LOCUS       NM_172284               6639 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus DEAD box helicase 19b (Ddx19b), transcript variant 2,
            mRNA.
ACCESSION   NM_172284 NM_030242 XM_001001084
VERSION     NM_172284.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6639)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6639)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6639)
  AUTHORS   Zhang,K., Zhang,Y., Xue,J., Meng,Q., Liu,H., Bi,C., Li,C., Hu,L.,
            Yu,H., Xiong,T., Yang,Y., Cui,S., Bu,Z., He,X., Li,J., Huang,L. and
            Weng,C.
  TITLE     DDX19 Inhibits Type I Interferon Production by Disrupting
            TBK1-IKKepsilon-IRF3 Interactions and Promoting TBK1 and IKKepsilon
            Degradation
  JOURNAL   Cell Rep 26 (5), 1258-1272 (2019)
   PUBMED   30699353
REFERENCE   4  (bases 1 to 6639)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   5  (bases 1 to 6639)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093451.25, AK147499.1 and BC079644.1.
            
            On Jul 1, 2010 this sequence version replaced NM_172284.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at an
            alternate start codon, compared to variant 1. The encoded isoform
            (2) has a distinct N-terminus and is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147499.1, SRR10223970.10815.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC093451.25        68255-68264         c
            11-6618             AK147499.1         6-6613
            6619-6639           BC079644.1         1917-1937
FEATURES             Location/Qualifiers
     source          1..6639
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.88 cM"
     gene            1..6639
                     /gene="Ddx19b"
                     /gene_synonym="2810457M08Rik; 4921519L13Rik"
                     /note="DEAD box helicase 19b"
                     /db_xref="GeneID:234733"
                     /db_xref="MGI:MGI:2148251"
     exon            1..173
                     /gene="Ddx19b"
                     /gene_synonym="2810457M08Rik; 4921519L13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..1556
                     /gene="Ddx19b"
                     /gene_synonym="2810457M08Rik; 4921519L13Rik"
                     /EC_number="3.6.4.13"
                     /note="isoform 2 is encoded by transcript variant 2; DEAD
                     (Asp-Glu-Ala-Asp) box polypeptide 19b"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase DDX19B isoform 2"
                     /protein_id="NP_758488.1"
                     /db_xref="CCDS:CCDS22669.1"
                     /db_xref="GeneID:234733"
                     /db_xref="MGI:MGI:2148251"
                     /translation="MATDSWALAVDEQEAAAESLSNLHLKEEKIKPDANGAVVKTNAN
                     TEKTEEDEKEDRAAQSLLNKLIRSNLVDNTNQVEVLQRDPSSPLYSVKSFEELRLKPQ
                     LLQGVYAMGFNRPSKIQENALPLMLAEPPQNLIAQSQSGTGKTAAFVLAVLSQVEPAN
                     KFAQCLCLSPTYELALQTGKVIEQMGKFYPELKLAYAVRGNKLERGQKVSEQIVIGTP
                     GTVLDWCSKLKFIDPKKIKVFVLDEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSAT
                     FEDSVWKFAQKVVPDPNIIKLKREEETLDTIKQYYVLCNNREEKFQALCNLYGAITIA
                     QAMIFCHTRKTASWLAAELSKEGHQVALLSGEMMVEQRAAVIERFREGKEKVLVTTNV
                     CARGIDVEQVSVVINFDLPVDKDGNPDNETYLHRIGRTGRFGKRGLAVNMVDSKHSMN
                     ILNRIQEHFNKKIERLDTDDLDEIEKIAN"
     exon            174..222
                     /gene="Ddx19b"
                     /gene_synonym="2810457M08Rik; 4921519L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            223..276
                     /gene="Ddx19b"
                     /gene_synonym="2810457M08Rik; 4921519L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            277..412
                     /gene="Ddx19b"
                     /gene_synonym="2810457M08Rik; 4921519L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            413..505
                     /gene="Ddx19b"
                     /gene_synonym="2810457M08Rik; 4921519L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            506..608
                     /gene="Ddx19b"
                     /gene_synonym="2810457M08Rik; 4921519L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            609..723
                     /gene="Ddx19b"
                     /gene_synonym="2810457M08Rik; 4921519L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            724..901
                     /gene="Ddx19b"
                     /gene_synonym="2810457M08Rik; 4921519L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1139
                     /gene="Ddx19b"
                     /gene_synonym="2810457M08Rik; 4921519L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1302
                     /gene="Ddx19b"
                     /gene_synonym="2810457M08Rik; 4921519L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1494
                     /gene="Ddx19b"
                     /gene_synonym="2810457M08Rik; 4921519L13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..6620
                     /gene="Ddx19b"
                     /gene_synonym="2810457M08Rik; 4921519L13Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1770..1775
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddx19b"
                     /gene_synonym="2810457M08Rik; 4921519L13Rik"
                     /note="hexamer: AATACA"
     polyA_site      1794
                     /gene="Ddx19b"
                     /gene_synonym="2810457M08Rik; 4921519L13Rik"
                     /note="major polyA site"
     regulatory      3131..3136
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddx19b"
                     /gene_synonym="2810457M08Rik; 4921519L13Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3151
                     /gene="Ddx19b"
                     /gene_synonym="2810457M08Rik; 4921519L13Rik"
     regulatory      6597..6602
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddx19b"
                     /gene_synonym="2810457M08Rik; 4921519L13Rik"
                     /note="hexamer: AATAAA"
     polyA_site      6620
                     /gene="Ddx19b"
                     /gene_synonym="2810457M08Rik; 4921519L13Rik"
ORIGIN      
        1 gctttagtga atgatttccc tcggggcggt gctggacttc tctgccaccc acctgagtcc
       61 gcggtcgcac cgcccaagcg ggcaagcctg ccagcgctgc cccggcaccg cgggccatgg
      121 ctacggattc ttgggcccta gcagtagacg aacaggaagc cgcagctgag tctttgagca
      181 acttgcatct taaggaggag aaaatcaaac cagatgccaa tggtgctgtt gttaagacca
      241 atgcaaacac agagaagaca gaggaagatg agaaagagga cagagctgct cagtctttac
      301 tcaacaagct gatcagaagc aatcttgtgg ataacaccaa ccaagtggaa gtcctgcaga
      361 gggacccaag ctccccgctc tactcagtga agtccttcga agagcttcgc ctgaaaccac
      421 agcttctcca gggagtctat gctatgggtt tcaaccgccc ttccaaaata caggaaaatg
      481 cattgccttt gatgcttgct gaacccccac agaacttaat tgcccagtct cagtctggta
      541 cgggtaaaac agctgccttt gttttggctg tgctcagcca agtagagcct gcaaacaagt
      601 ttgcccagtg tctctgcctc tctccaacct atgagcttgc tcttcaaaca ggaaaagtga
      661 ttgagcagat gggcaagttt taccctgaac tgaagctagc ttatgctgtt cgaggcaaca
      721 aattggagag gggtcagaag gtgagtgagc agattgtcat tggcaccccc gggaccgtct
      781 tggactggtg ctccaagctg aagttcattg accccaagaa gatcaaggtg tttgttctgg
      841 acgaggctga tgtgatgata gcgactcagg gccaccaaga ccagagcatc cgcatccaga
      901 ggatgctgcc cagaaactgc cagatgctgc ttttctcggc cacctttgaa gactcggtgt
      961 ggaagtttgc ccagaaggtg gtcccagacc ccaacatcat caagctgaag cgtgaggagg
     1021 agactctgga caccatcaaa cagtactacg tcctctgcaa taacagagag gagaagttcc
     1081 aggccctgtg caatctgtat ggggccatca ccatcgccca agccatgatc ttctgccata
     1141 cccgcaaaac agctagctgg ctggcagcag agctctcaaa agagggccac caggtggccc
     1201 tgctgagtgg agagatgatg gtggagcaga gggctgcggt gatcgagcgc ttccgagaag
     1261 gcaaagagaa ggttctggtg accaccaacg tgtgtgcccg tggtatcgat gttgaacagg
     1321 tgtctgtcgt catcaatttt gacctccctg tggacaagga cgggaaccca gacaatgaga
     1381 cctacctgca ccgcattggg cgcactggcc gctttggcaa gaggggtctg gcggtcaaca
     1441 tggtggacag caagcacagc atgaatatcc tcaacaggat ccaggagcat tttaataaga
     1501 agatagaaag actggacaca gatgatttgg acgagattga gaaaatcgcc aactgaggcg
     1561 ctcgcttctc catgggctgg cgccaccctc agcgctccct gcctgggagt ctagtgcttt
     1621 catggcatag gcctgacggg cccctcagag accacgggct gagtagagac tacctacctc
     1681 attcggaatt acgtttggac ttgacaaatt tgtgcaaatg atgagggatg gtagaaatgt
     1741 gtttacacaa ctttggaaga ttaggcatga atacacagaa atttaccttt tcaagtccca
     1801 tctttttttt ttggacagta ttttcccatc acactgatct agataatatg cctaggattc
     1861 ctcatgacaa accttagctg tttgtgactt ggagtttgca ggccagcctc gtggaagtga
     1921 cagcacagaa cagagagcac gtagaggcag agtcctcagg gaggaggagg atataagcca
     1981 gtcgtgtgtc aggaagatgg cacaaggcac tggagttggc ctgtggactg ctgcttagga
     2041 cttggttggt gtgtaatggc taagctgtgt gttacctgac ccctgctgac attctttcca
     2101 ggaaaagatt tgccatgttg gaccaaaatg cctttggggc ctctccttaa gctttgtggc
     2161 tcaggaacat gggcaaatct agttattggt gagttcttgg ctcatacttc agcaagacct
     2221 gtggagaagt tgtcctggag gattagtggt gcctctggct tccggtaaca cctggatcat
     2281 gggtacttga accatagttt ttacatctgt aacatcactt ggactgttag tagtcccagg
     2341 caaataacag ggtactgagg tttgggttct aagtgagtac tgtagcttaa agtttctgat
     2401 gggctggcag ccttgatcag agcaggctag gcatggtcag cagttgccaa aattccttgc
     2461 tttgtttgca gttcctgaaa gattagtcct gtcagagctg gggagtgact gcagatattg
     2521 ggcaacgtgg ctctaaaggg attctgatgg tctgtgttca cagtgagtgt gatgagggac
     2581 aggacggacc acagccgttt gtctgtccac aatgagtaat caacaagtac ttgctgcttt
     2641 ctcccttagc atccatcatt aggacagtaa aagcacacaa taaacagaga acttctcaca
     2701 ctggctaggc catagatact acagagtgac agcaatgtgg agggattgag aagcatcctc
     2761 ttcagttctt tgacttggac atggggtgag tcttctctct agggcttgtt ttgttagttt
     2821 tgttgcatgt atgtgttgtg ctgggactca aagccttgcg ttctgctacc taagcacggt
     2881 tactctgaac tattatttcc agccatgata gaggcttgtt gtggtgagaa gtatagacct
     2941 gtgttcccat atcttaaggc cagttccgtc ccctgggaaa ggagagtgcc atggctacca
     3001 cctggtggtg gttcaatgtc acagagaaat caacaggtgc ttgttctcca ctctccagtg
     3061 ggtatttgaa tagaattctc tgtgggctcc tggccaactt tgatctattt taggagtctt
     3121 aaaaggaaag aataaacttt ttctcccaaa atactgtgga tcaaacttga aataagtgaa
     3181 aacaagaact gtagttagag aagtgtatga ctcttccctg agtctgagaa ggagactggg
     3241 caaggcgagc agcagcccct ccagtggctt ctggtgggag tgtagatcaa cactcctaac
     3301 ctagtgtcct gcacctcgga gaatactgga tgggtttcat ggtgtctgtg aagttatata
     3361 cattagttta aggtttaaaa acttcttagg aagactccca aaagattttc caccttttaa
     3421 aaaggtgagt cctacattgt gaatggctct ggcatgtcac tagtgtcatg tggaccatac
     3481 tctttcccag cccacactca ctcctgccac catctatccc ccaggggcag attagcactg
     3541 tctggagcct taagaatgta ttgagcttac agagccttga tcccagggat ttgactgtta
     3601 tgtatctatg gagtgagaaa ctgagctctt ggacgaagga gctcagggaa agaaagaagg
     3661 gagaagctca gggaaagaca tatttttgtg taatgaaaag ttttgtgatg ctcattatcc
     3721 acaaacatat ttatattgga attttattcc ttgacctcaa acttaagttt ctgcctcagt
     3781 ttcctgggtg ctagaattgt aggtgtgtac tatcatgcca gactgtggta tttttgttct
     3841 gagtatcatt tattggttat atgcatgcat aagatctgat aagttgttga gacatagtct
     3901 tttagggatt tggggttttt gtttttttga gacagggttt ctttgtgtat ccctggctgt
     3961 cctggaattt gctctatagt agatcaggct ggctttgaac tccaagatcc acctgccttt
     4021 agctcctgag tgctgggatt aaaggtgtgc actaccacac cccgcacgat atagtttttg
     4081 ctggtgttaa ttatgaattg ttcatgttac taagacagta atgcttataa gaagcaagta
     4141 gtatcttgtg gttggtgata tattaagtaa agttaatacc accttcagct agtattagtc
     4201 tatgtcaggt ggtactgttc gaacgtgagc aacgagggca tctccataga accaggattc
     4261 tgctcacttg ccaggcattc acaaacacac atgcatacgc acacacacaa atacacacac
     4321 cattccactt tagtaaaaca ggatgattta ggtcacagca tgtaaggtca gtctgtgggt
     4381 gcatcctcca ggagtgatgg tatataccag tcagtccctg cattagcaac ggtgatagtc
     4441 catacctgta gtccctgcat accaagagcg atagtccata cctgtagtcc ctgcatacca
     4501 agagtgatag tccatacctg taaccccagc gttagcaaag ctgaggccag agggatttga
     4561 gttgaaagta aacccaggcc tacataggtc ctgtttcaaa aaacaaacaa ataaaacaaa
     4621 acaaaaaaca atctcaacat ggtagttcat gcctataatc ttggcatttg tgatataaaa
     4681 gcaggaagtt caggagttca aagctaacct aggcaataag aggctgggtc agggcatagc
     4741 acctggagat agatctttcc tatttcttac agaatcagtg tccgagactg gtatagagtt
     4801 ccagaggcca gagaatgttg aataaaggag tggggtttgt gtgtgaggaa gcaggctcgt
     4861 gacaagattt gcaaggaaag gactcatcct caggtacaaa gagaagttga ggctagcctg
     4921 gcctacagca agccctgtct cagaaaggaa aagagtagaa agtattgggt acagtggtcc
     4981 ttttttataa ttgcagcact caggaggctg agacagtatt gctgagttca aagccagcct
     5041 gggttactta gaaacaggcc agccttagct gtgttagtca agatgacaag ggtgacagag
     5101 atcccctggg aacacagctc aggtggccct gtgtgggaaa gtcagggttc acaggataaa
     5161 atgctgctgc tgctgctgct gttcagtttt tattgtgctt ggtgtagggt ctcactgttt
     5221 aacacagact ggcctggaaa tcaaagcaat tctacctcag cctcctgagt gctgggattc
     5281 taagcaggag ccactatgac ctggcaacta aattttgact gtctcacagt ccagtgtcct
     5341 gctgtgacgg agtagccagg gctgagtagt ctgaggacag gtgagcctgc aggcctggag
     5401 ggagacatca acatgagagc attagcagca ggatgaggga ttctgaaatc agcgtagcaa
     5461 aattggcttt ctgttgttgg aggagggaac tggactgcct gcctcctctg cccacaccac
     5521 tcgaggtaat gctgaaggct tcatggactc tcaagtttct cttgatcctc ttttagagac
     5581 actagactca tagaaattca ttgcaagttt acatggcttt gcttctgtgc ttgagagtaa
     5641 atatcctgtg ctttgttgcg tggctgttat ggtgtcttct ataaaggacc ctggtgcacg
     5701 gaattaactc aagaaacgta tgctgaggca catacactgc ttttcttacc cttagctgag
     5761 atagggcttt cccagaacag cttggaaccc tagtgtgaag atgcagaccc atgcttttct
     5821 tggcctccag actgtcttgg ctttagaatc cgatggggca ggggagtggc tgttcttgtc
     5881 gtagtttcag tcatgaagtg gggaatgact agaaggtgga ggaaggtgtg gtggcacaca
     5941 gctgtaatct taacacttgc agggctgatg gttgaaactt tagagtactg ttagggctac
     6001 agaggtctag actgtgtagt gagatcatgt ctcttcaaaa tgaaaagatt aggtcaagct
     6061 ttaccgtgat gcctgacatg cctgctgtcc aaatgaacca tgtctcccct ctgccttagc
     6121 tccagttaat ggacagaggg acgagggtga gagagcagat ctttgtcttt ttgagcggct
     6181 agcttttgcc aacgtaagaa atagctttcc ctacaagact gctgttgctc agtatgtttt
     6241 tcccattcca attcttcaac ttaagaacag cctactgagt gtaagttatt gtaatattcc
     6301 ctgagggcat gcctctcctg cttttttgtt tgtttatttg tttgtttctt tcttttggtt
     6361 tgggttttgt atgtgtgtat gtgtttagtt cattttgcta tctgacagca gtagctgcta
     6421 agtatgcgta gaaattatca agatatggct agtgagatga ctggttattg cagtccagtt
     6481 cctaaaggta ggagaaaact agctagcctc agggagttgt ccttagacct cagtagtggg
     6541 gcaatggtgc atagtcacac acaaatttta ttttttaaga cttgctcgtc tttttaaata
     6601 aatatatttt taaaaatgtg aaaaaaaaaa aaaaaaaaa
//
