LOCUS       NM_134040               2488 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Mus musculus DEAD box helicase 1 (Ddx1), mRNA.
ACCESSION   NM_134040
VERSION     NM_134040.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2488)
  AUTHORS   Fang,X., Tang,C., Zeng,D., Shan,Y., Liu,Q., Yin,X. and Li,Y.
  TITLE     CircInpp5b Ameliorates Renal Interstitial Fibrosis by Promoting the
            Lysosomal Degradation of DDX1
  JOURNAL   Biomolecules 14 (6), 613 (2024)
   PUBMED   38927017
  REMARK    GeneRIF: CircInpp5b Ameliorates Renal Interstitial Fibrosis by
            Promoting the Lysosomal Degradation of DDX1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2488)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2488)
  AUTHORS   de Amorim,J.L., Leung,S.W., Haji-Seyed-Javadi,R., Hou,Y., Yu,D.S.,
            Ghalei,H., Khoshnevis,S., Yao,B. and Corbett,A.H.
  TITLE     The putative RNA helicase DDX1 associates with the nuclear RNA
            exosome and modulates RNA/DNA hybrids (R-loops)
  JOURNAL   J Biol Chem 300 (2), 105646 (2024)
   PUBMED   38219817
  REMARK    GeneRIF: The putative RNA helicase DDX1 associates with the nuclear
            RNA exosome and modulates RNA/DNA hybrids (R-loops).
REFERENCE   4  (bases 1 to 2488)
  AUTHORS   Wang,Y., Yasmin,L., Li,L., Gao,P., Xu,X., Sun,X. and Godbout,R.
  TITLE     DDX1 vesicles control calcium-dependent mitochondrial activity in
            mouse embryos
  JOURNAL   Nat Commun 13 (1), 3794 (2022)
   PUBMED   35778392
  REMARK    GeneRIF: DDX1 vesicles control calcium-dependent mitochondrial
            activity in mouse embryos.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2488)
  AUTHORS   Wang,F., He,J., Liu,S., Gao,A., Yang,L., Sun,G., Ding,W., Li,C.Y.,
            Gou,F., He,M., Wang,F., Wang,X., Zhao,X., Zhu,P., Hao,S., Ma,Y.,
            Cheng,H., Yu,J. and Cheng,T.
  TITLE     A comprehensive RNA editome reveals that edited Azin1 partners with
            DDX1 to enable hematopoietic stem cell differentiation
  JOURNAL   Blood 138 (20), 1939-1952 (2021)
   PUBMED   34388251
  REMARK    GeneRIF: A comprehensive RNA editome reveals that edited Azin1
            partners with DDX1 to enable hematopoietic stem cell
            differentiation.
REFERENCE   6  (bases 1 to 2488)
  AUTHORS   Sato,N., Sugimura,Y., Hayashi,Y., Murase,T., Kanou,Y., Kikkawa,F.
            and Murata,Y.
  TITLE     Identification of genes differentially expressed in mouse fetuses
            from streptozotocin-induced diabetic pregnancy by cDNA subtraction
  JOURNAL   Endocr J 55 (2), 317-323 (2008)
   PUBMED   18323671
REFERENCE   7  (bases 1 to 2488)
  AUTHORS   Bielle,F., Griveau,A., Narboux-Neme,N., Vigneau,S., Sigrist,M.,
            Arber,S., Wassef,M. and Pierani,A.
  TITLE     Multiple origins of Cajal-Retzius cells at the borders of the
            developing pallium
  JOURNAL   Nat Neurosci 8 (8), 1002-1012 (2005)
   PUBMED   16041369
REFERENCE   8  (bases 1 to 2488)
  AUTHORS   Fowles,L.F., Bennetts,J.S., Berkman,J.L., Williams,E., Koopman,P.,
            Teasdale,R.D. and Wicking,C.
  TITLE     Genomic screen for genes involved in mammalian craniofacial
            development
  JOURNAL   Genesis 35 (2), 73-87 (2003)
   PUBMED   12533789
REFERENCE   9  (bases 1 to 2488)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2488)
  AUTHORS   Godbout,R. and Squire,J.
  TITLE     Amplification of a DEAD box protein gene in retinoblastoma cell
            lines
  JOURNAL   Proc Natl Acad Sci U S A 90 (16), 7578-7582 (1993)
   PUBMED   7689221
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC010624.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010624.1, SRR1660813.128770.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2488
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N-3"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 6.4 cM"
     gene            1..2488
                     /gene="Ddx1"
                     /gene_synonym="DBP-RB"
                     /note="DEAD box helicase 1"
                     /db_xref="GeneID:104721"
                     /db_xref="MGI:MGI:2144727"
     exon            1..71
                     /gene="Ddx1"
                     /gene_synonym="DBP-RB"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..2278
                     /gene="Ddx1"
                     /gene_synonym="DBP-RB"
                     /EC_number="3.6.4.13"
                     /note="DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 1;
                     DEAD box protein 1; DEAD (Asp-Glu-Ala-Asp) box polypeptide
                     1"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase DDX1"
                     /protein_id="NP_598801.1"
                     /db_xref="CCDS:CCDS25819.1"
                     /db_xref="GeneID:104721"
                     /db_xref="MGI:MGI:2144727"
                     /translation="MAAFSEMGVMPEIAQAVEEMDWLLPTDIQAESIPLILGGGDVLM
                     AAETGSGKTGAFSIPVIQIVYETLKDQQEGKKGKTTIKTGASVLNKWQMNPYDRGSAF
                     AIGSDGLCCQSREVKEWHGCRGTRGLLKGKHYYEVSCHDQGLCRVGWSTMQASLDLGT
                     DKFGFGFGGTGKKSHNKQFDNYGEEFTMHDTIGCYLDIDKGHVKFSKNGKDLGLAFEI
                     PAHIKNQALFPACVLKNAELKFNFGEEEFKFPPKDGFVALSKAPDNYIVKSQHTGNAQ
                     VSQTKFLPNAPKALIVEPSRELAEQTLNNVKQFKKYIDNPKLRELLIIGGVAARDQLS
                     VLDNGVDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDFINRMHNQIP
                     QITCDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWVDLKGEDSVPDTVHHVVVPVNP
                     KTDKLWERLGKNHIRTDDVHAKDNTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQ
                     AIIFCRTKIDCDNLEQYFMQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKKGDV
                     RFLICTDVAARGIDIHGVPYVINVTLPDEKQNYVHRIGRVGRAERMGLAISLVATEKE
                     KVWYHVCSNRGKGCYNTRLKEDGGCTIWYNEMQLLSEIEEHLNCTISQVEPDIKVPVD
                     EFDGKVTYGQKRAAGGGNYKGHVDVLAPTVQELAALEKEAQTSFLHLGYLPNQLFRTF
                     "
     exon            72..123
                     /gene="Ddx1"
                     /gene_synonym="DBP-RB"
                     /inference="alignment:Splign:2.1.0"
     exon            124..187
                     /gene="Ddx1"
                     /gene_synonym="DBP-RB"
                     /inference="alignment:Splign:2.1.0"
     exon            188..217
                     /gene="Ddx1"
                     /gene_synonym="DBP-RB"
                     /inference="alignment:Splign:2.1.0"
     exon            218..314
                     /gene="Ddx1"
                     /gene_synonym="DBP-RB"
                     /inference="alignment:Splign:2.1.0"
     exon            315..362
                     /gene="Ddx1"
                     /gene_synonym="DBP-RB"
                     /inference="alignment:Splign:2.1.0"
     exon            363..446
                     /gene="Ddx1"
                     /gene_synonym="DBP-RB"
                     /inference="alignment:Splign:2.1.0"
     exon            447..530
                     /gene="Ddx1"
                     /gene_synonym="DBP-RB"
                     /inference="alignment:Splign:2.1.0"
     exon            531..607
                     /gene="Ddx1"
                     /gene_synonym="DBP-RB"
                     /inference="alignment:Splign:2.1.0"
     exon            608..680
                     /gene="Ddx1"
                     /gene_synonym="DBP-RB"
                     /inference="alignment:Splign:2.1.0"
     exon            681..757
                     /gene="Ddx1"
                     /gene_synonym="DBP-RB"
                     /inference="alignment:Splign:2.1.0"
     exon            758..872
                     /gene="Ddx1"
                     /gene_synonym="DBP-RB"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1011
                     /gene="Ddx1"
                     /gene_synonym="DBP-RB"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1072
                     /gene="Ddx1"
                     /gene_synonym="DBP-RB"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1171
                     /gene="Ddx1"
                     /gene_synonym="DBP-RB"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1261
                     /gene="Ddx1"
                     /gene_synonym="DBP-RB"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1450
                     /gene="Ddx1"
                     /gene_synonym="DBP-RB"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1502
                     /gene="Ddx1"
                     /gene_synonym="DBP-RB"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1649
                     /gene="Ddx1"
                     /gene_synonym="DBP-RB"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1741
                     /gene="Ddx1"
                     /gene_synonym="DBP-RB"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1814
                     /gene="Ddx1"
                     /gene_synonym="DBP-RB"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1887
                     /gene="Ddx1"
                     /gene_synonym="DBP-RB"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..1930
                     /gene="Ddx1"
                     /gene_synonym="DBP-RB"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2026
                     /gene="Ddx1"
                     /gene_synonym="DBP-RB"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2147
                     /gene="Ddx1"
                     /gene_synonym="DBP-RB"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2469
                     /gene="Ddx1"
                     /gene_synonym="DBP-RB"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcgtgtct ggaaggaggg aatcgcccgg gcccgcagcg gaggagtgcg ggaagatggc
       61 ggccttctcc gaaatgggtg ttatgccgga gattgcacaa gctgtggagg agatggattg
      121 gcttctacca actgatatcc aggcagaatc tatcccattg atcctaggag gaggggatgt
      181 actcatggct gcagaaacag gaagtggaaa aactggtgca tttagtattc ccgttatcca
      241 gatagtgtat gaaactctga aagaccaaca ggaaggaaag aaagggaaaa caactattaa
      301 aactggtgct tcagtgctca acaagtggca gatgaaccca tatgatagag ggtctgcttt
      361 tgcaattgga tcagatggtc tgtgttgtca gagcagagaa gtgaaggagt ggcatggatg
      421 cagaggaact agaggactgc tgaaagggaa gcactactat gaggtgtcct gtcatgacca
      481 agggctatgc agagttgggt ggtctaccat gcaggcttcc ttagacctag gtactgacaa
      541 gtttggattt ggcttcggtg gaacaggaaa gaaatctcat aataaacaat ttgataatta
      601 tggagaggaa ttcactatgc atgataccat tggatgttac ttagatatcg ataaagggca
      661 tgtgaagttc tctaagaatg gaaaagatct tggtctggca tttgaaatac cagcacatat
      721 aaaaaaccaa gccctcttcc ctgcctgtgt tttgaagaat gctgaattga aatttaactt
      781 tggtgaagaa gaatttaagt ttccaccaaa agatggtttt gttgctcttt ccaaggcccc
      841 agataattac atcgtcaaat ctcagcacac aggtaatgca caggtgtcac aaacaaaatt
      901 tctcccgaat gctccaaaag ctctcattgt ggaaccctcc agagagttag ctgagcaaac
      961 cttgaacaac gtcaagcagt ttaagaagta tattgataat cctaaattgc gggagcttct
     1021 cataattggt ggcgttgcgg ctcgggatca gctctctgtt ctggataatg gggttgacat
     1081 tgttgtcggt actccaggaa gattggatga tttggtgtcg actggaaagc tcaacttgtc
     1141 tcaagttaga ttcctggtcc tggatgaagc agatgggctt ctctctcaag gctactctga
     1201 cttcattaac cggatgcaca accagattcc gcagattacg tgtgatggga aaagacttca
     1261 ggtgattgtt tgctctgcta ctctgcattc ttttgatgta aagaagctat cggagaagat
     1321 aatgcatttt cccacatggg tcgatttgaa aggagaagat tctgttccag atactgtgca
     1381 tcatgtcgtt gtccctgtga accccaaaac tgacaagctt tgggaaaggc tggggaagaa
     1441 ccacattcga actgatgatg tacacgcaaa ggataacaca agacctggtg ctaacagtcc
     1501 agagatgtgg tctgaagcta ttaaaatact gaagggggag tatgctgtcc gagcaatcaa
     1561 ggaacacaag atggatcaag caattatctt ctgtagaact aaaattgact gtgataactt
     1621 ggagcagtac tttatgcagc aaggaggagg acctgacaaa aaaggacacc agttctcatg
     1681 tgtatgtctt catggtgaca gaaagcctca tgagagaaag caaaacttgg aacgatttaa
     1741 gaaaggagac gtaagattct tgatttgcac agatgtagct gctagaggga ttgatatcca
     1801 tggcgttcct tatgtgatca acgtcaccct gcctgatgag aagcagaatt atgtgcaccg
     1861 gatcggcaga gtgggacgag ctgaaaggat gggcctggct atttccctgg tggcaaccga
     1921 gaaagaaaag gtttggtatc atgtatgtag caaccgtggg aagggatgct ataacactag
     1981 actcaaggaa gatggcggct gtactatctg gtacaatgaa atgcagctac tttccgagat
     2041 agaagagcac ctgaactgca ccatttccca ggtcgagcca gatataaagg ttccagtgga
     2101 tgagtttgat gggaaagtca catacggtca aaaaagggct gctggcggtg gaaactacaa
     2161 aggccatgtg gatgtcctgg cacctaccgt tcaagagttg gctgcccttg aaaaggaagc
     2221 acagacctct ttcctacacc ttggctacct tcccaaccag ctgttccgaa ccttctgacg
     2281 tcatgtagac agaggagcat tggagtcata aagtctgtag tcttaactct aaccctctgg
     2341 tgctgctctc tgagcagcag tatttacaat aaccgagcta tcacggctaa ctctcgcatg
     2401 tcaggaaaca cagaccttag cgattctcca taaaatggca gcccaatgaa aataaacttg
     2461 acaactataa aaaaaaaaaa aaaaaaaa
//
