LOCUS       NP_001013763             710 aa            linear   ROD 27-APR-2025
DEFINITION  dendrin [Mus musculus].
ACCESSION   NP_001013763 XP_001476266 XP_001480815 XP_619356
VERSION     NP_001013763.1
DBSOURCE    REFSEQ: accession NM_001013741.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 710)
  AUTHORS   Empitu,M.A., Kikyo,M., Shirata,N., Yamada,H., Makino,S.I.,
            Kadariswantiningsih,I.N., Aizawa,M., Patrakka,J., Nishimori,K. and
            Asanuma,K.
  TITLE     Inhibition of Importin- alpha -Mediated Nuclear Localization of
            Dendrin Attenuates Podocyte Loss and Glomerulosclerosis
  JOURNAL   J Am Soc Nephrol 34 (7), 1222-1239 (2023)
   PUBMED   37134307
  REMARK    GeneRIF: Inhibition of Importin- alpha -Mediated Nuclear
            Localization of Dendrin Attenuates Podocyte Loss and
            Glomerulosclerosis.
REFERENCE   2  (residues 1 to 710)
  AUTHORS   Weins,A., Wong,J.S., Basgen,J.M., Gupta,R., Daehn,I.,
            Casagrande,L., Lessman,D., Schwartzman,M., Meliambro,K.,
            Patrakka,J., Shaw,A., Tryggvason,K., He,J.C., Nicholas,S.B.,
            Mundel,P. and Campbell,K.N.
  TITLE     Dendrin ablation prolongs life span by delaying kidney failure
  JOURNAL   Am J Pathol 185 (8), 2143-2157 (2015)
   PUBMED   26073036
  REMARK    GeneRIF: ablation of the podocyte death-promoting protein dendrin
            delays onset of end-stage kidney disease, thereby expanding the
            life span of mice lacking the adapter protein CD2AP. Ablation of
            dendrin delays onset and severity of proteinuria and podocyte loss.
REFERENCE   3  (residues 1 to 710)
  AUTHORS   Xiao,Z., Rodriguez,P.Q., He,L., Betsholtz,C., Tryggvason,K. and
            Patrakka,J.
  TITLE     Wtip- and gadd45a-interacting protein dendrin is not crucial for
            the development or maintenance of the glomerular filtration barrier
  JOURNAL   PLoS One 8 (12), e83133 (2013)
   PUBMED   24376653
  REMARK    GeneRIF: Dendrin is dispensable for the function of the normal
            glomerular filtration barrier, and it interacts with Wtip and
            Gadd45a.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 710)
  AUTHORS   Yaddanapudi,S., Altintas,M.M., Kistler,A.D., Fernandez,I.,
            Moller,C.C., Wei,C., Peev,V., Flesche,J.B., Forst,A.L., Li,J.,
            Patrakka,J., Xiao,Z., Grahammer,F., Schiffer,M., Lohmuller,T.,
            Reinheckel,T., Gu,C., Huber,T.B., Ju,W., Bitzer,M., Rastaldi,M.P.,
            Ruiz,P., Tryggvason,K., Shaw,A.S., Faul,C., Sever,S. and Reiser,J.
  TITLE     CD2AP in mouse and human podocytes controls a proteolytic program
            that regulates cytoskeletal structure and cellular survival
  JOURNAL   J Clin Invest 121 (10), 3965-3980 (2011)
   PUBMED   21911934
  REMARK    Erratum:[J Clin Invest. 2012 Feb 1;122(2):780]
REFERENCE   5  (residues 1 to 710)
  AUTHORS   Asanuma,K., Akiba-Takagi,M., Kodama,F., Asao,R., Nagai,Y.,
            Lydia,A., Fukuda,H., Tanaka,E., Shibata,T., Takahara,H., Hidaka,T.,
            Asanuma,E., Kominami,E., Ueno,T. and Tomino,Y.
  TITLE     Dendrin location in podocytes is associated with disease
            progression in animal and human glomerulopathy
  JOURNAL   Am J Nephrol 33 (6), 537-549 (2011)
   PUBMED   21606645
  REMARK    GeneRIF: relocation of dendrin from the slit diaphragm to the
            podocyte nucleus in adriamycin-induced glomerulosclerosis
REFERENCE   6  (residues 1 to 710)
  AUTHORS   Duner,F., Patrakka,J., Xiao,Z., Larsson,J., Vlamis-Gardikas,A.,
            Pettersson,E., Tryggvason,K., Hultenby,K. and Wernerson,A.
  TITLE     Dendrin expression in glomerulogenesis and in human minimal change
            nephrotic syndrome
  JOURNAL   Nephrol Dial Transplant 23 (8), 2504-2511 (2008)
   PUBMED   18356187
  REMARK    GeneRIF: In glomerulogenesis, dendrin mRNA and protein appeared
            first at the early capillary loop stage. It was concentrated to the
            pre-podocytes on the basal side of podocalyxin, an apical cell
            membrane marker.
REFERENCE   7  (residues 1 to 710)
  AUTHORS   Done,S.C., Takemoto,M., He,L., Sun,Y., Hultenby,K., Betsholtz,C.
            and Tryggvason,K.
  TITLE     Nephrin is involved in podocyte maturation but not survival during
            glomerular development
  JOURNAL   Kidney Int 73 (6), 697-704 (2008)
   PUBMED   18046313
REFERENCE   8  (residues 1 to 710)
  AUTHORS   Asanuma,K., Campbell,K.N., Kim,K., Faul,C. and Mundel,P.
  TITLE     Nuclear relocation of the nephrin and CD2AP-binding protein dendrin
            promotes apoptosis of podocytes
  JOURNAL   Proc Natl Acad Sci U S A 104 (24), 10134-10139 (2007)
   PUBMED   17537921
  REMARK    GeneRIF: Nuclear relocation of dendrin promotes apoptosis of
            podocytes.
REFERENCE   9  (residues 1 to 710)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   10 (residues 1 to 710)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK158894.1 and AK122363.1.
            
            On or before Mar 2, 2008 this sequence version replaced
            XP_001476266.1, XP_001480815.1, XP_619356.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122363.1, AK158894.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..710
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 54.69 cM"
     Protein         1..710
                     /product="dendrin"
                     /calculated_mol_wt=76276
     Region          1..22
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TS7.3)"
     Region          55..708
                     /region_name="Dendrin"
                     /note="Nephrin and CD2AP-binding protein, Dendrin;
                     pfam15498"
                     /db_xref="CDD:464749"
     Region          62..195
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TS7.3)"
     Region          113..131
                     /region_name="Nuclear localization. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TS7.3)"
     Region          186..236
                     /region_name="Interaction with MAGI2.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TS7.3)"
     Region          213..274
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TS7.3)"
     Region          324..375
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TS7.3)"
     Region          341..435
                     /region_name="Interaction with ACTN1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TS7.3)"
     Site            388
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q80TS7.3)"
     Region          390..422
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TS7.3)"
     Region          407..708
                     /region_name="Interaction with CD2AP and NPHS1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TS7.3)"
     Region          469..508
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TS7.3)"
     Region          521..710
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TS7.3)"
     CDS             1..710
                     /gene="Ddn"
                     /gene_synonym="Gm748"
                     /coded_by="NM_001013741.1:113..2245"
                     /db_xref="CCDS:CCDS49723.1"
                     /db_xref="GeneID:13199"
                     /db_xref="MGI:MGI:108101"
ORIGIN      
        1 mldgplfseg pdsprelqde esgsclwvqk skllvievkt ischysrrap srqsmdiqas
       61 ywargpqsrt crlrpgspep pprrpwasrv lqeatnwrag ppaevrareq ekrkaasqer
      121 eaketerkrr kaggarrspl gqprpeprna lraaqptgfp vfsrperfgq vgraprpsvl
      181 pqgdpgvawa gpwggrrpgp psyeahlllr gsagtaprrr wdrpppyvap psyegphrtl
      241 gtkrgpelsr aptssapvpa ttrteggrtk krldpriyrd vlgawglrqg rgllggapgc
      301 taararpesc kgaiekssgl vaaglnsagd shsqgkttgg pgtdaalsrs aisspprpvp
      361 rsrqhlrgsr kgkegseqiw lptcwlaspk kppvrhsqtl prpwapggtg wkeslgqreg
      421 aehetlevwk vtrrahtlpr isrgpagreg ifvidatcvv iksqyvptpr tqqgqlvpsg
      481 escsvsdsls qpkpcheeeg egaaanpsvc qkrllssrvl nqpsegrece aevgqqgdss
      541 leersssglg fpvgevnprd aptqpgsqeh ptlgpaapvc agslkgseaa gvprragggw
      601 artpgpyaga lreavsrirr htapdsdsde aedlsvhsgs sdgsdtdapg aswrnertlp
      661 algntrpreg gktaglsdsi reivdvisqt eegfiredtr ktpqgnrere
//
