LOCUS       NM_029083               1685 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus DNA-damage-inducible transcript 4 (Ddit4), mRNA.
ACCESSION   NM_029083
VERSION     NM_029083.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1685)
  AUTHORS   Chen,Q., Hu,R., Qiu,H., Li,S., Xiang,P., Lu,Y., Wang,X., Wang,T.,
            Zhou,L., Zhang,W., Wen,E., Ma,L. and Yu,C.
  TITLE     REDD1 knockdown ameliorates endothelial cell senescence through
            repressing TXNIP-mediated oxidative stress
  JOURNAL   Mech Ageing Dev 221, 111962 (2024)
   PUBMED   39004152
  REMARK    GeneRIF: REDD1 knockdown ameliorates endothelial cell senescence
            through repressing TXNIP-mediated oxidative stress.
REFERENCE   2  (bases 1 to 1685)
  AUTHORS   Stevens,S.A., Sunilkumar,S., Subrahmanian,S.M., Toro,A.L.,
            Cavus,O., Omorogbe,E.V., Bradley,E.A. and Dennis,M.D.
  TITLE     REDD1 Deletion Suppresses NF-kappaB Signaling in Cardiomyocytes and
            Prevents Deficits in Cardiac Function in Diabetic Mice
  JOURNAL   Int J Mol Sci 25 (12), 6461 (2024)
   PUBMED   38928166
  REMARK    GeneRIF: REDD1 Deletion Suppresses NF-kappaB Signaling in
            Cardiomyocytes and Prevents Deficits in Cardiac Function in
            Diabetic Mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1685)
  AUTHORS   McCurry,C.M., Sunilkumar,S., Subrahmanian,S.M., Yerlikaya,E.I.,
            Toro,A.L., VanCleave,A.M., Stevens,S.A., Barber,A.J.,
            Sundstrom,J.M. and Dennis,M.D.
  TITLE     NLRP3 Inflammasome Priming in the Retina of Diabetic Mice Requires
            REDD1-Dependent Activation of GSK3beta
  JOURNAL   Invest Ophthalmol Vis Sci 65 (3), 34 (2024)
   PUBMED   38546584
  REMARK    GeneRIF: NLRP3 Inflammasome Priming in the Retina of Diabetic Mice
            Requires REDD1-Dependent Activation of GSK3beta.
REFERENCE   4  (bases 1 to 1685)
  AUTHORS   Sunilkumar,S., VanCleave,A.M., McCurry,C.M., Toro,A.L.,
            Stevens,S.A., Kimball,S.R. and Dennis,M.D.
  TITLE     REDD1-dependent GSK3beta dephosphorylation promotes NF-kappaB
            activation and macrophage infiltration in the retina of diabetic
            mice
  JOURNAL   J Biol Chem 299 (8), 104991 (2023)
   PUBMED   37392853
  REMARK    GeneRIF: REDD1-dependent GSK3beta dephosphorylation promotes
            NF-kappaB activation and macrophage infiltration in the retina of
            diabetic mice.
REFERENCE   5  (bases 1 to 1685)
  AUTHORS   Xie,X., Sun,L., Duan,Y., Lv,Z., Yao,X., Wang,C., Chen,X., Tian,S.,
            Yan,L., Shao,Y., Luo,H. and Liu,J.
  TITLE     SRSF2 in Sertoli cells is essential for testicular development and
            spermatogenesis in mice
  JOURNAL   FASEB J 37 (5), e22918 (2023)
   PUBMED   37039821
REFERENCE   6  (bases 1 to 1685)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 1685)
  AUTHORS   Wang,Z., Malone,M.H., Thomenius,M.J., Zhong,F., Xu,F. and
            Distelhorst,C.W.
  TITLE     Dexamethasone-induced gene 2 (dig2) is a novel pro-survival stress
            gene induced rapidly by diverse apoptotic signals
  JOURNAL   J Biol Chem 278 (29), 27053-27058 (2003)
   PUBMED   12736248
  REMARK    GeneRIF: dig2 appears to have a pro-survival function, as
            overexpression of dig2 reduces the sensitivity of WEHI7.2 cells to
            dexamethasone-induced apoptosis.
REFERENCE   8  (bases 1 to 1685)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 1685)
  AUTHORS   Ellisen,L.W., Ramsayer,K.D., Johannessen,C.M., Yang,A., Beppu,H.,
            Minda,K., Oliner,J.D., McKeon,F. and Haber,D.A.
  TITLE     REDD1, a developmentally regulated transcriptional target of p63
            and p53, links p63 to regulation of reactive oxygen species
  JOURNAL   Mol Cell 10 (5), 995-1005 (2002)
   PUBMED   12453409
  REMARK    GeneRIF: REDD1 encodes a shared transcriptional target that
            implicates ROS in the p53-dependent DNA damage response and in
            p63-mediated regulation of epithelial differentiation [REDD1]
REFERENCE   10 (bases 1 to 1685)
  AUTHORS   Shoshani,T., Faerman,A., Mett,I., Zelin,E., Tenne,T., Gorodin,S.,
            Moshel,Y., Elbaz,S., Budanov,A., Chajut,A., Kalinski,H., Kamer,I.,
            Rozen,A., Mor,O., Keshet,E., Leshkowitz,D., Einat,P., Skaliter,R.
            and Feinstein,E.
  TITLE     Identification of a novel hypoxia-inducible factor 1-responsive
            gene, RTP801, involved in apoptosis
  JOURNAL   Mol Cell Biol 22 (7), 2283-2293 (2002)
   PUBMED   11884613
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK017926.1.
            
            On Apr 6, 2007 this sequence version replaced NM_029083.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK017926.1, BC132645.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1685              AK017926.1         1-1685
FEATURES             Location/Qualifiers
     source          1..1685
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 29.66 cM"
     gene            1..1685
                     /gene="Ddit4"
                     /gene_synonym="5830413E08Rik; dig2; REDD1; Rtp801"
                     /note="DNA-damage-inducible transcript 4"
                     /db_xref="GeneID:74747"
                     /db_xref="MGI:MGI:1921997"
     exon            1..74
                     /gene="Ddit4"
                     /gene_synonym="5830413E08Rik; dig2; REDD1; Rtp801"
                     /inference="alignment:Splign:2.1.0"
     exon            75..330
                     /gene="Ddit4"
                     /gene_synonym="5830413E08Rik; dig2; REDD1; Rtp801"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..824
                     /gene="Ddit4"
                     /gene_synonym="5830413E08Rik; dig2; REDD1; Rtp801"
                     /note="HIF-1 responsive RTP801; REDD-1; HIF-1 responsive
                     protein RTP801; dexamethasone-induced gene 2 protein;
                     protein regulated in development and DNA damage response
                     1"
                     /codon_start=1
                     /product="DNA damage-inducible transcript 4 protein"
                     /protein_id="NP_083359.1"
                     /db_xref="CCDS:CCDS23868.1"
                     /db_xref="GeneID:74747"
                     /db_xref="MGI:MGI:1921997"
                     /translation="MPSLWDRFSSSSSSSSSSRTPAADRPPRSAWGSAAREEGLDRCA
                     SLESSDCESLDSSNSGFGPEEDSSYLDGVSLPDFELLSDPEDEHLCANLMQLLQESLS
                     QARLGSRRPARLLMPSQLVSQVGKELLRLAYSEPCGLRGALLDVCVEQGKSCHSVAQL
                     ALDPSLVPTFQLTLVLRLDSRLWPKIQGLLSSANSSLVPGYSQSLTLSTGFRVIKKKL
                     YSSEQLLIEEC"
     exon            331..1685
                     /gene="Ddit4"
                     /gene_synonym="5830413E08Rik; dig2; REDD1; Rtp801"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggttggcacc agttcgctca cccttcgaga ggcagagcgc tcttgtccgc aatcttcgct
       61 gaccgcgcta gctgcggctt ctgtgcgcct tcattcggac cttagcagcc agcgtcctgg
      121 cgtctgaccc cgccatgcct agcctctggg atcgtttctc gtcctcctct tcctcttcgt
      181 cctcgtctcg aactccggcc gctgatcggc cgccgcgctc cgcctggggg tctgcagcca
      241 gagaagaggg ccttgaccgc tgcgcgagcc tggagagctc ggactgcgag tccctggaca
      301 gcagcaacag tggcttcggg ccggaggaag actcctcata cctggatggg gtgtccctgc
      361 ccgactttga gctgctcagt gaccccgagg atgagcacct gtgtgccaac ctgatgcagc
      421 tgctgcagga gagcctgtcc caggcgcgat tgggctcgcg gcgccctgcg cgtttgctca
      481 tgccgagcca gctggtgagc caggtgggca aggaactcct gcgcctggca tacagtgagc
      541 cgtgcggcct gcggggggca ctgctggacg tgtgtgtgga gcaaggcaag agctgccata
      601 gcgtggctca gctggccctc gaccccagcc tggtgcccac ctttcagttg accctggtgc
      661 tgcgtctgga ctctcgcctc tggcccaaga tccaggggct gttaagttct gccaactctt
      721 ccttggtccc tggttacagc cagtccctga cgctaagtac cggcttcaga gtcatcaaga
      781 agaaactcta cagctccgag cagctgctca ttgaagagtg ttgaactaca tcctggggtg
      841 gggtgcgggg agggtttctc actgcccccc aaagtgaaga caaggaattt ctgtggtgga
      901 gacccgcagg caaggactga aggactgtcc cctgtgttag aaaactgacg atagccacct
      961 gaggggcgca gggccaggtg ggggaaggaa gtgttctcca ggaagtctct aggttgtatg
     1021 caggtggctc cctgttgggg cacacgcccc tcagtactgt agcatgaaac aaaggcttag
     1081 gagtcacaca ggcttctggc tggatgtgta tgtagcatgt accttatttt tttttattac
     1141 tgacaagtta caacagcagt tgtgggccag agccagaagg gcagctggtc tgcactggcc
     1201 tctgccccgg ctgggggttg ggggctgggg gggaggcagg gggaggtggc cgacagtttg
     1261 tgtatcttct ggtctgaaag gacctagtgt gttttgtcat ttgttttgta tcttggtttt
     1321 ggggggtggg gatcggcgct tcactactga cctgttcgag gcagctatct tacagactgc
     1381 atgaatgtaa gagtaggaat ggggtgggtg ttaggatcat tcgggatctt cgacacttga
     1441 aacaaaatta cacctgggag ctgcagccag cccatcccgg tgcccatgta ctggaggatt
     1501 caactgtgag gagaggggct ggggtggggg tggggggctg gaaccctctt ttcccagagg
     1561 agtgccacct gggtcttcca tctagaacct gtttacatga agttactcgc ggttcatgaa
     1621 tacacttgat gttcaagtat taagacctat gcaatatttt tacttttcta ataaacatgt
     1681 ttgtt
//
