LOCUS       NM_001040187            4766 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus DEAD box helicase 17 (Ddx17), transcript variant 4,
            mRNA.
ACCESSION   NM_001040187
VERSION     NM_001040187.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4766)
  AUTHORS   Yan,M., Gao,J., Lan,M., Wang,Q., Cao,Y., Zheng,Y., Yang,Y., Li,W.,
            Yu,X., Huang,X., Dou,L., Liu,B., Liu,J., Cheng,H., Ouyang,K.,
            Xu,K., Sun,S., Liu,J., Tang,W., Zhang,X., Man,Y., Sun,L., Cai,J.,
            He,Q., Tang,F., Li,J. and Shen,T.
  TITLE     DEAD-box helicase 17 (DDX17) protects cardiac function by promoting
            mitochondrial homeostasis in heart failure
  JOURNAL   Signal Transduct Target Ther 9 (1), 127 (2024)
   PUBMED   38782919
  REMARK    GeneRIF: DEAD-box helicase 17 (DDX17) protects cardiac function by
            promoting mitochondrial homeostasis in heart failure.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4766)
  AUTHORS   Jin,C., Han-Hua,D., Qiu-Meng,L., Deng,N., Peng-Chen,D., Jie,M.,
            Lei,X., Xue-Wu,Z., Hui-Fang,L., Yan,C., Xiao-Ping,C. and
            Bi-Xiang,Z.
  TITLE     MTDH-stabilized DDX17 promotes tumor initiation and progression
            through interacting with YB1 to induce EGFR transcription in
            Hepatocellular Carcinoma
  JOURNAL   Oncogene 42 (3), 169-183 (2023)
   PUBMED   36385375
REFERENCE   3  (bases 1 to 4766)
  AUTHORS   Wang,S.B., Narendran,S., Hirahara,S., Varshney,A., Pereira,F.,
            Apicella,I., Ambati,M., Ambati,V.L., Yerramothu,P., Ambati,K.,
            Nagasaka,Y., Argyle,D., Huang,P., Baker,K.L., Marion,K.M.,
            Gupta,K., Liu,B., Hinton,D.R., Canna,S.W., Sallam,T., Sadda,S.R.,
            Kerur,N., Gelfand,B.D. and Ambati,J.
  TITLE     DDX17 is an essential mediator of sterile NLRC4 inflammasome
            activation by retrotransposon RNAs
  JOURNAL   Sci Immunol 6 (66), eabi4493 (2021)
   PUBMED   34860583
  REMARK    GeneRIF: DDX17 is an essential mediator of sterile NLRC4
            inflammasome activation by retrotransposon RNAs.
REFERENCE   4  (bases 1 to 4766)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4766)
  AUTHORS   Godin,P., Tsoi,M., Paquet,M. and Boerboom,D.
  TITLE     YAP and TAZ are required for the postnatal development and the
            maintenance of the structural integrity of the oviduct
  JOURNAL   Reproduction 160 (2), 307-318 (2020)
   PUBMED   32520726
REFERENCE   6  (bases 1 to 4766)
  AUTHORS   Germann,S., Gratadou,L., Zonta,E., Dardenne,E., Gaudineau,B.,
            Fougere,M., Samaan,S., Dutertre,M., Jauliac,S. and Auboeuf,D.
  TITLE     Dual role of the ddx5/ddx17 RNA helicases in the control of the
            pro-migratory NFAT5 transcription factor
  JOURNAL   Oncogene 31 (42), 4536-4549 (2012)
   PUBMED   22266867
  REMARK    GeneRIF: Data indicate that transcriptional coregulator ddx5/ddx17
            RNA helicases can simultaneously regulate the transcriptional
            activity and alternative splicing of NFAT5 transcription factor.
REFERENCE   7  (bases 1 to 4766)
  AUTHORS   Wilson,B.J. and Giguere,V.
  TITLE     Identification of novel pathway partners of p68 and p72 RNA
            helicases through Oncomine meta-analysis
  JOURNAL   BMC Genomics 8, 419 (2007)
   PUBMED   18005418
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4766)
  AUTHORS   Nagamori,I., Yomogida,K., Adams,P.D., Sassone-Corsi,P. and
            Nojima,H.
  TITLE     Transcription factors, cAMP-responsive element modulator (CREM) and
            Tisp40, act in concert in postmeiotic transcriptional regulation
  JOURNAL   J Biol Chem 281 (22), 15073-15081 (2006)
   PUBMED   16595651
REFERENCE   9  (bases 1 to 4766)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 4766)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC096036.1 and CX220180.1.
            
            Summary: This gene encodes the mouse homolog of human DEAD box
            polypeptide 17. DEAD box proteins, characterized by the conserved
            motif Asp-Glu-Ala-Asp (DEAD). RNA helicases of the DEAD-box family
            are involved in a number of cellular processes involving alteration
            of RNA secondary structure such as translation initiation, nuclear
            and mitochondrial splicing, and ribosome and splicesosome assembly.
            Alternative splicing of this gene results in several transcript
            variants encoding different isoforms. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (4) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1,
            resulting in a shorter protein (isoform 4).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096036.1, SRR1660819.117676.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4726              BC096036.1         1-4726
            4727-4766           CX220180.1         540-579
FEATURES             Location/Qualifiers
     source          1..4766
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.77 cM"
     gene            1..4766
                     /gene="Ddx17"
                     /gene_synonym="2610007K22Rik; A430025E01Rik; Gm926; p72"
                     /note="DEAD box helicase 17"
                     /db_xref="GeneID:67040"
                     /db_xref="MGI:MGI:1914290"
     exon            1..547
                     /gene="Ddx17"
                     /gene_synonym="2610007K22Rik; A430025E01Rik; Gm926; p72"
                     /inference="alignment:Splign:2.1.0"
     CDS             498..2450
                     /gene="Ddx17"
                     /gene_synonym="2610007K22Rik; A430025E01Rik; Gm926; p72"
                     /EC_number="3.6.4.13"
                     /note="isoform 4 is encoded by transcript variant 4;
                     probable ATP-dependent RNA helicase DDX17; DEAD box
                     protein 17; DEAD (Asp-Glu-Ala-Asp) box polypeptide 17"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DDX17
                     isoform 4"
                     /protein_id="NP_001035277.1"
                     /db_xref="CCDS:CCDS88805.1"
                     /db_xref="GeneID:67040"
                     /db_xref="MGI:MGI:1914290"
                     /translation="MRGGGFGDRDRDRDRGGFGARGGSGLPPKKFGNPGERLRKKKWD
                     LSELPKFEKNFYVEHPEVARLTPYEVDELRRKKEITVRGGDVCPKPVFAFHHANFPQY
                     VMDVLMDQHFTEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYL
                     ERGDGPICLVLAPTRELAQQVQQVADDYGKCSRLKSTCIYGGAPKGPQIRDLERGVEI
                     CIATPGRLIDFLESGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMW
                     SATWPKEVRQLAEDFLRDYTQINVGNLELSANHNILQIVDVCMESEKDHKLIQLMEEI
                     MAEKENKTIIFVETKRRCDDLTRRMRRDGWPAMCIHGDKSQPERDWVLNEFRSGKAPI
                     LIATDVASRGLDVEDVKFVINYDYPNSSEDYVHRIGRTARSTNKGTAYTFFTPGNLKQ
                     ARELIKVLEEANQAINPKLMQLVDHRGGGGGGGGRSRYRTTSSANNPNLMYQDECDRR
                     LRGVKDGGRRDSTSYRDRSETDRASYANGSGYGSPNSAFGAQAGQYTYAQGTYGAAAY
                     GTSGYTAQEYAAGTYGASSTASAGRSSQSSSQQFSGIGRSGQQPQPLMSQQFAQPPGA
                     TNMIGYMGQTAYQYPPPPPPPPPSRK"
     exon            548..698
                     /gene="Ddx17"
                     /gene_synonym="2610007K22Rik; A430025E01Rik; Gm926; p72"
                     /inference="alignment:Splign:2.1.0"
     exon            699..798
                     /gene="Ddx17"
                     /gene_synonym="2610007K22Rik; A430025E01Rik; Gm926; p72"
                     /inference="alignment:Splign:2.1.0"
     exon            799..932
                     /gene="Ddx17"
                     /gene_synonym="2610007K22Rik; A430025E01Rik; Gm926; p72"
                     /inference="alignment:Splign:2.1.0"
     exon            933..998
                     /gene="Ddx17"
                     /gene_synonym="2610007K22Rik; A430025E01Rik; Gm926; p72"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1140
                     /gene="Ddx17"
                     /gene_synonym="2610007K22Rik; A430025E01Rik; Gm926; p72"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1301
                     /gene="Ddx17"
                     /gene_synonym="2610007K22Rik; A430025E01Rik; Gm926; p72"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1474
                     /gene="Ddx17"
                     /gene_synonym="2610007K22Rik; A430025E01Rik; Gm926; p72"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1585
                     /gene="Ddx17"
                     /gene_synonym="2610007K22Rik; A430025E01Rik; Gm926; p72"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1647
                     /gene="Ddx17"
                     /gene_synonym="2610007K22Rik; A430025E01Rik; Gm926; p72"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1707
                     /gene="Ddx17"
                     /gene_synonym="2610007K22Rik; A430025E01Rik; Gm926; p72"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1944
                     /gene="Ddx17"
                     /gene_synonym="2610007K22Rik; A430025E01Rik; Gm926; p72"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..4766
                     /gene="Ddx17"
                     /gene_synonym="2610007K22Rik; A430025E01Rik; Gm926; p72"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4707..4712
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddx17"
                     /gene_synonym="2610007K22Rik; A430025E01Rik; Gm926; p72"
                     /note="hexamer: AATAAA"
     regulatory      4721..4726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddx17"
                     /gene_synonym="2610007K22Rik; A430025E01Rik; Gm926; p72"
                     /note="hexamer: AATAAA"
     polyA_site      4726
                     /gene="Ddx17"
                     /gene_synonym="2610007K22Rik; A430025E01Rik; Gm926; p72"
                     /note="major polyA site"
     regulatory      4746..4751
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddx17"
                     /gene_synonym="2610007K22Rik; A430025E01Rik; Gm926; p72"
                     /note="hexamer: ATTAAA"
     polyA_site      4752
                     /gene="Ddx17"
                     /gene_synonym="2610007K22Rik; A430025E01Rik; Gm926; p72"
     polyA_site      4760
                     /gene="Ddx17"
                     /gene_synonym="2610007K22Rik; A430025E01Rik; Gm926; p72"
ORIGIN      
        1 gaaccctacg ccggttgcgc acattgcctt gtttaaggtg ggccgaccag ggcccccatc
       61 tccgtcaccg acgtaaagcg gttccgagaa tgtccgtggc gtcgcgcgga gccctccaga
      121 cgctgtttac gtagcgtctg ggccgtgcgt agcgttaagt tggagcggtc tccgcggccg
      181 ccgccatttt gtgcagttgc tgggaaggaa gggagacgcc tcaaccgtgg caccgcccgg
      241 tttgagcggg accagacctc ccgactgtcc taacaacccc gattctctga gttgtgctcc
      301 cgtctccgac gagagaggcg gcgacggtgg cgtctgcgac gggagacagc gcgtcggagc
      361 gagacagcgc cgcgcctgcc gccgccccaa cagcggaggc gccgccgccg ccatcggtca
      421 tcactagacc cgagccgcag gccctcccga gctcggtcat ccgtgccccg ctcccagatc
      481 tttatccgtt tgggaccatg cgtggaggcg gctttgggga tcgggatcgt gacagggacc
      541 gtggagggtt tggagcaaga ggtggtagtg ggcttccccc taagaagttt ggtaatcctg
      601 gggagcggtt acgaaaaaag aagtgggatt tgagtgaact ccctaaattt gagaagaatt
      661 tttatgttga gcatccagaa gtagcaagac tgactccgta tgaggttgat gagctacggc
      721 gtaagaaaga gattacagtg agagggggag atgtttgtcc aaaacctgtc tttgccttcc
      781 atcatgctaa ctttccacag tatgtgatgg atgtgctgat ggatcagcac tttacagaac
      841 ccactcccat tcagtgccag ggatttcctt tggctcttag tggcagggat atggttggca
      901 ttgcacagac tggctctggg aagacattgg cgtatttgct gcctgcgatt gttcatataa
      961 accaccagcc atacttggaa agaggagatg gtccaatttg tctagtgctg gctcctacca
     1021 gagagcttgc gcagcaggtg cagcaggtgg ctgacgatta tggaaaatgc tccaggttga
     1081 agagtacgtg catttacgga ggtgctccta aaggtcccca aattcgagac ttggaaagag
     1141 gtgttgagat ttgcatagcc actcctgggc gcctaataga tttcctggag tcaggaaaga
     1201 caaaccttcg ccgatgtact taccttgtgt tggatgaggc tgaccggatg cttgatatgg
     1261 gctttgagcc ccagatccgt aaaattgttg atcaaatcag gcctgaccgg cagacactga
     1321 tgtggagtgc aacctggccg aaggaagtga ggcagcttgc agaggatttc ctgcgggact
     1381 acacccagat caatgtgggc aatctggagc tgagtgccaa ccacaacatc ctacagattg
     1441 tagatgtctg tatggagagt gaaaaagacc acaaattgat ccagctgatg gaggaaatca
     1501 tggcggaaaa ggaaaataag actataatat ttgtggagac aaagaggcgc tgtgatgacc
     1561 tcacacgaag aatgcgcaga gatggttggc ctgctatgtg tatccatgga gacaagagtc
     1621 aaccagaaag agattgggta cttaatgagt tccgatctgg aaaggctcct atcctcattg
     1681 ccacggatgt agcctcccgt gggctagatg tggaagatgt caagtttgtc atcaactacg
     1741 attatccaaa cagctcagag gattatgttc accgtattgg ccgaacggcc cgcagcacca
     1801 acaagggcac tgcctatact ttctttaccc cgggcaacct gaagcaggct agagagctga
     1861 tcaaagtatt ggaagaggcc aatcaagcca tcaatccaaa attgatgcag cttgtggacc
     1921 acagaggtgg cggcggagga gggggaggcc gctcacgata ccggactact tcttcagcca
     1981 acaatcccaa tctgatgtat caggacgagt gtgaccggag gcttcgaggg gtcaaggatg
     2041 gtggccggag agattctaca agctacaggg atcgtagtga aaccgataga gccagttatg
     2101 ctaatggcag tggctatgga agcccaaatt ctgcctttgg ggcacaagca ggccaataca
     2161 cctatgctca aggcacctat ggggcagctg cctatggcac cagtggctac acggcgcagg
     2221 agtatgctgc tggcacttac ggggcgagca gcactgcctc agcagggagg agctctcaga
     2281 gctccagcca gcagtttagt gggataggcc gatctgggca gcagccacag ccactgatgt
     2341 cacagcagtt tgcacagcct ccaggagcta ccaatatgat aggctacatg gggcagactg
     2401 cttaccagta ccctccccct ccccctcccc ctcctccatc tcgcaaatga aactgcatgg
     2461 caggagtgac tcgtgcagat gaattacaca tctaaaggaa cactgtcttt tacccttcta
     2521 gaccttttca tttttatttt ttcttttctc aaccattacg gtttatcttt ttttaatgca
     2581 gatagttaaa atttcactgc caggtttctt ctgcccaccc aaaagatcca gtctataatt
     2641 acagattttg taagaaaaaa tatatataca cataactgac tggaaagaat taatttcttt
     2701 cccccagctt aatgcatgtt gaggatattg agctattttt catcttaaag gtattaggca
     2761 cttttgttgg agcctgttta tccatgggag ggtgggtagg gaaggaggga ctgctctgca
     2821 ggaagtggta tctgttcttt agactgctct ccttagggag gagccaagag ggatttccat
     2881 gcacactgcc catggtgggt ttaagttact gaagttcgat tactcaggcc tgatgaattt
     2941 ttaagactgc tttgttggtc atttggctga tggcttctta tgtgcattca acagttaaaa
     3001 attcctaatc gattctgtca tcatgccccc tccccacttg ttcctgcagt tattaaatat
     3061 taaccaggtt agtgttgagt tagaaattac atttctgagt tcaagcgttg tctttttaag
     3121 tttaaaaaac tataaagggt tgtttttact aggtagactg gcatctgggt agaggctgcc
     3181 tgggattttt atccccacat aaccaggggc catctgaaag tcattttcta gccagatcag
     3241 ccactgagcg gtaagcatca gcgctcagca gagccttccg agcagcattt agaaagcacc
     3301 tttgggaatg atggactgca agggagtggg cggatcttcc tcttaaacag tattcttaga
     3361 gtaggattga cctcatgggc tgctctgccc acttggtcag gctctcctga gcaggactgc
     3421 taaagagctt gcctcctcaa agcctggtct ctgaggtgct ttctaacagc tggaggcact
     3481 tgttctgggc tttcctttgc cctcagtttt tcacaggtag gtagtagcca tggagggctg
     3541 aagcccaggc tctccttact ctctggagtg tgaaggtagg ggtgagctcg tctcacccct
     3601 ttattaaatg ctcctggaac ttggaagagc agcagatgaa gttggaaaga aaattctgct
     3661 cttatcacct aaacaggaca ggagagcaga tgccccagcg cctctagtag atggtagtgg
     3721 tggggctagt gtgtggctgt tacctgggcc gctcaaattc attccaggga ggaggctcca
     3781 ctgcattctt tggctgtgcc ctgagggtgc ctgctccttt gtacggtaac agtcaatttt
     3841 gaggtttctt tcaggaagag aaagggatgg ttttgagggg ctcagaaaat aggattcagt
     3901 gtgtaacata acaggtaggt tgtcagcatg cttggcattc ttctgttttc cttaccgttt
     3961 tacagactat gaagctgagg ggggatggta ggcacagatg tgtggcaacc ctgctctgtg
     4021 ctctgaaacc aaagtgtgtc ctgtcttgtc tgtctctcac cctgccaaaa gcaagtgtct
     4081 aatcactgat gctgaccagc ctgttacaga tactttctac aaccaaattc agatttattt
     4141 tttattaagc attataccat gggctgtcct gtgctcctgt cactcttcaa aaacacccct
     4201 tctattactg cctccgggga tgaagcagta gctaggttgc ttaacctccc ctctccagca
     4261 gaggcataat ccagataagt agcagatgtc atatttcata agctcttttg gcctgggtac
     4321 agcagaaaac tagcagtttt cctacttggc gcaagtgact tgtgcctcct tgtctgtcct
     4381 ttgtcagcac aggtgcaggc aaacccttcc agctgggtta attgccgttt atggtttact
     4441 cacttaggga aagggcttag gtgttaggct gtgggctgct tctccctaac catccattgt
     4501 gcagacttct catctaaaaa ggttggtggc ttttgcttgg gatcagtgct ctgctaacgc
     4561 ccttgctggt ctctccacac attcctgtca ttgagacttg aattgtaggt gtgatgttat
     4621 gcacaggatg ctcagagcta tgttactact attcttagtt tgtaaattgt ccttttgata
     4681 ccatcttgtt ttcttttgta ggtataaata aatacttgac aataaaggtg tgaatttttt
     4741 attacattaa aacttaaaaa gagttt
//
