LOCUS       NM_025860               2249 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus DEAD box helicase 18 (Ddx18), mRNA.
ACCESSION   NM_025860
VERSION     NM_025860.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2249)
  AUTHORS   Zhang,H., Wu,Z., Lu,J.Y., Huang,B., Zhou,H., Xie,W., Wang,J. and
            Shen,X.
  TITLE     DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in
            Pluripotency Regulation
  JOURNAL   Cell Rep 30 (1), 81-97 (2020)
   PUBMED   31914400
  REMARK    GeneRIF: DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard
            Ribosomal DNA in Pluripotency Regulation.
REFERENCE   2  (bases 1 to 2249)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY084565.1, BC103776.1 and BY381480.1.
            
            On Aug 15, 2009 this sequence version replaced NM_025860.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC103776.1, AK075864.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                BY084565.1         2-64
            64-2232             BC103776.1         1-2169
            2233-2249           BY381480.1         439-455
FEATURES             Location/Qualifiers
     source          1..2249
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 52.98 cM"
     gene            1..2249
                     /gene="Ddx18"
                     /gene_synonym="2310005B10Rik"
                     /note="DEAD box helicase 18"
                     /db_xref="GeneID:66942"
                     /db_xref="MGI:MGI:1914192"
     exon            1..190
                     /gene="Ddx18"
                     /gene_synonym="2310005B10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..2088
                     /gene="Ddx18"
                     /gene_synonym="2310005B10Rik"
                     /EC_number="3.6.4.13"
                     /note="DEAD box protein 18; DEAD (Asp-Glu-Ala-Asp) box
                     polypeptide 18"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase DDX18"
                     /protein_id="NP_080136.2"
                     /db_xref="CCDS:CCDS15240.1"
                     /db_xref="GeneID:66942"
                     /db_xref="MGI:MGI:1914192"
                     /translation="MSQLQMKLLRRKIEKRNAKLRQRNLKLQETSDTSLSQPQNGDVP
                     KETGKGGKVKKALKRSVPVDSAEAQSGGMPEETLENGKVKKSPQKLTTLANGEAAPTP
                     PPDSEVKKKKKKKRKMANDAGPDTKKAKTEESAEACEEPEDDVKKADDSEVPSLPLGL
                     TGAFEDTSFASLSNLVNENTLKAIEEMGFKRMTEIQHKSIRPLLEGRDLLAAAKTGSG
                     KTLAFLIPVIELIVKLKFMPRNGTGVLILSPTRELAMQTFGVLKELMTHHVHTYGLIM
                     GGSNRSAEVQKLLNGINIIVATPGRLLDHMQNTPGFMYKNLQCLVIDEADRILDVGFE
                     EELKQIIKLLPARRQTMLFSATQTRKVEDLARISLKKEPLYVGVDDDKEVATVDGLEQ
                     GYVVCPSEKRFLLLFTFLKKNRKKKVMVFFSSCMSVKYHYELLNYIDLPVLAIHGKQK
                     QNKRTTTFFQFCNADSGILLCTDVAARGLDIPEVDWIVQYDPPDDPKEYIHRVGRTAR
                     GLNGRGHALLILRPEELGFLRYLKQSKVPLNQFDFSWSKVSDIQSQLEKLIEKNYFLH
                     KSAQEAYKSYIRAYDSHSLKQIFNVNNLNLPQVALSFGFKVPPFVDLNVSSHDGKLKK
                     RGGGGGFGYQKTKKVEKSKIFKHISKKPADRRQFSH"
     exon            191..478
                     /gene="Ddx18"
                     /gene_synonym="2310005B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            479..589
                     /gene="Ddx18"
                     /gene_synonym="2310005B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            590..725
                     /gene="Ddx18"
                     /gene_synonym="2310005B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            726..826
                     /gene="Ddx18"
                     /gene_synonym="2310005B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1141
                     /gene="Ddx18"
                     /gene_synonym="2310005B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1281
                     /gene="Ddx18"
                     /gene_synonym="2310005B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1443
                     /gene="Ddx18"
                     /gene_synonym="2310005B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1596
                     /gene="Ddx18"
                     /gene_synonym="2310005B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1710
                     /gene="Ddx18"
                     /gene_synonym="2310005B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1767
                     /gene="Ddx18"
                     /gene_synonym="2310005B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1945
                     /gene="Ddx18"
                     /gene_synonym="2310005B10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2249
                     /gene="Ddx18"
                     /gene_synonym="2310005B10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2222..2227
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddx18"
                     /gene_synonym="2310005B10Rik"
                     /note="hexamer: CATAAA"
     regulatory      2227..2232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddx18"
                     /gene_synonym="2310005B10Rik"
                     /note="hexamer: AACAAA"
     polyA_site      2245
                     /gene="Ddx18"
                     /gene_synonym="2310005B10Rik"
                     /note="major polyA site"
     polyA_site      2249
                     /gene="Ddx18"
                     /gene_synonym="2310005B10Rik"
ORIGIN      
        1 gaagcatttc cgccccgcgg gtccgcaggc tccagcggta cacttccgac ttgcaattgc
       61 gcacgtgcat ctgtctcggt gcagacggct gggcggcctg gcaagatgtc gcagttacag
      121 atgaaactcc tgcgcaggaa gatcgagaag cggaatgcca agctgcggca gcgaaacctg
      181 aagctgcaag aaacatcaga cacaagcctg tcccaacctc aaaatggaga tgtgcctaaa
      241 gaaacaggaa aaggtggaaa agtgaaaaag gccctgaaac gttctgtgcc tgtggactca
      301 gcagaagcac aaagtggagg catgcctgag gagaccttgg aaaatggcaa agttaaaaag
      361 tcaccccaga aactcacaac tttagccaac ggagaagcag caccaacacc acctcctgat
      421 tcagaagtaa aaaagaaaaa gaagaaaaag aggaaaatgg caaatgatgc cgggcctgat
      481 acaaaaaaag cgaaaactga agaaagtgct gaggcttgtg aggaaccaga agatgatgtg
      541 aaaaaggcag atgacagcga ggtgcccagc ctgcccctag gactgacagg tgcttttgag
      601 gacacttcat ttgcttcctt gtctaatctc gtcaatgaga acaccctgaa ggccatagaa
      661 gaaatgggct tcaagcgcat gacggagatc cagcataaaa gtatcaggcc acttctggaa
      721 ggcagggacc ttctggcggc tgcgaaaacc ggcagtggca aaaccctcgc tttcctcatc
      781 cctgtgatcg agctcattgt caagttgaag ttcatgccca ggaatggaac aggagtcctg
      841 attctctctc ctaccagaga actggccatg cagacctttg gtgttctcaa ggagctgatg
      901 acgcaccacg ttcacacgta tgggctgatc atgggcggca gcaacaggtc tgctgaagtg
      961 cagaagctcc tcaatgggat caacatcatc gtggccacgc ccggccggct cctggaccac
     1021 atgcagaaca cgccagggtt tatgtacaag aacctgcagt gtctggttat tgatgaggct
     1081 gaccgtatct tggatgttgg gtttgaagaa gaattaaagc aaattattaa acttttgcca
     1141 gcccgtaggc aaaccatgct cttttctgcc acacaaactc gaaaagttga agacttggca
     1201 agaatttctc tgaaaaagga gcctttgtac gtgggtgttg atgacgacaa agaggttgcc
     1261 acagtggatg gccttgagca gggctatgtt gtttgtccct ctgagaagag gttccttctg
     1321 cttttcacat tccttaagaa gaaccggaag aagaaagtga tggtcttctt ttcatcttgt
     1381 atgtctgtga aataccacta tgagctgttg aactacattg accttcccgt cttggccatc
     1441 catggaaagc aaaagcaaaa taagcgaaca accacgtttt tccagttctg caacgcggat
     1501 tcaggaatac tgctgtgtac tgatgtggca gccagagggc tggacatccc cgaagtggac
     1561 tggattgttc agtacgaccc tcccgatgac cccaaggaat acattcatcg tgttggtaga
     1621 acagccaggg gcctgaatgg aagagggcac gccctgctca tcctgcgccc tgaagagttg
     1681 ggtttccttc gttacttgaa acagtccaag gttccattga atcagtttga cttctcctgg
     1741 tctaaagttt ctgatatcca gtctcagctg gaaaaactga tcgaaaagaa ctactttctc
     1801 cacaagtctg cccaggaagc atacaaatcc tacataagag catatgactc tcactctctc
     1861 aagcagatct tcaacgtgaa caacttaaat ctgcctcagg ttgctctgtc ttttggtttt
     1921 aaggtccctc cttttgttga tctgaatgtg agcagccatg atggcaagct taagaagaga
     1981 ggcggtggtg gcggattcgg ctaccagaaa acaaagaaag tggagaagtc caagatcttt
     2041 aaacacatca gtaagaagcc agcagaccgc aggcagttct cacactgagg caatctgcct
     2101 tcagcctgga ctgactttgc ccagcttccc ccctccccag taccctttaa aaaggaactt
     2161 tatcaccttt aggatctttt tgtctttact atgatgataa tattttattt ttaaatactt
     2221 ccataaaaca aattttatca ctgttttaa
//
