LOCUS       NM_029832               1124 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Mus musculus DDRGK domain containing 1 (Ddrgk1), transcript variant
            1, mRNA.
ACCESSION   NM_029832 XM_485067 XM_901930 XM_901933 XM_901934 XM_918247
            XM_925578 XM_925581 XM_925583 XM_994018 XM_994040 XM_994059
            XM_994077
VERSION     NM_029832.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1124)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1124)
  AUTHORS   Jin,H., Yang,Y., Zhu,X., Zhou,Y., Xu,Y., Li,J., Qi,C., Shao,X.,
            Wu,J., Wu,S., Cai,H., Gu,L., Mou,S., Ni,Z., Li,S. and Lin,Q.
  TITLE     DDRGK1-mediated ER-phagy attenuates acute kidney injury through
            ER-stress and apoptosis
  JOURNAL   Cell Death Dis 15 (1), 63 (2024)
   PUBMED   38233375
  REMARK    GeneRIF: DDRGK1-mediated ER-phagy attenuates acute kidney injury
            through ER-stress and apoptosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1124)
  AUTHORS   Luo,H., Jiao,Q.B., Shen,C.B., Gong,W.Y., Yuan,J.H., Liu,Y.Y.,
            Chen,Z., Liu,J., Xu,X.L., Cong,Y.S. and Zhang,X.W.
  TITLE     UFMylation of HRD1 regulates endoplasmic reticulum homeostasis
  JOURNAL   FASEB J 37 (11), e23221 (2023)
   PUBMED   37795761
REFERENCE   4  (bases 1 to 1124)
  AUTHORS   Yang,X., Zhou,T., Wang,X., Xia,Y., Cao,X., Cheng,X., Cao,Y., Ma,P.,
            Ma,H., Qin,A. and Zhao,J.
  TITLE     Loss of DDRGK1 impairs IRE1alpha UFMylation in spondyloepiphyseal
            dysplasia
  JOURNAL   Int J Biol Sci 19 (15), 4709-4725 (2023)
   PUBMED   37781516
  REMARK    GeneRIF: Loss of DDRGK1 impairs IRE1alpha UFMylation in
            spondyloepiphyseal dysplasia.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1124)
  AUTHORS   Tandra,V., Anderson,T., Ayala,J.D., Weintraub,N.L., Singh,N., Li,H.
            and Li,J.
  TITLE     Ufmylation of UFBP1 Is Dispensable for Endoplasmic Reticulum Stress
            Response, Embryonic Development, and Cardiac and Intestinal
            Homeostasis
  JOURNAL   Cells 12 (15), 1923 (2023)
   PUBMED   37566002
  REMARK    GeneRIF: Ufmylation of UFBP1 Is Dispensable for Endoplasmic
            Reticulum Stress Response, Embryonic Development, and Cardiac and
            Intestinal Homeostasis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1124)
  AUTHORS   Yoo,H.M., Kang,S.H., Kim,J.Y., Lee,J.E., Seong,M.W., Lee,S.W.,
            Ka,S.H., Sou,Y.S., Komatsu,M., Tanaka,K., Lee,S.T., Noh,D.Y.,
            Baek,S.H., Jeon,Y.J. and Chung,C.H.
  TITLE     Modification of ASC1 by UFM1 is crucial for ERalpha transactivation
            and breast cancer development
  JOURNAL   Mol Cell 56 (2), 261-274 (2014)
   PUBMED   25219498
REFERENCE   7  (bases 1 to 1124)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 1124)
  AUTHORS   Lemaire,K., Moura,R.F., Granvik,M., Igoillo-Esteve,M.,
            Hohmeier,H.E., Hendrickx,N., Newgard,C.B., Waelkens,E., Cnop,M. and
            Schuit,F.
  TITLE     Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect
            pancreatic beta cells from ER stress-induced apoptosis
  JOURNAL   PLoS One 6 (4), e18517 (2011)
   PUBMED   21494687
  REMARK    GeneRIF: These data suggest that UFM1-UFBP1 participate in
            preventing endoplasmic reticulum stress-induced apoptosis in
            protein secretory cells.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1124)
  AUTHORS   Wu,J., Lei,G., Mei,M., Tang,Y. and Li,H.
  TITLE     A novel C53/LZAP-interacting protein regulates stability of
            C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and
            modulates NF-kappaB signaling
  JOURNAL   J Biol Chem 285 (20), 15126-15136 (2010)
   PUBMED   20228063
REFERENCE   10 (bases 1 to 1124)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772162.4 and AL731707.12.
            
            On Mar 24, 2023 this sequence version replaced NM_029832.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC115616.2, ERR3835353.147285.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               AL772162.4         8155-8300           c
            147-353             AL772162.4         7028-7234           c
            354-466             AL772162.4         5757-5869           c
            467-568             AL772162.4         5417-5518           c
            569-691             AL772162.4         2269-2391           c
            692-709             AL772162.4         2001-2018           c
            710-730             AL731707.12        205561-205581       c
            731-787             AL731707.12        202447-202503       c
            788-836             AL731707.12        201923-201971       c
            837-1124            AL731707.12        201296-201583       c
FEATURES             Location/Qualifiers
     source          1..1124
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.24 cM"
     gene            1..1124
                     /gene="Ddrgk1"
                     /gene_synonym="1110001I20Rik; 2600009E05Rik; Ufbp1"
                     /note="DDRGK domain containing 1"
                     /db_xref="GeneID:77006"
                     /db_xref="MGI:MGI:1924256"
     exon            1..146
                     /gene="Ddrgk1"
                     /gene_synonym="1110001I20Rik; 2600009E05Rik; Ufbp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1003
                     /gene="Ddrgk1"
                     /gene_synonym="1110001I20Rik; 2600009E05Rik; Ufbp1"
                     /note="isoform a is encoded by transcript variant 1; DDRGK
                     domain-containing protein 1; UFM1-binding protein 1
                     containing a PCI domain; UFM1-binding and PCI
                     domain-containing protein 1"
                     /codon_start=1
                     /product="DDRGK domain-containing protein 1 isoform a"
                     /protein_id="NP_084108.1"
                     /db_xref="CCDS:CCDS38243.1"
                     /db_xref="GeneID:77006"
                     /db_xref="MGI:MGI:1924256"
                     /translation="MVGPWVYLVAAVLLIGLILFLTRSRGRAAAADGEPLHNEEERAG
                     AGQVGRSLPQESEEQRTGSRPRRRRDLGSRLQAQRRAQRVAWEDGDENVGQTVIPAQE
                     EEGIEKPAEVHPTGKIGAKKLRKLEEKQARKAQREAEEAEREERKRLESQREAEWKKE
                     EERLRLKEEQKEEEERKAQEEQARREHEEYLKLKEAFVVEEEGVSETMTEEQSHSFLT
                     EFINYIKKSKVVLLEDLAFQMGLRTQDAINRIQDLLTEGTLTGVIDDRGKFIYITPEE
                     LAAVANFIRQRGRVSITELAQASNSLISWGQDLPAQASA"
     exon            147..353
                     /gene="Ddrgk1"
                     /gene_synonym="1110001I20Rik; 2600009E05Rik; Ufbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            354..466
                     /gene="Ddrgk1"
                     /gene_synonym="1110001I20Rik; 2600009E05Rik; Ufbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            467..568
                     /gene="Ddrgk1"
                     /gene_synonym="1110001I20Rik; 2600009E05Rik; Ufbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            569..691
                     /gene="Ddrgk1"
                     /gene_synonym="1110001I20Rik; 2600009E05Rik; Ufbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            692..730
                     /gene="Ddrgk1"
                     /gene_synonym="1110001I20Rik; 2600009E05Rik; Ufbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            731..787
                     /gene="Ddrgk1"
                     /gene_synonym="1110001I20Rik; 2600009E05Rik; Ufbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            788..836
                     /gene="Ddrgk1"
                     /gene_synonym="1110001I20Rik; 2600009E05Rik; Ufbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            837..1124
                     /gene="Ddrgk1"
                     /gene_synonym="1110001I20Rik; 2600009E05Rik; Ufbp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1104..1109
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddrgk1"
                     /gene_synonym="1110001I20Rik; 2600009E05Rik; Ufbp1"
                     /note="hexamer: ATTAAA"
     polyA_site      1124
                     /gene="Ddrgk1"
                     /gene_synonym="1110001I20Rik; 2600009E05Rik; Ufbp1"
                     /note="major polyA site"
ORIGIN      
        1 ctggcgatcc ggatcccgca ggcgcgctgg ctgcgctgcc cggctgtctg tcgtcatggt
       61 ggggccctgg gtgtatctgg tggcggcagt tttgctcatc ggcctgatcc tcttcctgac
      121 tcgcagccgg ggtcgggcgg cagcagctga cggagaacca ctgcacaatg aggaagagag
      181 ggcaggagca ggccaggtag gccgctcttt gccccaggag tctgaagaac agagaactgg
      241 aagcagaccc cggcgtcgga gggacttggg cagccgtcta caggcccagc gtcgagccca
      301 gcgagtggcc tgggaagacg gggatgagaa tgtgggtcaa actgttattc cagcccagga
      361 ggaagaaggc attgagaagc cagcagaagt tcacccaaca gggaaaattg gagccaagaa
      421 actacggaag ctagaggaaa aacaggctcg aaaggctcag cgagaggcag aggaggctga
      481 acgtgaagaa cggaaacgcc tagagtccca acgtgaggcc gaatggaaga aggaagagga
      541 acggcttcgc ctgaaggaag aacagaagga ggaggaagag aggaaggctc aggaggagca
      601 ggcccggcgg gagcacgagg agtacctgaa actgaaggag gccttcgtgg tagaagaaga
      661 aggtgttagc gaaaccatga ctgaggagca gtctcacagc ttcctgacag aattcatcaa
      721 ttacatcaag aagtccaagg ttgtgctttt ggaagatctg gctttccaga tgggcctaag
      781 gactcaggac gccataaacc gcatccagga cctgctgacg gaggggactc taacaggtgt
      841 gattgacgac cggggcaagt ttatctacat aaccccagag gaactggctg ccgtggccaa
      901 tttcatccga cagcggggcc gggtgtccat cacagagctt gcccaggcca gcaactccct
      961 catctcctgg ggccaggacc tccctgccca ggcttcagcc tgactccagt ccttccttga
     1021 gtgtatcctg tggcctacat gtgtcttcat ccttccctaa tgccgtcttg gggcagggat
     1081 ggaatatgac cagaaagttg tggattaaag gcctgtgaat actg
//
