LOCUS       NM_010027                609 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus D-dopachrome tautomerase (Ddt), mRNA.
ACCESSION   NM_010027
VERSION     NM_010027.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 609)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 609)
  AUTHORS   Huth,S., Huth,L., Heise,R., Marquardt,Y., Lopopolo,L.,
            Piecychna,M., Boor,P., Fingerle-Rowson,G., Kapurniotu,A.,
            Yazdi,A.S., Bucala,R., Bernhagen,J. and Baron,J.M.
  TITLE     Macrophage migration inhibitory factor (MIF) and its homolog
            D-dopachrome tautomerase (D-DT) are significant promotors of UVB-
            but not chemically induced non-melanoma skin cancer
  JOURNAL   Sci Rep 13 (1), 11611 (2023)
   PUBMED   37464010
  REMARK    GeneRIF: Macrophage migration inhibitory factor (MIF) and its
            homolog D-dopachrome tautomerase (D-DT) are significant promotors
            of UVB- but not chemically induced non-melanoma skin cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 609)
  AUTHORS   Vandenbark,A.A., Meza-Romero,R., Wiedrick,J., Gerstner,G.,
            Seifert,H., Kent,G., Piechycna,M., Benedek,G., Bucala,R. and
            Offner,H.
  TITLE     'Near Cure' treatment of severe acute EAE in MIF-1-deficient female
            and male mice with a bifunctional MHCII-derived molecular construct
  JOURNAL   Cell Immunol 378, 104561 (2022)
   PUBMED   35738135
REFERENCE   4  (bases 1 to 609)
  AUTHORS   Tilstam,P.V., Schulte,W., Holowka,T., Kim,B.S., Nouws,J.,
            Sauler,M., Piecychna,M., Pantouris,G., Lolis,E., Leng,L.,
            Bernhagen,J., Fingerle-Rowson,G. and Bucala,R.
  TITLE     MIF but not MIF-2 recruits inflammatory macrophages in an
            experimental polymicrobial sepsis model
  JOURNAL   J Clin Invest 131 (23) (2021)
   PUBMED   34850744
REFERENCE   5  (bases 1 to 609)
  AUTHORS   Ma,Y., Su,K.N., Pfau,D., Rao,V.S., Wu,X., Hu,X., Leng,L., Du,X.,
            Piecychna,M., Bedi,K., Campbell,S.G., Eichmann,A., Testani,J.M.,
            Margulies,K.B., Bucala,R. and Young,L.H.
  TITLE     Cardiomyocyte d-dopachrome tautomerase protects against heart
            failure
  JOURNAL   JCI Insight 4 (17), 128900 (2019)
   PUBMED   31484822
  REMARK    GeneRIF: Cardiomyocyte d-dopachrome tautomerase protects against
            heart failure.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 609)
  AUTHORS   Wiltshire,T., Pletcher,M., Cole,S.E., Villanueva,M., Birren,B.,
            Lehoczky,J., Dewar,K. and Reeves,R.H.
  TITLE     Perfect conserved linkage across the entire mouse chromosome 10
            region homologous to human chromosome 21
  JOURNAL   Genome Res 9 (12), 1214-1222 (1999)
   PUBMED   10613844
REFERENCE   7  (bases 1 to 609)
  AUTHORS   Cole,S.E., Wiltshire,T., Rue,E.E., Morrow,D., Hieter,P., Brahe,C.,
            Fisher,E.M., Katsanis,N. and Reeves,R.H.
  TITLE     High-resolution comparative physical mapping of mouse chromosome 10
            in the region of homology with human chromosome 21
  JOURNAL   Mamm Genome 10 (3), 229-234 (1999)
   PUBMED   10051316
REFERENCE   8  (bases 1 to 609)
  AUTHORS   Kuriyama,T., Fujinaga,M., Koda,T. and Nishihira,J.
  TITLE     Cloning of the mouse gene for D-dopachrome tautomerase
  JOURNAL   Biochim Biophys Acta 1388 (2), 506-512 (1998)
   PUBMED   9858785
REFERENCE   9  (bases 1 to 609)
  AUTHORS   Esumi,N., Budarf,M., Ciccarelli,L., Sellinger,B., Kozak,C.A. and
            Wistow,G.
  TITLE     Conserved gene structure and genomic linkage for D-dopachrome
            tautomerase (DDT) and MIF
  JOURNAL   Mamm Genome 9 (9), 753-757 (1998)
   PUBMED   9716662
REFERENCE   10 (bases 1 to 609)
  AUTHORS   Cole,S.E., Wiltshire,T. and Reeves,R.H.
  TITLE     Physical mapping of the evolutionary boundary between human
            chromosomes 21 and 22 on mouse chromosome 10
  JOURNAL   Genomics 50 (1), 109-111 (1998)
   PUBMED   9628829
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF012431.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144193.1, CA457149.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..609
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 38.58 cM"
     gene            1..609
                     /gene="Ddt"
                     /note="D-dopachrome tautomerase"
                     /db_xref="GeneID:13202"
                     /db_xref="MGI:MGI:1298381"
     exon            1..159
                     /gene="Ddt"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..408
                     /gene="Ddt"
                     /EC_number="4.1.1.84"
                     /codon_start=1
                     /product="D-dopachrome decarboxylase"
                     /protein_id="NP_034157.1"
                     /db_xref="CCDS:CCDS23930.1"
                     /db_xref="GeneID:13202"
                     /db_xref="MGI:MGI:1298381"
                     /translation="MPFVELETNLPASRIPAGLENRLCAATATILDKPEDRVSVTIRP
                     GMTLLMNKSTEPCAHLLVSSIGVVGTAEQNRTHSASFFKFLTEELSLDQDRIVIRFFP
                     LEAWQIGKKGTVMTFL"
     exon            160..335
                     /gene="Ddt"
                     /inference="alignment:Splign:2.1.0"
     exon            336..609
                     /gene="Ddt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctcacccg gtgcagttac cgtttggcga tcccactctt ctcccgctaa catgccattc
       61 gttgagttgg aaacaaactt gccggctagc cgcatacccg cggggctgga gaaccggctg
      121 tgtgcggcca cagccaccat cctggacaaa cccgaagacc gcgtgagcgt tacgatacga
      181 cctggcatga ccctgttgat gaacaaatcc acagagcctt gtgctcacct tctggtctct
      241 tccatcgggg ttgtgggcac cgcggagcag aaccgcactc acagcgccag cttcttcaag
      301 ttcctcaccg aggagctgtc cctggaccag gaccggatcg ttatccgctt cttccccttg
      361 gaggcttggc agatcggaaa gaaaggaact gtcatgacat ttctgtgacg gaaacaaaga
      421 acccagggtg tttgctcgaa ccgggccaga gcccttccag agaggccctc ccggcagaat
      481 cgtggcctgg tagataggat ggtaaatccc tcttttgcct aaacgtctgc gacttcagtg
      541 gtccattttt ctcttcccca gcctcgtgaa taattgaaag agagcaaata aatgaagaga
      601 atatcattc
//
