LOCUS       NM_027442               2986 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus D-aspartate oxidase (Ddo), transcript variant 1, mRNA.
ACCESSION   NM_027442
VERSION     NM_027442.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2986)
  AUTHORS   Santillo,A., Falvo,S., Venditti,M., Di Maio,A., Chieffi Baccari,G.,
            Errico,F., Usiello,A., Minucci,S. and Di Fiore,M.M.
  TITLE     D-Aspartate Depletion Perturbs Steroidogenesis and Spermatogenesis
            in Mice
  JOURNAL   Biomolecules 13 (4), 621 (2023)
   PUBMED   37189369
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2986)
  AUTHORS   Lombardo,B., Pagani,M., De Rosa,A., Nunziato,M., Migliarini,S.,
            Garofalo,M., Terrile,M., D'Argenio,V., Galbusera,A., Nuzzo,T.,
            Ranieri,A., Vitale,A., Leggiero,E., Di Maio,A., Barsotti,N.,
            Borello,U., Napolitano,F., Mandarino,A., Carotenuto,M.,
            Heresco-Levy,U., Pasqualetti,M., Malatesta,P., Gozzi,A., Errico,F.,
            Salvatore,F., Pastore,L. and Usiello,A.
  TITLE     D-aspartate oxidase gene duplication induces social recognition
            memory deficit in mice and intellectual disabilities in humans
  JOURNAL   Transl Psychiatry 12 (1), 305 (2022)
   PUBMED   35915065
  REMARK    GeneRIF: D-aspartate oxidase gene duplication induces social
            recognition memory deficit in mice and intellectual disabilities in
            humans.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2986)
  AUTHORS   Puggioni,V., Savinelli,A., Miceli,M., Molla,G., Pollegioni,L. and
            Sacchi,S.
  TITLE     Biochemical characterization of mouse d-aspartate oxidase
  JOURNAL   Biochim Biophys Acta Proteins Proteom 1868 (10), 140472 (2020)
   PUBMED   32553892
REFERENCE   4  (bases 1 to 2986)
  AUTHORS   De Rosa,A., Mastrostefano,F., Di Maio,A., Nuzzo,T., Saitoh,Y.,
            Katane,M., Isidori,A.M., Caputo,V., Marotta,P., Falco,G., De
            Stefano,M.E., Homma,H., Usiello,A. and Errico,F.
  TITLE     Prenatal expression of D-aspartate oxidase causes early cerebral
            D-aspartate depletion and influences brain morphology and cognitive
            functions at adulthood
  JOURNAL   Amino Acids 52 (4), 597-617 (2020)
   PUBMED   32185508
  REMARK    GeneRIF: Prenatal expression of D-aspartate oxidase causes early
            cerebral D-aspartate depletion and influences brain morphology and
            cognitive functions at adulthood.
REFERENCE   5  (bases 1 to 2986)
  AUTHORS   Nuzzo,T., Feligioni,M., Cristino,L., Pagano,I., Marcelli,S.,
            Iannuzzi,F., Imperatore,R., D'Angelo,L., Petrella,C., Carella,M.,
            Pollegioni,L., Sacchi,S., Punzo,D., De Girolamo,P., Errico,F.,
            Canu,N. and Usiello,A.
  TITLE     Free d-aspartate triggers NMDA receptor-dependent cell death in
            primary cortical neurons and perturbs JNK activation, Tau
            phosphorylation, and protein SUMOylation in the cerebral cortex of
            mice lacking d-aspartate oxidase activity
  JOURNAL   Exp Neurol 317, 51-65 (2019)
   PUBMED   30822420
REFERENCE   6  (bases 1 to 2986)
  AUTHORS   Weil,Z.M., Huang,A.S., Beigneux,A., Kim,P.M., Molliver,M.E.,
            Blackshaw,S., Young,S.G., Nelson,R.J. and Snyder,S.H.
  TITLE     Behavioural alterations in male mice lacking the gene for
            D-aspartate oxidase
  JOURNAL   Behav Brain Res 171 (2), 295-302 (2006)
   PUBMED   16725213
  REMARK    GeneRIF: reports that the behavioral phenotype of the Dco-/- mouse
            is characterized by deficits in prepulse inhibition of the acoustic
            startle reflex and in motor coordination on the RotoRod
REFERENCE   7  (bases 1 to 2986)
  AUTHORS   Errico,F., Pirro,M.T., Affuso,A., Spinelli,P., De Felice,M.,
            D'Aniello,A. and Di Lauro,R.
  TITLE     A physiological mechanism to regulate D-aspartic acid and NMDA
            levels in mammals revealed by D-aspartate oxidase deficient mice
  JOURNAL   Gene 374, 50-57 (2006)
   PUBMED   16516413
REFERENCE   8  (bases 1 to 2986)
  AUTHORS   Huang,A.S., Beigneux,A., Weil,Z.M., Kim,P.M., Molliver,M.E.,
            Blackshaw,S., Nelson,R.J., Young,S.G. and Snyder,S.H.
  TITLE     D-aspartate regulates melanocortin formation and function:
            behavioral alterations in D-aspartate oxidase-deficient mice
  JOURNAL   J Neurosci 26 (10), 2814-2819 (2006)
   PUBMED   16525061
REFERENCE   9  (bases 1 to 2986)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 2986)
  AUTHORS   Nagasaki,H.
  TITLE     Gender-related differences of mouse liver D-aspartate oxidase in
            the activity and response to administration of D-aspartate and
            peroxisome proliferators
  JOURNAL   Int J Biochem 26 (3), 415-423 (1994)
   PUBMED   8187937
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139760.6.
            
            On Jan 24, 2023 this sequence version replaced NM_027442.5.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK161548.1, AK085947.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AC139760.6         98587-98649
            64-238              AC139760.6         100164-100338
            239-347             AC139760.6         101496-101604
            348-524             AC139760.6         105903-106079
            525-2986            AC139760.6         116032-118493
FEATURES             Location/Qualifiers
     source          1..2986
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 22.0 cM"
     gene            1..2986
                     /gene="Ddo"
                     /gene_synonym="5330420D20Rik; 5730402C02Rik; DASPO"
                     /note="D-aspartate oxidase"
                     /db_xref="GeneID:70503"
                     /db_xref="MGI:MGI:1925528"
     exon            1..63
                     /gene="Ddo"
                     /gene_synonym="5330420D20Rik; 5730402C02Rik; DASPO"
                     /inference="alignment:Splign:2.1.0"
     exon            64..238
                     /gene="Ddo"
                     /gene_synonym="5330420D20Rik; 5730402C02Rik; DASPO"
                     /inference="alignment:Splign:2.1.0"
     exon            239..347
                     /gene="Ddo"
                     /gene_synonym="5330420D20Rik; 5730402C02Rik; DASPO"
                     /inference="alignment:Splign:2.1.0"
     exon            348..524
                     /gene="Ddo"
                     /gene_synonym="5330420D20Rik; 5730402C02Rik; DASPO"
                     /inference="alignment:Splign:2.1.0"
     exon            525..2986
                     /gene="Ddo"
                     /gene_synonym="5330420D20Rik; 5730402C02Rik; DASPO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2457..2462
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddo"
                     /gene_synonym="5330420D20Rik; 5730402C02Rik; DASPO"
                     /note="hexamer: AATAAA"
     polyA_site      2479
                     /gene="Ddo"
                     /gene_synonym="5330420D20Rik; 5730402C02Rik; DASPO"
                     /note="major polyA site"
     regulatory      2962..2967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddo"
                     /gene_synonym="5330420D20Rik; 5730402C02Rik; DASPO"
                     /note="hexamer: AATAAA"
     regulatory      2967..2972
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddo"
                     /gene_synonym="5330420D20Rik; 5730402C02Rik; DASPO"
                     /note="hexamer: AATAAA"
     polyA_site      2983
                     /gene="Ddo"
                     /gene_synonym="5330420D20Rik; 5730402C02Rik; DASPO"
     polyA_site      2986
                     /gene="Ddo"
                     /gene_synonym="5330420D20Rik; 5730402C02Rik; DASPO"
ORIGIN      
        1 actggaaaac aagtgttggt gccaggacct ccggtggata ccagactgct ttttcagaga
       61 caggccatgg acacagtgtg tattgcggtc gttggagctg gcgtgatagg gctgtctact
      121 gcagcatgca tttcccaact ggttcccgga tgcaccgtca ctgtcatctc agacaggttc
      181 actcctgata ccaccagtaa tgtagcggct gggatgctta ttcctcacac gtgtgcagat
      241 accccggtac ccacacagaa gcgatggttt agagagacct tcgagcatct ttctgaaatc
      301 gccaagtctg cagaggctgc agatgcgggt gttcacctgg tatctggttg gcagatattc
      361 cgcagcgtcc ccgctgaaga agtgcctttc tgggctgatg tggtgctggg atttcgaaag
      421 atgacagagg ctgagctgaa gcggttccct cagtatgtgt ttggccaggc ttttacaacc
      481 ctgaagtgcg agacttctgc ctacctcccg tggctggaga gaaggataaa ggggagtgga
      541 ggtctgctac tcaccaggag aatagaagac ctgtgggagc tgcagccatc ttttgatatc
      601 gtggtcaatt gctcaggcct gggaagccgg cgacttgtag gtgaccccat gatttccccg
      661 gtaaggggcc aggtgctcca ggcacgggcc ccctgggtga agcatttcat ccgagatggg
      721 ggcgggctga cttatgttta ccctggtatg tcctatgtaa ccctgggagg aactagacag
      781 aaaggagact ggaatcgatc cccagatgca gaacttagca gagagatttt ttctcgatgc
      841 tgcactctcg agccttccct ccacagagcc tacgacataa aagagaaagt ggggctgaga
      901 cccagcaggc caggtgtgcg gctgcagaag gagatcctag tccggggaca acagacgctg
      961 cctgtggtcc acaactacgg ccacgggagt gggggcatct ctgtgcactg gggctctgct
     1021 ctggaagcca ccaggctggt gatggagtgt atccataccc tcaggacccc tgcttccttg
     1081 tcgaagctgt agctgacacc aagtaacagc agctaatcca ggtgatatgg gtcaaagcac
     1141 aatttaaggt ccgtaaccgg gtctcgtaac tttcatactg cttgaacgtt gagtctgacc
     1201 ttctttgttt ttacgcaatg agtatcagta gacttagaaa gcttgtcagt aatgacacag
     1261 aacacaaagc tcggtttttg tcaaaatatg tgctatttaa aaatacttgt tctatggggt
     1321 agatttgggg aggatcgaat gctaacttat atgaatgatg taagcgatag ggagttcgta
     1381 tttttggctc agaagcacat aagcacataa gagaagatta atgtgtgaga aatatacttg
     1441 gctccctgtc agccctagag ctgtgcatga tcctctcagg tcatagagcc aacagaggaa
     1501 gttatcatcc cactagatgg gaccacacag tgtggacccc cggtatttaa ccgagggtag
     1561 gcagcagcag cttcctcacg ccagctggta ttcatggtag ctgacagagg tggagttgcc
     1621 ctcgaaggct gcgccagttt tggagcaact ttgtgtctgt tttgttgttt ctgggaccaa
     1681 acacctaaca gaaacaacct aaagcattgt tcatagctgc agcccatagc gccagggagg
     1741 gccttgtaga acagagctgt tcaactcaca tctgcaagaa agcagtgtga acaggtagca
     1801 gggcagatgg ggtgacagtg tctaagcgct cattcccagt tgtctactcc ccgtcccaac
     1861 tttcctccta tacctctacc atctcccaac agttcattta attctcaaat ctgtccatgg
     1921 attgagtcat cgattaggtc atccatatct agaaacacct tcagccccac ccaaagggcg
     1981 ggctttacgt ctgtcttaag caatccccta tcttgtcaag ctgccaggag ggatttacca
     2041 tagcaatcgt ggaggctgca tacttcatta ccacaaatga tcaagagctg ctgactgcgc
     2101 agtgaatgag cactgttgga gactgaatcg tctatgcgac ctaggagcta atttgctaat
     2161 ggagacgaaa caatcatttt tttaaatgac atacgacaca aagtgttcat gtcgcaagta
     2221 ttggggagaa agggaatatg tcttgtgata atgtaagttt gagaattgct gagttgaata
     2281 attttacctg gctccctaac ttcaggctac tcagaacctt taccgtcccg ggttcattgt
     2341 aggtcctcgg gagggttttt ggcctgggag aagattgttc actgaagtaa gcaatcctgg
     2401 agcagggatg tcattacatt ttggagagaa gtactttttt gttgttgttg ttgaataata
     2461 aagcctgttt tgaacctcct aggagtctta cgattggcca taagtatagg gacagggctg
     2521 gagagatggc tcaacaatta agattgcttg ttgctcttcc agcagacaag agtttgtttc
     2581 ctagtgccca tgaagtgcct acaacctcct gtaactacag cttcagggtt tccaacatac
     2641 tcttctggcc tttgtaggta cacacacaca cacacacaca cacacacaca cacacacaca
     2701 gaggaattaa ataaatcttt taaaaacatt ataaaactta tggacaagaa gcttgtgttt
     2761 gcgtttttgt tgaggtttcg tgtgcgattt tgtttgaaga gagcactgag ctggggtttc
     2821 ataccaaaca gtgtttaatg ggctacaaaa attcttgtta aatcaagcag tctcatttct
     2881 attaattttc accagggggc gatgttgtat caatctcaaa taaaccagag catctgaaaa
     2941 tttagaaatg acaagatata aaataaaata aaaataaaat aaggaa
//
