LOCUS       NM_019693               1756 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus DEAD box helicase 39b (Ddx39b), transcript variant 1,
            mRNA.
ACCESSION   NM_019693
VERSION     NM_019693.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1756)
  AUTHORS   Bhattacharjee,R., Jolly,L.A., Corbett,M.A., Wee,I.C., Rao,S.R.,
            Gardner,A.E., Ritchie,T., van Hugte,E.J.H., Ciptasari,U., Piltz,S.,
            Noll,J.E., Nazri,N., van Eyk,C.L., White,M., Fornarino,D.,
            Poulton,C., Baynam,G., Collins-Praino,L.E., Snel,M.F., Nadif
            Kasri,N., Hemsley,K.M., Thomas,P.Q., Kumar,R. and Gecz,J.
  TITLE     Compromised transcription-mRNA export factor THOC2 causes R-loop
            accumulation, DNA damage and adverse neurodevelopment
  JOURNAL   Nat Commun 15 (1), 1210 (2024)
   PUBMED   38331934
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1756)
  AUTHORS   Xu,Z., Li,X., Li,H., Nie,C., Liu,W., Li,S., Liu,Z., Wang,W. and
            Wang,J.
  TITLE     Suppression of DDX39B sensitizes ovarian cancer cells to
            DNA-damaging chemotherapeutic agents via destabilizing BRCA1 mRNA
  JOURNAL   Oncogene 39 (47), 7051-7062 (2020)
   PUBMED   32989256
REFERENCE   3  (bases 1 to 1756)
  AUTHORS   Szymura,S.J., Bernal,G.M., Wu,L., Zhang,Z., Crawley,C.D.,
            Voce,D.J., Campbell,P.A., Ranoa,D.E., Weichselbaum,R.R. and
            Yamini,B.
  TITLE     DDX39B interacts with the pattern recognition receptor pathway to
            inhibit NF-kappaB and sensitize to alkylating chemotherapy
  JOURNAL   BMC Biol 18 (1), 32 (2020)
   PUBMED   32209106
  REMARK    GeneRIF: DDX39B interacts with the pattern recognition receptor
            pathway to inhibit NF-kappaB and sensitize to alkylating
            chemotherapy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1756)
  AUTHORS   Cui,X., Han,W., Li,J., Feng,R., Zhou,Z., Han,J., Li,M., Wang,S.,
            Zhang,W., Lei,Q., Zhang,J., Liu,Y. and Hu,Y.
  TITLE     Heat shock factor 4 regulates the expression of HSP25 and alpha
            B-crystallin by associating with DEXD/H-box RNA helicase UAP56
  JOURNAL   Cell Stress Chaperones 23 (4), 571-579 (2018)
   PUBMED   29164525
  REMARK    GeneRIF: Ectopic UAP56 upregulated HSF4-controlled HSP25 and alpha
            B-crystallin proteins expression, while knocking down UAP56 by
            shRNA reversed it.
REFERENCE   5  (bases 1 to 1756)
  AUTHORS   Alvarez-Dominguez,J.R., Zhang,X. and Hu,W.
  TITLE     Widespread and dynamic translational control of red blood cell
            development
  JOURNAL   Blood 129 (5), 619-629 (2017)
   PUBMED   27899360
REFERENCE   6  (bases 1 to 1756)
  AUTHORS   Dagenais,S.L. and Nakamura,I.
  TITLE     A physical map of the mouse H2 Bat5/Db interval
  JOURNAL   Mamm Genome 8 (1), 39-41 (1997)
   PUBMED   9021146
REFERENCE   7  (bases 1 to 1756)
  AUTHORS   Peelman,L.J., Chardon,P., Nunes,M., Renard,C., Geffrotin,C.,
            Vaiman,M., Van Zeveren,A., Coppieters,W., van de Weghe,A.,
            Bouquet,Y. et al.
  TITLE     The BAT1 gene in the MHC encodes an evolutionarily conserved
            putative nuclear RNA helicase of the DEAD family
  JOURNAL   Genomics 26 (2), 210-218 (1995)
   PUBMED   7601445
REFERENCE   8  (bases 1 to 1756)
  AUTHORS   Wroblewski,J.M., Kaminsky,S.G. and Nakamura,I.
  TITLE     Bat-1 genes and the origin of multiple class I loci in the H-2D
            region
  JOURNAL   Immunogenetics 39 (4), 276-280 (1994)
   PUBMED   8119735
REFERENCE   9  (bases 1 to 1756)
  AUTHORS   Snoek,M., Groot,P.C., Spies,T., Campbell,R.D. and Demant,P.
  TITLE     Fine mapping of the crossover-sites in the C4-H-2D region of H-2
            recombinant mouse strains
  JOURNAL   Immunogenetics 34 (6), 409-412 (1991)
   PUBMED   1684177
REFERENCE   10 (bases 1 to 1756)
  AUTHORS   Wroblewski,J.M., Kaminsky,S.G., Milisauskas,V.K., Pittman,A.M.,
            Chaplin,D.D., Spies,T. and Nakamura,I.
  TITLE     The B144-H-2Db interval and the location of a mouse homologue of
            the human D6S81E locus
  JOURNAL   Immunogenetics 32 (3), 200-204 (1990)
   PUBMED   2228046
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974444.18, CN716634.1, AK051034.1 and AA231260.1.
            
            On Sep 1, 2009 this sequence version replaced NM_019693.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK051034.1, BC011067.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 CR974444.18        177741-177745
            6-68                CN716634.1         1-63
            69-1712             AK051034.1         2-1645
            1713-1756           AA231260.1         284-327
FEATURES             Location/Qualifiers
     source          1..1756
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.6 cM"
     gene            1..1756
                     /gene="Ddx39b"
                     /gene_synonym="0610030D10Rik; Bat-1; Bat1; Bat1a;
                     D17H6S81E; D17H6S81E-1; D6S81Eh"
                     /note="DEAD box helicase 39b"
                     /db_xref="GeneID:53817"
                     /db_xref="MGI:MGI:99240"
     exon            1..107
                     /gene="Ddx39b"
                     /gene_synonym="0610030D10Rik; Bat-1; Bat1; Bat1a;
                     D17H6S81E; D17H6S81E-1; D6S81Eh"
                     /inference="alignment:Splign:2.1.0"
     exon            108..445
                     /gene="Ddx39b"
                     /gene_synonym="0610030D10Rik; Bat-1; Bat1; Bat1a;
                     D17H6S81E; D17H6S81E-1; D6S81Eh"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..1521
                     /gene="Ddx39b"
                     /gene_synonym="0610030D10Rik; Bat-1; Bat1; Bat1a;
                     D17H6S81E; D17H6S81E-1; D6S81Eh"
                     /EC_number="3.6.4.13"
                     /note="HLA-B-associated transcript 1A; nuclear RNA
                     helicase Bat1; spliceosome RNA helicase Bat1; DEAD box
                     protein UAP56; 56 kDa U2AF65-associated protein; DEAD
                     (Asp-Glu-Ala-Asp) box polypeptide 39B"
                     /codon_start=1
                     /product="spliceosome RNA helicase Ddx39b"
                     /protein_id="NP_062667.1"
                     /db_xref="CCDS:CCDS28695.1"
                     /db_xref="GeneID:53817"
                     /db_xref="MGI:MGI:99240"
                     /translation="MAENDVDNELLDYEDDEVETAAGADGTEAPAKKDVKGSYVSIHS
                     SGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLA
                     TLQQLEPVTGQVSVLVMCHTRELAFQISKEYERFSKYMPNVKVAVFFGGLSIKKDEEV
                     LKKNCPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEQLDMRRDVQEIFRMT
                     PHEKQVMMFSATLSKEIRPVCRKFMQDPMEIFVDDETKLTLHGLQQYYVKLKDNEKNR
                     KLFDLLDVLEFNQVVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFK
                     DFQRRILVATNLFGRGMDIERVNIAFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVS
                     DENDAKILNDVQDRFEVNISELPDEIDISSYIEQTR"
     exon            446..573
                     /gene="Ddx39b"
                     /gene_synonym="0610030D10Rik; Bat-1; Bat1; Bat1a;
                     D17H6S81E; D17H6S81E-1; D6S81Eh"
                     /inference="alignment:Splign:2.1.0"
     exon            574..666
                     /gene="Ddx39b"
                     /gene_synonym="0610030D10Rik; Bat-1; Bat1; Bat1a;
                     D17H6S81E; D17H6S81E-1; D6S81Eh"
                     /inference="alignment:Splign:2.1.0"
     exon            667..850
                     /gene="Ddx39b"
                     /gene_synonym="0610030D10Rik; Bat-1; Bat1; Bat1a;
                     D17H6S81E; D17H6S81E-1; D6S81Eh"
                     /inference="alignment:Splign:2.1.0"
     exon            851..969
                     /gene="Ddx39b"
                     /gene_synonym="0610030D10Rik; Bat-1; Bat1; Bat1a;
                     D17H6S81E; D17H6S81E-1; D6S81Eh"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1101
                     /gene="Ddx39b"
                     /gene_synonym="0610030D10Rik; Bat-1; Bat1; Bat1a;
                     D17H6S81E; D17H6S81E-1; D6S81Eh"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1211
                     /gene="Ddx39b"
                     /gene_synonym="0610030D10Rik; Bat-1; Bat1; Bat1a;
                     D17H6S81E; D17H6S81E-1; D6S81Eh"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1356
                     /gene="Ddx39b"
                     /gene_synonym="0610030D10Rik; Bat-1; Bat1; Bat1a;
                     D17H6S81E; D17H6S81E-1; D6S81Eh"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1504
                     /gene="Ddx39b"
                     /gene_synonym="0610030D10Rik; Bat-1; Bat1; Bat1a;
                     D17H6S81E; D17H6S81E-1; D6S81Eh"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1739
                     /gene="Ddx39b"
                     /gene_synonym="0610030D10Rik; Bat-1; Bat1; Bat1a;
                     D17H6S81E; D17H6S81E-1; D6S81Eh"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1709..1714
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddx39b"
                     /gene_synonym="0610030D10Rik; Bat-1; Bat1; Bat1a;
                     D17H6S81E; D17H6S81E-1; D6S81Eh"
                     /note="hexamer: AATGAA"
     polyA_site      1711
                     /gene="Ddx39b"
                     /gene_synonym="0610030D10Rik; Bat-1; Bat1; Bat1a;
                     D17H6S81E; D17H6S81E-1; D6S81Eh"
     polyA_site      1715
                     /gene="Ddx39b"
                     /gene_synonym="0610030D10Rik; Bat-1; Bat1; Bat1a;
                     D17H6S81E; D17H6S81E-1; D6S81Eh"
                     /note="major polyA site"
ORIGIN      
        1 ctggcggccg ggaaggcggg aggccggggc gagcctggaa ccggaagtga aggcagcttc
       61 ccgcctccgt ccccgttgct gccgccatac acgctcgcag tgcttagctc ttctgtcgga
      121 aactggtgtc tttccccttg ctgttcttca acccctctct ttggcccttg cttcctcacc
      181 tgctctggga cacctaactc aagagacctc ccttctcccc ctgccggccc aattatggca
      241 gagaacgatg tggacaatga gctcttggac tacgaagacg acgaggtgga gacagccgct
      301 ggggcagatg ggaccgaggc tcccgccaag aaagacgtca agggctccta cgtctccatc
      361 cacagctccg gcttccgaga ttttctactc aagccagagc tgctccgggc catcgttgac
      421 tgtggctttg agcatccatc agaggtccag catgagtgca tcccgcaggc cattctgggg
      481 atggatgtcc tgtgccaggc caagtcaggc atgggaaaaa cagcagtgtt tgtcctggcc
      541 acactgcagc agctggagcc cgttactggg caggtgtctg tgctggtgat gtgtcacact
      601 agggagctgg cttttcagat cagcaaggaa tatgagcgct tctctaagta catgccgaat
      661 gtcaaggtgg cagtgttttt tggcggtctg tctatcaaga aggacgaaga ggtgctgaag
      721 aagaactgcc cacacatcgt cgtggggact cctggccgaa ttctagccct ggctcgaaat
      781 aagagcctga acctcaaaca cattaaacac tttattttgg acgagtgtga caagatgctt
      841 gaacagctcg acatgcgtcg ggatgtccag gaaatttttc gcatgacccc ccatgagaag
      901 caggtcatga tgttcagtgc taccttgagc aaagagatcc gcccagtctg ccgcaagttc
      961 atgcaagatc ctatggagat cttcgtggat gacgagacca agttgacgct gcacgggttg
     1021 cagcagtact acgtgaaact gaaggacaac gagaagaacc ggaagctctt tgatcttctc
     1081 gatgtcctcg agttcaacca ggtggtgatc tttgtgaagt ccgtgcagcg ctgcatcgcc
     1141 ctggcccagc ttctagtgga acagaacttc ccagccattg ctatccatcg tggaatgccc
     1201 caggaggaga ggctctctcg gtatcagcag ttcaaggatt ttcagcggag gattcttgtg
     1261 gctaccaacc tgtttggccg aggcatggat attgagcgtg tgaacattgc tttcaactat
     1321 gacatgccag aggactcgga cacctacctg cacagggtgg ccagagcggg ccggtttggc
     1381 accaagggct tggccatcac atttgtgtca gatgagaatg atgccaagat cctgaatgac
     1441 gttcaggacc gtttcgaggt caacatcagc gagctgcccg atgagattga catttcctcc
     1501 tacattgagc agacacggta gaggactcgc gtggtcagtc tgctgtagaa gaggacacgg
     1561 gtcaggagga gacactgccg ccccacccga caccgacgcc tctgcccacc ctatctatgc
     1621 ttctctctgc gtcaccacca ctcctaaacc tagtcctgat ttatcagagt tgtttgtttg
     1681 tttgtttttg ttttttaaca aaactaagaa tgaaacaacc gtgtctgtgg tgtctgtaaa
     1741 aaaaaaaaaa aaaaaa
//
