcccta ttcaaagttg atgagaaaaa tttttgtaac tggattaatt cacttcctgc
     2281 ttggttgtac cctaaacagc atttataatt tgtgagtgag gatcatttgt taatgtacta
     2341 tgacttttaa ctttaaacaa cttatttaat gtcctgttgt ctcaataatg ctcaagatat
     2401 aaattgtttt aataagttaa ttgaattttg gctacaagca aaccttggca cacaagtgta
     2461 atacacctta ataggaatca attcattgct aagtatgatg gtgaatgaac ttatcctgga
     2521 taataaattt ttggtatatg cagagttgtt ggtaaaactt cttttttaag tttgtaatgt
     2581 ggcagacata caaaactaaa gttctgaact gctcactata tcctgcattg acacttagaa
     2641 ccttaaagta ttaaatatat gattatatat ggttatatcc tttattttca aaagcactaa
     2701 tgcagataac tacagtgatt cctcatttac tgttttaagt aatttatatt ggcatactcc
     2761 tacatgaaag tttaaaattt tggtgaagaa tttgggatat aaagtttagg tatatttaat
     2821 gcctgccatg cataaaaaat ggtaaattac taggtgacta tggcaatgac cagaccttat
     2881 taaagctttg ttaattctgg tctttaatgc atgctagtgt tggtgttttt tggtcaagag
     2941 agtatgaaca gattatgcag cagcaggctt tacttttaca cagtcaggtt tttctgtaac
     3001 aactatgttg aaatgtaaaa ataaaataaa ataaaataaa aaaggcttac atacatacta
     3061 tgtaaatata agaataaaaa attgaaattg ctgagatctc acaggttgga tttatgtact
     3121 aattatacat gatggtcagt acagtgcagt tttcatctat tttcgttgca taggtttcca
     3181 ttgtattata gtcatatttt aattggccaa aaatgattgt ccctcacaaa aaatgccttt
     3241 tcctttgaga atttcctgga aagaatacaa taaatttaaa aacgtaagtc cttaaaaata
     3301 ctataagttg ataaattttt ctaaaagtgc aatagatttt caagtgtatt gtgccttgta
     3361 ttaaaatttt aaagtaggtg tacttgacag tattatcaag gtcatttgtt acggtgctat
     3421 ttcaattata gaagtttaga ctgtacattg cccataactt tttacaaagt acttatttta
     3481 ttgcacatga agagaatttt atatgtgtat cttatgtaca agtccttgaa gttccaattg
     3541 gatattgttg attacagtgt gtcaagaact tggttcagaa aattttccat ggaccataga
     3601 atgatagtta agaaaaacta tttgcagcct gaagtggtgg cacacgcctt taattgcagc
     3661 actcaggagg cagaggcagg tggatttctg aatttgtggc cagcctgttc tgcatagtga
     3721 gttccaggac agctagggct ctacagagaa accttgtctc aaaaaaccaa aaaaaagaaa
     3781 aaaaagaaaa agaaaaaaaa gaaagaaaaa ctatttgcac ataacagact ttttgctgct
     3841 aggttgtgta atatttattg aacattttga caaatattta tttttgtaag cctaaaaatg
     3901 attctttgaa agcttaaaga aacttgacca aaagacagta ttaaaaaaaa cactggtatt
     3961 tgattgtcac tgtatgtgaa atagtatatt ttgggtaatg tgagcttttt aatgttaagt
     4021 tctactaaac ttgagtcaaa ttgatctaac ccagtattag tgatgtagct acactatttt
     4081 tctttttttc ttttgacaaa atgaaaggca attggaataa tgaaaattta aaacatgcca
     4141 aggttttgat gtatttaaga tattagtgaa aactaaaaat tttctcagtt tgtttgaatt
     4201 taccttactt acatgatcta tttgttcagt attgtaactg tctggcatat ttataatctt
     4261 caaacatgtg gttatatctt tgtattgcca taatcagtga tgttttacat tcagtttatc
     4321 agccagcaat actttcagta aataatacac taaatttgct gactgtagac atggaacttt
     4381 aagtttctat aaagttagta attgctttat tgtattagta ttaggtgcta gcactgcata
     4441 tgtctgatct attctcattt tattaaaata aaaagtatag caaaatgttt actgtaactt
     4501 gtgacttaat gttcttgtga acttgcatgc ttgaactgtt ggaaatctca tttttagtta
     4561 ataaaagaag gtatttgtaa agtacactgt tatgtatgtg tttgcttttt agttaataaa
     4621 agaaggtatt tgtaaagtac
//
