LOCUS       NM_001198833            3758 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus discoidin domain receptor family, member 1 (Ddr1),
            transcript variant 4, mRNA.
ACCESSION   NM_001198833
VERSION     NM_001198833.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3758)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3758)
  AUTHORS   Jiang,D., Gao,X., Tan,R., Liu,X., Zhu,Y. and Zhang,L.
  TITLE     Euphorbia factor L1 suppresses breast cancer liver metastasis via
            DDR1-mediated immune infiltration
  JOURNAL   Aging (Albany NY) 15 (17), 9217-9229 (2023)
   PUBMED   37709489
  REMARK    GeneRIF: Euphorbia factor L1 suppresses breast cancer liver
            metastasis via DDR1-mediated immune infiltration.
REFERENCE   3  (bases 1 to 3758)
  AUTHORS   Li,H., Li,J., Bai,Z., Yan,S. and Li,J.
  TITLE     Collagen-induced DDR1 upregulates CXCL5 to promote neutrophil
            extracellular traps formation and Treg infiltration in breast
            cancer
  JOURNAL   Int Immunopharmacol 120, 110235 (2023)
   PUBMED   37201403
  REMARK    GeneRIF: Collagen-induced DDR1 upregulates CXCL5 to promote
            neutrophil extracellular traps formation and Treg infiltration in
            breast cancer.
REFERENCE   4  (bases 1 to 3758)
  AUTHORS   Mei,R., Qiu,W., Yang,Y., Xu,S., Rao,Y., Li,Q., Luo,Y., Huang,H.,
            Yang,A., Tao,H., Qiu,M. and Zhao,X.
  TITLE     Evidence That DDR1 Promotes Oligodendrocyte Differentiation during
            Development and Myelin Repair after Injury
  JOURNAL   Int J Mol Sci 24 (12), 10318 (2023)
   PUBMED   37373466
  REMARK    GeneRIF: Evidence That DDR1 Promotes Oligodendrocyte
            Differentiation during Development and Myelin Repair after Injury.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3758)
  AUTHORS   Stevenson,M., Varghese,R., Hebron,M.L., Liu,X., Ratliff,N.,
            Smith,A., Turner,R.S. and Moussa,C.
  TITLE     Inhibition of discoidin domain receptor (DDR)-1 with nilotinib
            alters CSF miRNAs and is associated with reduced inflammation and
            vascular fibrosis in Alzheimer's disease
  JOURNAL   J Neuroinflammation 20 (1), 116 (2023)
   PUBMED   37194065
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3758)
  AUTHORS   Bozza,M., Kolakowski,L.F. Jr., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G., David,J.R. and Gerard,C.
  TITLE     Structural characterization and chromosomal location of the mouse
            macrophage migration inhibitory factor gene and pseudogenes
  JOURNAL   Genomics 27 (3), 412-419 (1995)
   PUBMED   7558021
REFERENCE   7  (bases 1 to 3758)
  AUTHORS   Edelhoff,S., Sweetser,D.A. and Disteche,C.M.
  TITLE     Mapping of the NEP receptor tyrosine kinase gene to human
            chromosome 6p21.3 and mouse chromosome 17C
  JOURNAL   Genomics 25 (1), 309-311 (1995)
   PUBMED   7774938
REFERENCE   8  (bases 1 to 3758)
  AUTHORS   Sanchez,M.P., Tapley,P., Saini,S.S., He,B., Pulido,D. and
            Barbacid,M.
  TITLE     Multiple tyrosine protein kinases in rat hippocampal neurons:
            isolation of Ptk-3, a receptor expressed in proliferative zones of
            the developing brain
  JOURNAL   Proc Natl Acad Sci U S A 91 (5), 1819-1823 (1994)
   PUBMED   8127887
REFERENCE   9  (bases 1 to 3758)
  AUTHORS   Perez,J.L., Shen,X., Finkernagel,S., Sciorra,L., Jenkins,N.A.,
            Gilbert,D.J., Copeland,N.G. and Wong,T.W.
  TITLE     Identification and chromosomal mapping of a receptor tyrosine
            kinase with a putative phospholipid binding sequence in its
            ectodomain
  JOURNAL   Oncogene 9 (1), 211-219 (1994)
   PUBMED   8302582
REFERENCE   10 (bases 1 to 3758)
  AUTHORS   Gilardi-Hebenstreit,P., Nieto,M.A., Frain,M., Mattei,M.G.,
            Chestier,A., Wilkinson,D.G. and Charnay,P.
  TITLE     An Eph-related receptor protein tyrosine kinase gene segmentally
            expressed in the developing mouse hindbrain
  JOURNAL   Oncogene 7 (12), 2499-2506 (1992)
   PUBMED   1281307
  REMARK    Erratum:[Oncogene. 1993 Apr;8(4):1103.. PMID: 8455939]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY062785.1, AK143088.1, BC037108.1 and L57509.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR,
            compared to variant 1. Variants 1, 3, and 4 encode the same protein
            (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF026259.1, SRR13948564.3484605.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-281               BY062785.1         2-282
            282-1709            AK143088.1         231-1658
            1710-2877           BC037108.1         1845-3012
            2878-3746           AK143088.1         2716-3584
            3747-3758           L57509.1           3663-3674
FEATURES             Location/Qualifiers
     source          1..3758
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.7 cM"
     gene            1..3758
                     /gene="Ddr1"
                     /gene_synonym="6030432F18; Cak; CD167a; Nep; PTK3A"
                     /note="discoidin domain receptor family, member 1"
                     /db_xref="GeneID:12305"
                     /db_xref="MGI:MGI:99216"
     exon            1..160
                     /gene="Ddr1"
                     /gene_synonym="6030432F18; Cak; CD167a; Nep; PTK3A"
                     /inference="alignment:Splign:2.1.0"
     exon            161..290
                     /gene="Ddr1"
                     /gene_synonym="6030432F18; Cak; CD167a; Nep; PTK3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..2938
                     /gene="Ddr1"
                     /gene_synonym="6030432F18; Cak; CD167a; Nep; PTK3A"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 4; epithelial discoidin domain-containing receptor
                     1; tyrosine kinase DDR; tyrosine-protein kinase CAK;
                     protein-tyrosine kinase MPK-6; CD167 antigen-like family
                     member A; discoidin receptor tyrosine kinase; epithelial
                     discoidin domain receptor 1; cell adhesion kinase"
                     /codon_start=1
                     /product="epithelial discoidin domain-containing receptor
                     1 isoform 1 precursor"
                     /protein_id="NP_001185762.1"
                     /db_xref="CCDS:CCDS28703.1"
                     /db_xref="GeneID:12305"
                     /db_xref="MGI:MGI:99216"
                     /translation="MGTGTLSSLLLLLLLVTIGDADMKGHFDPAKCRYALGMQDRTIP
                     DSDISVSSSWSDSTAARHSRLESSDGDGAWCPAGPVFPKEEEYLQVDLRRLHLVALVG
                     TQGRHAGGLGKEFSRSYRLRYSRDGRRWMDWKDRWGQEVISGNEDPGGVVLKDLGPPM
                     VARLVRFYPRADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMQLSEVMVHLNDSTYD
                     GYTAGGLQYGGLGQLADGVVGLDDFRQSQELRVWPGYDYVGWSNQSFPTGYVEMEFEF
                     DRLRTFQTMQVHCNNMHTLGARLPGGVECRFKRGPAMAWEGEPVRHALGGSLGDPRAR
                     AISVPLGGHVGRFLQCRFLFAGPWLLFSEISFISDVVNDSSDTFPPAPWWPPGPPPTN
                     FSSLELEPRGQQPVAKAEGSPTAILIGCLVAIILLLLLIIALMLWRLHWRRLLSKAER
                     RVLEEELTVHLSVPGDTILINNRPGPREPPPYQEPRPRGTPPHSAPCVPNGSALLLSN
                     PAYRLLLATYARPPRGPGPPTPAWAKPTNTQACSGDYMEPEKPGAPLLPPPPQNSVPH
                     YAEADIVTLQGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHL
                     CEVEDPQDLVSSDFPISVHKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNI
                     IRLLGVCVQDDPLCMITDYMENGDLNQFLSARQLENKATQGLSGDTESDQGPTISYPM
                     LLHVGAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQ
                     GRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRSQPFGQLTDEQVIENAG
                     EFFRDQGRQVYLSRPPACPQTLYELMLRCWSREPEQRPPFAQLHRFLADDALNTV"
     exon            291..393
                     /gene="Ddr1"
                     /gene_synonym="6030432F18; Cak; CD167a; Nep; PTK3A"
                     /inference="alignment:Splign:2.1.0"
     exon            394..622
                     /gene="Ddr1"
                     /gene_synonym="6030432F18; Cak; CD167a; Nep; PTK3A"
                     /inference="alignment:Splign:2.1.0"
     exon            623..770
                     /gene="Ddr1"
                     /gene_synonym="6030432F18; Cak; CD167a; Nep; PTK3A"
                     /inference="alignment:Splign:2.1.0"
     exon            771..873
                     /gene="Ddr1"
                     /gene_synonym="6030432F18; Cak; CD167a; Nep; PTK3A"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1060
                     /gene="Ddr1"
                     /gene_synonym="6030432F18; Cak; CD167a; Nep; PTK3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1307
                     /gene="Ddr1"
                     /gene_synonym="6030432F18; Cak; CD167a; Nep; PTK3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1391
                     /gene="Ddr1"
                     /gene_synonym="6030432F18; Cak; CD167a; Nep; PTK3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1543
                     /gene="Ddr1"
                     /gene_synonym="6030432F18; Cak; CD167a; Nep; PTK3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1709
                     /gene="Ddr1"
                     /gene_synonym="6030432F18; Cak; CD167a; Nep; PTK3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1820
                     /gene="Ddr1"
                     /gene_synonym="6030432F18; Cak; CD167a; Nep; PTK3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..2065
                     /gene="Ddr1"
                     /gene_synonym="6030432F18; Cak; CD167a; Nep; PTK3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2193
                     /gene="Ddr1"
                     /gene_synonym="6030432F18; Cak; CD167a; Nep; PTK3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2412
                     /gene="Ddr1"
                     /gene_synonym="6030432F18; Cak; CD167a; Nep; PTK3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..2647
                     /gene="Ddr1"
                     /gene_synonym="6030432F18; Cak; CD167a; Nep; PTK3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2797
                     /gene="Ddr1"
                     /gene_synonym="6030432F18; Cak; CD167a; Nep; PTK3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2798..3749
                     /gene="Ddr1"
                     /gene_synonym="6030432F18; Cak; CD167a; Nep; PTK3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3710..3715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddr1"
                     /gene_synonym="6030432F18; Cak; CD167a; Nep; PTK3A"
                     /note="hexamer: AATAAA"
     polyA_site      3749
                     /gene="Ddr1"
                     /gene_synonym="6030432F18; Cak; CD167a; Nep; PTK3A"
                     /note="major polyA site"
ORIGIN      
        1 tggctcctct ccccggaaca ggcccccgac agctgctcgc gggagccgcc tcccgacacc
       61 cgagccccgc cggcgcctgc gctcccctcc cgcgccccgc cgccgaggag gccccaagcc
      121 ggggcctgac gcccgggtcc gccccggaga gccatgagag agatgctgtc ccctcctcca
      181 tagaccagag ggatccagag cgatggggac agggaccctc tcatctctac tgctgctgct
      241 actcttggtg acaattggag atgctgacat gaagggacat tttgaccctg ccaagtgccg
      301 ctatgccctg ggcatgcagg accgcaccat tcctgacagc gatatctctg tgtccagctc
      361 ctggtcggac tctaccgctg cccgccacag caggctggaa agcagtgatg gagatggggc
      421 ttggtgccct gcagggcctg tgttccccaa agaagaggag tacttgcagg tggaccttcg
      481 taggctacac ctggtggctc tggtgggcac ccagggccgc catgctgggg gtctgggcaa
      541 agagttctcc cgaagctatc ggttgcgtta ctcccgagat ggccgccgct ggatggactg
      601 gaaggaccgc tggggacagg aggtgatttc gggtaacgag gatcccgggg gagtagtgct
      661 gaaggacctt gggcccccca tggtggcccg gctggtccgc ttctacccca gggctgaccg
      721 ggtcatgagt gtctgtcttc gggtggagct ctatggctgc ctctggcggg atggactcct
      781 gtcatataca gcccccgtgg ggcagaccat gcagttatct gaggtgatgg tacatctcaa
      841 tgattccact tacgatggat atactgctgg agggctgcag tatggcggtc tgggccagct
      901 ggcagatggc gtggtgggcc tggatgattt caggcagagc caggagctgc gggtctggcc
      961 aggctatgac tatgtgggat ggagcaatca gagcttcccc acgggctacg tggagatgga
     1021 gtttgagttt gatcggttga ggaccttcca gaccatgcag gtccactgta acaacatgca
     1081 cactctggga gcccgcctac caggcggggt ggaatgccgg tttaaaaggg gtcccgccat
     1141 ggcctgggaa ggagagcctg tccgccatgc tctgggaggc agccttggag accccagagc
     1201 ccgggccatc tcagtgcccc tgggtggcca cgtgggccgc tttctgcagt gcagattcct
     1261 ctttgcaggt ccttggttac tcttcagtga gatctctttc atctcagatg tggtgaacga
     1321 ctcctctgac accttcccac cagccccctg gtggccacct ggcccgcctc ccaccaactt
     1381 cagcagcttg gagctggagc cccggggtca acagccagtg gccaaggcgg aggggagccc
     1441 aactgccatc ctcattggct gcctggtggc catcatcctg ctgctgcttc tcatcatcgc
     1501 gctgatgctc tggaggctgc actggcgccg gctgctcagc aaggctgagc gccgcgtgtt
     1561 ggaggaggag ctgacggttc acctttctgt ccctggggac accatcctca tcaacaaccg
     1621 cccaggaccc cgagagccac ccccttacca ggagccccgg cctcggggga ctccacccca
     1681 ttctgcaccc tgcgtcccca acggctctgc gttgctgctc tccaatccgg cctaccgcct
     1741 ccttctggcc acttacgccc gtccccctcg aggcccgggc ccccccacac ccgcctgggc
     1801 caaacccacc aacacccagg cctgcagtgg ggactatatg gagcccgaga agccgggtgc
     1861 cccgcttcta cccccacctc cccagaacag cgtcccccat tatgccgaag ctgacattgt
     1921 caccctgcag ggcgtcactg ggggcaacac ctacgctgtg cctgcactgc ccccaggggc
     1981 ggttggggat gggcccccca gagtggattt ccctcggtca cggctccgct tcaaggagaa
     2041 gcttggcgag ggccaatttg gggaggtaca cctgtgtgaa gtagaggacc cgcaagatct
     2101 ggtcagtagt gacttcccta tcagtgtgca caagggacac cccttgctgg tagcagtgaa
     2161 gatcctccgg ccagatgcca ccaaaaatgc caggaatgat ttcctgaagg aggtaaagat
     2221 catgtcacgg ctgaaggacc caaacatcat ccggctcctg ggtgtgtgtg tgcaggatga
     2281 ccccctctgc atgatcacag actacatgga gaacggcgat ctgaaccagt tcctcagtgc
     2341 ccgccagctg gagaacaagg ccactcaggg gctctctggg gacacagagt ctgaccaggg
     2401 gcccacaatc agctacccta tgctgttaca cgtgggggcc cagatcgcct ctggcatgcg
     2461 ttatctcgcc acgctgaact ttgtgcatcg ggacctggcc acccggaact gcttggttgg
     2521 ggaaaatttc accatcaaaa tcgccgactt tggcatgagc cggaatctct acgctgggga
     2581 ttattaccgt gtccagggcc gggcggtgct gcccatcagg tggatggctt gggagtgcat
     2641 tctcatgggg aagttcacaa cagccagtga cgtttgggcc ttcggagtga ccctgtggga
     2701 ggtgctgatg ctctgcaggt cccagccctt tgggcagctt acagatgagc aggttatcga
     2761 gaatgccggc gagttcttca gggaccaggg ccggcaggtc tacttgtcca ggccacccgc
     2821 ctgcccacag accctgtatg agctgatgct ccggtgttgg agccgggagc ccgagcagcg
     2881 gccgcccttc gcccagcttc atcggttcct ggcggatgat gcgctcaaca cggtgtaaac
     2941 tcaggacccg gcagcccttt cccaatggga gccatccagg ggaagctgga ctcgaaaacc
     3001 agagaagcct atggcaccgc accccaccgt ctccatactt gcccattccc aagaggcagt
     3061 gtctctgcgg gtgggctggg cctgcccgag gagcagatac acacactccc ttccgtttct
     3121 tccttccatc tgccaagtgc caccctccca gctggccctg tggttgggat cctgcctgac
     3181 ttcttccagc tatccccttg gggaagaacg ggggcaaatg ctgggcgtac actggacaag
     3241 gcccactgga caacactggt tcctgggagg tgacggtgcc ccccagcttt cttcttgtca
     3301 cacactggac gccgccagct gagaattaga ggggtgaggg ggacaaggac ggccaacccc
     3361 tacagcggtc ctcagccctg gcttccttct gttccgcccc ctgacacact ggacctgggg
     3421 gcgatccctg ccgttgatcc tcagtcacac acccctcctt ctcacctgcc atgctgcagc
     3481 tagaacttcg caaagcctct atgtttctgt ggagtaaata ttaggatggg gaacagaggg
     3541 agcaatagct tgaggctggg ggtggggatt tctattgtag ctaccacatt ggtttttcta
     3601 taatcacgcg gggtttgtac attttttggg gggagagaaa cacagatttt tacactaata
     3661 tatggaccta gcttaaggcg attttaatcc cctgtcctag gcaggtaata ataaaagttg
     3721 agttgttttt tgttttttgt ttttccacaa aaaaaaaa
//
