LOCUS       NM_010028               4571 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Mus musculus DEAD box helicase 3, X-linked (Ddx3x), mRNA.
ACCESSION   NM_010028 NM_008015 XM_908815
VERSION     NM_010028.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4571)
  AUTHORS   Wei,C., Kesner,B., Yin,H. and Lee,J.T.
  TITLE     Imprinted X chromosome inactivation at the gamete-to-embryo
            transition
  JOURNAL   Mol Cell 84 (8), 1442-1459 (2024)
   PUBMED   38458200
REFERENCE   2  (bases 1 to 4571)
  AUTHORS   Jowhar,Z., Xu,A., Venkataramanan,S., Dossena,F., Hoye,M.L.,
            Silver,D.L., Floor,S.N. and Calviello,L.
  TITLE     A ubiquitous GC content signature underlies multimodal mRNA
            regulation by DDX3X
  JOURNAL   Mol Syst Biol 20 (3), 276-290 (2024)
   PUBMED   38273160
  REMARK    GeneRIF: A ubiquitous GC content signature underlies multimodal
            mRNA regulation by DDX3X.
REFERENCE   3  (bases 1 to 4571)
  AUTHORS   Sharma,N., Kessler,P. and Sen,G.C.
  TITLE     Cell-type-specific need of Ddx3 and PACT for interferon induction
            by RNA viruses
  JOURNAL   J Virol 97 (12), e0130423 (2023)
   PUBMED   37982645
  REMARK    GeneRIF: Cell-type-specific need of Ddx3 and PACT for interferon
            induction by RNA viruses.
REFERENCE   4  (bases 1 to 4571)
  AUTHORS   Zhao,P., Ma,G. and Ma,L.
  TITLE     miR-181a-5p targets DDX3X to inhibit the progression of
            osteoarthritis via NF-KappaB signaling pathway
  JOURNAL   J Orthop Surg Res 18 (1), 606 (2023)
   PUBMED   37587519
  REMARK    GeneRIF: miR-181a-5p targets DDX3X to inhibit the progression of
            osteoarthritis via NF-KappaB signaling pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4571)
  AUTHORS   Luo,T., Yang,S., Zhao,T., Zhu,H., Chen,C., Shi,X., Chen,D.,
            Wang,K., Jiang,K., Xu,D., Cheng,M., Li,J., Li,W., Xu,W., Zhou,L.,
            Jiang,M. and Xu,B.
  TITLE     Hepatocyte DDX3X protects against drug-induced acute liver injury
            via controlling stress granule formation and oxidative stress
  JOURNAL   Cell Death Dis 14 (7), 400 (2023)
   PUBMED   37407573
  REMARK    GeneRIF: Hepatocyte DDX3X protects against drug-induced acute liver
            injury via controlling stress granule formation and oxidative
            stress.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4571)
  AUTHORS   Sowden,J.C., Morrison,K., Putt,W., Beddington,R. and Edwards,Y.H.
  TITLE     The identification of novel sequences expressed in the mouse
            notochord
  JOURNAL   Mamm Genome 8 (1), 42-44 (1997)
   PUBMED   9021147
REFERENCE   7  (bases 1 to 4571)
  AUTHORS   Bermingham,N.A., McKay,T., Hoyle,J., Hernandez,D., Martin,J.E. and
            Fisher,E.M.
  TITLE     The gene encoding tripeptidyl peptidase II maps to chromosome 1 in
            the mouse
  JOURNAL   Mamm Genome 7 (5), 390 (1996)
   PUBMED   8661741
REFERENCE   8  (bases 1 to 4571)
  AUTHORS   Guthridge,M.A., Seldin,M. and Basilico,C.
  TITLE     Induction of expression of growth-related genes by FGF-4 in mouse
            fibroblasts
  JOURNAL   Oncogene 12 (6), 1267-1278 (1996)
   PUBMED   8649829
REFERENCE   9  (bases 1 to 4571)
  AUTHORS   Sowden,J., Putt,W., Morrison,K., Beddington,R. and Edwards,Y.
  TITLE     The embryonic RNA helicase gene (ERH): a new member of the DEAD box
            family of RNA helicases
  JOURNAL   Biochem J 308 (Pt 3) (Pt 3), 839-846 (1995)
   PUBMED   8948440
REFERENCE   10 (bases 1 to 4571)
  AUTHORS   Gee,S.L. and Conboy,J.G.
  TITLE     Mouse erythroid cells express multiple putative RNA helicase genes
            exhibiting high sequence conservation from yeast to mammals
  JOURNAL   Gene 140 (2), 171-177 (1994)
   PUBMED   8144024
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB854842.1, AK163250.1 and AL833805.11.
            
            On Jan 11, 2008 this sequence version replaced NM_010028.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.81423.1,
                                           SRR1660813.139331.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BB854842.1         3-30
            29-2979             AK163250.1         4-2954
            2980-4571           AL833805.11        101818-103409
FEATURES             Location/Qualifiers
     source          1..4571
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 8.17 cM"
     gene            1..4571
                     /gene="Ddx3x"
                     /gene_synonym="D1Pas1-rs2; Ddx3; Fin14"
                     /note="DEAD box helicase 3, X-linked"
                     /db_xref="GeneID:13205"
                     /db_xref="MGI:MGI:103064"
     exon            1..136
                     /gene="Ddx3x"
                     /gene_synonym="D1Pas1-rs2; Ddx3; Fin14"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..2080
                     /gene="Ddx3x"
                     /gene_synonym="D1Pas1-rs2; Ddx3; Fin14"
                     /EC_number="3.6.4.13"
                     /note="mDEAD3; D1Pas1-related sequence 2; DEAD box RNA
                     helicase DEAD3; DEAD/H (Asp-Glu-Ala-Asp/His) box
                     polypeptide 3, X-linked; DEAD box protein 3,
                     X-chromosomal; embryonic RNA helicase; DEAD
                     (aspartate-glutamate-alanine-aspartate) box polypeptide 3;
                     D-E-A-D (aspartate-glutamate-alanine-aspartate) box
                     polypeptide 3; fibroblast growth factor inducible 14;
                     DEAD-box protein 3 (DEAD-box RNA helicase DEAD3) (mDEAD3)
                     (Embryonic RNA helicase) (D1PAS1 related sequence 2)"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase DDX3X"
                     /protein_id="NP_034158.1"
                     /db_xref="CCDS:CCDS30027.1"
                     /db_xref="GeneID:13205"
                     /db_xref="MGI:MGI:103064"
                     /translation="MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLR
                     NREATKGFYDKDSSGWSSSKDKDAYSSFGSRGDSRGKSSFFGDRGSGSRGRFDDRGRG
                     DYDGIGGRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINF
                     EKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKR
                     DLMACAQTGSGKTAAFLLPILSQIYADGPGEALRAMKENGRYGRRKQYPISLVLAPTR
                     ELAVQIYEEARKFSYRSRVRPCVVYGGAEIGQQIRDLERGCHLLVATPGRLVDMMERG
                     KIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQML
                     ARDFLDEYIFLAVGRVGSTSENITQKVVWVEEIDKRSFLLDLLNATGKDSLTLVFVET
                     KKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDIS
                     NVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQE
                     VPSWLENMAFEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSG
                     GGGHGGSRGFGGGGYGGFYNSDGYGGNYNSQGVDWWGN"
     exon            137..194
                     /gene="Ddx3x"
                     /gene_synonym="D1Pas1-rs2; Ddx3; Fin14"
                     /inference="alignment:Splign:2.1.0"
     exon            195..242
                     /gene="Ddx3x"
                     /gene_synonym="D1Pas1-rs2; Ddx3; Fin14"
                     /inference="alignment:Splign:2.1.0"
     exon            243..375
                     /gene="Ddx3x"
                     /gene_synonym="D1Pas1-rs2; Ddx3; Fin14"
                     /inference="alignment:Splign:2.1.0"
     exon            376..534
                     /gene="Ddx3x"
                     /gene_synonym="D1Pas1-rs2; Ddx3; Fin14"
                     /inference="alignment:Splign:2.1.0"
     exon            535..634
                     /gene="Ddx3x"
                     /gene_synonym="D1Pas1-rs2; Ddx3; Fin14"
                     /inference="alignment:Splign:2.1.0"
     exon            635..770
                     /gene="Ddx3x"
                     /gene_synonym="D1Pas1-rs2; Ddx3; Fin14"
                     /inference="alignment:Splign:2.1.0"
     exon            771..856
                     /gene="Ddx3x"
                     /gene_synonym="D1Pas1-rs2; Ddx3; Fin14"
                     /inference="alignment:Splign:2.1.0"
     exon            857..955
                     /gene="Ddx3x"
                     /gene_synonym="D1Pas1-rs2; Ddx3; Fin14"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1116
                     /gene="Ddx3x"
                     /gene_synonym="D1Pas1-rs2; Ddx3; Fin14"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1261
                     /gene="Ddx3x"
                     /gene_synonym="D1Pas1-rs2; Ddx3; Fin14"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1406
                     /gene="Ddx3x"
                     /gene_synonym="D1Pas1-rs2; Ddx3; Fin14"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1588
                     /gene="Ddx3x"
                     /gene_synonym="D1Pas1-rs2; Ddx3; Fin14"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1706
                     /gene="Ddx3x"
                     /gene_synonym="D1Pas1-rs2; Ddx3; Fin14"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1860
                     /gene="Ddx3x"
                     /gene_synonym="D1Pas1-rs2; Ddx3; Fin14"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..2000
                     /gene="Ddx3x"
                     /gene_synonym="D1Pas1-rs2; Ddx3; Fin14"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..4571
                     /gene="Ddx3x"
                     /gene_synonym="D1Pas1-rs2; Ddx3; Fin14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagccgcag ttctcccgtg agagggcctt tgcggtagag gcagcctttg ctcagcagcg
       61 gaagactccg atttctcggt actcttcagg gatgagtcat gtggcagtgg aaaatgcgct
      121 cgggctggac cagcagtttg ctggcctaga cctgaactct tcagataatc agagtggagg
      181 aagtacagca agcaaagggc gttatatccc acctcattta aggaacagag aagctactaa
      241 aggattctat gacaaagaca gttcagggtg gagttctagt aaagataagg atgcatacag
      301 cagttttgga tcacggggtg attcaagagg gaagtctagc ttctttggag atcgtggaag
      361 tggatcaagg ggaaggtttg atgatcgtgg acggggagac tatgatggca ttggtggccg
      421 tggagataga agtggctttg gcaaatttga aagaggtgga aatagtcgct ggtgtgacaa
      481 atcagatgaa gatgactggt caaagccact cccaccaagt gaacgattgg aacaggaact
      541 cttttctgga ggcaatactg ggattaactt tgagaaatat gatgacattc cagtcgaagc
      601 aacaggcaac aactgtcctc cacacattga aagtttcagt gatgtcgaga tgggagaaat
      661 tattatggga aacattgagc ttactcgtta tactcgccca actccagtgc agaagcatgc
      721 tattcctatt atcaaagaga aaagagactt gatggcttgt gctcaaacag gctctggaaa
      781 aactgcagca tttctcttgc ccatcttgag tcagatctat gctgatggtc caggagaagc
      841 tctgagggct atgaaggaaa atggaagata tggccgtcgt aaacagtatc caatctcttt
      901 ggtactggca ccaacgagag aattggcagt gcagatctat gaggaagcca gaaaattctc
      961 ataccgatct agagtccgtc cttgcgtggt ttatggtggt gctgaaattg gccagcagat
     1021 tcgagactta gaacgtggat gccacttgtt agtagccact ccaggacgtc tagtggatat
     1081 gatggagaga gggaagatcg ggttagactt ctgcaaatac ctggtgttag atgaagctga
     1141 ccggatgtta gatatggggt ttgaacctca gatacgaaga atagttgaac aagacactat
     1201 gcctccaaaa ggtgtccgcc acactatgat gtttagtgct acttttccta aggaaataca
     1261 gatgctggcc cgtgatttct tagatgagta catatttctg gctgtaggaa gagttgggtc
     1321 tacttcagag aacatcacac aaaaagtggt ttgggtggag gagatagaca aaaggtcatt
     1381 tctgcttgac cttctaaatg caacaggcaa ggattccctg actctagtgt ttgtggagac
     1441 caaaaagggg gcagattcgc tggaggattt cttataccat gaaggatatg cttgtaccag
     1501 tatccatgga gaccgttctc agagagatag ggaagaggcc cttcaccagt tccgctcagg
     1561 aaaaagccca attctagtgg ctacagcagt agcagcaaga ggactggata tttcaaatgt
     1621 gaagcatgtt attaattttg acctgcctag tgatatcgaa gaatatgtgc atcgcatagg
     1681 ccgtacaggc cgtgtgggaa accttggtct tgccacctca ttctttaatg aaaggaatat
     1741 aaatatcaca aaggatttac tggatcttct tgttgaagca aaacaagaag tgccttcttg
     1801 gttagagaac atggcttttg aacaccacta caagggtagc agtcgtggac gttctaagag
     1861 cagtcgattt agtggagggt ttggtgccag agactaccga cagagtagcg gtgccagcag
     1921 ttccagcttc agcagcagcc gtgcaagcag cagtcgaagt ggtggaggtg gccatggcgg
     1981 cagtcgagga tttggtggag gtggctacgg aggcttttac aacagtgatg gatatggagg
     2041 gaattataac tcccaggggg ttgactggtg gggtaactga gcctgctctg tagtaggtca
     2101 ccctgccaaa caagctaata tggaaaccac atgtaactta gccagactat accttgtgta
     2161 gcttcaagaa ctcgcagtac attaccagct gtgattctcc actgaaattt tttttttaag
     2221 ggagctcaag gtcacaagta aagatgaaag gaacaatcag cagccctgtc tgaaggtggt
     2281 ttgaagactt cattgctgta gtttggatta acgcccctcc cgcctacccc tatcccaaac
     2341 tgcatttata attttgtgac tgaggatcat ttgtttgtta atgtactgtg cctttaactt
     2401 tagacaactt tttattttga tgtcctgttg gctcagtaat gctcaagatt ccaattgttt
     2461 ttgacaaaat aaatttactg aacttgggct aaaatcaaac cttggcacac aggtgtgata
     2521 caacttaaca ggaatcatcg attcatccat aaataatata aggaaaaact caagtggtag
     2581 cctgtcttaa ggcttttgat acttgcagat tggggaaaaa caaacaacaa acgtcttgaa
     2641 gcatattaat ggaattagtt tctaatgtgg caaactgtat taagttaaaa gttctgattt
     2701 gctcactcta tcctggatag gtatttagaa cctgataata gtctttaaac aagccattcc
     2761 agtcatgatg aggtgatgta tggatacatg catacattca aagcactgtt ctcaaagtta
     2821 atgcaagtaa atacagcaat tcctctttca atgtttaggc agatcgttaa ctatgagcta
     2881 gccaaatgtg ggcatgttat tacagggaaa gtttaaaggt ctgataactt gaaataggtt
     2941 taggagaatt catctactta gactttttaa atgcctgcca taaaaaattg aaatggtaga
     3001 atggctgacc acagcaatga ccagccctca cctagggctc tggatgattt ttggtctaat
     3061 aacgcatgct agtgttgatg ttttttggtc aagatgggaa tgaacaggaa gaattatgca
     3121 gcaggcttta ttttaaatgc cgattcacat tactctgttc aagctgcgtt gagatgttaa
     3181 actggcttac tatagacttt gtaaaaaaaa aaaaaacaaa acaaatggct ccagaagagt
     3241 aacaaactga aatctgagat cacacaggtt ggaaatatgt acataactgc acaaggtgtc
     3301 aattctgctc tacagtgcag tttagtcagt tttagttgca taggtttcca ttgtatttat
     3361 agtctgttta tgctaaatct ggccaaagat gagcattgtc caccactaaa atgcctatgc
     3421 cactgggaat tctgggttaa ttttgtgacc agaatgcagt gatcaaaatg ttcaatcttt
     3481 ttacagtggc ataggaagat ggcaaaaatt tcctaaagtg caatagattt tcaagtgtat
     3541 tgtgccttgt tctaaaactt ttattaagta ggtgcacttg acagtattga ggtcatttgt
     3601 tatggtgcta tttcaattag tctaggttta ggcccttgta cattttgccc ataacttttt
     3661 acaaagtact tcttttattg cacattcaga gaattttata tatatgtctt gtgtgcgtgt
     3721 ccttaaactt ccaatcttat tttgtctctt ggagattgtt gaacgcagct tgtctaggaa
     3781 agggatggga ctagattcta aaatttattt gggaccatgg gaatgatagt tgggaagaaa
     3841 actttgcaca cgacagattt ctagatactt tttgctgcta gttttatgta atatttattg
     3901 aacattttga caaatattta tttttgtaag cctaaaagtg attctttgaa agtttaaaga
     3961 aacttgacca aaagacagta caaaaacact ggcacttgaa tgttgaatgt caccgtatgc
     4021 gtgaaattat atatttcggg gtagtgtgag cttttaatgt taagtcataa taaactctta
     4081 agtcaaatta agcagacccg gcattggcgg tgtagccata actttctgat gttagtaaaa
     4141 acaaaattgg cgacttgaaa ctaaatcatg ccaaggtttt gatacacttg tcttgagata
     4201 ttaacgaaac acttcaaaac actgatacaa agtgtccaga ttctcagatg tttgttgtgt
     4261 gagttttgtt tagttgtatt tttttttcag tgaatgtctg gcacattgca atcctcaaac
     4321 atgtggttat ctttgttgta ttggcatatt cagtgacttg tacattcagc aatagcattt
     4381 gagcaagttt tatcagcaag caatattttc agttatgttt caaaattaag aatgggttta
     4441 aacttgctga atgtaaagat tgaccctcaa gtcactgtag ctttagtagt tgcttattgt
     4501 attagtttag atgctagcac tgcatgtgct gtgcatattc tggttttatt aaaataaaaa
     4561 gttgaactgc a
//
