LOCUS       NP_036138                658 aa            linear   ROD 03-APR-2025
DEFINITION  ATP-dependent RNA helicase DDX3Y [Mus musculus].
ACCESSION   NP_036138
VERSION     NP_036138.1
DBSOURCE    REFSEQ: accession NM_012008.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 658)
  AUTHORS   Subrini,J., Varsally,W., Balsells,I.B., Bensberg,M., Sioutas,G.,
            Ojarikre,O., Maciulyte,V., Gylemo,B., Crawley,K., Courtis,K., de
            Rooij,D.G. and Turner,J.M.A.
  TITLE     Systematic identification of Y-chromosome gene functions in mouse
            spermatogenesis
  JOURNAL   Science 387 (6732), 393-400 (2025)
   PUBMED   39847625
REFERENCE   2  (residues 1 to 658)
  AUTHORS   Horitani,K., Chavkin,N.W., Arai,Y., Wang,Y., Ogawa,H., Yura,Y.,
            Evans,M.A., Cochran,J.D., Thel,M.C., Polizio,A.H., Sano,M.,
            Miura-Yura,E., Arai,Y., Doviak,H., Arnold,A.P., Gelfand,B.D.,
            Hirschi,K.K., Sano,S. and Walsh,K.
  TITLE     Disruption of the Uty epigenetic regulator locus in hematopoietic
            cells phenocopies the profibrotic attributes of Y chromosome loss
            in heart failure
  JOURNAL   Nat Cardiovasc Res 3 (3), 343-355 (2024)
   PUBMED   39183958
REFERENCE   3  (residues 1 to 658)
  AUTHORS   Kazi,S., Castaneda,J.M., Savolainen,A., Xu,Y., Liu,N., Qiao,H.,
            Ramirez-Solis,R., Nozawa,K., Yu,Z., Matzuk,M.M. and
            Prunskaite-Hyyrylainen,R.
  TITLE     MRNIP interacts with sex body chromatin to support meiotic
            progression, spermatogenesis, and male fertility in mice
  JOURNAL   FASEB J 36 (9), e22479 (2022)
   PUBMED   35920200
REFERENCE   4  (residues 1 to 658)
  AUTHORS   Hoye,M.L., Calviello,L., Poff,A.J., Ejimogu,N.E., Newman,C.R.,
            Montgomery,M.D., Ou,J., Floor,S.N. and Silver,D.L.
  TITLE     Aberrant cortical development is driven by impaired cell cycle and
            translational control in a DDX3X syndrome model
  JOURNAL   Elife 11, e78203 (2022)
   PUBMED   35762573
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 658)
  AUTHORS   Hirata,W., Tomoda,T., Yuri,S. and Isotani,A.
  TITLE     Generation of the Y-chromosome linked red fluorescent protein
            transgenic mouse model and sexing at the preimplantation stage
  JOURNAL   Exp Anim 71 (1), 82-89 (2022)
   PUBMED   34544911
REFERENCE   6  (residues 1 to 658)
  AUTHORS   Xu,J., Burgoyne,P.S. and Arnold,A.P.
  TITLE     Sex differences in sex chromosome gene expression in mouse brain
  JOURNAL   Hum Mol Genet 11 (12), 1409-1419 (2002)
   PUBMED   12023983
REFERENCE   7  (residues 1 to 658)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (residues 1 to 658)
  AUTHORS   Mazeyrat,S., Saut,N., Grigoriev,V., Mahadevaiah,S.K.,
            Ojarikre,O.A., Rattigan,A., Bishop,C., Eicher,E.M., Mitchell,M.J.
            and Burgoyne,P.S.
  TITLE     A Y-encoded subunit of the translation initiation factor Eif2 is
            essential for mouse spermatogenesis
  JOURNAL   Nat Genet 29 (1), 49-53 (2001)
   PUBMED   11528390
REFERENCE   9  (residues 1 to 658)
  AUTHORS   Mazeyrat,S., Saut,N., Sargent,C.A., Grimmond,S., Longepied,G.,
            Ehrmann,I.E., Ellis,P.S., Greenfield,A., Affara,N.A. and
            Mitchell,M.J.
  TITLE     The mouse Y chromosome interval necessary for spermatogonial
            proliferation is gene dense with syntenic homology to the human
            AZFa region
  JOURNAL   Hum Mol Genet 7 (11), 1713-1724 (1998)
   PUBMED   9736773
REFERENCE   10 (residues 1 to 658)
  AUTHORS   Gee,S.L. and Conboy,J.G.
  TITLE     Mouse erythroid cells express multiple putative RNA helicase genes
            exhibiting high sequence conservation from yeast to mammals
  JOURNAL   Gene 140 (2), 171-177 (1994)
   PUBMED   8144024
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD552910.1, AJ007376.1, BC051046.1, AK160604.1, AK162630.1 and
            BB671323.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ007376.1, BC021453.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849376,
                                           SAMN00849377 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..658
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="Y"
                     /map="Y"
     Protein         1..658
                     /product="ATP-dependent RNA helicase DDX3Y"
                     /EC_number="3.6.4.13"
                     /note="mDEAD2; DEAD-box RNA helicase DEAD2; DEAD box
                     protein 3, Y-chromosomal; DEAD
                     (aspartate-glutamate-alanine-aspartate) box polypeptide, Y
                     chromosome; D1Pas1 related sequence 1; DEAD
                     (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked"
                     /calculated_mol_wt=73297
     Region          1..143
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62095.2)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:O00571; propagated from
                     UniProtKB/Swiss-Prot (Q62095.2)"
     Site            56
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q62167; propagated from
                     UniProtKB/Swiss-Prot (Q62095.2)"
     Site            86
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00571; propagated from
                     UniProtKB/Swiss-Prot (Q62095.2)"
     Site            90
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00571; propagated from
                     UniProtKB/Swiss-Prot (Q62095.2)"
     Site            101
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q62167; propagated from
                     UniProtKB/Swiss-Prot (Q62095.2)"
     Site            104
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q62167; propagated from
                     UniProtKB/Swiss-Prot (Q62095.2)"
     Site            110
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q62167; propagated from
                     UniProtKB/Swiss-Prot (Q62095.2)"
     Site            117
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:O00571; propagated from
                     UniProtKB/Swiss-Prot (Q62095.2)"
     Site            130
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00571; propagated from
                     UniProtKB/Swiss-Prot (Q62095.2)"
     Region          159..409
                     /region_name="DEADc_DDX3"
                     /note="DEAD-box helicase domain of DEAD box protein 3;
                     cd18051"
                     /db_xref="CDD:350809"
     Site            order(159,169,181,199,201..203,206,224..230,346..347,382)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350809"
     Region          179..207
                     /region_name="Q motif"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62095.2)"
     Site            182
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00571; propagated from
                     UniProtKB/Swiss-Prot (Q62095.2)"
     Site            order(273..275,301..302,322..325,328,350,356)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:350809"
     Region          346..349
                     /region_name="DEAD box"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62095.2)"
     Region          414..544
                     /region_name="SF2_C_DEAD"
                     /note="C-terminal helicase domain of the DEAD box
                     helicases; cd18787"
                     /db_xref="CDD:350174"
     Site            455
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q62095.2)"
     Site            order(503,505,530,533..534)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350174"
     Site            590
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:O00571; propagated from
                     UniProtKB/Swiss-Prot (Q62095.2)"
     Site            592
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00571; propagated from
                     UniProtKB/Swiss-Prot (Q62095.2)"
     Region          597..627
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62095.2)"
     Site            603
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00571; propagated from
                     UniProtKB/Swiss-Prot (Q62095.2)"
     Site            615
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:O00571; propagated from
                     UniProtKB/Swiss-Prot (Q62095.2)"
     Site            628
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:O00571; propagated from
                     UniProtKB/Swiss-Prot (Q62095.2)"
     CDS             1..658
                     /gene="Ddx3y"
                     /gene_synonym="8030469F12Rik; D1Pas1-rs1; Dby"
                     /coded_by="NM_012008.2:91..2067"
                     /db_xref="CCDS:CCDS30543.1"
                     /db_xref="GeneID:26900"
                     /db_xref="MGI:MGI:1349406"
ORIGIN      
        1 msqvaaesta gldqqfvgld lkssdnqngg gnteskgryi pphlrnrets kgvcdkdssg
       61 wscskdkday ssfgsrdsrg kpnyfsdrgs gsrgrfddhg rndydgiggr drtgfgkfer
      121 sghsrwsdrs deddwskplp pserleqelf sggntginfe kyddipveat gnncpphien
      181 fsdiemgeii mgnieltryt rptpvqkhai piikekrdlm acaqtgsgkt aafllpilsq
      241 iytdgpgeal kamkengryg rrkqypislv laptrelavq iyeearkfsy rsrvrpcvvy
      301 ggadtvqqir dlergchllv atpgrlvdmm ergkigldfc kylvldeadr mldmgfepqi
      361 rriveqdtmp pkgvrhtmmf satfpkeiqm lardfldeyi flavgrvgst senitqkvvw
      421 veeldkrsfl ldllnatgkd sltlvfvetk kgadslenfl fqeryactsi hgdrsqkdre
      481 ealhqfrsgr kpilvatava argldisnvk hvinfdlpsd ieeyvhrigr tgrvgnlgla
      541 tsffnernln itkdlldllv eakqevpswl esmayehhyk gssrgrsksr fsggfgardy
      601 rqssgsanag fnsnranssr ssgsshnrgf ggggyggfyn ndgyggnyns qavdwwgn
//
