LOCUS       NM_022563               8306 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus discoidin domain receptor family, member 2 (Ddr2),
            mRNA.
ACCESSION   NM_022563
VERSION     NM_022563.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8306)
  AUTHORS   Ling,S., Kwak,D., Takuwa,Y., Ge,C., Franceschi,R. and Kim,K.K.
  TITLE     Discoidin domain receptor 2 signaling through PIK3C2alpha in
            fibroblasts promotes lung fibrosis
  JOURNAL   J Pathol 262 (4), 505-516 (2024)
   PUBMED   38332727
  REMARK    GeneRIF: Discoidin domain receptor 2 signaling through PIK3C2alpha
            in fibroblasts promotes lung fibrosis.
REFERENCE   2  (bases 1 to 8306)
  AUTHORS   Akinjiyan,F.A., Ibitoye,Z., Zhao,P., Shriver,L.P., Patti,G.J.,
            Longmore,G.D. and Fuh,K.C.
  TITLE     DDR2-regulated arginase activity in ovarian cancer-associated
            fibroblasts promotes collagen production and tumor progression
  JOURNAL   Oncogene 43 (3), 189-201 (2024)
   PUBMED   37996700
  REMARK    GeneRIF: DDR2-regulated arginase activity in ovarian
            cancer-associated fibroblasts promotes collagen production and
            tumor progression.
REFERENCE   3  (bases 1 to 8306)
  AUTHORS   Bok,S., Yallowitz,A.R., Sun,J., McCormick,J., Cung,M., Hu,L.,
            Lalani,S., Li,Z., Sosa,B.R., Baumgartner,T., Byrne,P., Zhang,T.,
            Morse,K.W., Mohamed,F.F., Ge,C., Franceschi,R.T., Cowling,R.T.,
            Greenberg,B.H., Pisapia,D.J., Imahiyerobo,T.A., Lakhani,S.,
            Ross,M.E., Hoffman,C.E., Debnath,S. and Greenblatt,M.B.
  TITLE     A multi-stem cell basis for craniosynostosis and calvarial
            mineralization
  JOURNAL   Nature 621 (7980), 804-812 (2023)
   PUBMED   37730988
REFERENCE   4  (bases 1 to 8306)
  AUTHORS   Huang,X.H., Cheng,T., Mou,L., Bo,X. and Wei,X.R.
  TITLE     [Application of precision-cut lung slice technology to study the
            role of DDR2 in pulmonary fibrosis]
  JOURNAL   Sheng Li Xue Bao 75 (4), 515-520 (2023)
   PUBMED   37583038
  REMARK    GeneRIF: [Application of precision-cut lung slice technology to
            study the role of DDR2 in pulmonary fibrosis].
REFERENCE   5  (bases 1 to 8306)
  AUTHORS   Liu,Q., Wang,X., Chen,Y., Ma,X., Kang,X., He,F., Feng,D. and
            Zhang,Y.
  TITLE     Ablation of myeloid discoidin domain receptor 2 exacerbates
            arthritis and high fat diet induced inflammation
  JOURNAL   Biochem Biophys Res Commun 649, 47-54 (2023)
   PUBMED   36745969
  REMARK    GeneRIF: Ablation of myeloid discoidin domain receptor 2
            exacerbates arthritis and high fat diet induced inflammation.
REFERENCE   6  (bases 1 to 8306)
  AUTHORS   Sommers,C.L., Huang,K., Shores,E.W., Grinberg,A., Charlick,D.A.,
            Kozak,C.A. and Love,P.E.
  TITLE     Murine txk: a protein tyrosine kinase gene regulated by T cell
            activation
  JOURNAL   Oncogene 11 (2), 245-251 (1995)
   PUBMED   7542761
REFERENCE   7  (bases 1 to 8306)
  AUTHORS   Edelhoff,S., Lai,C. and Disteche,C.M.
  TITLE     Mapping of the receptor protein-tyrosine kinase 10 to human
            chromosome 1q21-q23 and mouse chromosome 1H1-5 by fluorescence in
            situ hybridization
  JOURNAL   Genomics 25 (1), 337-339 (1995)
   PUBMED   7774952
REFERENCE   8  (bases 1 to 8306)
  AUTHORS   Ruiz,J.C., Conlon,F.L. and Robertson,E.J.
  TITLE     Identification of novel protein kinases expressed in the myocardium
            of the developing mouse heart
  JOURNAL   Mech Dev 48 (3), 153-164 (1994)
   PUBMED   7893599
REFERENCE   9  (bases 1 to 8306)
  AUTHORS   Lai,C. and Lemke,G.
  TITLE     Structure and expression of the Tyro 10 receptor tyrosine kinase
  JOURNAL   Oncogene 9 (3), 877-883 (1994)
   PUBMED   8108131
REFERENCE   10 (bases 1 to 8306)
  AUTHORS   Lai,C. and Lemke,G.
  TITLE     An extended family of protein-tyrosine kinase genes differentially
            expressed in the vertebrate nervous system
  JOURNAL   Neuron 6 (5), 691-704 (1991)
   PUBMED   2025425
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            X76505.1, AC139673.9 and AI838577.1.
            
            On Oct 19, 2007 this sequence version replaced NM_022563.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253014.1035579.1,
                                           SRR17253013.524874.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2939              X76505.1           308-3246
            2940-7986           AC139673.9         210391-215437       c
            7987-8306           AI838577.1         1-320               c
FEATURES             Location/Qualifiers
     source          1..8306
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 76.84 cM"
     gene            1..8306
                     /gene="Ddr2"
                     /gene_synonym="Ntrkr3; tyro10"
                     /note="discoidin domain receptor family, member 2"
                     /db_xref="GeneID:18214"
                     /db_xref="MGI:MGI:1345277"
     exon            1..150
                     /gene="Ddr2"
                     /gene_synonym="Ntrkr3; tyro10"
                     /inference="alignment:Splign:2.1.0"
     exon            151..259
                     /gene="Ddr2"
                     /gene_synonym="Ntrkr3; tyro10"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..2742
                     /gene="Ddr2"
                     /gene_synonym="Ntrkr3; tyro10"
                     /EC_number="2.7.10.1"
                     /note="discoidin domain-containing receptor 2; discoidin
                     domain receptor 2; tyrosine-protein kinase TYRO10; CD167
                     antigen-like family member B; receptor protein-tyrosine
                     kinase TKT; neurotrophic tyrosine kinase, receptor-related
                     3"
                     /codon_start=1
                     /product="discoidin domain-containing receptor 2
                     precursor"
                     /protein_id="NP_072075.2"
                     /db_xref="CCDS:CCDS48436.1"
                     /db_xref="GeneID:18214"
                     /db_xref="MGI:MGI:1345277"
                     /translation="MIPIPRMPLVLLLLLLILGSAKAQVNPAICRYPLGMSGGHIPDE
                     DITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVQPDDLKEFLQIDLRTLHFITLVGT
                     QGRHAGGHGIEFAPMYKINYSRDGSRWISWRNRHGKQVLDGNSNPYDVFLKDLEPPIV
                     ARFVRLIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYD
                     GAVGYSMTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGFIEIMFEFD
                     RIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPTAVYFPLVLDDVNPSARFV
                     TVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAMYNNSGALPTSPMAPTTYDPMLK
                     VDDSNTRILIGCLVAIIFILLAIIVIILWRQFWQKMLEKASRRMLDDEMTVSLSLPSE
                     SSMFNNNRSSSPSEQESNSTYDRIFPLRPDYQEPSRLIRKLPEFAPGEEESGCSGVVK
                     PAQPNGPEGVPHYAEADIVNLQGVTGGNTYCVPAVTMDLLSGKDVAVEEFPRKLLAFK
                     EKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLK
                     EIKIMSRLKDPNIIRLLAVCITEDPLCMITEYMENGDLNQFLSRHEPLSSCSSDATVS
                     YANLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYY
                     RIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIE
                     NTGEFFRDQGRQIYLPQPALCPDSVYKLMLSCWRRETKHRPSFQEIHLLLLQQGAE"
     exon            260..362
                     /gene="Ddr2"
                     /gene_synonym="Ntrkr3; tyro10"
                     /inference="alignment:Splign:2.1.0"
     exon            363..594
                     /gene="Ddr2"
                     /gene_synonym="Ntrkr3; tyro10"
                     /inference="alignment:Splign:2.1.0"
     exon            595..742
                     /gene="Ddr2"
                     /gene_synonym="Ntrkr3; tyro10"
                     /inference="alignment:Splign:2.1.0"
     exon            743..848
                     /gene="Ddr2"
                     /gene_synonym="Ntrkr3; tyro10"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1032
                     /gene="Ddr2"
                     /gene_synonym="Ntrkr3; tyro10"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1276
                     /gene="Ddr2"
                     /gene_synonym="Ntrkr3; tyro10"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1339
                     /gene="Ddr2"
                     /gene_synonym="Ntrkr3; tyro10"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1470
                     /gene="Ddr2"
                     /gene_synonym="Ntrkr3; tyro10"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1681
                     /gene="Ddr2"
                     /gene_synonym="Ntrkr3; tyro10"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1905
                     /gene="Ddr2"
                     /gene_synonym="Ntrkr3; tyro10"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2033
                     /gene="Ddr2"
                     /gene_synonym="Ntrkr3; tyro10"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2222
                     /gene="Ddr2"
                     /gene_synonym="Ntrkr3; tyro10"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2457
                     /gene="Ddr2"
                     /gene_synonym="Ntrkr3; tyro10"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2607
                     /gene="Ddr2"
                     /gene_synonym="Ntrkr3; tyro10"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..8290
                     /gene="Ddr2"
                     /gene_synonym="Ntrkr3; tyro10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8270..8275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddr2"
                     /gene_synonym="Ntrkr3; tyro10"
                     /note="hexamer: ATTAAA"
     polyA_site      8290
                     /gene="Ddr2"
                     /gene_synonym="Ntrkr3; tyro10"
                     /note="major polyA site"
ORIGIN      
        1 ggaaatctac aagcgacctg acatttggtg ctctagagca ttctaaggct tgctgcttga
       61 cttctaaaga agctgaaata attgaggagg agcggggacc ctctgtttcc aaggactctg
      121 ttctgcagag aatgttctgc accctctgat actccagatc caactccgtc ttctgaaatg
      181 atcccgattc ccagaatgcc cctggtgctg ctcctgctct tgctcatcct gggttctgca
      241 aaagctcagg ttaatccagc catatgccgc tatcctctgg gcatgtcagg aggccacatt
      301 ccagatgagg acatcacagc ctcaagtcag tggtcagaat ccacggctgc caaatatggg
      361 aggctggact ctgaagaagg agatggagcc tggtgtcctg agattccagt gcaacccgat
      421 gacctgaagg aatttctgca gattgacttg cgaaccctac actttatcac tcttgtgggg
      481 acccaggggc gccatgcagg gggtcatggc attgaatttg cacccatgta caagatcaac
      541 tacagtcggg atggcagtcg ctggatctcc tggcgtaacc ggcatgggaa gcaggtgctt
      601 gatggaaaca gtaaccctta tgatgtattc ctgaaggact tggagccacc catcgtcgcc
      661 agatttgttc gccttatccc agtcactgac cactccatga acgtgtgcat gagggttgag
      721 ctttatggtt gtgtctggct agatggcttg gtatcctaca atgctccagc tggacagcag
      781 tttgtactcc ctggaggctc catcatttat ctgaatgatt ctgtctatga tggagctgtt
      841 gggtacagca tgactgaagg gctaggccag ttgactgatg gagtatccgg cctggatgat
      901 tttacccaga cccatgaata ccacgtgtgg cctggctatg actacgtggg atggcggaac
      961 gaaagtgcta ccaacggttt cattgagatc atgtttgaat ttgaccgaat caggaatttt
     1021 actaccatga aggtccactg caacaacatg tttgctaaag gtgtgaagat ttttaaggag
     1081 gtccagtgct actttcgctc ggaagccagc gagtgggaac ccactgctgt ctactttccc
     1141 ctggtcctgg acgatgtgaa ccccagtgcc cggtttgtca cggtgcccct ccaccaccga
     1201 atggccagtg ccatcaagtg ccaataccat tttgccgaca cgtggatgat gttcagcgag
     1261 atcactttcc aatcagatgc tgcaatgtat aacaactctg gagcccttcc cacctctcct
     1321 atggcaccca ccacctatga tcccatgctt aaagttgatg atagcaacac tcggatcctg
     1381 attggttgct tggtggccat catcttcatc ctgctggcta tcatcgtcat catcctgtgg
     1441 aggcagttct ggcagaagat gctagaaaag gcttcacgga ggatgctgga tgatgaaatg
     1501 acagtcagcc tttccctgcc cagcgagtcc agcatgttca ataacaaccg ctcctcatca
     1561 ccaagtgaac aggagtccaa ctctacttat gatcgaatct tcccccttcg ccctgactac
     1621 caggagccat ccagactgat ccgaaagctt ccagagtttg ctccaggaga ggaggagtca
     1681 gggtgcagtg gtgttgtgaa gccggcccag cccaatggac ctgagggcgt gccccactat
     1741 gcagaagccg acatagtgaa tctccaggga gtgacaggtg gcaacaccta ctgtgtgcct
     1801 gctgtaacca tggatctgct atcggggaaa gatgtggctg tggaagagtt ccccaggaaa
     1861 ctgttggcct tcaaggagaa gctgggagaa ggccagtttg gggaggttca tctctgtgaa
     1921 gtggagggaa tggaaaaatt caaagacaaa gattttgcac tagatgtcag tgccaaccag
     1981 cctgtcctgg tggccgtgaa aatgctccga gcagatgcca acaagaatgc caggaatgat
     2041 tttcttaagg agatcaagat catgtctcgg ctcaaggacc caaacatcat ccgtctctta
     2101 gctgtgtgca tcactgagga cccgctctgc atgatcacgg aatacatgga gaatggagat
     2161 cttaatcagt ttctttctcg ccacgagcct ctgagttcct gttctagtga tgccacagtc
     2221 agttacgcca acctgaagtt tatggcaacc cagattgcct ctggtatgaa gtacctttcg
     2281 tctctcaact ttgtccaccg agatctggcc acacgaaact gtttagtggg caagaattac
     2341 accatcaaga tagctgattt tggcatgagc agaaacctgt acagtggtga ttactaccgg
     2401 atccagggcc gggcggtgct ccccattcgc tggatgtcct gggaaagcat cttgctgggc
     2461 aaattcacca cggcaagtga tgtgtgggcc tttggggtga ctctgtggga gaccttcacc
     2521 ttttgccagg agcagcccta ttcccagctg tcggatgagc aggttatcga gaacactgga
     2581 gagttcttcc gagaccaagg gaggcagatc tatctccctc aaccagccct ttgccccgac
     2641 tctgtgtata agctgatgct cagctgctgg agaagagaaa ccaagcaccg gccatccttc
     2701 caggaaatac acctcctgct tcttcagcaa ggagccgagt gatgatgcat cagcacctgg
     2761 cagtgttcct gtggcccaga tccttcccac aagacctact gctcacccac atctaagcca
     2821 ctccagctgg acattcaatg gacccgagag acagagaatt agtcactctg ccctctctgt
     2881 cccttgcctc ctccactaca cctccctgct ccctactatt gactcatata tactttttta
     2941 catgaaataa ctaaaagaag aaaaaaaaat atagagcaga tattagtaaa agaaatgtta
     3001 cttgatatac caaatggtta gataatgaag actagaaact cagataattt ataaaggtta
     3061 tgcttctgtt tataagtgtg cagatcctac aatatttttc cgtgtcactt tctgtaaaat
     3121 acctttagaa agaaaaactt gaagaatatg aatgtcttga gaaacatgag attaggctta
     3181 aggaaaatac ttagaggtaa tgaagaattg caggacttgg cattccacaa caaatggatg
     3241 attttctgat ttggacgtga ctctcagatc tctctgtctc tgtctctgtc tctgtctctc
     3301 tcctctctct ctctctctct ctctctctct ctctctctct ctctctctct ctctctctct
     3361 ctctctctct cgtcaaagtg agtggcatgt acttaaaaac ctctatcttg tgtcttggaa
     3421 tgaatgtttt cttcaatcat ggccagagat cagagcctac ccatgaaaca gggcatatgg
     3481 atagaaagaa atgtctgttg taaggcttga agtaggacac agaaagggaa agattgcaca
     3541 agcttcccgg tagaccatgg tcataggaaa gaaggtcctc ggaggatgac tcgcaagtgt
     3601 actatttgtt gttcatctgt gagggtcttc acctgtgtgt tctagtgaca acttgacttt
     3661 actctgtaaa gcctcaagtt ttgatatttt aatggttgct ccatcagttc ctcttgtcca
     3721 gttctatatc tttcactatg tgatgccttt gtgggattta tagactaggg cttcaacttc
     3781 tcaggcacaa gtatccaatg tcatgtccaa tatacaagag atatgtttag agtgtttcca
     3841 aaagtttggc caagacccct ggaaaaagtt ataggaagac tgatttccac ttttgggaaa
     3901 atatggaaat agaacatatg caggtggggg ttttcccaga gatggggaat ctctcatctc
     3961 cgaaaagttt cagatactag ctgaagaact ctgcagggaa gaggttgttg actactgggt
     4021 atatatgtat gggataataa aaggatgacc atttggtgtt actgaaagtg cttttgccaa
     4081 agagagggtg gccagcggca aagcatgaag ttcttttctg gctttgggat tcacgagaac
     4141 tgatgcatga tcaagcagga gtcaccttag tgactaactt agtgacccta agttttcatc
     4201 cttcacagac tctaagattc agcagcaatc tacactacaa aacccttaaa tcctatagag
     4261 gaaaccaagc tgaggtaaaa tagtggtgat ctgcttctgt ctatccagtc agcttgctcc
     4321 atggtctctt agaaacctga gagcttcttg gttcagcctt cagcatggct acaggacaca
     4381 gcagatgtat aactctaagt cttgacatta atttcataga tcccattcgc tcacagcaca
     4441 tttacctcct ctcccatggc ttttctacca ttctcagcaa gactaacttc gatcccagag
     4501 gtaggagaga acattggatt gggaactctg gccctgtgct gcctcaagcc aagtatgtca
     4561 ttttcccaag tcttgcttct ctctgaattt gttttcttat ctgtctcaaa ggaaaaccga
     4621 atctatgatt taggaatctc ttggagtttt gctttgtttt gtgcttgctg gagaactaga
     4681 tttgtggttg atgtaggttc agttactgct cagacaattg tggccagtaa tagtgatccc
     4741 gagagacatc atttaagtaa gagcaacacc tgcattatat ctgctttaga gtgaccagtg
     4801 ctgcttcacg ttatctcatt tgatagttct agggccagac atgtttcttt cacaactctt
     4861 gactatatac tcttcaggat tctgccccca gttcactgta ttcctttaca aatgaaattt
     4921 ccaggacttt gctttatgga actaatctat cccagatggc tatcaaatat gtatcttcat
     4981 gtacaggcac tttgtttttg gtatgaagaa ggttccacct tctggcactg aaacctttgt
     5041 attacagaca caggtttagt ttctagttac actagtagag tttagcagta caggtctgag
     5101 tagccaacca tggtagaagg taaagactta ctctgtagac aggtagctca aatctaaact
     5161 agggaaatga aggtaggttt tggaaaagaa agcagaaaca gatgagaaac tgtgggatct
     5221 tgttatttcc ccaagtaact cgtgatcacg atatatgtga accatttatg tcaagatgtc
     5281 ctttagacta tcatatttca atttatacct ttattgatga atgcatacat taaccaggtc
     5341 catttatgtt tttattattg gggatcatac ccagaactca catttgctag gcatgggtcc
     5401 tgtcattgat ctatgttcaa atcttgatct ggtgaccaga taaatgtgta accatgtcac
     5461 atatgtgacc tggagtggaa atgagtgccc agaggagagc atgcattgtt ggagctgtgg
     5521 aaagattgtc tgtgaacgct caaaactgta atacaaaaga gggctgtatg caagtatgtg
     5581 agtagtgttt ttttttttta agttgttaca tgaatgtgtg tgtgtggctg gaaggagagg
     5641 atgggtagaa aataagaaag aaggcacagt gaaaagaggc aaggagaggt tctggggaag
     5701 atatggggtg aggcaagtca aacgtggtag agacagggtt ggctggaggc catgaagtca
     5761 acgctgatgc atgccaagag atctgagaga ggttagaaaa agtgacttgg gaagaatgga
     5821 gggtaggtaa aggagaaatg ctgggtgaag gagcctgtct ttagtaaatc gatgtcaggt
     5881 acaccgtagg taatgcaagg gatttttgta gagttgaaga aggacatggt cttcatggat
     5941 atagaaacat gtggccacca gaaccattag ggagtcacct attcatctca ggaagtgggt
     6001 acagaaggca tttcgctctc ctgtgggttc tagaccacat gtagggttgg tgacaatgct
     6061 gtctgcgcac tggcctttgg tgttccatgt gctgttgggg catgaaggtg tatgagcgtt
     6121 tggtagttac caaatacact ttcaataatg ctcatccttc catggtctaa aatggccaca
     6181 gcaaacatgg aaacaatagg tgtaagttag acaatactaa gtttcatctg atctttgaca
     6241 gaggggtgtg ccatattgga aacatgtttt ccacacaggc accccacaag aacagtgtga
     6301 tgtgggcgta gaccatgtgt tttaagtaaa gaggaaatca gggggcgtgt caggatgaag
     6361 ggaatgtggg aagatgttcc gaagacatgc actagaaaac agaacggtgt ctgttttcgt
     6421 ccagtactaa atgaaaagaa ttgcaataca ttgcttattg caatttttat cctaagttga
     6481 atccatgagc ctggtgcttg cagcatagtt tttttgtttt gttttgaagc ctatgtcctt
     6541 gggcactgtg tggggcaagg ccctgatgtt ttggcaacat gcagattctg gtctcctgga
     6601 aaccttcata ttctttcata ttctagaaac agatgaatgt cattggcact tggtgaatta
     6661 attagaatcc tgagctaaga gggaaggaag ctgggtagtg acgaaggact tgagtaggct
     6721 ggcaggaaag gactggggag ggaccattta gttgtcccgt gtttttcaga aatttctcat
     6781 tttgcaatga tctgagactt gaaagaagtt acaaaagaat cagcacctta ccttggttct
     6841 gttttccaca cactgaaaat atttcagtct attttcatct atttggacca ttttcaaaac
     6901 taaaccctag gcccggcttg gctttcacca gttttcctac attgtattca gttgctcact
     6961 ggatactttt agcctttgtt ggtttgtaat ctggctttgg tggcatacag gataaaggat
     7021 tctacctaga tattactcta caaatgagag aaaacatcaa actgacaagc tcttttatca
     7081 gggaccagta ctccagctgt ttgctgaacc cactttcgat tacagctcat cattgctgga
     7141 cccagaacgg ccacagcgtt acacgggagt catatgtaat gatcagctct gctgtttggc
     7201 cacccaaaca atccaaggac aacttaagaa aagtaacaat ataaaaggct tcaaagtgga
     7261 agggaattgt aaacagaaga acgggacttt tgttggtgac cagaggggtc tatgataaag
     7321 cggtactttg gtcaagaatt aagtggtact gaatggaggt agggatagtt tgtggctaga
     7381 ctatggcaca aatataaacc cctaatgtga ggttaaaaca ctgtctttgg aggaccagag
     7441 gagcttcatt cgcctaactg ttcatcctta attgtaatat cagctgctaa gctaaatgca
     7501 aacacatcag ctccctgggg aaaagttgaa actctcgttt cttggaccat tactttgggt
     7561 ttcctgctag acatttttaa gctgccttgc ttaagggcta caggataaca actgtctgtg
     7621 gcttatgaga ttcctagcac acaaatgagt agtttgtgta tgttatattt ttaatgaata
     7681 aagagtggaa aaattatgta tcacatgtgt taatttgggg agaagcgctt tataacagag
     7741 ggcttactct caaagagaac aaaggaaaac gtgttctaca gacagtgtat acctttgacc
     7801 tctgaaaaaa gctatatagt ttctcctaca gacaccttgc cagtaacctt acaggtctta
     7861 taggagagca gatccaagtt gccaggctga tctgcaagca caaacatttg tcaagggaaa
     7921 gcacaggtcg ttactttcag tacaaaatgg ttctttgcta tggatggatt ctcttcttct
     7981 tgccccatgt cctgttccca aggaccgact tcctgcagca ctgtggtgga ctcttctatg
     8041 aggagacaac atctgggcct tattcaatag cctgtggtgg gtaatgtgtt ttgtcaagag
     8101 ctaaacagca aatggattta atttctgctt aacatggtca tagtcattct gaaatggcta
     8161 cagaaatatt ctctgtacta gaaaaaggaa tggaacgtgg tgccaattgt ctattttcct
     8221 ttatttattc cctgtaagtc tgtcagatga taaattgtac ataacagtga ttaaagagtc
     8281 atgctactga aaaaaaaaaa aaaaaa
//
