LOCUS       NM_019553               4763 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus DExD box helicase 21 (Ddx21), mRNA.
ACCESSION   NM_019553
VERSION     NM_019553.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4763)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4763)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4763)
  AUTHORS   Bora,P., Gahurova,L., Hauserova,A., Stiborova,M., Collier,R.,
            Potesil,D., Zdrahal,Z. and Bruce,A.W.
  TITLE     DDX21 is a p38-MAPK-sensitive nucleolar protein necessary for mouse
            preimplantation embryo development and cell-fate specification
  JOURNAL   Open Biol 11 (7), 210092 (2021)
   PUBMED   34255976
  REMARK    GeneRIF: DDX21 is a p38-MAPK-sensitive nucleolar protein necessary
            for mouse preimplantation embryo development and cell-fate
            specification.
REFERENCE   4  (bases 1 to 4763)
  AUTHORS   Bi,X., Xu,Y., Li,T., Li,X., Li,W., Shao,W., Wang,K., Zhan,G.,
            Wu,Z., Liu,W., Lu,J.Y., Wang,L., Zhao,J., Wu,J., Na,J., Li,G.,
            Li,P. and Shen,X.
  TITLE     RNA Targets Ribogenesis Factor WDR43 to Chromatin for Transcription
            and Pluripotency Control
  JOURNAL   Mol Cell 75 (1), 102-116 (2019)
   PUBMED   31128943
REFERENCE   5  (bases 1 to 4763)
  AUTHORS   Liu,H.B., Muhammad,T., Guo,Y., Li,M.J., Sha,Q.Q., Zhang,C.X.,
            Liu,H., Zhao,S.G., Zhao,H., Zhang,H., Du,Y.Z., Sun,K., Liu,K.,
            Lu,G., Guo,X.J., Sha,J., Fan,H.Y., Gao,F. and Chen,Z.J.
  TITLE     RNA-Binding Protein IGF2BP2/IMP2 is a Critical Maternal Activator
            in Early Zygotic Genome Activation
  JOURNAL   Adv Sci (Weinh) 6 (15), 1900295 (2019)
   PUBMED   31406667
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4763)
  AUTHORS   Valdez,B.C., Yang,H., Hong,E. and Sequitin,A.M.
  TITLE     Genomic structure of newly identified paralogue of RNA helicase
            II/Gu: detection of pseudogenes and multiple alternatively spliced
            mRNAs
  JOURNAL   Gene 284 (1-2), 53-61 (2002)
   PUBMED   11891046
REFERENCE   7  (bases 1 to 4763)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 4763)
  AUTHORS   Bryda,E.C., Kim,H.J., Legare,M.E., Frankel,W.N. and Noben-Trauth,K.
  TITLE     High-resolution genetic and physical mapping of
            modifier-of-deafwaddler (mdfw) and Waltzer (Cdh23v)
  JOURNAL   Genomics 73 (3), 338-342 (2001)
   PUBMED   11350126
REFERENCE   9  (bases 1 to 4763)
  AUTHORS   Valdez,B.C. and Wang,W.
  TITLE     Mouse RNA helicase II/Gu: cDNA and genomic sequences, chromosomal
            localization, and regulation of expression
  JOURNAL   Genomics 66 (2), 184-194 (2000)
   PUBMED   10860663
REFERENCE   10 (bases 1 to 4763)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF182162.1, BC059237.1 and BC060220.1.
            
            On Aug 12, 2005 this sequence version replaced NM_019553.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060220.1, BC059237.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                CF182162.1         18-57
            41-2404             BC059237.1         1-2364
            2405-4096           BC060220.1         2355-4046
            4097-4737           BC059237.1         4057-4697
            4738-4763           BC060220.1         4688-4713
FEATURES             Location/Qualifiers
     source          1..4763
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.43 cM"
     gene            1..4763
                     /gene="Ddx21"
                     /gene_synonym="D10Ertd645e; D10Wsu42e"
                     /note="DExD box helicase 21"
                     /db_xref="GeneID:56200"
                     /db_xref="MGI:MGI:1860494"
     exon            1..171
                     /gene="Ddx21"
                     /gene_synonym="D10Ertd645e; D10Wsu42e"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..2640
                     /gene="Ddx21"
                     /gene_synonym="D10Ertd645e; D10Wsu42e"
                     /EC_number="3.6.4.13"
                     /note="gu-alpha; DEAD box protein 21; nucleolar RNA
                     helicase Gu; nucleolar RNA helicase II; RH-II/Gualpha;
                     DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21 (RNA
                     helicase II/Gu); RH II/Gu; DEAD (Asp-Glu-Ala-Asp) box
                     polypeptide 21"
                     /codon_start=1
                     /product="nucleolar RNA helicase 2"
                     /protein_id="NP_062426.2"
                     /db_xref="CCDS:CCDS23891.1"
                     /db_xref="GeneID:56200"
                     /db_xref="MGI:MGI:1860494"
                     /translation="MPGKLRSGAKLGSDGAEESMETLPKPSEKKTRKEKTKSKTEEAT
                     EGMEEAVSSKAKKTNKKGPSEDDVDPPKSRKAKKQEEEPQDDTASTSKTSKKKKEPLE
                     KQADSETKEIITEEPSEEEADMPKPKKMKKGKEANGDAGEKSPKLKNGLSQPSEEEAD
                     IPKPKKMKKGKEANGDAGEKSPKLKNGLSQPSEEEVDIPKPKKMKKGKEASGDAGEKS
                     PRLKDGLSQPSEPKSNSSDAPGEESSSETEKEIPVEQKEGAFSNFPISEETVKLLKAR
                     GVNFLFPIQAKTFHHVYSGKDLIAQARTGTGKTFSFAIPLIEKLQGGLQERKRGRAPQ
                     VLVLAPTRELANQVSKDFSDITKKLSVACFYGGTPYGGQIERMRSGIDILVGTPGRIK
                     DHLQNGKLDLTKLKHVVLDEVDQMLDMGFADQVEEILCVAYKKDSEDNPQTLLFSATC
                     PHWVFNVAKKYMKSTYEQVDLIGKKTQKAAITVEHLAIKCHWTERAAVIGDVIRVYSG
                     HQGRTIIFCETKKDAQELSQNTCIKQDAQSLHGDIPQKQREITLKGFRNGNFGVLVAT
                     NVAARGLDIPEVDLVVQSCPPKDVESYIHRSGRTGRAGRTGVCICFYQNKEEYQLAQV
                     EQKAGIKFKRIGVPSATEIIKASSKDAIRLLDSVPPTAISHFKQSAEKLIEEKGAVEA
                     LAAALAHISGATSVDQRSLINSQAGFVTMILRCSIEMPNISYAWKELKEQLGESIDAK
                     VKGMVFLKGKLGVCFDVRTEAVTEIQEKWHDSRRWQLTVATEQPELEGPPDGYRGRMG
                     QRDGSRGAFRGQRGGSRNFRGQGQRGGSRNFRGQRPGGGNRGQKRSFSKAFGQ"
     exon            172..831
                     /gene="Ddx21"
                     /gene_synonym="D10Ertd645e; D10Wsu42e"
                     /inference="alignment:Splign:2.1.0"
     exon            832..907
                     /gene="Ddx21"
                     /gene_synonym="D10Ertd645e; D10Wsu42e"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1086
                     /gene="Ddx21"
                     /gene_synonym="D10Ertd645e; D10Wsu42e"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1204
                     /gene="Ddx21"
                     /gene_synonym="D10Ertd645e; D10Wsu42e"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1390
                     /gene="Ddx21"
                     /gene_synonym="D10Ertd645e; D10Wsu42e"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1536
                     /gene="Ddx21"
                     /gene_synonym="D10Ertd645e; D10Wsu42e"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1686
                     /gene="Ddx21"
                     /gene_synonym="D10Ertd645e; D10Wsu42e"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1848
                     /gene="Ddx21"
                     /gene_synonym="D10Ertd645e; D10Wsu42e"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1968
                     /gene="Ddx21"
                     /gene_synonym="D10Ertd645e; D10Wsu42e"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2042
                     /gene="Ddx21"
                     /gene_synonym="D10Ertd645e; D10Wsu42e"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2202
                     /gene="Ddx21"
                     /gene_synonym="D10Ertd645e; D10Wsu42e"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2337
                     /gene="Ddx21"
                     /gene_synonym="D10Ertd645e; D10Wsu42e"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..2382
                     /gene="Ddx21"
                     /gene_synonym="D10Ertd645e; D10Wsu42e"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..4743
                     /gene="Ddx21"
                     /gene_synonym="D10Ertd645e; D10Wsu42e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2852..2857
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddx21"
                     /gene_synonym="D10Ertd645e; D10Wsu42e"
                     /note="hexamer: AGTAAA"
     polyA_site      2877
                     /gene="Ddx21"
                     /gene_synonym="D10Ertd645e; D10Wsu42e"
                     /note="major polyA site"
     regulatory      4717..4722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddx21"
                     /gene_synonym="D10Ertd645e; D10Wsu42e"
                     /note="hexamer: AATAAA"
     polyA_site      4743
                     /gene="Ddx21"
                     /gene_synonym="D10Ertd645e; D10Wsu42e"
ORIGIN      
        1 gaggggcggt ccgctttctc tgtcgccctc tctcctagca cgcggttgag gaagccggta
       61 ggcctgagaa gctgctgctg aataatgccg ggaaaactcc gcagtggggc caagttgggc
      121 tcagacgggg ccgaggagag catggagacg ctgccgaagc caagcgagaa gaaaactaga
      181 aaagagaaga caaaatcaaa gaccgaagaa gcaacagaag gaatggaaga ggccgtttcc
      241 tccaaagcaa agaaaacaaa caagaaaggg ccttctgagg atgatgtgga tccccctaaa
      301 tccaggaagg ccaagaagca ggaggaggag cctcaagacg acactgcttc tacaagcaaa
      361 acctccaaga agaaaaagga gccccttgag aagcaagcag actctgaaac caaagagata
      421 ataacagagg agccttccga agaagaggca gacatgccta agcccaagaa gatgaagaaa
      481 gggaaagaag caaacggaga tgccggagag aaaagcccca agctgaagaa tggactctcc
      541 caaccttccg aagaagaggc agacattcct aagcccaaga agatgaagaa agggaaagaa
      601 gcaaacggag atgctggaga gaaaagcccc aagctgaaga atggactctc ccaaccttcc
      661 gaagaagagg tagacattcc taagcccaag aagatgaaga aagggaaaga agcaagcgga
      721 gatgcgggag agaaaagccc caggctgaag gatggactct cccaaccttc tgaaccgaaa
      781 tccaactcca gtgatgctcc tggtgaggaa agtagtagcg agacagaaaa ggaaatacct
      841 gtggagcaga aagagggagc tttctctaat tttcccattt ctgaagagac tgtcaagctt
      901 ctcaaagctc gtggggtgaa cttcctgttt cctatacaag ccaagacctt tcatcatgtg
      961 tacagtggga aagacttaat tgcccaggca cggacaggaa ccggaaagac attctctttt
     1021 gccatccctt taattgagaa acttcaaggt gggctacaag agaggaagag aggccgagcc
     1081 cctcaggtgc tagtccttgc acccacaaga gaattagcaa atcaagtgag caaagacttc
     1141 agcgacatca ccaaaaagct ctctgtagct tgtttttatg gtggaacacc ctacggtggt
     1201 cagattgaac gaatgcggag tgggattgat atcctggttg ggaccccagg tcgtattaaa
     1261 gaccacttgc agaatggcaa gctagatctc accaaactta aacatgttgt cctggatgaa
     1321 gtcgaccaga tgttggatat gggttttgct gatcaagtgg aagaaatttt atgtgttgca
     1381 tacaagaaag attctgaaga caacccccaa acattgcttt tctctgcaac ttgccctcat
     1441 tgggtgttta atgttgctaa gaaatacatg aaatctacat acgaacaggt ggacctgatt
     1501 ggtaaaaaga ctcagaaagc agctataact gtggagcacc tggcgattaa gtgtcactgg
     1561 acagaaaggg cagcggtgat tggggatgtg atccgagtgt acagtggtca tcaagggcgc
     1621 acgatcatct tctgtgaaac caagaaggat gcccaggagc tatctcagaa cacgtgcata
     1681 aagcaggatg cccagtcctt acatggcgac attccacaga agcaaaggga aatcaccctg
     1741 aaaggtttcc gaaatggcaa ttttggagtt ttggtggcaa ccaatgttgc tgcccgtggg
     1801 ttagacatcc ctgaggttga cttggttgtt cagagctgcc caccaaagga tgtggagtct
     1861 tacattcatc gttcggggcg gacaggcaga gctggaagga caggagtttg catctgcttt
     1921 taccagaaca aagaagagta ccagttagca caagtggagc agaaagcggg aattaaattt
     1981 aaacggatag gtgttccttc tgcaacggaa ataataaaag cctccagcaa agacgccatc
     2041 aggctcttgg attctgtgcc tcccactgcc attagccatt tcaagcagtc agctgagaag
     2101 ctgattgagg agaagggagc tgtagaggcc ttggcagctg ctctggccca catctcagga
     2161 gccacatcag tcgatcagcg ctccctgatc aactcgcaag caggctttgt gaccatgatc
     2221 ctgcggtgct ccattgagat gcccaacatc agttacgctt ggaaagaact taaggagcag
     2281 ctgggcgaga gcatcgatgc caaagtgaag ggaatggtct tcctcaaagg aaaactgggg
     2341 gtttgttttg atgtccgaac tgaagcagtc acagaaatac aggagaagtg gcatgattcg
     2401 agacgctggc agctcaccgt ggccaccgag cagccagagc tggagggacc tccagacgga
     2461 tatcgaggcc gcatgggtca gcgtgatggc agccgtggtg ctttcagagg acagcggggt
     2521 ggaagcagga acttccgggg acagggacag cgaggaggaa gtagaaactt ccgaggacag
     2581 cgaccaggag gtggcaacag aggccagaag cggagtttta gtaaagcgtt tggtcagtga
     2641 gtagaggcca gaagggactg ttcccactgt ggaccccagg gtccaccctg ctgacaaagc
     2701 ccgagtgctt ccttcctttt tttaccactt ctcagcgccc cctttcttgc agagaggctt
     2761 ctgaactgtc cactaaccat cacaaattct tcattttgaa aaaggataag aattcattgc
     2821 atcgttttcc aacatacttt tagatttaca aagtaaaacc aaccatggat ctgcctatct
     2881 tggtgtgtcg atcttgtaat tttatctttg tgtgtgtgtg tgtgtgtgtg tgtgcactca
     2941 ctggggccta agctcagaac ctcacacagg cagagtatac acacgccctg caactaaact
     3001 gcatctctag tccctataca tgtgtcctac tcatccttca aagtgagtcc ctaggggatg
     3061 cctcagtctc tggaggattg caagagccag ggcggaatgt gtttgtttgc attccttggc
     3121 atcctggact cttgcaaaca attgctgtgt tcatatgtgt ctgctgaggt ttgatgctga
     3181 gcagagcttt tcaagagccg cttcagactt agctgattga atagtttgtg cccggctctg
     3241 ggtgttgagc gtagaacaga cagcagattc actccagtgt cttcacacac tcattaggtg
     3301 ttttctgttc cagtgaagtc tccagacaag ggtatataga aagacatttt tataggaccc
     3361 agtgtaaagt tcaggcccaa atgcctaaca tgtctaggtg tttttgtcag taatgagact
     3421 ggataaatgg tatgtaagtg cttgcacccc acttttggaa gattaattta ccaagaagca
     3481 tggggttcag ttggtgttgc tgacaaatat ctcaaaaaag ccacaaaggt gtctttgatc
     3541 gtgacaggtg aggaggtgga gaagcgtgct ttgagtggtg agcaggtcct gactcgtggc
     3601 tcctggaggg gctgtgtctg ctagtgtgca gtctggggct gttaaagggg cacagtggga
     3661 caggcttgtt ttcagtggct tagatcttaa accacaacgt aaaatctatt tctgttaagc
     3721 agcttctctg aaaaattatc acagctcaga gagcccttct atgacaagct gtgccatttt
     3781 aagctcttac tttgagggaa ctgaagcata gcccctgcct actgctggtg ttctttattt
     3841 gggaatcatc ccgcctagca cagaagcttg agtggtgggg tcctctagct gtactagaga
     3901 ttctgcgcag ggctcttaga acaggcttgg gaggaaagtc agaaccacgc actgtcattt
     3961 tggttttttt ttaatttttc ttaattgttt ggatcaacta agaccttcat tttagtatgg
     4021 tccttacctc ctaactggcc tttacctggc attaaagggc tctgataacc aatcagctcc
     4081 cggtagctga agcagtgccc ttttttctat ttaaattcag ttttcccctt gaactctgac
     4141 cagatggctc atcctctgtg ctcaggattt gttgggtttt gtttttcttg ttttctttgt
     4201 tgataactgt agcttgtaag aaatgtgggc atggtttaat gaagcatgtc actgttggga
     4261 taaaagagtt tgccagttca agatgatgaa aggacatact ggctctgctt gcaggaggaa
     4321 aggctaaaag acattttgaa ttaatgggtt accctataga aaaatgatct gtcataaacc
     4381 aaacagtgaa ggggaagaag ggaagaattc caattgacac aatttaaatg aaacatgact
     4441 tttcaaacaa atgaagtttc ttttggattg cagaaactaa gcaatattta tatgtataat
     4501 tcaactatta tttggtttaa atgggcttgt tgggaaatgt tatcattttt actattttct
     4561 acagagaaaa tattttccac tttatcaaat aaatctggac tttgaaatta cagcctgttt
     4621 ttatgttcca gctgtctatg tatgttttcc tgaaactgta cataaaatgt ttttacatta
     4681 aaatgaattg ctgtataaag tactgcatta tgccataata aagataccga tgctttatat
     4741 ttaaaaaaaa aaaaaaaaaa aaa
//
