LOCUS       NM_001042719            5201 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus DDHD domain containing 1 (Ddhd1), transcript variant
            3, mRNA.
ACCESSION   NM_001042719
VERSION     NM_001042719.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5201)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5201)
  AUTHORS   Sato,T., Umebayashi,S., Senoo,N., Akahori,T., Ichida,H.,
            Miyoshi,N., Yoshida,T., Sugiura,Y., Goto-Inoue,N., Kawana,H.,
            Shindou,H., Baba,T., Maemoto,Y., Kamei,Y., Shimizu,T., Aoki,J. and
            Miura,S.
  TITLE     LPGAT1/LPLAT7 regulates acyl chain profiles at the sn-1 position of
            phospholipids in murine skeletal muscles
  JOURNAL   J Biol Chem 299 (7), 104848 (2023)
   PUBMED   37217003
REFERENCE   3  (bases 1 to 5201)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5201)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5201)
  AUTHORS   Inloes,J.M., Jing,H. and Cravatt,B.F.
  TITLE     The Spastic Paraplegia-Associated Phospholipase DDHD1 Is a Primary
            Brain Phosphatidylinositol Lipase
  JOURNAL   Biochemistry 57 (39), 5759-5767 (2018)
   PUBMED   30221923
  REMARK    GeneRIF: DDHD1 is a principal regulator of bioactive
            lysophosphatidylinositol lipids and other lysophospholipids, as
            well as phosphatidylinositol phosphates, in the mammalian nervous
            system, pointing to a potential role for these lipid pathways in
            hereditary spastic paraplegia
REFERENCE   6  (bases 1 to 5201)
  AUTHORS   Baba,T., Kashiwagi,Y., Arimitsu,N., Kogure,T., Edo,A., Maruyama,T.,
            Nakao,K., Nakanishi,H., Kinoshita,M., Frohman,M.A., Yamamoto,A. and
            Tani,K.
  TITLE     Phosphatidic acid (PA)-preferring phospholipase A1 regulates
            mitochondrial dynamics
  JOURNAL   J Biol Chem 289 (16), 11497-11511 (2014)
   PUBMED   24599962
  REMARK    GeneRIF: a possible mechanism of PA regulation of the mitochondrial
            membrane and demonstrate an in vivo function of PA-PLA1 in the
            organization of mitochondria during spermiogenesis.
REFERENCE   7  (bases 1 to 5201)
  AUTHORS   Spierings,D.C., McGoldrick,D., Hamilton-Easton,A.M., Neale,G.,
            Murchison,E.P., Hannon,G.J., Green,D.R. and Withoff,S.
  TITLE     Ordered progression of stage-specific miRNA profiles in the mouse
            B2 B-cell lineage
  JOURNAL   Blood 117 (20), 5340-5349 (2011)
   PUBMED   21403133
REFERENCE   8  (bases 1 to 5201)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   9  (bases 1 to 5201)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC107711.13, AK048690.1, BC043475.1 and AK036369.1.
            
            On Oct 1, 2013 this sequence version replaced NM_001042719.1.
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (3).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK048690.1, SRR7974084.17227.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-543               AC107711.13        160308-160850       c
            544-3315            AK048690.1         2-2773
            3316-3650           BC043475.1         2468-2802
            3651-5201           AK036369.1         55-1605
FEATURES             Location/Qualifiers
     source          1..5201
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 23.14 cM"
     gene            1..5201
                     /gene="Ddhd1"
                     /gene_synonym="Mir5131; PA-PLA1"
                     /note="DDHD domain containing 1"
                     /db_xref="GeneID:114874"
                     /db_xref="MGI:MGI:2150302"
     exon            1..922
                     /gene="Ddhd1"
                     /gene_synonym="Mir5131; PA-PLA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..2889
                     /gene="Ddhd1"
                     /gene_synonym="Mir5131; PA-PLA1"
                     /EC_number="3.1.1.32"
                     /EC_number="3.1.1.111"
                     /EC_number="3.1.1.118"
                     /note="isoform 3 is encoded by transcript variant 3;
                     phospholipase DDHD1; phospholipid sn-1 acylhydrolase; DDHD
                     domain-containing protein 1; phosphatidic acid-preferring
                     phospholipase A1 homolog"
                     /codon_start=1
                     /product="phospholipase DDHD1 isoform 3"
                     /protein_id="NP_001036184.1"
                     /db_xref="CCDS:CCDS36895.1"
                     /db_xref="GeneID:114874"
                     /db_xref="MGI:MGI:2150302"
                     /translation="MNYPGRGAPRSPERNGRGGGAWELGSDAAGVFGGGGCCFEHQPG
                     DSVPLSLLRAEPLHLAPGADDLSHLALDPCLSDETYDFSSAESGSSLRYYSEGESAGG
                     GSSSSPPPPLVAQNSGGGGAAGGGPGDRKRARPGGAAARHRYEVVTELGPEEVRWFYK
                     EDKKTWKPFIGYDSLRIELAFRTLLQTTGAQARAAGRDGDRVCGPSSSFGEEDEEDSA
                     CGFCPRAAGPEPEMEELVTIEPVCVRGGLYEVDVTQGECYPVYWNQADKIPVMRGQWF
                     IDGTWQPLEEEESNLIEQEHLSCFRGQQMQENFDIEVSKSLDGKDVVYHLPPFSLPSL
                     FKWRGYKESTDATGLKRKRSQAVHSFKLSRNHVDWHSMDEVYLYSDATTSKIARTVTQ
                     KLGFSKASSSGTRLHRGYVEEATLEDKPSQTSHIVFVVHGIGQKMDQGRIIKNTAMMR
                     EAARKMEEKHFSNHATHVEFLPVEWRSKLTLDGDTVDSITPDKVRGLRDMLNSSAMDI
                     MYYTSPLYRDELVKGLQQELNRLYSLFCSRNPDFEEKGGKVSIVSHSLGCVITYDIMM
                     GWNPGGLYEQLLQKEEELPDERWMSYEERHLLDELYITKRRLREIEDRLHGLKAPSIS
                     QTPALKFKVENFFCMGSPLAVFLALRGIRPGNSGSQDHILPREICNRLLNIFHPTDPV
                     AYRLEPLILKHYSNISPVQIHWYNTSNPLPYEHMKPNFLNPAKEPTSVSDSENIAAIP
                     SPVTSPVLSRRHYGESITNIGKASILGAASIGKGLGGMLFSRFGRSSASQPSEPSKDS
                     LEDDKKPSASPSTTTVATQTLPHSGSGFLDSAYFRLQESFFYLPQLLFPENVMQSKDD
                     SLVELEHRIDFELREGLVESRYWSAVTSHTAYWSSLDVALFLLTFMYKHEHDTEAKPS
                     LGSL"
     exon            923..1096
                     /gene="Ddhd1"
                     /gene_synonym="Mir5131; PA-PLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1198
                     /gene="Ddhd1"
                     /gene_synonym="Mir5131; PA-PLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1327
                     /gene="Ddhd1"
                     /gene_synonym="Mir5131; PA-PLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1475
                     /gene="Ddhd1"
                     /gene_synonym="Mir5131; PA-PLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1582
                     /gene="Ddhd1"
                     /gene_synonym="Mir5131; PA-PLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1689
                     /gene="Ddhd1"
                     /gene_synonym="Mir5131; PA-PLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1952
                     /gene="Ddhd1"
                     /gene_synonym="Mir5131; PA-PLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2028
                     /gene="Ddhd1"
                     /gene_synonym="Mir5131; PA-PLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2178
                     /gene="Ddhd1"
                     /gene_synonym="Mir5131; PA-PLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2431
                     /gene="Ddhd1"
                     /gene_synonym="Mir5131; PA-PLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2623
                     /gene="Ddhd1"
                     /gene_synonym="Mir5131; PA-PLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2624..2707
                     /gene="Ddhd1"
                     /gene_synonym="Mir5131; PA-PLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2708..5201
                     /gene="Ddhd1"
                     /gene_synonym="Mir5131; PA-PLA1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3051
                     /gene="Ddhd1"
                     /gene_synonym="Mir5131; PA-PLA1"
                     /note="major polyA site"
     regulatory      3628..3633
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddhd1"
                     /gene_synonym="Mir5131; PA-PLA1"
                     /note="hexamer: ATTAAA"
     polyA_site      3649
                     /gene="Ddhd1"
                     /gene_synonym="Mir5131; PA-PLA1"
                     /note="major polyA site"
     regulatory      5174..5179
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddhd1"
                     /gene_synonym="Mir5131; PA-PLA1"
                     /note="hexamer: ATTAAA"
     polyA_site      5198
                     /gene="Ddhd1"
                     /gene_synonym="Mir5131; PA-PLA1"
ORIGIN      
        1 cggccggggg ccggcgggga ggcggagtcg cctcggccgc agctgctgcc ctgctcggga
       61 tttgaaagat tataaagtcc gggccgagag ggcggcggcg tcggatgcgc gtgtggcgga
      121 agcgccggcg gcatgaacta cccgggccgc ggcgccccac ggagccccga gcgtaacggc
      181 cgcggcggcg gtgcctggga gctgggctcg gacgcggcgg gcgtgttcgg cggcggcggc
      241 tgctgcttcg agcaccagcc gggcgacagc gtgccgctgt cgctgctgcg cgccgagccg
      301 ctgcacctgg caccgggcgc cgacgacctg agccacctgg ctctggaccc gtgcctcagc
      361 gacgagacct acgacttcag ctcggccgag tccggctcgt cgttgcgcta ctacagcgag
      421 ggcgagagcg cgggcggcgg cagctcttct tcgcctccgc cgccgctcgt cgcccagaac
      481 tcggggggcg gcggggcggc gggagggggc cccggggaca ggaagcgcgc ccggcccggc
      541 ggcgcagccg cccggcaccg ctacgaggtg gtgacggagc tgggccccga ggaggtgcgc
      601 tggttctaca aggaagacaa gaagacctgg aagcccttca tcggctacga ctctctgcgc
      661 atcgagctcg ccttccggac cctgctgcag accacgggcg cccaggcccg ggcggcgggc
      721 cgcgatggag accgggtgtg tggcccaagc tccagcttcg gggaggaaga cgaggaggac
      781 agcgcctgcg gcttctgccc gcgcgcggcg gggcctgagc cggagatgga ggagctggtg
      841 accatcgagc cggtgtgcgt gcgcggcggc ctctacgagg tggatgtcac tcaaggagag
      901 tgctacccgg tgtactggaa ccaagctgat aaaataccag taatgcgtgg acagtggttt
      961 attgatggga cgtggcaacc tctagaagaa gaagaaagta atttaattga gcaagaacat
     1021 ctcagttgtt ttaggggtca gcagatgcaa gaaaattttg atattgaagt gtcaaaatcc
     1081 ttagatggaa aagacgttgt ctaccacctc cctcccttct ccctcccttc tctgttcaaa
     1141 tggagaggat ataaggagag cacagatgcc acaggtctta agcgaaagcg ttcccaagct
     1201 gttcacagtt tcaagctgag tcggaaccac gtggactggc acagcatgga tgaagtctat
     1261 ctctacagtg acgcaacaac atccaaaatt gcgagaaccg ttacccaaaa actgggcttt
     1321 tctaaagcct ccagcagtgg gaccagactg cacagaggtt atgtagaaga agccacactg
     1381 gaagacaagc cgtcgcagac ttctcatatc gtgtttgttg tgcacggcat tggacagaag
     1441 atggaccaag gaagaatcat caaaaacaca gccatgatga gagaggctgc aaggaaaatg
     1501 gaagaaaagc atttttccaa ccatgcaaca catgttgaat ttctgcctgt tgaatggcga
     1561 tcaaagctta ctcttgatgg agacacagtt gattccatca ctcctgacaa agtgcgaggc
     1621 ctgagggaca tgctcaacag cagcgcgatg gacatcatgt actacaccag cccactctac
     1681 agggatgagc tagttaaagg ccttcagcaa gagctgaatc gattatattc ccttttctgt
     1741 tcccggaatc cagactttga agagaaaggg ggtaaagtct caatagtgtc ccattccttg
     1801 gggtgtgtaa tcacttatga catcatgatg ggctggaatc caggtggact ctatgagcag
     1861 ctgctgcaga aggaggaaga gctgcccgac gagcggtgga tgagctatga agagcggcat
     1921 cttcttgacg agctctatat aacaaagcga cggctgaggg aaatagaaga tcggctgcac
     1981 ggattgaagg cgccatccat atcacaaaca cctgccttaa aatttaaggt tgaaaatttc
     2041 ttctgtatgg gatctccgct agcagttttt ttggcattac gcggcatccg accaggaaat
     2101 tctggaagtc aagaccacat tttacctaga gagatctgta accgcttact aaatattttt
     2161 catcctacgg acccagtggc ctacagatta gaaccgttga ttttgaaaca ctacagcaac
     2221 atttctccag tccagatcca ctggtacaac acttcaaacc ctctacctta tgagcatatg
     2281 aagccaaatt ttctcaaccc agcaaaagaa cctacctcag tttcagacag tgagaacata
     2341 gcagctatcc caagccctgt gacctccccc gtcttatctc ggcgccacta tggagaatct
     2401 ataactaaca ttggcaaagc aagcatattg ggggctgcta gcattggaaa gggccttgga
     2461 ggaatgttgt tctcaagatt tggacgttct tcagcatcac agccgtctga gccatctaaa
     2521 gactcactgg aagatgataa gaagccttca gcttcaccct ctaccaccac cgtggcaacg
     2581 cagaccctgc cgcacagtgg ctccggcttc ctcgactccg catatttcag acttcaagaa
     2641 tcgttctttt atctcccaca acttcttttt ccggaaaatg taatgcagag taaagatgat
     2701 agcctcgtgg aactggaaca caggatcgac tttgaactca gagaaggcct tgtggagagc
     2761 cgctattggt cagccgtcac gtcgcacact gcctattggt catccttgga tgtcgctctt
     2821 tttcttttaa cattcatgta caaacacgag catgataccg aggccaagcc cagcctaggt
     2881 tcactctgaa ctcttgaagg acgtgaatgc ccaaagcttt tctgttaaac atgtgtcaag
     2941 atgcagagac ttcaaggttc cagttttgtt aagggcaaga actattttaa tttaaaagca
     3001 ctttatttta tttttaaaag agaaaaaaac cacatgttca gttctaaagg agttatttat
     3061 gtttctgtcg ttttgattct gtctggcaga gccctgcaaa gaatcaccag agtagaagtg
     3121 tggtgggctt aggagaactg catgaaggca gccatcacag tccaggtctc cagaggagcc
     3181 taatgtagcg ttttaaccaa aaggcgtcac agcactaaca gccctaagtc cagtacactc
     3241 tgcatagact acaaggtggc atcatggttt cttgattctg tgaaggcttc cgtgtccgca
     3301 gttcctttga aagaagagta taacaaattt taaatgttct aaatttaact tgttttgaaa
     3361 aactaatgct aaaaagcaat atttgaacta ctgcacttat aatttataat ctctacttat
     3421 tcagcatatg aaacattttt aatatttctt ttaagccaca cttattttgt atcatgttga
     3481 ggcccctttt tctcaaaact ccatctttgt aaatgagcag atgatcctgt gacgtacttt
     3541 cagggttttt ttgtttgttt gttttggttt ggttttttct ttttgttttt tttgttgttg
     3601 ttttattttt gttttctttt ctttttcatt aaaaacatgg tttcacacag cactagttca
     3661 attatttttt taatttttta ttatgtcaca tatacttcaa agaaagttaa atgttttcag
     3721 cacagagact ccactctgta tgtattgcat tagctgtatt agaaaattaa gaaacagctt
     3781 tgggctagag aatatgataa cttgaaatat ataaccgtct gtgtgccaaa cagctaacac
     3841 atgtgtggga gcaggatgca tttactgtgt acagtgctaa ccagagcatg gtgactcgga
     3901 cacagaaaat ggatggacgc tgaggtactg ggggggtctg agctgtagat attttccacc
     3961 atgcttttca tctgtgatgt gcatccagca acccccgtgt gtatgcttcc tgaggtaagt
     4021 gtgcacgtta ccatgtgtta ccatgtcaca tgttcataca ctgaggcacc agtttctcaa
     4081 gtgccttgca ttagatcaca cagcaaatgg agagagtgtg gcttaaagcc agaccatatt
     4141 ctttcctgtg ctgtttaatg gtgtcactca ccagtgacct tgagaagcct gcagatgtta
     4201 gtaggttaga agatggccat aaagcccagt gttacctagc agatgcagtc gagattctta
     4261 cactcagaag aggagttaac atcaaaggaa caggagccga tcctgctgta gccaacactc
     4321 gcatctggtg gctctcccta ggttcactca aggtgctgtc tttcttgtgt gtgggaaact
     4381 tggtagcttc tggcagtcac tgtcactgct gggagcagag ctggtcagcc cacgtgtccc
     4441 ttgctctttt ctctgtaggg tggcagagcc tgtgactttt ttgtgggtgt tactccttgt
     4501 cctcgctgtt gcctgctcct cagctgtcat tgaatttgtg caatagacag cacttctttc
     4561 tagggcttaa gaattccaag gctgtgtggc tcactaaaaa cctttgttct acaggctgaa
     4621 tcttagccgt gctaaagcga catctttgag tttagaggtt cctgtcaact caggtcagct
     4681 tcagagccta tttcttagca ggtctcgtct aactctcagg aaaattaagc ccgtgtcata
     4741 tggctgtcat taaaggtagt tgagaatatg ttgttgaata tcaactgaaa ggagaagttt
     4801 gcccctgcaa gcaaaggagt gtgcccactt tctttcctca caccgcaaag tcaggtttca
     4861 ctgcttgcgt ttttgtcggc tcttgggaag agcagcgttc aaaccactct gtcaatggga
     4921 agcagatgtt ctgcacctct ggacagctgc tttcagttca tgttctcatc aataccagtg
     4981 gcagttttgg tcatagagct cttgtctccc cgtctctgca tgtaatcatg ggatgtgctt
     5041 gtatacacta aagtaatata cagagtatgt gtaattttga tgatttagaa gataagtcag
     5101 ttaccaagta acagttggcg attttattcc agcaagtact gaatcgaccc ccaaaagtcc
     5161 tgattttgat actattaaaa ttctattctc tccctgtgtc c
//
