LOCUS       NM_001017966            3539 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus DNA-damage inducible protein 2 (Ddi2), mRNA.
ACCESSION   NM_001017966
VERSION     NM_001017966.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3539)
  AUTHORS   Nedomova,M., Haberecht-Muller,S., Moller,S., Venz,S.,
            Prochazkova,M., Prochazka,J., Sedlak,F., Chawengsaksophak,K.,
            Hammer,E., Kasparek,P., Adamek,M., Sedlacek,R., Konvalinka,J.,
            Kruger,E. and Grantz Saskova,K.
  TITLE     DDI2 protease controls embryonic development and inflammation via
            TCF11/NRF1
  JOURNAL   iScience 27 (10), 110893 (2024)
   PUBMED   39328932
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3539)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3539)
  AUTHORS   Ribeiro,S.T., de Gassart,A., Bettigole,S., Zaffalon,L.,
            Chavarria,C., Op,M., Nugraha,K. and Martinon,F.
  TITLE     The protease DDI2 regulates NRF1 activation in response to cadmium
            toxicity
  JOURNAL   iScience 25 (10), 105227 (2022)
   PUBMED   36248746
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3539)
  AUTHORS   Ramirez,J., Lectez,B., Osinalde,N., Siva,M., Elu,N., Aloria,K.,
            Prochazkova,M., Perez,C., Martinez-Hernandez,J., Barrio,R.,
            Saskova,K.G., Arizmendi,J.M. and Mayor,U.
  TITLE     Quantitative proteomics reveals neuronal ubiquitination of
            Rngo/Ddi1 and several proteasomal subunits by Ube3a, accounting for
            the complexity of Angelman syndrome
  JOURNAL   Hum Mol Genet 27 (11), 1955-1971 (2018)
   PUBMED   29788202
REFERENCE   5  (bases 1 to 3539)
  AUTHORS   Liu,Y., Liang,Y., Zhang,J.F. and Fu,W.M.
  TITLE     MicroRNA-133 mediates cardiac diseases: Mechanisms and clinical
            implications
  JOURNAL   Exp Cell Res 354 (2), 65-70 (2017)
   PUBMED   28322824
  REMARK    Review article
REFERENCE   6  (bases 1 to 3539)
  AUTHORS   Sha,Z. and Goldberg,A.L.
  TITLE     Reply to Vangala et al.: Complete inhibition of the proteasome
            reduces new proteasome production by causing Nrf1 aggregation
  JOURNAL   Curr Biol 26 (18), R836-R837 (2016)
   PUBMED   27676298
REFERENCE   7  (bases 1 to 3539)
  AUTHORS   Koizumi,S., Irie,T., Hirayama,S., Sakurai,Y., Yashiroda,H.,
            Naguro,I., Ichijo,H., Hamazaki,J. and Murata,S.
  TITLE     The aspartyl protease DDI2 activates Nrf1 to compensate for
            proteasome dysfunction
  JOURNAL   Elife 5, e18357 (2016)
   PUBMED   27528193
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3539)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY731719.1, BF468816.1, CD550969.1 and AL671733.6.
            
            [WARNING] On Feb 5, 2025 this sequence was replaced by
            NM_001017966.3.
            
            On Oct 9, 2005 this sequence version replaced NM_001017966.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021415.1, AK129015.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-706               BY731719.1         1-706
            707-1163            BF468816.1         4-460               c
            1164-1626           CD550969.1         76-538
            1627-3539           AL671733.6         131009-132921       c
FEATURES             Location/Qualifiers
     source          1..3539
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 74.69 cM"
     gene            1..3539
                     /gene="Ddi2"
                     /gene_synonym="1110056G13Rik; 1700027M01Rik;
                     9130022E05Rik"
                     /note="DNA-damage inducible protein 2"
                     /db_xref="GeneID:68817"
                     /db_xref="MGI:MGI:1917244"
     exon            1..363
                     /gene="Ddi2"
                     /gene_synonym="1110056G13Rik; 1700027M01Rik;
                     9130022E05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1425
                     /gene="Ddi2"
                     /gene_synonym="1110056G13Rik; 1700027M01Rik;
                     9130022E05Rik"
                     /codon_start=1
                     /product="protein DDI1 homolog 2"
                     /protein_id="NP_001017966.1"
                     /db_xref="CCDS:CCDS18880.1"
                     /db_xref="GeneID:68817"
                     /db_xref="MGI:MGI:1917244"
                     /translation="MLLTVYCVRRDLSEVTFSLQVDADFELHNFRALCELESGIPAAE
                     SQIVYAERPLTDNHRSLASYGLKDGDVVILRQKENADPRPAVQFSNLPRIDFSSIAVP
                     GTSNPQQRQLPRTQAQHSSPGEMASSPQGLDNPALLRDMLLANPHELSLLKERNPPLA
                     EALLSGDLEKFSRVLVEQQQDRARREQERIRLFSADPFDLEAQAKIEEDIRQQNIEEN
                     MTIAMEEAPESFGQVAMLYINCRVNGHPVKAFVDSGAQMTIMSQACAERCNIMRLVDR
                     RWAGIAKGVGTQKIIGRVHLAQVQIEGDFLACSFSILEEQPMDMLLGLDMLKRHQCSI
                     DLKKNVLVIGTTGSQTTFLPEGELPECARLAYGTGREDIRPEEIADQELAEAIQKSAE
                     DAERQKP"
     exon            364..493
                     /gene="Ddi2"
                     /gene_synonym="1110056G13Rik; 1700027M01Rik;
                     9130022E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            494..730
                     /gene="Ddi2"
                     /gene_synonym="1110056G13Rik; 1700027M01Rik;
                     9130022E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            731..857
                     /gene="Ddi2"
                     /gene_synonym="1110056G13Rik; 1700027M01Rik;
                     9130022E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            858..985
                     /gene="Ddi2"
                     /gene_synonym="1110056G13Rik; 1700027M01Rik;
                     9130022E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1114
                     /gene="Ddi2"
                     /gene_synonym="1110056G13Rik; 1700027M01Rik;
                     9130022E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1218
                     /gene="Ddi2"
                     /gene_synonym="1110056G13Rik; 1700027M01Rik;
                     9130022E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1408
                     /gene="Ddi2"
                     /gene_synonym="1110056G13Rik; 1700027M01Rik;
                     9130022E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1470
                     /gene="Ddi2"
                     /gene_synonym="1110056G13Rik; 1700027M01Rik;
                     9130022E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..3539
                     /gene="Ddi2"
                     /gene_synonym="1110056G13Rik; 1700027M01Rik;
                     9130022E05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3511..3516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddi2"
                     /gene_synonym="1110056G13Rik; 1700027M01Rik;
                     9130022E05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3538
                     /gene="Ddi2"
                     /gene_synonym="1110056G13Rik; 1700027M01Rik;
                     9130022E05Rik"
                     /note="major polyA site"
ORIGIN      
        1 aggcagacgg cgtcgcaggc gggtggcggc ggccgcgctg gctgccgagg gcgggagcga
       61 gtgagtcatt gcgcgcgtgt gagggaggaa aggagcgagc gagcgagcga gcgagcagcc
      121 cgcgcccgtc gccctcccgc cgctgccgcc aggtctcccc agccgccgac tgccttccgc
      181 ccagcgccca ggccgggccg agtcgagccg ggtcgggccc gggccatgct gctcaccgtg
      241 tactgtgtgc ggagggacct ctccgaggtg accttttccc tccaggtcga cgccgacttc
      301 gagctgcaca acttccgcgc gctgtgcgag ctcgagtccg gcatccccgc cgccgagagc
      361 cagattgtct atgcagaaag gcctctcacc gacaaccaca ggtcactggc ttcttacggt
      421 ttaaaagatg gtgatgttgt gattctacga cagaaggaga atgcagaccc tcgccctgca
      481 gtgcagttct caaacttacc ccggattgac ttcagtagca tagctgtgcc tggcacgtca
      541 aacccccaac agcgccagct gcccagaacc caggctcagc actcatctcc tggggaaatg
      601 gcatcttctc ctcaaggcct agacaaccca gccctgctcc gagacatgct gctggccaac
      661 ccgcatgagt tgtccttgct gaaggagcgc aacccaccct tggcggaagc tctgctcagt
      721 ggagatcttg agaaattctc tagggtcttg gtggagcagc agcaggaccg agcccggaga
      781 gaacaagaac ggattcgtct gttttctgct gacccctttg atctcgaagc tcaggcaaag
      841 atagaagaag atataaggca gcagaacatc gaggagaaca tgacgatagc tatggaggag
      901 gccccggaga gcttcggcca ggtcgccatg ctgtacatca actgcagagt gaacgggcat
      961 cctgtgaaag cctttgtcga ctcaggagcc cagatgacta ttatgagcca ggcctgtgca
     1021 gaaaggtgta acataatgag actggtagat cgtcggtggg ctggcattgc caaaggagta
     1081 ggcacacaga agattattgg aagggtgcat ctagctcagg ttcagattga aggcgatttt
     1141 ctggcgtgct ccttctcaat tctggaagaa cagcctatgg acatgcttct gggtctggac
     1201 atgctgaaac ggcaccagtg ttctattgac ttgaagaaaa atgttctggt gattggcacc
     1261 acgggctcac agaccacctt ccttcctgag ggggagttac cagagtgtgc tcgtttggca
     1321 tatggaaccg ggcgagagga catacggcca gaggaaattg cagaccaaga attagcagaa
     1381 gccattcaaa aatcagccga ggatgcagag cgtcagaagc catgatgcat gtagtgtgtg
     1441 tgtgctgcag ctggagtggg cccggaccag agaaaagcag taaagaatct acctcactgg
     1501 gaatgtcatc attgccgact tcagatgggt ttgaccatcc agctccttca gggcagagtc
     1561 ctgaggttgg tagcccgacg agtctcgctc gctctgtttc tgcttccgtc tgcgccatca
     1621 agcccggtga ccccaatagc attgaatctc tagctatgga ggctacgaag gcttcagctg
     1681 aattccagac aaactctaag aaaacagacc ctcctcctct gcaggttctt cctgaccttg
     1741 cttcctcagc agagcagagt ctagccatgc ctttccataa gtcatcaaaa gaagccgttg
     1801 ttgcaggtaa tctggagaaa tctgttgaga aaggaaccca gggcctcaga gtgtatctcc
     1861 acacaagaca ggacgctagt ttaactctca caactactgg gatgcgggag ccacagatat
     1921 ttgcggagga aaagagttgg catccagaaa atcagacccc aagtcccgtg aacggccttc
     1981 agcagcacag agaaacaggg agtgtacagc gagaggctgg acagcagagt gttccacagg
     2041 accagggctg tctttgtgac gcagaagacc ttgagcttca tgaagaagtt gtcagtttgg
     2101 aagctctgag gaaaggtgag ctacaaagac acgctcatct tcccagtgca gagaagggtc
     2161 ttccagcttc aggactctgt agctgtccat gctcagaagc cctgatggaa gtagatacag
     2221 ctgaacagtc tctggttgct atgtgcagct caacaggcag gcaggatgcc gtcatcaaga
     2281 gccctagtgt agcacatctc gcttcagata atcccactat ggaagtggag acattacagt
     2341 ctaacccgtc ctgtgagcct gtggaacatt ccatcttgac tcgggaattg cagctcccag
     2401 aagataatgt tgacatgtct acaatggata acaaagatga caattcctct tcccttctaa
     2461 gtggccacgg tcagccctct gtggaatcag cagaagaatt ttgttcatct gtcacagtgg
     2521 ccttgaaaga actccatgag cttttggtca ttagctgtaa gccagcttca gaagagtcac
     2581 ctgagcatgt tacctgtcag tcagagatag gagctgagag ccaaccaagt gtttcagacc
     2641 tttcaggaag aagggtccaa agtgtgcatt tgacccctag tgaccagtac tcacaaggct
     2701 cctgtcacca ggccacctct gaatcaggaa agacagaaat cgtaggaact gccccttgtg
     2761 ctgcggtaga agatgaagca tccactagct ttgaaggtct gggtgatggc ttgtcacctg
     2821 accgagaaga tgtccgcaga tcaacagagt cagccaggaa gagctgttct gtcgccataa
     2881 cctcagctaa actgtctgag cagttgccct gcacctcagg ggtagaaata gcacctgaac
     2941 ttgcagcaag tgagggtgcc cacagtcagc cttcagagca tgtgcataat ccaggcccag
     3001 acaggccgga gaccagcagt gtctgccctg gagctgggtt gccccgtagt ggattggacc
     3061 aacctcccac acagtccttg tccaccccct ccgttcttcc accgttcatc tttcctgctg
     3121 cagatgttga caggattctt ggtgccggct tcactctgca ggaagcgctc ggggctctgc
     3181 atcgagttgg tgggaatgca gaccttgccc ttcttgtttt gttagcaaag aacattgtag
     3241 tcccaacata attgtgggaa gtgggctagg ccacacgtca ttccttttga aaaagccctt
     3301 ttcacacaaa tatactacac acacacacac acaatgtgta gaaaatctgc aagcaaaatg
     3361 ttgagccaga tttttttttt gccggccaaa gtaatttatg atcttttgtc tgaatttgtc
     3421 tattctactt gttaacattt gggcctttta aatgtattgg cagtgtgtgc atacaaagct
     3481 ttttattctc atgacgatga tgtattctgg aataaagcag atggttttgt gtatagcat
//
