LOCUS       NM_020494               2884 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus DEAD box helicase 24 (Ddx24), transcript variant 2,
            mRNA.
ACCESSION   NM_020494
VERSION     NM_020494.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2884)
  AUTHORS   Axenhus,M., Doeswijk,T., Nilsson,P., Matton,A., Winblad,B.,
            Tjernberg,L. and Schedin-Weiss,S.
  TITLE     DEAD Box Helicase 24 Is Increased in the Brain in Alzheimer's
            Disease and AppN-LF Mice and Influences Presymptomatic Pathology
  JOURNAL   Int J Mol Sci 25 (7), 3622 (2024)
   PUBMED   38612434
  REMARK    GeneRIF: DEAD Box Helicase 24 Is Increased in the Brain in
            Alzheimer's Disease and App[N-LF] Mice and Influences
            Presymptomatic Pathology.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2884)
  AUTHORS   Gan,H., Cai,J., Li,L., Zheng,X., Yan,L., Hu,X., Zhao,N., Li,B.,
            He,J., Wang,D. and Pang,P.
  TITLE     Endothelium-targeted Ddx24 conditional knockout exacerbates
            ConA-induced hepatitis in mice due to vascular hyper-permeability
  JOURNAL   Int Immunopharmacol 129, 111618 (2024)
   PUBMED   38354508
  REMARK    GeneRIF: Endothelium-targeted Ddx24 conditional knockout
            exacerbates ConA-induced hepatitis in mice due to vascular
            hyper-permeability.
REFERENCE   3  (bases 1 to 2884)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2884)
  AUTHORS   Gong,Y., Liang,Y., Liu,J., Wei,J., Zhang,S., Chen,F., Zhang,Q.,
            Wang,L., Lan,H., Wu,L., Ge,W., Li,S., Wang,L., Shan,H. and He,H.
  TITLE     DDX24 Is Essential for Cell Cycle Regulation in Vascular Smooth
            Muscle Cells During Vascular Development via Binding to FANCA mRNA
  JOURNAL   Arterioscler Thromb Vasc Biol 43 (9), 1653-1667 (2023)
   PUBMED   37470182
REFERENCE   5  (bases 1 to 2884)
  AUTHORS   Ma,Z., Moore,R., Xu,X. and Barber,G.N.
  TITLE     DDX24 negatively regulates cytosolic RNA-mediated innate immune
            signaling
  JOURNAL   PLoS Pathog 9 (10), e1003721 (2013)
   PUBMED   24204270
  REMARK    GeneRIF: data provide a new function for DDX24 and help explain
            innate immune gene regulation, mechanisms that may additionally
            provide insight into the causes of inflammatory disease.
REFERENCE   6  (bases 1 to 2884)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 2884)
  AUTHORS   Zhao,Y., Yu,L., Fu,Q., Chen,W., Jiang,J., Gao,J. and Zhao,S.
  TITLE     Cloning and characterization of human DDX24 and mouse Ddx24, two
            novel putative DEAD-Box proteins, and mapping DDX24 to human
            chromosome 14q32
  JOURNAL   Genomics 67 (3), 351-355 (2000)
   PUBMED   10936056
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ141277.1, BC043721.1 and BB006411.1.
            
            On Jun 9, 2018 this sequence version replaced NM_020494.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF214732.1, BC043721.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                CJ141277.1         21-32
            13-2844             BC043721.1         1-2832
            2845-2884           BB006411.1         183-222
FEATURES             Location/Qualifiers
     source          1..2884
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 52.92 cM"
     gene            1..2884
                     /gene="Ddx24"
                     /gene_synonym="1700055J08Rik; 2510027P10Rik"
                     /note="DEAD box helicase 24"
                     /db_xref="GeneID:27225"
                     /db_xref="MGI:MGI:1351337"
     exon            1..69
                     /gene="Ddx24"
                     /gene_synonym="1700055J08Rik; 2510027P10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            70..795
                     /gene="Ddx24"
                     /gene_synonym="1700055J08Rik; 2510027P10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..2648
                     /gene="Ddx24"
                     /gene_synonym="1700055J08Rik; 2510027P10Rik"
                     /EC_number="3.6.4.13"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ATP-dependent RNA helicase DDX24; DEAD box protein 24;
                     DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 13 (RNA
                     helicase A); DEAD (Asp-Glu-Ala-Asp) box polypeptide 24"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase DDX24 isoform 2"
                     /protein_id="NP_065240.2"
                     /db_xref="CCDS:CCDS26129.1"
                     /db_xref="GeneID:27225"
                     /db_xref="MGI:MGI:1351337"
                     /translation="MKVKETNSKPKLASRGTFQRKGIKIVGKWKQVTIDPNLFADGQM
                     DDLVCFEELTDYRLVKNPSRLFSSEETKKRKAQAVSEEEEEEEGQSSSPKKKIKLKKQ
                     RDAARAAEGAAAQNEYEVKASEPEAQGEVTACSDQKVGGAKSESLAQAAPRKKKNKGK
                     KKLDTFQSTSPKLPKKSKKTWMAEVHDQKADVSAWRDLFVPKAVLRALSFLGFSAPTP
                     IQALTLAPAIRDKLDILGAAETGSGKTLAFAIPMIHSVLQWHKMKAPPIPRSTGMPPR
                     EMRFGATAHLGSPCKDRTESGVLPEEARIETEAQPSDSGVQATPETSASASAQTLLVC
                     DDDAGEGPSSLEEKPVPKQNEDGEEKFDAEQAGKLKQELCDQIAIYKVHPRRPLLGLV
                     LTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIATPGRLWE
                     LVKEKHPHLSNLRQLRCLVIDEADRMVEKGHFAELSQLLEMLNDSQYNPSRQTLVFSA
                     TLTLVHQAPARILHKKHVKKMDKTDKLDLLMQKVGMRGKPKVIDLTRNEGTVETLTET
                     KIHCETDEKDLYLYYFLMQYPGRSLVFANSISCIKRLSGLLKVLDVMPLTLHACMHQK
                     QRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEIYIHRSGRTARAA
                     SEGLSLMLIGPEDVINFKKIYKTLQKDEDIPLFPVQSKYMDVVKERIRLARQIEKAEY
                     RNFQACLHNSWIEQAAAALEIELEEEMYKGGKADQQEERRRQKQMKMLKQELRHLLSQ
                     PLFQENLKTRYPTQSGRPPQPVLASRNIESALSCLSRQKRRRKKPKEPRAPPQPGSST
                     S"
     exon            796..1317
                     /gene="Ddx24"
                     /gene_synonym="1700055J08Rik; 2510027P10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1471
                     /gene="Ddx24"
                     /gene_synonym="1700055J08Rik; 2510027P10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1987
                     /gene="Ddx24"
                     /gene_synonym="1700055J08Rik; 2510027P10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2063
                     /gene="Ddx24"
                     /gene_synonym="1700055J08Rik; 2510027P10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2252
                     /gene="Ddx24"
                     /gene_synonym="1700055J08Rik; 2510027P10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2382
                     /gene="Ddx24"
                     /gene_synonym="1700055J08Rik; 2510027P10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2884
                     /gene="Ddx24"
                     /gene_synonym="1700055J08Rik; 2510027P10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2854..2859
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddx24"
                     /gene_synonym="1700055J08Rik; 2510027P10Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2879
                     /gene="Ddx24"
                     /gene_synonym="1700055J08Rik; 2510027P10Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtactgaag ctgctgcagt tccgggtcgg gttggcgcaa acggcccggc gtgtgaggtg
       61 actgcggcgc aaccatgaag gtgaaggaga caaactcaaa gccaaagttg gcaagccgtg
      121 gcacgttcca gaggaagggc atcaagattg tggggaaatg gaagcaagtg acgatcgacc
      181 cgaatctgtt tgcagatgga cagatggatg acctggtgtg ctttgaagag ctgacagatt
      241 accgtttagt caagaatccc tcccgtttgt tctcaagtga ggagacaaag aagagaaagg
      301 cccaggctgt ttcagaagag gaagaagagg aggaaggaca gtccagctcc ccaaagaaaa
      361 agatcaagtt gaagaagcag agagatgcgg cacgagctgc cgaaggcgct gctgcccaga
      421 atgagtatga agtcaaagcg tccgagccag aggctcaggg agaagtcact gcttgttctg
      481 atcaaaaggt cggaggagcc aaatcagaaa gcctggccca ggctgctcca agaaagaaga
      541 aaaacaaagg gaaaaaaaaa ttggatactt ttcagagcac ttcccccaaa ttgcccaaaa
      601 aatcgaagaa gacatggatg gctgaggtgc acgaccagaa ggcagatgtg tctgcctgga
      661 gggacctgtt tgtgcccaag gctgttctgc gcgctctcag cttcttaggc ttctctgcac
      721 ctaccccaat ccaggctctg actttggccc ctgccatccg tgacaaactg gacatccttg
      781 gagctgctga gacaggaagc gggaaaactc tggcttttgc catcccgatg attcactcag
      841 tgctgcagtg gcataagatg aaggctccac ccatcccaag gagcactgga atgccaccaa
      901 gggagatgag gtttggagct acagcccatc ttggatcacc ttgcaaggac agaactgaat
      961 ctggagtgtt gcctgaggag gccagaattg agactgaagc acagcccagt gactctgggg
     1021 tccaggccac acctgagact agtgcctctg cctcagccca gacactgctc gtctgtgatg
     1081 atgatgctgg tgaaggacct tcttccttag aggaaaagcc tgtccccaag caaaatgagg
     1141 acggagaaga aaagtttgat gcagaacagg ctggaaagtt aaaacaggag ttatgtgacc
     1201 aaattgctat ttataaagta cacccaaggc gccctctgct tggactggtg ctgactccta
     1261 ctcgagagct ggccatccag gtcagacagc acatcgatgc tgtggccaag tttacaggga
     1321 ttaatacagc aattttagtt ggtggaatgt ccacacagaa acagcaaagg atgctgaacc
     1381 gccatcctga gattgtgatc gccacccctg gtcggctctg ggagttagtt aaagaaaaac
     1441 accctcattt gagtaacctt cggcagctca ggtgcctggt catagatgaa gctgatcgca
     1501 tggttgagaa aggccatttt gctgaactct ctcagctgct agagatgcta aatgactccc
     1561 agtacaaccc cagtcggcag actcttgttt tttctgccac cctaaccctg gtacaccaag
     1621 ctcctgctcg aatccttcat aagaaacacg tgaagaagat ggataaaacc gacaaacttg
     1681 accttctcat gcagaaggtt ggcatgaggg gcaagccgaa agtcattgac ctcacaagga
     1741 acgagggtac agtggagacg ctaacggaga ccaagatcca ctgcgagaca gatgagaaag
     1801 acttgtatct ctactacttt ctcatgcagt acccaggtcg tagcctggtg tttgccaaca
     1861 gcatctcctg catcaaacgc ctctctgggc tcctcaaggt cctggatgtc atgccgctga
     1921 ccctgcatgc ctgcatgcac caaaagcaaa ggctcagaaa cctggagcag tttgctcgtc
     1981 tgcaagactg tgttctcttg gcaacagatg tggcagctcg aggtctggat attcctaaag
     2041 ttcaacatgt catccattac caggtgcctc gcacctcaga gatttacatc caccgaagtg
     2101 gtcggactgc ccgcgctgcc agtgaaggcc tcagcttgat gctgattggg cctgaggatg
     2161 tgatcaactt caagaagatc tacaaaactc tccagaaaga tgaggacatc ccactgtttc
     2221 cagtgcagtc caagtacatg gatgtggtca aggagcggat ccgtctagcc cgacagattg
     2281 aaaaagctga ataccggaac ttccaggctt gtctgcacaa ctcatggatt gagcaggcgg
     2341 cagcagccct agagattgag ctagaagaag agatgtacaa aggaggaaaa gctgaccagc
     2401 aagaagaacg tcggcgacag aagcagatga agatgctgaa gcaggagcta cgccatctgc
     2461 tctcccagcc actcttccag gagaacctga agaccagata ccccacacag tctggcaggc
     2521 cgcctcagcc tgtgctggcc tccaggaata tcgagtctgc gctgagctgc ctgtctaggc
     2581 agaagaggag gaggaagaag ccaaaagaac cccgggcacc accacagcca ggttcaagca
     2641 cgagttaact gcccggtcaa tgtggtgact gttgtctgta aaggcttccc tccttgcctt
     2701 tcactccacc atccacctgc gcaaacctcc cgctcttcca tcctttagca ggaaagacct
     2761 cccgcacaca tgttgtggag ttaaatgtgg caggtgacgc tgtgtgtctg tagtcagtgt
     2821 atgcagactt cttgtgctca ccttgttttc cagattaaac caagtaggag tcagagacat
     2881 cctg
//
