LOCUS       NM_030143               2721 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus DNA-damage-inducible transcript 4-like (Ddit4l), mRNA.
ACCESSION   NM_030143 XM_974954
VERSION     NM_030143.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2721)
  AUTHORS   Feng,W., Bais,A., He,H., Rios,C., Jiang,S., Xu,J., Chang,C.,
            Kostka,D. and Li,G.
  TITLE     Single-cell transcriptomic analysis identifies murine heart
            molecular features at embryonic and neonatal stages
  JOURNAL   Nat Commun 13 (1), 7960 (2022)
   PUBMED   36575170
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2721)
  AUTHORS   Wang,N., Langfelder,P., Stricos,M., Ramanathan,L., Richman,J.B.,
            Vaca,R., Plascencia,M., Gu,X., Zhang,S., Tamai,T.K., Zhang,L.,
            Gao,F., Ouk,K., Lu,X., Ivanov,L.V., Vogt,T.F., Lu,Q.R.,
            Morton,A.J., Colwell,C.S., Aaronson,J.S., Rosinski,J., Horvath,S.
            and Yang,X.W.
  TITLE     Mapping brain gene coexpression in daytime transcriptomes unveils
            diurnal molecular networks and deciphers perturbation gene
            signatures
  JOURNAL   Neuron 110 (20), 3318-3338 (2022)
   PUBMED   36265442
REFERENCE   3  (bases 1 to 2721)
  AUTHORS   Ye,Q., Bhojwani,A. and Hu,J.K.
  TITLE     Understanding the development of oral epithelial organs through
            single cell transcriptomic analysis
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831953
REFERENCE   4  (bases 1 to 2721)
  AUTHORS   Xiang,C., Frietze,K.K., Bi,Y., Li,Y., Dal Pozzo,V., Pal,S.,
            Alexander,N., Baubet,V., D'Acunto,V., Mason,C.E., Davuluri,R.V. and
            Dahmane,N.
  TITLE     RP58 Represses Transcriptional Programs Linked to Nonneuronal Cell
            Identity and Glioblastoma Subtypes in Developing Neurons
  JOURNAL   Mol Cell Biol 41 (7), e0052620 (2021)
   PUBMED   33903225
REFERENCE   5  (bases 1 to 2721)
  AUTHORS   Bohnenpoll,T., Wittern,A.B., Mamo,T.M., Weiss,A.C., Rudat,C.,
            Kleppa,M.J., Schuster-Gossler,K., Wojahn,I., Ludtke,T.H.,
            Trowe,M.O. and Kispert,A.
  TITLE     A SHH-FOXF1-BMP4 signaling axis regulating growth and
            differentiation of epithelial and mesenchymal tissues in ureter
            development
  JOURNAL   PLoS Genet 13 (8), e1006951 (2017)
   PUBMED   28797033
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2721)
  AUTHORS   Hecht,J., Seitz,V., Urban,M., Wagner,F., Robinson,P.N., Stiege,A.,
            Dieterich,C., Kornak,U., Wilkening,U., Brieske,N., Zwingman,C.,
            Kidess,A., Stricker,S. and Mundlos,S.
  TITLE     Detection of novel skeletogenesis target genes by comprehensive
            analysis of a Runx2(-/-) mouse model
  JOURNAL   Gene Expr Patterns 7 (1-2), 102-112 (2007)
   PUBMED   16829211
REFERENCE   7  (bases 1 to 2721)
  AUTHORS   Sofer,A., Lei,K., Johannessen,C.M. and Ellisen,L.W.
  TITLE     Regulation of mTOR and cell growth in response to energy stress by
            REDD1
  JOURNAL   Mol Cell Biol 25 (14), 5834-5845 (2005)
   PUBMED   15988001
REFERENCE   8  (bases 1 to 2721)
  AUTHORS   Corradetti,M.N., Inoki,K. and Guan,K.L.
  TITLE     The stress-inducted proteins RTP801 and RTP801L are negative
            regulators of the mammalian target of rapamycin pathway
  JOURNAL   J Biol Chem 280 (11), 9769-9772 (2005)
   PUBMED   15632201
  REMARK    GeneRIF: RTP801 and RTP801L work downstream of AKT and upstream of
            TSC2 to inhibit mTOR functions
REFERENCE   9  (bases 1 to 2721)
  AUTHORS   Pisani,D.F., Leclerc,L., Jarretou,G., Marini,J.F. and Dechesne,C.A.
  TITLE     SMHS1 is involved in oxidative/glycolytic-energy metabolism balance
            of muscle fibers
  JOURNAL   Biochem Biophys Res Commun 326 (4), 788-793 (2005)
   PUBMED   15607738
  REMARK    GeneRIF: SMHS1 was found to be expressed in skeletal muscle, and
            comparisons of its expression in atrophied versus hypertrophied
            muscles and in oxidative versus glycolytic muscles suggested that
            SMHS1 contributes to muscle energy metabolism phenotypes.
REFERENCE   10 (bases 1 to 2721)
  AUTHORS   Shoshani,T., Faerman,A., Mett,I., Zelin,E., Tenne,T., Gorodin,S.,
            Moshel,Y., Elbaz,S., Budanov,A., Chajut,A., Kalinski,H., Kamer,I.,
            Rozen,A., Mor,O., Keshet,E., Leshkowitz,D., Einat,P., Skaliter,R.
            and Feinstein,E.
  TITLE     Identification of a novel hypoxia-inducible factor 1-responsive
            gene, RTP801, involved in apoptosis
  JOURNAL   Mol Cell Biol 22 (7), 2283-2293 (2002)
   PUBMED   11884613
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK018944.1 and AC140486.4.
            
            On Jun 18, 2009 this sequence version replaced NM_030143.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK053333.1, AK018944.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-783               AK018944.1         3-785
            784-2721            AC140486.4         93031-94968         c
FEATURES             Location/Qualifiers
     source          1..2721
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 63.81 cM"
     gene            1..2721
                     /gene="Ddit4l"
                     /gene_synonym="1700037B15Rik; 1700108M02Rik; REDD2;
                     RTP801L; Smhs1"
                     /note="DNA-damage-inducible transcript 4-like"
                     /db_xref="GeneID:73284"
                     /db_xref="MGI:MGI:1920534"
     exon            1..212
                     /gene="Ddit4l"
                     /gene_synonym="1700037B15Rik; 1700108M02Rik; REDD2;
                     RTP801L; Smhs1"
                     /inference="alignment:Splign:2.1.0"
     exon            213..354
                     /gene="Ddit4l"
                     /gene_synonym="1700037B15Rik; 1700108M02Rik; REDD2;
                     RTP801L; Smhs1"
                     /inference="alignment:Splign:2.1.0"
     exon            355..2721
                     /gene="Ddit4l"
                     /gene_synonym="1700037B15Rik; 1700108M02Rik; REDD2;
                     RTP801L; Smhs1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      882..887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddit4l"
                     /gene_synonym="1700037B15Rik; 1700108M02Rik; REDD2;
                     RTP801L; Smhs1"
                     /note="hexamer: AATAAA"
     polyA_site      907
                     /gene="Ddit4l"
                     /gene_synonym="1700037B15Rik; 1700108M02Rik; REDD2;
                     RTP801L; Smhs1"
                     /note="major polyA site"
ORIGIN      
        1 aggtgggcgt gccggccagg aggagaggcg ggacctataa agcgctctcc attcgggagg
       61 cggagcggcc gggtgcagcc tgtgctggtg ggcgcggtgg cccgcagcct tcggcttgct
      121 gcaggactgt gcaggggacc actgtccaag cttcggacta ctgaggggcg cctgcctcgg
      181 tttacccttc agcgtctggt gaaatccggc agcgcctagg gaaagatccg ttctgctccg
      241 cgagggaaac agagccgttg accatggttg caacgggcag tttgagcagt aagaacccgg
      301 ccagcatttc agagttgttg gacggtggct atcaccctgg gagtctgcta agtgatttcg
      361 actactggga ttatgttgtc cctgagccca acctcaacga ggtggtattt gaagagacaa
      421 catgccagaa tttggttaaa atgttggaga actgtctgtc cagatcaaag caaaccaaac
      481 ttggttgctc taaggtcttg gtccctgaga aactgaccca gagaattgct caagatgtcc
      541 tgcggctctc gtccacggag ccctgcggcc ttcggggttg tgttatgcac gtgaacttgg
      601 agattgaaaa tgtatgtaaa aagctggata ggatcgtgtg tgatgctagc gtggtgccga
      661 cctttgagct cacgcttgtg tttaagcagg agagctgccc gtggaccagc ctcaaggact
      721 tcttctttag cagaggtcgc ttctcctcag gccttaagcg aactctgatt ctcagctcag
      781 gatttcgact tgtgaagaaa aaactgtact ccctgattgg aacgacagtc attgaagagt
      841 gctaaggagg aaaaacaatt aaaggcccct aatgagtgga taataaacct ctgaagctat
      901 ccagccagtc atttgtagtt tgcctgcttg ccctcaccag gaaatcccag atttaggccc
      961 ttttccttct gtgtgtctca cccatagcaa cccactttaa aggctgattt tttttttttt
     1021 tgtccagctt ttaagacata attcaagaga gcaaattgcc cacatatgtg tccatatggg
     1081 atagaatgga ataaggagga aaaagaagca atctccttta attttatatt tggtctcata
     1141 tttagcaggt agtcttagca acagagcaag atccactttg cctaatttga ctttcatgtg
     1201 cccagggctt gctgttattg tacccgcctc tctctctctc tctctctctc tctctgtgtg
     1261 tgtgtgtgtg tgtgtgtgta tatatatata tctgtctgtc tctctctgtc tctctgtctc
     1321 tctctctctc ctcccctccc tccctctctg agagccatct tttcaatgac aggacctgac
     1381 aagatgatgt gcagccccat caaaacatat agagatctgc actaccagct tcctccctga
     1441 atttgaagag cttttacaca agagggtaca gttaaattga tccgctggat taaaacatca
     1501 ccttacatag agcgaataaa catcacagtg acaagagcat ggcttccctg cctggtggtc
     1561 tccccacacc cgtgcccagg agacacgaga agtgtgcctc ttactgcaat gattacatga
     1621 tggctttcag tgcctttgta gtattgtgtc aacttggttt tcctagttac caactgttga
     1681 atgttatcat tttttacatt gtctttgagt agataaaaaa aaaaaaagaa atgactgtct
     1741 ttttgcatag agttgatttg actgagcaaa tattgattac ccatctctaa agatggagaa
     1801 gggtaatttc agatcccgtc cctttcggat ccactaggtc acattgctgc tttgtgccac
     1861 caagatgctt cctctccagt gaagtgtctc accacatggc agttagctca tctctggtct
     1921 tttctaggaa ctggatcacc tttccttaac atcacacttc tttttagtta ccaatgtgct
     1981 tatattggca gagcctgact tgactctgag atgttgttgc taccacagac tagatatgaa
     2041 agtcctatga taacttaaga caatcactgc acatacccag ctccatccac tatatcacag
     2101 cccattccta ggaaacagca aatgcctctt ttgcttagct tttgcttcat ttcaagtaac
     2161 tagatgtttc tcaggtttta tggccatgag acaatttacc ttccacgtaa ctctgttcta
     2221 ttcagcaagg tcttttcttc cttgggtcat ggaaagtaac attttcgggt cacctgccta
     2281 ggccttcagt atgagtttgt atacctcagg caccagcttg gctgggacaa atgtcttcat
     2341 cctgacctta cacaaacaag cctgatagtt actggtctta tgggtgacct aggacatcac
     2401 tgttccaatg agcacgtctt ctaacttggg gaggtaccac ggagctagtc ttcacaagac
     2461 tgggccagta ggcaaaaccc tgttgatctg taggcttaca gatgcccagg ttctgaaggt
     2521 cgctgtgttt ctgtagctgt tttgagtctt gctggggaag atggtgaggc ttctcaggca
     2581 tggacataga tcttttaccc gttagcagtt ctctggttct cctgcccatt tgactctcaa
     2641 aatagtaatg gctgaaggag gctcttgcaa taacaatcct gttaaagtca attttttaca
     2701 ataaaatgtt atatattttt a
//
