LOCUS       NM_001190448            2018 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus dopa decarboxylase (Ddc), transcript variant 1, mRNA.
ACCESSION   NM_001190448
VERSION     NM_001190448.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2018)
  AUTHORS   Mo,C., Li,H., Yan,M., Xu,S., Wu,J., Li,J., Yang,X., Li,Y., Yang,J.,
            Su,X., Liu,J., Wu,C., Wang,Y., Dong,H., Chen,L., Dai,L., Zhang,M.,
            Pu,Q., Yang,L., Ye,T., Cao,Z. and Ding,B.S.
  TITLE     Dopaminylation of endothelial TPI1 suppresses ferroptotic
            angiocrine signals to promote lung regeneration over fibrosis
  JOURNAL   Cell Metab 36 (8), 1839-1857 (2024)
   PUBMED   39111287
REFERENCE   2  (bases 1 to 2018)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2018)
  AUTHORS   Ranjbar,R., Zamanzadeh,Z. and Ahadi,A.M.
  TITLE     Effects of Venlafaxine on the Size of Brain and Expression of
            SHANK3, TUBB5 and DDC Genes in BALB/c Mice
  JOURNAL   Psychopharmacol Bull 53 (3), 22-34 (2023)
   PUBMED   37601086
  REMARK    GeneRIF: Effects of Venlafaxine on the Size of Brain and Expression
            of SHANK3, TUBB5 and DDC Genes in BALB/c Mice.
REFERENCE   4  (bases 1 to 2018)
  AUTHORS   Ohmoto,M., Jyotaki,M., Yee,K.K. and Matsumoto,I.
  TITLE     A Transcription Factor Etv1/Er81 Is Involved in the Differentiation
            of Sweet, Umami, and Sodium Taste Cells
  JOURNAL   eNeuro 10 (4) (2023)
   PUBMED   37045597
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2018)
  AUTHORS   Sheng,K.Y., Nakano,T. and Yamaguchi,S.
  TITLE     A region-dependent allele-biased expression of Dopa decarboxylase
            in mouse brain
  JOURNAL   Front Cell Dev Biol 10, 1078927 (2022)
   PUBMED   36568970
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2018)
  AUTHORS   Saucedo-Cardenas,O., Quintana-Hau,J.D., Le,W.D., Smidt,M.P.,
            Cox,J.J., De Mayo,F., Burbach,J.P. and Conneely,O.M.
  TITLE     Nurr1 is essential for the induction of the dopaminergic phenotype
            and the survival of ventral mesencephalic late dopaminergic
            precursor neurons
  JOURNAL   Proc Natl Acad Sci U S A 95 (7), 4013-4018 (1998)
   PUBMED   9520484
REFERENCE   7  (bases 1 to 2018)
  AUTHORS   Lengeling,A., Zimmer,W.E., Goodman,S.R., Ma,Y., Bloom,M.L.,
            Bruneau,G., Krieger,M., Thibault,J., Kaupmann,K. and Jockusch,H.
  TITLE     Exclusion of two candidate genes, Spnb-2 and Dcd, for the wobbler
            spinal muscular atrophy gene on proximal mouse chromosome 11
  JOURNAL   Mamm Genome 5 (3), 163-166 (1994)
   PUBMED   8199405
REFERENCE   8  (bases 1 to 2018)
  AUTHORS   Eaton,M.J., Gudehithlu,K.P., Quach,T., Silvia,C.P.,
            Hadjiconstantinou,M. and Neff,N.H.
  TITLE     Distribution of aromatic L-amino acid decarboxylase mRNA in mouse
            brain by in situ hybridization histology
  JOURNAL   J Comp Neurol 337 (4), 640-654 (1993)
   PUBMED   7904615
REFERENCE   9  (bases 1 to 2018)
  AUTHORS   Vassort,C., Riviere,M., Bruneau,G., Gros,F., Thibault,J., Levan,G.,
            Szpirer,J. and Szpirer,C.
  TITLE     Assignment of the rat genes coding for dopa decarboxylase (DDC) and
            glutamic acid decarboxylases (GAD1 and GAD2)
  JOURNAL   Mamm Genome 4 (4), 202-206 (1993)
   PUBMED   8499653
REFERENCE   10 (bases 1 to 2018)
  AUTHORS   Bruneau,G., Thibault,J., Gros,F. and Mattei,M.G.
  TITLE     Mapping of the dopa decarboxylase gene to the 11A band of the
            murine genome
  JOURNAL   Biochem Biophys Res Commun 186 (2), 926-930 (1992)
   PUBMED   1497675
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645803.19 and AL596450.8.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060989.1, SRR5189682.133276.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AL645803.19        64425-64557         c
            134-342             AL645803.19        46855-47063         c
            343-456             AL645803.19        42658-42771         c
            457-576             AL645803.19        39547-39666         c
            577-711             AL645803.19        31307-31441         c
            712-855             AL645803.19        30064-30207         c
            856-922             AL645803.19        13049-13115         c
            923-1017            AL645803.19        5811-5905           c
            1018-1085           AL645803.19        2155-2222           c
            1086-1162           AL596450.8         6410-6486
            1163-1182           AL596450.8         10720-10739
            1183-1281           AL596450.8         13295-13393
            1282-1383           AL596450.8         16196-16297
            1384-1601           AL596450.8         20160-20377
            1602-2018           AL596450.8         21071-21487
FEATURES             Location/Qualifiers
     source          1..2018
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 7.09 cM"
     gene            1..2018
                     /gene="Ddc"
                     /gene_synonym="Aadc"
                     /note="dopa decarboxylase"
                     /db_xref="GeneID:13195"
                     /db_xref="MGI:MGI:94876"
     exon            1..133
                     /gene="Ddc"
                     /gene_synonym="Aadc"
                     /inference="alignment:Splign:2.1.0"
     exon            134..342
                     /gene="Ddc"
                     /gene_synonym="Aadc"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..1584
                     /gene="Ddc"
                     /gene_synonym="Aadc"
                     /EC_number="4.1.1.28"
                     /codon_start=1
                     /product="aromatic-L-amino-acid decarboxylase"
                     /protein_id="NP_001177377.1"
                     /db_xref="CCDS:CCDS24439.1"
                     /db_xref="GeneID:13195"
                     /db_xref="MGI:MGI:94876"
                     /translation="MDSREFRRRGKEMVDYIADYLDGIEGRPVYPDVEPGYLRPLIPA
                     TAPQEPETYEDIIKDIEKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIG
                     FSWAASPACTELETVMMDWLGKMLELPEAFLAGRAGEGGGVIQGSASEATLVALLAAR
                     TKVIRQLQAASPEFTQAAIMEKLVAYTSDQAHSSVERAGLIGGIKLKAVPSDGNFSMR
                     ASALREALERDKAAGLIPFFVVATLGTTSCCSFDNLLEVGPICNQEGVWLHIDAAYAG
                     SAFICPEFRYLLNGVEFADSFNFNPHKWLLVNFDCSAMWVKRRTDLTGAFNMDPVYLK
                     HSHQDSGFITDYRHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVELSHEFESLV
                     RQDPRFEICTEVILGLVCFRLKGSNELNETLLQRINSAKKIHLVPCRLRDKFVLRFAV
                     CARTVESAHVQLAWEHISDLASSVLRAEKE"
     exon            343..456
                     /gene="Ddc"
                     /gene_synonym="Aadc"
                     /inference="alignment:Splign:2.1.0"
     exon            457..576
                     /gene="Ddc"
                     /gene_synonym="Aadc"
                     /inference="alignment:Splign:2.1.0"
     exon            577..711
                     /gene="Ddc"
                     /gene_synonym="Aadc"
                     /inference="alignment:Splign:2.1.0"
     exon            712..855
                     /gene="Ddc"
                     /gene_synonym="Aadc"
                     /inference="alignment:Splign:2.1.0"
     exon            856..922
                     /gene="Ddc"
                     /gene_synonym="Aadc"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1017
                     /gene="Ddc"
                     /gene_synonym="Aadc"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1085
                     /gene="Ddc"
                     /gene_synonym="Aadc"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1162
                     /gene="Ddc"
                     /gene_synonym="Aadc"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1182
                     /gene="Ddc"
                     /gene_synonym="Aadc"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1281
                     /gene="Ddc"
                     /gene_synonym="Aadc"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1383
                     /gene="Ddc"
                     /gene_synonym="Aadc"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1601
                     /gene="Ddc"
                     /gene_synonym="Aadc"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..2018
                     /gene="Ddc"
                     /gene_synonym="Aadc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1993..1998
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddc"
                     /gene_synonym="Aadc"
                     /note="hexamer: AATAAA"
     polyA_site      2018
                     /gene="Ddc"
                     /gene_synonym="Aadc"
                     /note="major polyA site"
ORIGIN      
        1 agttcaaagc atcgatgaga gtaagttgcc caagcaccaa gttcacagtt gtgtcgccac
       61 ctcctcttca gttcgcagag ctggacaatc ccgacaacag agtggacctg tgaagaatcc
      121 aaattccaag caattttcaa catggattcc cgtgaattcc ggaggagagg caaggagatg
      181 gtggattata tagctgacta tctggatggc attgagggtc gtccagtgta ccctgatgtg
      241 gagcctggct atcttcggcc cctgatccct gccactgccc cccaggagcc agaaacatac
      301 gaggacataa tcaaagacat cgagaagata atcatgccag gggtgacaca ctggcacagt
      361 ccctatttct tcgcttactt ccccacggct agctcatacc cagctatgct tgcagacatg
      421 ctgtgtggtg ctattggctg cattggtttc tcctgggctg caagcccagc gtgcacagag
      481 ctggagaccg tgatgatgga ctggctgggg aagatgctgg agctgccaga ggcctttttg
      541 gctggaagag ctggggaagg gggaggagtg atccagggaa gtgccagtga agccaccttg
      601 gtggccctac tggctgctcg gactaaagtt atccgccagc tgcaggcagc ctccccagag
      661 ttcacacaag ctgctatcat ggaaaagctg gttgcttaca catctgatca ggcgcattcc
      721 tctgtagaaa gagctgggtt aattggtgga ataaagctaa aagcagtccc ttcggatggc
      781 aacttttcca tgagagcttc tgcccttcgg gaagccctgg agcgggacaa ggcagctggc
      841 ctgattccat tctttgtggt cgctacactg gggaccacat cctgctgttc ttttgacaat
      901 ctcctggaag tgggtcccat ctgcaaccag gagggtgtgt ggctgcacat tgacgctgct
      961 tacgcgggca gtgcctttat ctgtcctgaa ttccggtatc ttctgaatgg tgtggagttt
     1021 gcagattcct ttaactttaa tccccacaag tggcttttgg tgaactttga ctgctctgcc
     1081 atgtgggtga agaggaggac tgacttaacc ggagccttta atatggaccc tgtttatcta
     1141 aagcacagtc accaggactc aggattcatc actgactaca ggcactggca gatcccactg
     1201 gggcgacgat ttcgctcttt gaaaatgtgg tttgttttta gaatgtacgg agtcaagggg
     1261 ctgcaggctt acatccgaaa gcacgtggag ctgtctcatg agtttgagtc actggtacgc
     1321 caggaccctc gctttgaaat ttgcacagaa gtcattcttg ggttggtctg cttccggcta
     1381 aagggctcca atgagttgaa cgaaactctc ttacaaagaa taaacagcgc caaaaaaatc
     1441 cacttggttc catgtcgtct ccgagacaag tttgtgctac gctttgctgt gtgcgctcgc
     1501 actgtggagt ctgcccacgt gcagctggcc tgggaacaca tcagtgatct agcaagcagt
     1561 gtgctgaggg cagagaaaga atgaaagcag agctgcttca gagatcaaaa gttgaaaaga
     1621 agtttatctg aaaactggaa agagaaaaat aactaccact ccgtcttcgt gaaatcatga
     1681 ttacatgtgg cgtcatgtgt gtctccaaca ttaaccagaa acctctgact gactttttgg
     1741 tgacttatca atgaagaaat attttctgta ttgtccaggg aaaagtattt tctgtgtgga
     1801 aagctattgt cagtggctct agcttctgtt ctttgtgtgg ccgtgacttc tgttgataat
     1861 aagatgtctt tgtgctcata aggtcattgg tggcaggata ggcttataga aatagtttcc
     1921 agggcagtct ttggtcttac cttcagagta tatctatggc tgttaactta tcctctgtgt
     1981 ggctaaatac taaataaaca acctatgtgc aatactaa
//
