LOCUS       NP_031942                478 aa            linear   ROD 02-JUN-2024
DEFINITION  ATP-dependent RNA helicase DDX19A isoform 1 [Mus musculus].
ACCESSION   NP_031942 XP_001001073
VERSION     NP_031942.2
DBSOURCE    REFSEQ: accession NM_007916.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 478)
  AUTHORS   Pinter,S., Knodel,F., Choudalakis,M., Schnee,P., Kroll,C.,
            Fuchs,M., Broehm,A., Weirich,S., Roth,M., Eisler,S.A., Zuber,J.,
            Jeltsch,A. and Rathert,P.
  TITLE     A functional LSD1 coregulator screen reveals a novel
            transcriptional regulatory cascade connecting R-loop homeostasis
            with epigenetic regulation
  JOURNAL   Nucleic Acids Res 49 (8), 4350-4370 (2021)
   PUBMED   33823549
  REMARK    GeneRIF: A functional LSD1 coregulator screen reveals a novel
            transcriptional regulatory cascade connecting R-loop homeostasis
            with epigenetic regulation.
REFERENCE   2  (residues 1 to 478)
  AUTHORS   Zhang,K., Zhang,Y., Xue,J., Meng,Q., Liu,H., Bi,C., Li,C., Hu,L.,
            Yu,H., Xiong,T., Yang,Y., Cui,S., Bu,Z., He,X., Li,J., Huang,L. and
            Weng,C.
  TITLE     DDX19 Inhibits Type I Interferon Production by Disrupting
            TBK1-IKKepsilon-IRF3 Interactions and Promoting TBK1 and IKKepsilon
            Degradation
  JOURNAL   Cell Rep 26 (5), 1258-1272 (2019)
   PUBMED   30699353
REFERENCE   3  (residues 1 to 478)
  AUTHORS   Rajakyla,E.K., Viita,T., Kyheroinen,S., Huet,G., Treisman,R. and
            Vartiainen,M.K.
  TITLE     RNA export factor Ddx19 is required for nuclear import of the SRF
            coactivator MKL1
  JOURNAL   Nat Commun 6, 5978 (2015)
   PUBMED   25585691
  REMARK    GeneRIF: Ddx19 is an RNA export factor required for nuclear import
            of the SRF coactivator MKL1
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 478)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 478)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (residues 1 to 478)
  AUTHORS   Yang,H.S., Jansen,A.P., Komar,A.A., Zheng,X., Merrick,W.C.,
            Costes,S., Lockett,S.J., Sonenberg,N. and Colburn,N.H.
  TITLE     The transformation suppressor Pdcd4 is a novel eukaryotic
            translation initiation factor 4A binding protein that inhibits
            translation
  JOURNAL   Mol Cell Biol 23 (1), 26-37 (2003)
   PUBMED   12482958
REFERENCE   7  (residues 1 to 478)
  AUTHORS   Gee,S.L. and Conboy,J.G.
  TITLE     Mouse erythroid cells express multiple putative RNA helicase genes
            exhibiting high sequence conservation from yeast to mammals
  JOURNAL   Gene 140 (2), 171-177 (1994)
   PUBMED   8144024
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY302446.1, AK146548.1 and BG094410.1.
            
            On Mar 27, 2008 this sequence version replaced NP_031942.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011270.1, AK146548.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.86 cM"
     Protein         1..478
                     /product="ATP-dependent RNA helicase DDX19A isoform 1"
                     /EC_number="3.6.4.13"
                     /note="Ddx19-like protein; ATP-dependent RNA helicase
                     DDX19A; mDEAD5; DEAD box protein 19A; DEAD box RNA
                     helicase DEAD5; eukaryotic translation initiation factor
                     4A-related sequence 1; DEAD/H (Asp-Glu-Ala-Asp/His) box
                     polypeptide 19; DEAD (Asp-Glu-Ala-Asp) box polypeptide
                     19a"
                     /calculated_mol_wt=53802
     Region          2..299
                     /region_name="N-terminal lobe. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61655.2)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q9NUU7; propagated from
                     UniProtKB/Swiss-Prot (Q61655.2)"
     Region          34..53
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61655.2)"
     Site            42
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9QY15; propagated from
                     UniProtKB/Swiss-Prot (Q61655.2)"
     Region          54..67
                     /region_name="N-terminal helix. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61655.2)"
     Region          74..302
                     /region_name="DEAD-like_helicase_N"
                     /note="N-terminal helicase domain of the DEAD-box helicase
                     superfamily; cl28899"
                     /db_xref="CDD:475120"
     Region          91..119
                     /region_name="Q motif"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61655.2)"
     Site            order(139..145,241)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:350670"
     Region          241..244
                     /region_name="DEAD box"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61655.2)"
     Region          300..478
                     /region_name="C-terminal lobe. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61655.2)"
     Region          306..442
                     /region_name="SF2_C_DEAD"
                     /note="C-terminal helicase domain of the DEAD box
                     helicases; cd18787"
                     /db_xref="CDD:350174"
     Site            order(395,397,428,431..432)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350174"
     CDS             1..478
                     /gene="Ddx19a"
                     /gene_synonym="DBP5; Ddx19; Eif4a-rs1"
                     /coded_by="NM_007916.2:101..1537"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS22668.1"
                     /db_xref="GeneID:13680"
                     /db_xref="MGI:MGI:99526"
ORIGIN      
        1 matdswalav deqeaavksm sslqikeekv kadtngvikt sttaekteee ekedraaqsl
       61 lnklirsnlv dntnqvevlq rdpssplysv ksfeelrlkp qllqgvyamg fnrpskiqen
      121 alpmmlaepp qnliaqsqsg tgktaafvla mlsrvepadr ypqclclspt yelalqtgkv
      181 ieqmgkfhpe lklayavrgn klergqkvse qivigtpgtv ldwcsklkfi dpkkikvfvl
      241 deadvmiatq ghqdqsiriq rmlprncqml lfsatfedsv wkfaqkvvpd pniiklkree
      301 etldtikqyy vlcnnreekf qalcnlygai tiaqamifch trktaswlaa elskeghqva
      361 llsgemmveq raavierfre gkekvlvttn vcargidveq vsvvinfdlp vdkdgnpdne
      421 tylhrigrtg rfgkrglavn mvdskhsmni lnriqehfnk kierldtddl deiekian
//
