LOCUS       NM_001355126            3386 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus DNA damage-induced apoptosis suppressor (Ddias),
            transcript variant 2, mRNA.
ACCESSION   NM_001355126 XM_006508245
VERSION     NM_001355126.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3386)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3386)
  AUTHORS   Nakaya,N., Hemish,J., Krasnov,P., Kim,S.Y., Stasiv,Y.,
            Michurina,T., Herman,D., Davidoff,M.S., Middendorff,R. and
            Enikolopov,G.
  TITLE     noxin, a novel stress-induced gene involved in cell cycle and
            apoptosis
  JOURNAL   Mol Cell Biol 27 (15), 5430-5444 (2007)
   PUBMED   17515607
  REMARK    GeneRIF: Noxin may be a component of the cell defense system: it is
            activated by various stress stimuli, helps cells to withdraw from
            cycling, and opposes apoptosis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158138.13.
            
            On Sep 8, 2017 this sequence version replaced XM_006508245.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154915.1, BC066148.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               AC158138.13        105009-105115
            108-190             AC158138.13        106412-106494
            191-319             AC158138.13        112557-112685
            320-481             AC158138.13        116770-116931
            482-599             AC158138.13        117739-117856
            600-3386            AC158138.13        118944-121730
FEATURES             Location/Qualifiers
     source          1..3386
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 51.64 cM"
     gene            1..3386
                     /gene="Ddias"
                     /gene_synonym="4632434I11Rik; noxin"
                     /note="DNA damage-induced apoptosis suppressor"
                     /db_xref="GeneID:74041"
                     /db_xref="MGI:MGI:1921291"
     exon            1..107
                     /gene="Ddias"
                     /gene_synonym="4632434I11Rik; noxin"
                     /inference="alignment:Splign:2.1.0"
     exon            108..190
                     /gene="Ddias"
                     /gene_synonym="4632434I11Rik; noxin"
                     /inference="alignment:Splign:2.1.0"
     exon            191..319
                     /gene="Ddias"
                     /gene_synonym="4632434I11Rik; noxin"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..2906
                     /gene="Ddias"
                     /gene_synonym="4632434I11Rik; noxin"
                     /note="nitric oxide-inducible gene protein"
                     /codon_start=1
                     /product="DNA damage-induced apoptosis suppressor protein"
                     /protein_id="NP_001342055.1"
                     /db_xref="CCDS:CCDS40022.1"
                     /db_xref="GeneID:74041"
                     /db_xref="MGI:MGI:1921291"
                     /translation="MNKRRKFLFASVLAVQNWNFIYPSCQRCFSKIILESKRFTCPKC
                     GSSGDTGSTNYRYKLSLKVAESSKLFFITVFGSCLDTFFGLTATGLHRYLEDSIKNLE
                     TLDSGRTQSLLTTAVEKCFVGQSFVFGVTNFGDVCGHDSDSSNFQQPCCKLRGEVRTL
                     VASQIILPSPHVKGFTVIAYLHPLLHKKPHCGSQEHSSQSLTSDDSDSDLNNIQGSGN
                     TSWFSESSVGEDFFRFWEPSLELTSSDSQVTSSDDFPASKQIMASGTPNQNRHCISVS
                     EVTSSKNCHDSLQSLWSLHSCMDKNNTTGKLGEELGLPSPVCNSCHESRLSDSHFFPS
                     QMQEPFEEHNLECYSKAGKDDYSQYDIACYQHYEVNTTPILQQRSSAFSLSSLKPEET
                     ANPSQNSDSLIWDDLPLSESLNKFLAVVESEVAVTEIDAKNRKQGMDKSIDKCHKNYS
                     RLSLTPWKNTRPLNTSSFSLRSSQAMMKEDSGKEALFSNCKSNASPHIQKESKADKTE
                     AAVSIAGSRSDISEDFLPDTCSSALFTSSKDREAFITQKRTSGVLQQKNEISCRPSTS
                     ISDCSDLRSRYFTGCGQKLHSGTKGKLAIQNCSKKYSDASDLHKLENKHRWPKKEDDN
                     FTICRKLTYPLETLCSSPESINTSKEMPCRPSNNNLTPSSSGDHEGSYNASADLFDYI
                     ANDKDIGTEITKIPQDNLLPLEVPCTENYPINENRGQPSQKLSLQSISPSRYSRPRSQ
                     SDSECDFEESQDFVPCSQSTPVAGFHQRIHGLNGASKILPSIYSNPNANYKNRKNSPL
                     TGQYEATSACSKNVKAFRQKPESPFVSSLTQANVFNHCPAAESLENDVDEWVPPTTKK
                     VFISDILGFRVMGLRKCLDLHYSPDPKELPRKKLIKVTHKTNI"
     exon            320..481
                     /gene="Ddias"
                     /gene_synonym="4632434I11Rik; noxin"
                     /inference="alignment:Splign:2.1.0"
     exon            482..599
                     /gene="Ddias"
                     /gene_synonym="4632434I11Rik; noxin"
                     /inference="alignment:Splign:2.1.0"
     exon            600..3386
                     /gene="Ddias"
                     /gene_synonym="4632434I11Rik; noxin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggaagag gacgcgggag attcgattgc tggcgtttgg agagcggcgg accgagcggc
       61 cggagggcgg agcggttgcc cgggcttgtc tgtgtccttt gcctcagata aaattttaag
      121 tgcctccatt atgccaagaa gggccaggtt ttggatgact tcaactaaca atagagactg
      181 ctgtcctagg gacaaagtat agacacatga ataaaagacg gaaattcctt tttgcctcag
      241 tacttgctgt ccagaattgg aattttatat atccatcatg tcaaaggtgc ttctctaaga
      301 taatccttga gtccaaaagg tttacttgtc ccaaatgtgg ctcttctggt gacactggaa
      361 gtaccaatta cagatacaaa ctgtccttga aagtggcaga atccagcaaa ctatttttca
      421 ttactgtatt tgggagctgc ttagatacat tttttggact tacggccact ggtttacaca
      481 ggtaccttga agattctatt aaaaacctag aaaccctgga cagtggtaga actcagagcc
      541 tactgaccac agcagtagaa aagtgttttg ttggacaaag ctttgtattt ggagtaacga
      601 attttggaga tgtatgtgga catgattcag attccagtaa ctttcagcag ccttgctgta
      661 agctcagagg agaagtcagg acacttgtag cttcccagat tattctgcct agcccacatg
      721 ttaaaggatt tacagtcatt gcctatttgc atccgctttt acacaagaaa cctcactgtg
      781 gctcccagga acatagcagc cagtcactca cttcagatga ctcagacagt gatcttaaca
      841 acatacaggg ctctgggaat acatcctggt tttcagagtc tagtgtcgga gaggattttt
      901 tcagattctg ggagccatct cttgaactga cttcttctga ctcacaagta acatctagtg
      961 atgactttcc agcatcaaaa caaatcatgg ccagtggtac tcctaaccaa aacagacact
     1021 gcatctccgt ttccgaggtc actagttcta agaactgcca tgattccctt cagagtttat
     1081 ggagccttca ttcttgtatg gacaagaata atacaacagg aaagttgggt gaagaattag
     1141 gcttaccgag tccagtttgc aacagttgcc atgaaagtag attgtctgac tctcattttt
     1201 tcccttcaca aatgcaagaa cccttcgagg aacataattt agaatgctat agtaaagcag
     1261 gaaaagatga ttattcccag tatgatatcg catgttacca gcattatgaa gtaaatacta
     1321 cccccatcct tcaacagagg tcttctgcat tttcattgtc atcactgaaa cccgaagaaa
     1381 cagcgaatcc ttcccagaac tctgactcct tgatttggga tgatctacca ctctctgaaa
     1441 gtctgaacaa gtttctagca gttgttgaaa gtgaggttgc tgtaactgag atagatgcta
     1501 agaacagaaa acagggtatg gataaaagca ttgataaatg tcacaaaaac tacagcagat
     1561 tatcactgac tccatggaaa aatactagac ccttaaatac atcatctttc agcttaagat
     1621 catcacaagc aatgatgaaa gaagactctg ggaaagaggc cctcttttcc aactgtaagt
     1681 ctaatgcaag tcctcacatt cagaaagaat cgaaagcaga caagacagaa gcggctgtct
     1741 ccatagccgg tagtagaagt gatatctctg aggattttct accagatact tgctcatcag
     1801 cactgtttac atcttcaaaa gatagggaag ccttcattac ccaaaagagg actagtgggg
     1861 tcttgcaaca aaagaatgaa atttcatgca ggcccagtac ctcaataagt gactgttctg
     1921 atctcaggag cagatatttt actggatgtg gacaaaaatt acattcagga acaaaaggaa
     1981 aattggcaat acaaaactgt tctaaaaaat acagcgatgc ttctgatctt cacaaattag
     2041 aaaataagca tagatggcca aaaaaggaag atgacaattt cacaatatgc agaaaactca
     2101 catatccttt agagaccctt tgcagtagcc cagaaagtat aaatacatcg aaagagatgc
     2161 cttgcaggcc tagcaataat aacttaacac caagttcttc tggtgatcat gaaggtagtt
     2221 acaatgcttc tgctgatctt tttgattata ttgctaacga taaggacatt ggaacagaaa
     2281 ttaccaaaat accacaggat aacttgttac cactggaagt accttgcaca gaaaattatc
     2341 ctataaatga gaaccgtggc cagccttcac aaaaattatc cttgcaaagc atatcaccct
     2401 caaggtattc aagaccaagg tctcagtcag actcagaatg tgattttgaa gaaagccaag
     2461 actttgttcc atgttcacag tcaactccag ttgcaggctt ccaccaaaga attcatggct
     2521 taaatggtgc ttccaaaata ctgccttcca tatattcaaa tcctaatgct aattataaaa
     2581 acagaaaaaa ttctcctcta actggccagt atgaagccac ctcagcctgc tcaaagaatg
     2641 taaaagcatt tcggcagaaa cccgaaagtc cttttgtgtc tagtttgaca caagcaaatg
     2701 ttttcaacca ctgccctgct gctgagagcc ttgaaaatga tgtggatgaa tgggtccccc
     2761 ctaccaccaa gaaagtattt atttcagata ttcttggatt cagagtcatg ggtttaagaa
     2821 aatgccttga tctccattat tcccctgacc caaaagagtt accaaggaag aaactgataa
     2881 aagtcacaca taaaaccaac atttaattaa gaagttaaag actataccta tagttgcaaa
     2941 accaaaagtg ctcaaagcat gactataaat gatgaggctg aaaataggaa aagcccagtt
     3001 ggggatggct tttcagaata atacttttag tgtctgatac aaaaagcact tagtaactga
     3061 aggtattttc atataaagtc acatgaaccc agttcccaga aattttaagt gatggcagat
     3121 ctgtttggaa atgtttgctt tcactgatac agagagcagt ctttatgttt tgaagactta
     3181 caggaagtcg ttaataggag tggactgtac tgaatgctgt tggatctttc aaggtttcca
     3241 ccatggcttt ctttttttct ccagaatact gtgattaaga taactgagca cttctcttta
     3301 cattgactgt ataaatatgt tgattttgta tttaaaagta tttgttaaaa tatagacatc
     3361 cagaagtaaa gtctttataa tccaaa
//
