LOCUS       NM_007837                888 bp    mRNA    linear   ROD 07-FEB-2024
DEFINITION  Mus musculus DNA-damage inducible transcript 3 (Ddit3), transcript
            variant 1, mRNA.
ACCESSION   NM_007837
VERSION     NM_007837.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 888)
  AUTHORS   Liu,C., Chen,H., Tao,X., Li,C., Li,A. and Wu,W.
  TITLE     ALKBH5 protects against stroke by reducing endoplasmic reticulum
            stress-dependent inflammation injury via the
            STAT5/PERK/EIF2alpha/CHOP signaling pathway in an
            m6A-YTHDF1-dependent manner
  JOURNAL   Exp Neurol 372, 114629 (2024)
   PUBMED   38056583
  REMARK    GeneRIF: ALKBH5 protects against stroke by reducing endoplasmic
            reticulum stress-dependent inflammation injury via the
            STAT5/PERK/EIF2alpha/CHOP signaling pathway in an
            m[6]A-YTHDF1-dependent manner.
REFERENCE   2  (bases 1 to 888)
  AUTHORS   Yan,W., Chen,S., Wang,Y., You,Y., Lu,Y., Wang,W., Wu,B., Du,J.,
            Peng,S., Cai,W. and Xiao,Y.
  TITLE     Loss of Mptx2 alters bacteria composition and intestinal
            homeostasis potentially by impairing autophagy
  JOURNAL   Commun Biol 7 (1), 94 (2024)
   PUBMED   38218976
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 888)
  AUTHORS   Liu,K., Zhao,C., Adajar,R.C., DeZwaan-McCabe,D. and Thomas
            Rutkowski,D.
  TITLE     A beneficial adaptive role for CHOP in driving cell fate selection
            during ER stress
  JOURNAL   EMBO Rep 25 (1), 228-253 (2024)
   PUBMED   38177915
  REMARK    GeneRIF: A beneficial adaptive role for CHOP in driving cell fate
            selection during ER stress.
REFERENCE   4  (bases 1 to 888)
  AUTHORS   Guo,C.G., Sun,R., Wang,X., Yuan,Y., Xu,Y., Li,S., Sun,X., Wang,J.,
            Hu,X., Guo,T., Chen,X.W., Xiao,R.P. and Zhang,X.
  TITLE     Intestinal SURF4 is essential for apolipoprotein transport and
            lipoprotein secretion
  JOURNAL   Mol Metab 79, 101847 (2024)
   PUBMED   38042368
REFERENCE   5  (bases 1 to 888)
  AUTHORS   Xiang,J., Pompetti,A.J., Faranda,A.P., Wang,Y., Novo,S.G., Li,D.W.
            and Duncan,M.K.
  TITLE     ATF4 May Be Essential for Adaption of the Ocular Lens to Its
            Avascular Environment
  JOURNAL   Cells 12 (22), 2636 (2023)
   PUBMED   37998373
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 888)
  AUTHORS   Jousse,C., Bruhat,A., Carraro,V., Urano,F., Ferrara,M., Ron,D. and
            Fafournoux,P.
  TITLE     Inhibition of CHOP translation by a peptide encoded by an open
            reading frame localized in the chop 5'UTR
  JOURNAL   Nucleic Acids Res 29 (21), 4341-4351 (2001)
   PUBMED   11691921
REFERENCE   7  (bases 1 to 888)
  AUTHORS   Zinszner,H., Kuroda,M., Wang,X., Batchvarova,N., Lightfoot,R.T.,
            Remotti,H., Stevens,J.L. and Ron,D.
  TITLE     CHOP is implicated in programmed cell death in response to impaired
            function of the endoplasmic reticulum
  JOURNAL   Genes Dev 12 (7), 982-995 (1998)
   PUBMED   9531536
REFERENCE   8  (bases 1 to 888)
  AUTHORS   Fleming,J.V., Fontanier,N., Harries,D.N. and Rees,W.D.
  TITLE     The growth arrest genes gas5, gas6, and CHOP-10 (gadd153) are
            expressed in the mouse preimplantation embryo
  JOURNAL   Mol Reprod Dev 48 (3), 310-316 (1997)
   PUBMED   9322241
REFERENCE   9  (bases 1 to 888)
  AUTHORS   Ubeda,M., Wang,X.Z., Zinszner,H., Wu,I., Habener,J.F. and Ron,D.
  TITLE     Stress-induced binding of the transcriptional factor CHOP to a
            novel DNA control element
  JOURNAL   Mol Cell Biol 16 (4), 1479-1489 (1996)
   PUBMED   8657121
REFERENCE   10 (bases 1 to 888)
  AUTHORS   Ron,D. and Habener,J.F.
  TITLE     CHOP, a novel developmentally regulated nuclear protein that
            dimerizes with transcription factors C/EBP and LAP and functions as
            a dominant-negative inhibitor of gene transcription
  JOURNAL   Genes Dev 6 (3), 439-453 (1992)
   PUBMED   1547942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY121546.1, AK028120.1 and CF982562.1.
            
            [WARNING] On Mar 12, 2024 this sequence was replaced by
            NM_007837.5.
            
            On Mar 1, 2014 this sequence version replaced NM_007837.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI409007.1, BC013718.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            regulatory uORF        :: PMID: 11691921
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-330               BY121546.1         1-330
            331-867             AK028120.1         328-864
            868-888             CF982562.1         518-538
FEATURES             Location/Qualifiers
     source          1..888
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 74.5 cM"
     gene            1..888
                     /gene="Ddit3"
                     /gene_synonym="AltDDIT3; chop; CHOP-10; CHOP10; gadd153"
                     /note="DNA-damage inducible transcript 3"
                     /db_xref="GeneID:13198"
                     /db_xref="MGI:MGI:109247"
     exon            1..99
                     /gene="Ddit3"
                     /gene_synonym="AltDDIT3; chop; CHOP-10; CHOP10; gadd153"
                     /inference="alignment:Splign:2.1.0"
     regulatory      46..141
                     /regulatory_class="uORF"
                     /gene="Ddit3"
                     /gene_synonym="AltDDIT3; chop; CHOP-10; CHOP10; gadd153"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:11691921]"
                     /note="this uORF is predicted to encode a 31 aa peptide
                     (PMID:11691921)"
     exon            100..147
                     /gene="Ddit3"
                     /gene_synonym="AltDDIT3; chop; CHOP-10; CHOP10; gadd153"
                     /inference="alignment:Splign:2.1.0"
     exon            148..305
                     /gene="Ddit3"
                     /gene_synonym="AltDDIT3; chop; CHOP-10; CHOP10; gadd153"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..674
                     /gene="Ddit3"
                     /gene_synonym="AltDDIT3; chop; CHOP-10; CHOP10; gadd153"
                     /note="C/EBP zeta; CCAAT/enhancer-binding protein
                     homologous protein; DDIT-3; growth arrest and
                     DNA-damage-inducible protein GADD153; c/EBP-homologous
                     protein 10; C/EBP homoologous protein 10; alternative
                     DDIT3 proteins"
                     /codon_start=1
                     /product="DNA damage-inducible transcript 3 protein"
                     /protein_id="NP_031863.3"
                     /db_xref="CCDS:CCDS24236.1"
                     /db_xref="GeneID:13198"
                     /db_xref="MGI:MGI:109247"
                     /translation="MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGN
                     EEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTR
                     KRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALID
                     RMVSLHQA"
     exon            306..871
                     /gene="Ddit3"
                     /gene_synonym="AltDDIT3; chop; CHOP-10; CHOP10; gadd153"
                     /inference="alignment:Splign:2.1.0"
     regulatory      849..854
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddit3"
                     /gene_synonym="AltDDIT3; chop; CHOP-10; CHOP10; gadd153"
     polyA_site      871
                     /gene="Ddit3"
                     /gene_synonym="AltDDIT3; chop; CHOP-10; CHOP10; gadd153"
ORIGIN      
        1 ggtcagttat cttgagccta acacgtcgat tatatcatgt tgaagatgag cgggtggcag
       61 cgacagagcc agaataacag ccggaacctg aggagagagt gttccagaag gaagtgcatc
      121 ttcatacacc accacacctg aaagcagaac ctggtccacg tgcagtcatg gcagctgagt
      181 ccctgccttt caccttggag acggtgtcca gctgggagct ggaagcctgg tatgaggatc
      241 tgcaggaggt cctgtcctca gatgaaattg ggggcaccta tatctcatcc ccaggaaacg
      301 aagaggaaga atcaaaaacc ttcactactc ttgaccctgc gtccctagct tggctgacag
      361 aggagccagg gccaacagag gtcacacgca catcccaaag ccctcgctct ccagattcca
      421 gtcagagttc tatggcccag gaggaagagg aggaagagca aggaagaact aggaaacgga
      481 aacagagtgg tcagtgccca gcccggcctg ggaagcaacg catgaaggag aaggagcagg
      541 agaacgagcg gaaagtggca cagctagctg aagagaacga gcggctcaag caggaaatcg
      601 agcgcctgac cagggaggtg gagaccacac ggcgggctct gatcgaccgc atggtcagcc
      661 tgcaccaagc atgaacagtg ggcatcacct cctgtctgtc tctccggaag tgtacccagc
      721 accatcgcgc cagcgccaag catgtgaccc tgcactgcac tgcacatgct gaggagggga
      781 ctgagggtag accaggagag ggctcggctt gcacatagac ggtacattgt ttattactgt
      841 ccatgtccag taaagtgact ttgtgtcaac aaaaaaaaaa aaaaaaaa
//
