LOCUS       NM_001348292            4234 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Mus musculus DEAD/H box helicase 11 (Ddx11), transcript variant 2,
            mRNA.
ACCESSION   NM_001348292
VERSION     NM_001348292.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4234)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4234)
  AUTHORS   Cota,C.D. and Garcia-Garcia,M.J.
  TITLE     The ENU-induced cetus mutation reveals an essential role of the DNA
            helicase DDX11 for mesoderm development during early mouse
            embryogenesis
  JOURNAL   Dev Dyn 241 (8), 1249-1259 (2012)
   PUBMED   22678773
REFERENCE   3  (bases 1 to 4234)
  AUTHORS   Inoue,A., Hyle,J., Lechner,M.S. and Lahti,J.M.
  TITLE     Mammalian ChlR1 has a role in heterochromatin organization
  JOURNAL   Exp Cell Res 317 (17), 2522-2535 (2011)
   PUBMED   21854770
REFERENCE   4  (bases 1 to 4234)
  AUTHORS   Inoue,A., Li,T., Roby,S.K., Valentine,M.B., Inoue,M., Boyd,K.,
            Kidd,V.J. and Lahti,J.M.
  TITLE     Loss of ChlR1 helicase in mouse causes lethality due to the
            accumulation of aneuploid cells generated by cohesion defects and
            placental malformation
  JOURNAL   Cell Cycle 6 (13), 1646-1654 (2007)
   PUBMED   17611414
  REMARK    GeneRIF: ChlR1 is essential for embryonic development and the
            prevention of aneuploidy in mammals.
REFERENCE   5  (bases 1 to 4234)
  AUTHORS   Garcia-Garcia,M.J., Eggenschwiler,J.T., Caspary,T., Alcorn,H.L.,
            Wyler,M.R., Huangfu,D., Rakeman,A.S., Lee,J.D., Feinberg,E.H.,
            Timmer,J.R. and Anderson,K.V.
  TITLE     Analysis of mouse embryonic patterning and morphogenesis by forward
            genetics
  JOURNAL   Proc Natl Acad Sci U S A 102 (17), 5913-5919 (2005)
   PUBMED   15755804
REFERENCE   6  (bases 1 to 4234)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC079656.1, AK152868.1 and CT025671.10.
            
            Transcript Variant: This variant (2) represents the longer
            transcript and encodes the longer isoform (2).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152868.1, SRR13422603.353036.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-567               BC079656.1         1-567
            568-654             AK152868.1         477-563
            655-4228            BC079656.1         577-4150
            4229-4234           CT025671.10        17596-17601
FEATURES             Location/Qualifiers
     source          1..4234
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 35.26 cM"
     gene            1..4234
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
                     /note="DEAD/H box helicase 11"
                     /db_xref="GeneID:320209"
                     /db_xref="MGI:MGI:2443590"
     exon            1..173
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            174..321
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..2898
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
                     /EC_number="5.6.2.3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     probable ATP-dependent RNA helicase DDX11; DEAD/H
                     (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like
                     helicase homolog, S. cerevisiae); ATP-dependent DNA
                     helicase DDX11; DEAD/H (Asp-Glu-Ala-Asp/His) box helicase
                     11; DNA 5'-3' helicase DDX11"
                     /codon_start=1
                     /product="ATP-dependent DNA helicase DDX11 isoform 2"
                     /protein_id="NP_001335221.1"
                     /db_xref="CCDS:CCDS89137.1"
                     /db_xref="GeneID:320209"
                     /db_xref="MGI:MGI:2443590"
                     /translation="MADENQEIGGIHFPFPFPPYPIQKDFMAELYKVLEGGKIGIFES
                     PTGTGKSLSLICGALSWLRDFEKKKLQAEALLLAPGSGPPSSEKNSLLTSSSCQEPTD
                     TPRPAGEPDWVTEFVQKKEERDLVERLREEQVRRRKREERLKEVCQDGRLRFAAKRTK
                     HEEEETEALLRLSREMLDAGTGPEQLEQLECGEEHLVLAEYESDEERRGSRVDEAEDD
                     LEEEHITKIYYCSRTHSQLAQFVREVLKSPFGKETRLVSLGSRQTLCVNEDVKNLGSV
                     QLMNDRCVDMQRSKREKNGTGEDKPKRKRQKIQTSCPFYNHEQMELLRDEILLEVKDM
                     EQLVALGKEARACPYYGSRFAIPAAQLVVLPYPMLLHAATRQAAGIRLQGQVVIIDEA
                     HNLIDTITNIHSTEVNGSQLCQAHSQLLQYMERYRKRLKAKNLMYIKQILYLLEKFVA
                     VLGGNVKQNPTTQSLSQTGSELKSINDFLFQSQVDNINLFKVQRYLEKSMLSRKLFGF
                     TECFGVVLPSLSDSQENRGLAGFQQFLKSLQSGPTEDSPEEGQAVALRPASPLMHIEA
                     FLAALTTANQDGRVIVNRQGSVGQSSLKFLLLNPAVHFAQVVKECRAVVIAGGTMQPM
                     SDFREQLLACSGVEAGRVVEFSCGHVIPPDNILPLIICSGPSNQQLEFTYQRRELPQM
                     VEETGRILCNLCNVVPGGVVCFLPSYEYLRQVHAHWDKTGLLTRLSVRKKIFQEPKRA
                     SQVEQVLMAYSKCIMSCSHSEGHLTGALLLSVVGGKMSEGINFSDDLGRCVVMVGMPY
                     PNIKSPELQEKMAYLNQTLPRTQGQPLPGTVLIENLCMKAINQSIGRAIRHQRDFASI
                     VLLDHRYARPSILAKLPAWIRDRVEVKATFGPAFAAVRKFHREKSHPSLV"
     exon            322..567
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            568..654
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            655..809
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            810..855
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            856..963
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1051
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1257
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1410
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1457
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1537
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1582
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1650
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1689
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1810
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1933
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2046
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2119
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2223
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2373
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2442
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2543
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            2544..2628
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..2707
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            2708..2862
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            2863..4234
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3513
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
                     /note="major polyA site"
     regulatory      4207..4212
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
                     /note="hexamer: ATTAAA"
     polyA_site      4228
                     /gene="Ddx11"
                     /gene_synonym="4732462I11Rik; CHL1; CHLR1; essa15a; KRG2"
ORIGIN      
        1 ggggcgtggc cacgtggagg gttttctgcg tgcgcgcatg ctccttcagt gaaactgcag
       61 tttaaattca gccgcggcgg ccaggctcgc ttgccggcct cagtgaggcg gtcctgcggt
      121 ggcgatcgag ttcggtgctg tgtgggagaa gcgctgcgac cgaaggcaga gagggcaatg
      181 gctgacgaaa accaggagat tggtggcatc cattttcctt ttcccttccc gccctatcct
      241 atccagaaag acttcatggc agagctctac aaggttttgg aaggtggcaa gattgggata
      301 tttgaaagtc caactggcac gggaaagtcc ttaagtctga tttgtggggc cctttcctgg
      361 ctgcgtgact ttgaaaagaa gaaattgcaa gcagaggctc ttctccttgc acctggatcc
      421 ggccctccaa gtagtgagaa gaactcgctc ctgacttcct catcttgcca agaacctacg
      481 gacaccccga ggcctgctgg agagcctgac tgggtcaccg aatttgtgca gaagaaagaa
      541 gaaagggacc tggtggagag gctaagggag gagcaggtga ggaggaggaa gcgagaggag
      601 cgactgaagg aggtctgcca ggatgggagg ctcaggtttg cagccaagcg cacgaaacat
      661 gaggaagagg agactgaggc tctcctgcgc ctcagcaggg agatgctgga tgcagggaca
      721 ggaccagagc agctggagca gctggagtgt ggggaggagc acctggttct ggcagaatat
      781 gagagtgatg aggagagaag aggcagcagg gtggacgagg ctgaggatga cttggaggaa
      841 gaacatataa ccaagattta ttactgcagt cggacacact cacagctggc ccagtttgtg
      901 cgggaagtac tgaagagccc ttttggcaag gagacccggc tagtctcact tggctctagg
      961 cagacccttt gtgtgaatga agatgtgaaa aacctgggtt ctgtgcaact tatgaatgac
     1021 cgctgtgtgg acatgcaaag aagcaaacgc gaaaagaacg ggactgggga agacaagcca
     1081 aagagaaaga gacagaagat ccagacctct tgccccttct acaaccacga gcagatggag
     1141 cttctccggg atgagattct gctggaagtg aaggacatgg aacaacttgt ggcccttggg
     1201 aaggaggccc gggcctgccc ctattacgga agccgctttg ccatccctgc agcccagcta
     1261 gtggtgctac cctacccaat gttgctgcat gcagctaccc gacaggctgc gggaatccgg
     1321 ctacaaggtc aggtggtcat tattgacgag gctcacaacc tgatcgacac catcaccaac
     1381 atccacagca cagaggtcaa tggttcccag ctctgccagg cccattccca gttgctccag
     1441 tacatggaaa gatacaggaa gcgtttaaag gccaagaact tgatgtacat caagcagatc
     1501 ctgtacttgc tggagaagtt tgtggctgtt ttgggaggta atgttaagca aaatcctact
     1561 acacagagcc tgtctcaaac agggtctgag ctgaagagca tcaacgactt tctctttcag
     1621 agccaggtgg acaacatcaa cctcttcaag gtgcagcggt acttggagaa gagcatgctc
     1681 agcaggaagc tctttggctt cacagaatgt ttcggagtgg ttcttccatc cctctcagac
     1741 tctcaggaaa accgaggtct ggctggcttc cagcagttcc tgaagagcct gcagtcaggg
     1801 cctactgagg actccccgga ggagggccag gctgtagccc tgcggcctgc ctctccactg
     1861 atgcacatcg aggccttcct ggcagctctc accacagcca atcaggatgg cagggttatt
     1921 gtgaaccgcc aaggcagtgt gggtcagagc agccttaaat tcttactctt gaacccagct
     1981 gtgcactttg cccaggtggt gaaggaatgc cgagcagtgg tcattgcagg tggcaccatg
     2041 cagccgatgt ctgactttcg ggagcagctg ctggcatgtt ctggagtaga agcggggcga
     2101 gtggtggagt tttcctgtgg tcacgtgatc cctccagaca acatcttgcc ccttattata
     2161 tgcagtgggc cctctaacca gcagctggaa ttcacctacc agagaagaga gctgcctcag
     2221 atggtggagg agacaggccg cattctctgt aacttgtgca atgtggtccc tggaggtgtg
     2281 gtatgctttc tcccttctta tgagtacctg cgccaggtac atgctcactg ggacaagact
     2341 ggcctgctga cacgtttgtc tgtcaggaaa aagatatttc aagagcccaa aagagcgagc
     2401 caggtggagc aggtgctgat ggcgtattcc aagtgcatta tgagctgcag tcactcagaa
     2461 ggccatctga caggggcctt gctcctctct gtggttggag ggaagatgag tgaagggatc
     2521 aatttctctg atgacctggg ccggtgtgtg gtgatggtgg ggatgccata tcccaacatt
     2581 aagtctccag agctgcaaga gaagatggcc tacttgaatc agacacttcc taggacacaa
     2641 ggtcagcccc tgccagggac ggtattgata gagaatctgt gtatgaaggc tataaaccaa
     2701 tccataggca gggccattag gcaccagagg gactttgcca gcattgtgct cctggatcac
     2761 cggtatgcgc gtccttctat tctggcgaag ctgccagcct ggatacgaga ccgagtggag
     2821 gtcaaagcta cctttgggcc tgcatttgct gctgtgcgga agtttcatcg agagaagtca
     2881 cacccaagtc tggtataagc gtctcatacc ctgcttgacc tggcctttgt atttggccta
     2941 agaagataga aaccatatgc agactgccaa gtgtacccca gccttccaga ggcagtggac
     3001 tctagtgttc aacttgcata gaaaagccag cagaacatcc tgaaggaacc tggcccgaga
     3061 caccttattc cctgctcagg ttcaactttc cgcctggctt caggaggctg tgctagcagc
     3121 agctttctgc ctgttctgag gtgagaccca cctgcctctg ccctttctgg agacagttag
     3181 cttttcttgg cctttgactc ccatctcagg caccgatgtc cccgtttcaa gcatcattgc
     3241 ctgacccact gcagtatgac acacacacca tctgtgcaga agagagtttt gagaaaaaac
     3301 taggacatac ataatattga aagagctgac atgaattttg acttttctga aggaccatca
     3361 caaagacttg gaccctggcc atagaccttt ctgtgtccca caattttttc tccttctact
     3421 tttcctcata aactaagagg cattgatcct gtccatggct gttcaggact ctgtgctcag
     3481 aacatctacc tgaagacatg tcattgggca aaagtgtctc cgtgtttttc atttttttct
     3541 gctgtcccat gaaggagaac cccagttaag agtccagctc ctttatattc aactgtggct
     3601 gtcccttgtg tgagcttcag caacctcagg ggcagtgccc ttgccattta ggcaatacac
     3661 tggttgcata ctgcttgcaa actgagagga gccatagaag aggacttctt tttcacagtt
     3721 cttgtgccgc ttacagctca aaagaattcc attcttgaat cttcctcaga ttgaaatggt
     3781 aaggcttctc caagcagtgg tggcccacgc ctttaatccc agcacttggg aagcagaggc
     3841 aggtgaattt ctgagttcga ggccagcctg gtctacaaag tgagttccag ggcagccaag
     3901 gctatacaga gaaaccctgt cttgaaaaca aacaaacaaa caaacaaatg gtaaggcctc
     3961 atacctgagg gatagtgttt agagacagga ctcctgtagg gaggtaggga cagatttttt
     4021 tgtcactagt gtagggcttt agcatacact aaagtgcagc tagaagtccc catcatagga
     4081 ggacccagag aatggcagcc tctgtaaacc ttgaagggtt gtcactggga atccactcat
     4141 ctgttacctg ttatagcaga gttcctaggc ttacatccta ggaatgtcat ccatgtgtca
     4201 tggccgatta aaagaacaac tgaacctaca tgaa
//
