LOCUS       NM_001013741            3740 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Mus musculus dendrin (Ddn), mRNA.
ACCESSION   NM_001013741 XM_001476216 XM_001480765 XM_619356
VERSION     NM_001013741.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3740)
  AUTHORS   Empitu,M.A., Kikyo,M., Shirata,N., Yamada,H., Makino,S.I.,
            Kadariswantiningsih,I.N., Aizawa,M., Patrakka,J., Nishimori,K. and
            Asanuma,K.
  TITLE     Inhibition of Importin- alpha -Mediated Nuclear Localization of
            Dendrin Attenuates Podocyte Loss and Glomerulosclerosis
  JOURNAL   J Am Soc Nephrol 34 (7), 1222-1239 (2023)
   PUBMED   37134307
  REMARK    GeneRIF: Inhibition of Importin- alpha -Mediated Nuclear
            Localization of Dendrin Attenuates Podocyte Loss and
            Glomerulosclerosis.
REFERENCE   2  (bases 1 to 3740)
  AUTHORS   Weins,A., Wong,J.S., Basgen,J.M., Gupta,R., Daehn,I.,
            Casagrande,L., Lessman,D., Schwartzman,M., Meliambro,K.,
            Patrakka,J., Shaw,A., Tryggvason,K., He,J.C., Nicholas,S.B.,
            Mundel,P. and Campbell,K.N.
  TITLE     Dendrin ablation prolongs life span by delaying kidney failure
  JOURNAL   Am J Pathol 185 (8), 2143-2157 (2015)
   PUBMED   26073036
  REMARK    GeneRIF: ablation of the podocyte death-promoting protein dendrin
            delays onset of end-stage kidney disease, thereby expanding the
            life span of mice lacking the adapter protein CD2AP. Ablation of
            dendrin delays onset and severity of proteinuria and podocyte loss.
REFERENCE   3  (bases 1 to 3740)
  AUTHORS   Xiao,Z., Rodriguez,P.Q., He,L., Betsholtz,C., Tryggvason,K. and
            Patrakka,J.
  TITLE     Wtip- and gadd45a-interacting protein dendrin is not crucial for
            the development or maintenance of the glomerular filtration barrier
  JOURNAL   PLoS One 8 (12), e83133 (2013)
   PUBMED   24376653
  REMARK    GeneRIF: Dendrin is dispensable for the function of the normal
            glomerular filtration barrier, and it interacts with Wtip and
            Gadd45a.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3740)
  AUTHORS   Yaddanapudi,S., Altintas,M.M., Kistler,A.D., Fernandez,I.,
            Moller,C.C., Wei,C., Peev,V., Flesche,J.B., Forst,A.L., Li,J.,
            Patrakka,J., Xiao,Z., Grahammer,F., Schiffer,M., Lohmuller,T.,
            Reinheckel,T., Gu,C., Huber,T.B., Ju,W., Bitzer,M., Rastaldi,M.P.,
            Ruiz,P., Tryggvason,K., Shaw,A.S., Faul,C., Sever,S. and Reiser,J.
  TITLE     CD2AP in mouse and human podocytes controls a proteolytic program
            that regulates cytoskeletal structure and cellular survival
  JOURNAL   J Clin Invest 121 (10), 3965-3980 (2011)
   PUBMED   21911934
  REMARK    Erratum:[J Clin Invest. 2012 Feb 1;122(2):780]
REFERENCE   5  (bases 1 to 3740)
  AUTHORS   Asanuma,K., Akiba-Takagi,M., Kodama,F., Asao,R., Nagai,Y.,
            Lydia,A., Fukuda,H., Tanaka,E., Shibata,T., Takahara,H., Hidaka,T.,
            Asanuma,E., Kominami,E., Ueno,T. and Tomino,Y.
  TITLE     Dendrin location in podocytes is associated with disease
            progression in animal and human glomerulopathy
  JOURNAL   Am J Nephrol 33 (6), 537-549 (2011)
   PUBMED   21606645
  REMARK    GeneRIF: relocation of dendrin from the slit diaphragm to the
            podocyte nucleus in adriamycin-induced glomerulosclerosis
REFERENCE   6  (bases 1 to 3740)
  AUTHORS   Duner,F., Patrakka,J., Xiao,Z., Larsson,J., Vlamis-Gardikas,A.,
            Pettersson,E., Tryggvason,K., Hultenby,K. and Wernerson,A.
  TITLE     Dendrin expression in glomerulogenesis and in human minimal change
            nephrotic syndrome
  JOURNAL   Nephrol Dial Transplant 23 (8), 2504-2511 (2008)
   PUBMED   18356187
  REMARK    GeneRIF: In glomerulogenesis, dendrin mRNA and protein appeared
            first at the early capillary loop stage. It was concentrated to the
            pre-podocytes on the basal side of podocalyxin, an apical cell
            membrane marker.
REFERENCE   7  (bases 1 to 3740)
  AUTHORS   Done,S.C., Takemoto,M., He,L., Sun,Y., Hultenby,K., Betsholtz,C.
            and Tryggvason,K.
  TITLE     Nephrin is involved in podocyte maturation but not survival during
            glomerular development
  JOURNAL   Kidney Int 73 (6), 697-704 (2008)
   PUBMED   18046313
REFERENCE   8  (bases 1 to 3740)
  AUTHORS   Asanuma,K., Campbell,K.N., Kim,K., Faul,C. and Mundel,P.
  TITLE     Nuclear relocation of the nephrin and CD2AP-binding protein dendrin
            promotes apoptosis of podocytes
  JOURNAL   Proc Natl Acad Sci U S A 104 (24), 10134-10139 (2007)
   PUBMED   17537921
  REMARK    GeneRIF: Nuclear relocation of dendrin promotes apoptosis of
            podocytes.
REFERENCE   9  (bases 1 to 3740)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   10 (bases 1 to 3740)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK158894.1 and AK122363.1.
            
            On or before Mar 2, 2008 this sequence version replaced
            XM_001476216.1, XM_001480765.1, XM_619356.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122363.1, AK158894.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AK158894.1         2-126
            126-3740            AK122363.1         1-3615
FEATURES             Location/Qualifiers
     source          1..3740
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 54.69 cM"
     gene            1..3740
                     /gene="Ddn"
                     /gene_synonym="Gm748"
                     /note="dendrin"
                     /db_xref="GeneID:13199"
                     /db_xref="MGI:MGI:108101"
     exon            1..321
                     /gene="Ddn"
                     /gene_synonym="Gm748"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..2245
                     /gene="Ddn"
                     /gene_synonym="Gm748"
                     /codon_start=1
                     /product="dendrin"
                     /protein_id="NP_001013763.1"
                     /db_xref="CCDS:CCDS49723.1"
                     /db_xref="GeneID:13199"
                     /db_xref="MGI:MGI:108101"
                     /translation="MLDGPLFSEGPDSPRELQDEESGSCLWVQKSKLLVIEVKTISCH
                     YSRRAPSRQSMDIQASYWARGPQSRTCRLRPGSPEPPPRRPWASRVLQEATNWRAGPP
                     AEVRAREQEKRKAASQEREAKETERKRRKAGGARRSPLGQPRPEPRNALRAAQPTGFP
                     VFSRPERFGQVGRAPRPSVLPQGDPGVAWAGPWGGRRPGPPSYEAHLLLRGSAGTAPR
                     RRWDRPPPYVAPPSYEGPHRTLGTKRGPELSRAPTSSAPVPATTRTEGGRTKKRLDPR
                     IYRDVLGAWGLRQGRGLLGGAPGCTAARARPESCKGAIEKSSGLVAAGLNSAGDSHSQ
                     GKTTGGPGTDAALSRSAISSPPRPVPRSRQHLRGSRKGKEGSEQIWLPTCWLASPKKP
                     PVRHSQTLPRPWAPGGTGWKESLGQREGAEHETLEVWKVTRRAHTLPRISRGPAGREG
                     IFVIDATCVVIKSQYVPTPRTQQGQLVPSGESCSVSDSLSQPKPCHEEEGEGAAANPS
                     VCQKRLLSSRVLNQPSEGRECEAEVGQQGDSSLEERSSSGLGFPVGEVNPRDAPTQPG
                     SQEHPTLGPAAPVCAGSLKGSEAAGVPRRAGGGWARTPGPYAGALREAVSRIRRHTAP
                     DSDSDEAEDLSVHSGSSDGSDTDAPGASWRNERTLPALGNTRPREGGKTAGLSDSIRE
                     IVDVISQTEEGFIREDTRKTPQGNRERE"
     exon            322..3740
                     /gene="Ddn"
                     /gene_synonym="Gm748"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atagttgcca gtccctgggc ctgccgctct gcagtgggcg ccggctccct gggttgggag
       61 ggggctcacg gggcgggtgg gagggtgggg ggccggggtg gggtggggca ggatgctgga
      121 tggcccgtta ttctccgagg ggcccgacag cccccgggag ctccaggatg aggagtccgg
      181 cagctgcctc tgggtgcaga agtccaagct gttggtgatt gaagtgaaga ctatttcctg
      241 tcattatagt cgtcgcgctc cttctcgaca gtccatggac atccaggcca gctactgggc
      301 ccgtgggccc cagagccgca cgtgtaggct gcgcccggga tcccctgagc cgccaccccg
      361 ccgaccctgg gcctccaggg tgctgcagga ggcaaccaac tggcgggcgg gcccccccgc
      421 cgaggtccga gcccgggaac aagagaaaag aaaggcggcg tcgcaggagc gggaggccaa
      481 ggagaccgag agaaaaaggc gcaaggctgg cggggcccga cggagtcccc taggtcagcc
      541 ccgcccagag ccccggaacg cccttcgggc agcccaacct acagggtttc cagttttctc
      601 cagaccagag cgcttcgggc aggtggggcg agcgccccga ccatccgtgc tcccgcaggg
      661 tgacccaggg gttgcatggg cggggccatg gggaggcaga aggccagggc cccctagcta
      721 cgaggctcac ctgctgttga gaggctctgc aggcacagcc ccaaggcgcc gctgggaccg
      781 gccgccaccc tatgtggctc caccttctta tgaaggtccc cacaggaccc tggggactaa
      841 gcgaggcccg gagctctccc gggcgcccac ctcatcagcc ccagttccag ccaccaccag
      901 gacagaggga gggcgcacga agaagaggct ggatcctcga atctaccggg atgttctagg
      961 agcttggggt ctcagacagg gacggggact cttaggaggt gctccaggct gtacagcagc
     1021 cagagctagg ccagagtctt gcaaaggggc tatagagaaa agctcaggcc tagttgctgc
     1081 tggcctgaac agtgctggcg atagtcattc ccaaggcaaa acgactggcg gtccaggcac
     1141 ggacgcagct ctctctaggt ccgcgatcag cagcccacct cgtcctgttc ccaggtccag
     1201 gcagcacctc agggggtcaa ggaaagggaa agaaggaagt gagcagatat ggcttcccac
     1261 gtgttggctt gcctccccta aaaagcctcc agttaggcac agccagacgc tccctagacc
     1321 ctgggctcct ggaggcaccg ggtggaaaga gtccctgggt caaagagagg gggcagaaca
     1381 tgagaccctg gaagtttgga aggtgacccg ccgtgcccac accctgcccc gcatttcccg
     1441 aggtcccgct ggtagagaag gcatctttgt cattgacgcc acatgcgtgg tgataaagtc
     1501 ccagtacgtt ccgacccctc gaacccagca gggtcagctc gtgccctctg gggagtcgtg
     1561 cagtgtgagc gacagcctta gtcaacccaa gccctgtcac gaggaggagg gcgagggggc
     1621 cgctgccaac ccttcagttt gccaaaagcg actgttgagc agtcgagtct taaaccaacc
     1681 gagcgagggt cgcgagtgcg aggccgaggt cggacagcag ggggattctt cattggagga
     1741 gcgctcctcc agcggtttgg ggttccctgt cggagaagtg aacccgcgag acgcccccac
     1801 gcagccaggt agccaagagc acccgacctt aggcccagcg gctccggtat gcgccggcag
     1861 cttgaagggc tcagaagcgg ctggtgtccc gcggcgcgcg ggcgggggct gggcgcggac
     1921 tccagggccc tacgccgggg cgttgcgaga agccgtgtcc cgcatccgcc gccacaccgc
     1981 cccagattcg gactcagacg aagcggagga tctcagcgtc catagcggct cctctgatgg
     2041 aagcgacaca gacgccccag gcgcctcctg gcggaatgag aggaccctgc ctgcgcttgg
     2101 gaacacccgg cccagggaag gcgggaagac agcagggctg agcgacagta tccgggagat
     2161 tgtggatgtc atcagtcaaa ccgaggaagg cttcatccga gaggacacca ggaaaacgcc
     2221 acagggaaat agagagaggg agtgagcgat gcccctcttt gttctcgtgt cgctcagccc
     2281 atccaccctg ggctcacctg ctccttctct ctctccaggc ttcgtttgct tccttttctt
     2341 ctttcccacc tatacctgtt cccacacttg aaacagagga gagaggagga accagggaag
     2401 gtagcgtctg ccaactcaag ggttagtttc agggaaagtg tgggtgggcc atccacacct
     2461 gctacattcg gtgtggaact gttccgacag agaaagagaa ggggcaggga tggtgcctgc
     2521 gatgggcagg gcagggtccc tgacaggaga gaaaaagtaa tggagaggcc ttgaacctag
     2581 tgactgagtg gaggagacag aggaactttg ggcagagaag aaatgaatgc atacacacaa
     2641 ccagcaacct ggcgagaggg ctctctttga tgttacaact caagtttcaa ttccaactct
     2701 gccactgacc tagctggtgg acctcagagt aactattttt gcgcccgggc atcccggact
     2761 tctgtaaatg taaaatgagc gctttctgcc tcccattctt ttgtccctag gattttgtga
     2821 ataagcgagt agagagaatc tgagggttct tacccacttc ggtcatcctc agttcggaag
     2881 actgtcaagg tcttcagatt taaacggaca aagggcttct attccaattt tcccagttta
     2941 ggtgagtgct cccacagccg agcaggatca tggccctctc actgcctcta gcctgctgtg
     3001 gcccaagctg gagagggaag gtagccaatg aatcagcttg ggacactttt aggccttccc
     3061 cttctcctcc atctccgtgt ccttagtgac gctctgaagt gttaccggga ttttccacgc
     3121 agacggtatc gcccaccgga taggaccttg acaatttctg tgtctctcca aggaaaacag
     3181 ccaggcaagg aggaaggtgg atttttcagc agacggtgcg gggtgtgata ctcgctgtag
     3241 ccactacggg gcgcgcgcag gtcgcggatt cccccggttg ctggtgctcg agtgccccta
     3301 caccagcact gccagttatc tggatcccta gttaccggcg ccggtttcct gccttgacac
     3361 ctccaaaccg cgcgcggggc cgggagcagg cctccggcct cccagacttc tggggcgcgc
     3421 cgagcccttc tttgtattaa tccacgccaa ccggtttgag actgacattt aagcctttct
     3481 tcttcttctt cttctttttt ctttttcttt tctttctttc caaccctggg cacttcctct
     3541 gtgtctgcca tttattagcc atgtgacctt ggccaaatca cttcacctcc ctgagcctca
     3601 gtttcctcat ctgtcaaatg ggggtttata aacacctacc tcgcagggtt gttgtgagga
     3661 tttaatgagg taatgtatat aaggcgtctt gcacagtgcc tggcacatag caggcgccca
     3721 ataaatctac tcgccccttt
//
