LOCUS       NM_017397               2710 bp    mRNA    linear   ROD 03-AUG-2024
DEFINITION  Mus musculus DEAD box helicase 20 (Ddx20), mRNA.
ACCESSION   NM_017397
VERSION     NM_017397.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2710)
  AUTHORS   Zou,D., Li,K., Su,L., Liu,J., Lu,Y., Huang,R., Li,M., Mang,X.,
            Geng,Q., Li,P., Tang,J., Yu,Z., Zhang,Z., Chen,D., Miao,S., Yu,J.,
            Yan,W. and Song,W.
  TITLE     DDX20 is required for cell-cycle reentry of prospermatogonia and
            establishment of spermatogonial stem cell pool during testicular
            development in mice
  JOURNAL   Dev Cell 59 (13), 1707-1723 (2024)
   PUBMED   38657611
  REMARK    GeneRIF: DDX20 is required for cell-cycle reentry of
            prospermatogonia and establishment of spermatogonial stem cell pool
            during testicular development in mice.
REFERENCE   2  (bases 1 to 2710)
  AUTHORS   Chen,Z., Zhang,J., Feng,T., Wang,X., Zhou,S., Pan,W., Chen,Z.,
            Yan,Y. and Dai,J.
  TITLE     DDX20 positively regulates the interferon pathway to inhibit viral
            infection
  JOURNAL   Antiviral Res 225, 105875 (2024)
   PUBMED   38552910
  REMARK    GeneRIF: DDX20 positively regulates the interferon pathway to
            inhibit viral infection.
REFERENCE   3  (bases 1 to 2710)
  AUTHORS   Bizen,N., Bepari,A.K., Zhou,L., Abe,M., Sakimura,K., Ono,K. and
            Takebayashi,H.
  TITLE     Ddx20, an Olig2 binding factor, governs the survival of neural and
            oligodendrocyte progenitor cells via proper Mdm2 splicing and p53
            suppression
  JOURNAL   Cell Death Differ 29 (5), 1028-1041 (2022)
   PUBMED   34974536
REFERENCE   4  (bases 1 to 2710)
  AUTHORS   Simankova,A., Bizen,N., Saitoh,S., Shibata,S., Ohno,N., Abe,M.,
            Sakimura,K. and Takebayashi,H.
  TITLE     Ddx20, DEAD box helicase 20, is essential for the differentiation
            of oligodendrocyte and maintenance of myelin gene expression
  JOURNAL   Glia 69 (11), 2559-2574 (2021)
   PUBMED   34231259
  REMARK    GeneRIF: Ddx20, DEAD box helicase 20, is essential for the
            differentiation of oligodendrocyte and maintenance of myelin gene
            expression.
REFERENCE   5  (bases 1 to 2710)
  AUTHORS   Fallini,C., Rouanet,J.P., Donlin-Asp,P.G., Guo,P., Zhang,H.,
            Singer,R.H., Rossoll,W. and Bassell,G.J.
  TITLE     Dynamics of survival of motor neuron (SMN) protein interaction with
            the mRNA-binding protein IMP1 facilitates its trafficking into
            motor neuron axons
  JOURNAL   Dev Neurobiol 74 (3), 319-332 (2014)
   PUBMED   23897586
REFERENCE   6  (bases 1 to 2710)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 2710)
  AUTHORS   Klappacher,G.W., Lunyak,V.V., Sykes,D.B., Sawka-Verhelle,D.,
            Sage,J., Brard,G., Ngo,S.D., Gangadharan,D., Jacks,T., Kamps,M.P.,
            Rose,D.W., Rosenfeld,M.G. and Glass,C.K.
  TITLE     An induced Ets repressor complex regulates growth arrest during
            terminal macrophage differentiation
  JOURNAL   Cell 109 (2), 169-180 (2002)
   PUBMED   12007404
REFERENCE   8  (bases 1 to 2710)
  AUTHORS   Pellizzoni,L., Baccon,J., Rappsilber,J., Mann,M. and Dreyfuss,G.
  TITLE     Purification of native survival of motor neurons complexes and
            identification of Gemin6 as a novel component
  JOURNAL   J Biol Chem 277 (9), 7540-7545 (2002)
   PUBMED   11748230
REFERENCE   9  (bases 1 to 2710)
  AUTHORS   Ou,Q., Mouillet,J.F., Yan,X., Dorn,C., Crawford,P.A. and
            Sadovsky,Y.
  TITLE     The DEAD box protein DP103 is a regulator of steroidogenic factor-1
  JOURNAL   Mol Endocrinol 15 (1), 69-79 (2001)
   PUBMED   11145740
REFERENCE   10 (bases 1 to 2710)
  AUTHORS   Campbell,L., Hunter,K.M., Mohaghegh,P., Tinsley,J.M., Brasch,M.A.
            and Davies,K.E.
  TITLE     Direct interaction of Smn with dp103, a putative RNA helicase: a
            role for Smn in transcription regulation?
  JOURNAL   Hum Mol Genet 9 (7), 1093-1100 (2000)
   PUBMED   10767334
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC125471.1.
            
            On Jun 3, 2007 this sequence version replaced NM_017397.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC137721.1, AJ250027.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2710
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.43 cM"
     gene            1..2710
                     /gene="Ddx20"
                     /gene_synonym="dp103; GEMIN3"
                     /note="DEAD box helicase 20"
                     /db_xref="GeneID:53975"
                     /db_xref="MGI:MGI:1858415"
     exon            1..448
                     /gene="Ddx20"
                     /gene_synonym="dp103; GEMIN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..2622
                     /gene="Ddx20"
                     /gene_synonym="dp103; GEMIN3"
                     /EC_number="3.6.1.15"
                     /EC_number="3.6.4.13"
                     /note="ROSF-1; gemin-3; DEAD box protein 20; component of
                     gems 3; DEAD box protein DP 103; regulator of
                     steroidogenic factor 1; DEAD/H (Asp-Glu-Ala-Asp/His) box
                     polypeptide 20; DEAD (Asp-Glu-Ala-Asp) box polypeptide 20"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DDX20"
                     /protein_id="NP_059093.3"
                     /db_xref="CCDS:CCDS38581.1"
                     /db_xref="GeneID:53975"
                     /db_xref="MGI:MGI:1858415"
                     /translation="MAAAAFEVPAALTTSESTMAAERAAAPVQAVEPTPASPWTQRTA
                     HDIGGPRTRTGDVVLAEPADFESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLD
                     LIVQAKSGTGKTCVFSTIALDSLILENYSTQILILAPTREIAVQIHSVITAIGIKMEG
                     LECHVFIGGTPLSQDKTRLKKCHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLL
                     EEGSFQEQINWIYSSLPASKQMLAVSATYPEVLANALTRYMRDPTFVRLNPSDPSLIG
                     LKQYYQVVNSYPLAHKIFEEKTQHLQELFSKVPFNQALVFSNLHSRAQHLADILSSKG
                     FPTECISGNMNQNQRLDAMAKLKQFHCRVLISTDLTSRGIDAEKVNLVVNLDVPLDWE
                     TYMHRIGRAGRFGTLGLTVTYCCRGEEENMMMKIAQKCNINLLPLPDPIPPGLMEECL
                     NWDVEVKAAMHTYSSPTVATQSPKKQVQKLERAFQSQRTPGNQTPSPRNTSASALSAR
                     PKHSKPKLPVKSHSECGVLEKAAPPQESGCPAQLEEQVKNSVQTSVEDSSSNSQHQAK
                     DSSPGSLPKIPCLSSFKVHQPSTLTFAELVDDYEHYIKEGLEKPVEIIRHYTGPEAQT
                     GNPQNGFVRNRVSEDRAQMLVSSSQSGDSESDSDSCSSRTSSQSKGNKSYLEGSSDTQ
                     LKDTECTPVGGPLSLEQVQNGNDTPTQVEYQEAPETQVKARHKEGANQRSKQSRRNPA
                     RRSSYRVQSEPQEESWYDCHRETTASFSDTYQDYEEYWRAYYRAWQEYYAAASHSYYW
                     NAQRHPSWMAAYHMNTVYLQEMMRGNQ"
     exon            449..543
                     /gene="Ddx20"
                     /gene_synonym="dp103; GEMIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            544..712
                     /gene="Ddx20"
                     /gene_synonym="dp103; GEMIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            713..827
                     /gene="Ddx20"
                     /gene_synonym="dp103; GEMIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            828..970
                     /gene="Ddx20"
                     /gene_synonym="dp103; GEMIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1109
                     /gene="Ddx20"
                     /gene_synonym="dp103; GEMIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1168
                     /gene="Ddx20"
                     /gene_synonym="dp103; GEMIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1251
                     /gene="Ddx20"
                     /gene_synonym="dp103; GEMIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1357
                     /gene="Ddx20"
                     /gene_synonym="dp103; GEMIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1459
                     /gene="Ddx20"
                     /gene_synonym="dp103; GEMIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..2710
                     /gene="Ddx20"
                     /gene_synonym="dp103; GEMIN3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcctccga cttccgttct tcccctccgc ttccaggcgt gtccgtgtct tctccgggag
       61 gctgccaata aagtttttct ccttctcgct cccaggagcc ccgcctcaag tctaaatatc
      121 gcgagatctg gaggcgcggc taccatggcg gcggcggcgt ttgaagtccc ggcggccttg
      181 acaacctccg agtccactat ggctgcggag cgtgcggccg cgccggtgca ggctgtggag
      241 ccgactccgg catccccgtg gacccagcgg accgcacacg acatcggcgg gccgcgcaca
      301 cgtaccgggg acgtggtgct ggcggagccc gcggacttcg agtcgctgct gctgtcgcga
      361 ccggtgctgg agggtctgcg ggcggccggc ttcgagagac cctctccggt gcagctcaag
      421 gccatcccgt tggggcgctg cgggctcgat ttaattgtcc aagctaagtc gggcactgga
      481 aaaacttgtg tattctccac cattgctctg gactctctga ttcttgaaaa ctatagtact
      541 cagattttga tattggctcc cacaagagaa attgctgttc agatacactc ggttatcaca
      601 gccattggaa taaaaatgga aggattagaa tgtcatgtct ttattggagg gactccatta
      661 tcacaagaca aaaccagact taaaaagtgt catattgctg ttggatctcc tggtagaatt
      721 aaacagctca tagaacttga ctacctgaat ccgggcagta tccgtctctt tattcttgat
      781 gaagcagata agcttttaga agaaggcagt ttccaggagc aaataaattg gatttactcc
      841 tctttacctg cgagtaagca gatgttggca gtatctgcta cttaccctga agttttggct
      901 aatgctttga caaggtatat gagagatccc acttttgtaa gattgaatcc cagcgatcca
      961 agtctcatag gtttgaagca gtactaccaa gttgtcaatt cttacccttt ggctcataag
     1021 atttttgagg aaaagactca gcacttacag gaacttttta gtaaagtccc atttaatcaa
     1081 gccttggtgt tttctaattt gcacagcaga gctcaacatt tggctgatat cctttcttct
     1141 aaaggttttc ctactgaatg catttcaggt aacatgaatc agaatcagcg ccttgatgct
     1201 atggctaaac tgaagcagtt tcattgcaga gtcctcattt ctacagactt gacgtcccgt
     1261 gggattgacg cagagaaggt gaatctagtt gtaaatctcg atgtgccgtt agactgggag
     1321 acttacatgc atcggattgg cagagctggc cgttttggta cattgggact gacagtgacc
     1381 tactgttgta gaggagaaga agaaaatatg atgatgaaaa ttgctcagaa atgtaatatc
     1441 aaccttcttc ctttaccaga tcctattcct cctggcctga tggaagaatg cttgaattgg
     1501 gatgtggaag ttaaagctgc catgcatact tacagctcac caactgtagc tactcagtcc
     1561 cccaaaaagc aagttcaaaa actagagaga gccttccagt ctcaaagaac gcctgggaac
     1621 caaacgcctt cccctagaaa tacttctgca tctgcactgt cagccaggcc aaagcacagc
     1681 aaaccaaagc ttcctgtgaa aagccactca gagtgtggag tcctagaaaa ggcagctcca
     1741 ccacaagagt cgggctgtcc cgcacagctg gaagagcaag ttaagaattc tgttcagacc
     1801 tctgttgagg attcctccag taacagccag catcaggcca aagatagctc acctgggtca
     1861 ctccctaaaa tcccttgtct gtcttctttt aaagtccatc agccgtctac tttgactttt
     1921 gcagaactgg tagacgatta tgagcactat attaaagagg ggttagagaa acctgtggaa
     1981 attatccggc actacacagg gcctgaggcc cagaccggga atcctcagaa tggctttgtg
     2041 agaaatagag tttctgaaga tagagcacag atgttggtga gtagtagcca gtctggagac
     2101 tcagagagtg acagcgattc ttgcagctca aggacttctt cccagagcaa aggtaataag
     2161 tcttacttgg aaggctcctc agacactcag ttgaaagaca ctgaatgtac tcctgtgggt
     2221 ggccctctct ctctggaaca agttcagaat ggaaatgata ccccgactca agtggagtat
     2281 caagaagccc ctgaaaccca ggtaaaggca aggcataaag aaggcgctaa ccaaaggtct
     2341 aagcaaagtc ggagaaaccc agcacggcgt tcttcttacc gagtacagtc agaaccccag
     2401 gaagagagtt ggtatgactg tcacagggaa acaactgcaa gtttttctga tacttaccag
     2461 gattatgagg agtactggag agcgtattac agggcatggc aagagtatta tgctgctgct
     2521 tcccattcat actattggaa tgctcagaga catccaagct ggatggctgc ctatcatatg
     2581 aatacagttt atctacaaga gatgatgcgt ggtaaccaat gaggttagca tgtgcttcag
     2641 actagtgact gtcaacggat aattggatat gcattcttca cctagaacaa gtggggtttg
     2701 gtggcatttt
//
