LOCUS       NM_028119               1929 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus damage specific DNA binding protein 2 (Ddb2),
            transcript variant 1, mRNA.
ACCESSION   NM_028119
VERSION     NM_028119.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1929)
  AUTHORS   Huang,S., Fantini,D., Merrill,B.J., Bagchi,S., Guzman,G. and
            Raychaudhuri,P.
  TITLE     DDB2 Is a Novel Regulator of Wnt Signaling in Colon Cancer
  JOURNAL   Cancer Res 77 (23), 6562-6575 (2017)
   PUBMED   29021137
  REMARK    GeneRIF: DDB2 plays a critical role in suppressing development of
            colon cancer at early stage by regulating Wnt signaling.  Mice
            genetically deficient in DDB2 exhibited increased susceptibility to
            colon tumor development in a manner associated with higher
            abundance of the Wnt receptor-expressing cells and greater
            activation of the downstream Wnt pathway.
REFERENCE   2  (bases 1 to 1929)
  AUTHORS   Yang,Y., He,S., Wang,Q., Li,F., Kwak,M.J., Chen,S., O'Connell,D.,
            Zhang,T., Pirooz,S.D., Jeon,Y.H., Chimge,N.O., Frenkel,B., Choi,Y.,
            Aldrovandi,G.M., Oh,B.H., Yuan,Z. and Liang,C.
  TITLE     Autophagic UVRAG Promotes UV-Induced Photolesion Repair by
            Activation of the CRL4(DDB2) E3 Ligase
  JOURNAL   Mol Cell 62 (4), 507-519 (2016)
   PUBMED   27203177
  REMARK    GeneRIF: UVRAG is a regulator of CRL4(DDB2)-mediated nucleotide
            excision repair and its expression levels may influence melanoma
            predisposition.
REFERENCE   3  (bases 1 to 1929)
  AUTHORS   Roy,N., Bommi,P.V., Bhat,U.G., Bhattacharjee,S., Elangovan,I.,
            Li,J., Patra,K.C., Kopanja,D., Blunier,A., Benya,R., Bagchi,S. and
            Raychaudhuri,P.
  TITLE     DDB2 suppresses epithelial-to-mesenchymal transition in colon
            cancer
  JOURNAL   Cancer Res 73 (12), 3771-3782 (2013)
   PUBMED   23610444
  REMARK    GeneRIF: Results indicate a transcriptional regulatory pathway of
            DDB2 that is directly linked to the mechanisms that suppress
            metastasis of colon cancer.
REFERENCE   4  (bases 1 to 1929)
  AUTHORS   Robu,M., Shah,R.G., Petitclerc,N., Brind'Amour,J.,
            Kandan-Kulangara,F. and Shah,G.M.
  TITLE     Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced
            DNA lesions by nucleotide excision repair
  JOURNAL   Proc Natl Acad Sci U S A 110 (5), 1658-1663 (2013)
   PUBMED   23319653
  REMARK    GeneRIF: Data indicate that poly(ADP-ribose) polymerase-1
            (PARP-1)collaborates with DNA-binding protein 2 (DDB2) to increase
            the efficiency of the lesion recognition step of global genomic
            subpathway of NER (GG-NER).
REFERENCE   5  (bases 1 to 1929)
  AUTHORS   Luijsterburg,M.S., Lindh,M., Acs,K., Vrouwe,M.G., Pines,A., van
            Attikum,H., Mullenders,L.H. and Dantuma,N.P.
  TITLE     DDB2 promotes chromatin decondensation at UV-induced DNA damage
  JOURNAL   J Cell Biol 197 (2), 267-281 (2012)
   PUBMED   22492724
REFERENCE   6  (bases 1 to 1929)
  AUTHORS   Alekseev,S., Kool,H., Rebel,H., Fousteri,M., Moser,J.,
            Backendorf,C., de Gruijl,F.R., Vrieling,H. and Mullenders,L.H.
  TITLE     Enhanced DDB2 expression protects mice from carcinogenic effects of
            chronic UV-B irradiation
  JOURNAL   Cancer Res 65 (22), 10298-10306 (2005)
   PUBMED   16288018
REFERENCE   7  (bases 1 to 1929)
  AUTHORS   Yoon,T., Chakrabortty,A., Franks,R., Valli,T., Kiyokawa,H. and
            Raychaudhuri,P.
  TITLE     Tumor-prone phenotype of the DDB2-deficient mice
  JOURNAL   Oncogene 24 (3), 469-478 (2005)
   PUBMED   15558025
  REMARK    GeneRIF: DDB2-deficient mice developed spontaneous malignant tumors
            at a high rate between the ages of 20 and 25 months.
REFERENCE   8  (bases 1 to 1929)
  AUTHORS   Itoh,T., Cado,D., Kamide,R. and Linn,S.
  TITLE     DDB2 gene disruption leads to skin tumors and resistance to
            apoptosis after exposure to ultraviolet light but not a chemical
            carcinogen
  JOURNAL   Proc Natl Acad Sci U S A 101 (7), 2052-2057 (2004)
   PUBMED   14769931
  REMARK    GeneRIF: results demonstrate that DDB2 is well conserved between
            humans and mice and functions as a tumor suppressor, at least in
            part, by controlling p53-mediated apoptosis after UV-irradiation
REFERENCE   9  (bases 1 to 1929)
  AUTHORS   Tan,T. and Chu,G.
  TITLE     p53 Binds and activates the xeroderma pigmentosum DDB2 gene in
            humans but not mice
  JOURNAL   Mol Cell Biol 22 (10), 3247-3254 (2002)
   PUBMED   11971958
  REMARK    GeneRIF: These results demonstrate direct activation of the human
            DDB2 gene by p53. The corresponding region in the mouse DDB2 gene
            shared significant sequence identity with the human gene but was
            deficient for p53 binding and transcriptional activation.
REFERENCE   10 (bases 1 to 1929)
  AUTHORS   Zolezzi,F. and Linn,S.
  TITLE     Studies of the murine DDB1 and DDB2 genes
  JOURNAL   Gene 245 (1), 151-159 (2000)
   PUBMED   10713455
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK627126.1, BU515611.1 and BC058589.1.
            
            On Apr 23, 2010 this sequence version replaced NM_028119.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY027937.1, SRR5189685.311635.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-634               CK627126.1         1-634
            635-1130            BU515611.1         141-636
            1131-1929           BC058589.1         1503-2301
FEATURES             Location/Qualifiers
     source          1..1929
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 50.56 cM"
     gene            1..1929
                     /gene="Ddb2"
                     /gene_synonym="2610043A19Rik"
                     /note="damage specific DNA binding protein 2"
                     /db_xref="GeneID:107986"
                     /db_xref="MGI:MGI:1355314"
     exon            1..377
                     /gene="Ddb2"
                     /gene_synonym="2610043A19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..1549
                     /gene="Ddb2"
                     /gene_synonym="2610043A19Rik"
                     /note="isoform 1 is encoded by transcript variant 1; DNA
                     damage-binding protein 2"
                     /codon_start=1
                     /product="DNA damage-binding protein 2 isoform 1"
                     /protein_id="NP_082395.2"
                     /db_xref="CCDS:CCDS16428.1"
                     /db_xref="GeneID:107986"
                     /db_xref="MGI:MGI:1355314"
                     /translation="MAPKKCPETQKSPDVAVLLRSKSRRGPQELEPEAKKLRVQGPVS
                     SRTCESCCLLAELSSLQIPSRSSSIVRDLYQHKLGKATWSSLQQGLQKSFLHSLASYQ
                     VFRKAAPFDRRTTSLAWHPTHPSTLAVGSKGGDIMIWNFGIKDKPIFLKGIGAGGSIT
                     GLKFNHLNTNQFFASSMEGTTRLQDFKGNILRVYTSSNSCKVWFCSLDVSAKSRVVVT
                     GDNMGHVILLSTDGKELWNLRMHKKKVAHVALNPCCDWLLATASIDQTVKIWDLRQIK
                     GKDSFLYSLPHRHPVNAACFSPDGARLLTTDQNNEIRVYSASQWDSPLNLISHPHRHF
                     QHLTPIKATWHSRHNLIVVGRYPDPNLKSCVPYELRTIDVFDGSSGKMMCQLYDPGYS
                     GITSLNEFNPMGDTLASTMGYHILIWSQEEDGSQKDHERL"
     exon            378..514
                     /gene="Ddb2"
                     /gene_synonym="2610043A19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            515..706
                     /gene="Ddb2"
                     /gene_synonym="2610043A19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            707..852
                     /gene="Ddb2"
                     /gene_synonym="2610043A19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            853..952
                     /gene="Ddb2"
                     /gene_synonym="2610043A19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1130
                     /gene="Ddb2"
                     /gene_synonym="2610043A19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1273
                     /gene="Ddb2"
                     /gene_synonym="2610043A19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1438
                     /gene="Ddb2"
                     /gene_synonym="2610043A19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1484
                     /gene="Ddb2"
                     /gene_synonym="2610043A19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1918
                     /gene="Ddb2"
                     /gene_synonym="2610043A19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1886..1891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ddb2"
                     /gene_synonym="2610043A19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1918
                     /gene="Ddb2"
                     /gene_synonym="2610043A19Rik"
                     /note="major polyA site"
ORIGIN      
        1 agacagcccc ctactgtggc aatcccgagg gggcggggca gttccaaggg gcgggacagc
       61 cctgagggga cggggcgggg ctaaaagtaa agcagcccgg aggagcgttt ggcgcgaagg
      121 tgtcttagct gcgctacctg cgacggcgct gcctcatacg tagtcccttc ctgttttctc
      181 cacggaggct tttccactcc ttgcttcgtt attttgccac agagcttgat atctcttcac
      241 cgagtacgtc atggctccca agaaatgccc agaaacccag aagtcccccg acgttgcggt
      301 gctcctcagg agcaaaagtc gcagaggtcc tcaggagctg gagcccgaag ccaagaagct
      361 gcgtgtgcag ggtcccgttt ctagcaggac atgtgagtcg tgctgccttc tggcagagtt
      421 gtccagcctg cagatccctt cacggagtag cagcattgtc agggatcttt accagcataa
      481 gttgggcaaa gccacctggt catcactaca gcagggtctg cagaagtcct ttttgcactc
      541 tctagcttct taccaggtat tccgaaaagc tgcccccttt gacaggagga ctacgtcctt
      601 ggcatggcac ccgactcatc ccagtaccct ggctgtgggc tccaaagggg gagatattat
      661 gatctggaac tttggcatca aggacaaacc tatcttcctt aaagggattg gagctggagg
      721 aagcatcact gggctgaagt ttaaccatct caataccaac cagttttttg cctcctcaat
      781 ggagggaaca accaggctgc aggattttaa aggcaacatt ctcagagttt ataccagctc
      841 aaactcttgc aaggtctggt tttgcagcct tgatgtttct gccaagagca gagtggtggt
      901 tacaggagac aatatgggac atgtgatcct gttgagcaca gatggcaagg agctttggaa
      961 cctccgaatg cacaagaaga aagtagccca cgtggccctg aatccctgct gtgattggct
     1021 tctggccaca gcctccatag atcaaacagt gaagatttgg gacctgcgcc aaattaaagg
     1081 gaaagacagc ttcctctact cactgcctca caggcatcct gtcaatgcag cttgttttag
     1141 cccagatgga gctcggctcc tgactactga ccagaacaat gagattcggg tttactctgc
     1201 ctcccagtgg gatagccccc tgaatctgat ctcccaccct caccgccatt ttcagcacct
     1261 cacacccatc aaggcgacct ggcattcacg gcacaacctc attgttgtgg gccgataccc
     1321 agatcctaat cttaaaagtt gtgttcccta tgaactaagg acaatagatg tgtttgatgg
     1381 aagctcaggg aagatgatgt gtcagctcta tgatccagga tactccggta ttacttcgct
     1441 caatgagttc aatcctatgg gagacacact ggcctctact atgggttatc atattctcat
     1501 ttggagccaa gaggaagatg ggtcacagaa agatcatgaa agactatgaa gatggtgtgg
     1561 gacagcaata ctggacccca cagatgggaa cacattctgt gaggagtggc agctgtttgt
     1621 taataggcca aaagtaccca attcttaggg ttggagcagg gacacttgtg acaagggata
     1681 ctgtgggact aggatgctga catgttactg ctctagattt tgctccagaa aattaaagag
     1741 taaaccagct acgctcaggg tcccagctat atctagcctg gaggccaagt ttatgctaga
     1801 gccaaggtac ttttcttttt tctgatgtat aggagcaaaa taaccagaga attttaaaac
     1861 ttttatgttc aattttagca tggccaataa aagcatatcc tttgtatcta actaaaaaaa
     1921 aaaaaaaaa
//
