LOCUS       NP_001397148            1152 aa            linear   ROD 01-MAY-2025
DEFINITION  DNA damage-binding protein 1 isoform 1 [Mus musculus].
ACCESSION   NP_001397148 XP_006526702
VERSION     NP_001397148.1
DBSOURCE    REFSEQ: accession NM_001410219.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1152)
  AUTHORS   Gu,Q., Chang,Y., Jin,Y., Fang,J., Ji,T., Lin,J., Zhu,X., Dong,B.,
            Ying,H., Fan,X., Li,Z., Gao,Z., Zhu,Y., Tong,Y. and Cai,X.
  TITLE     Hepatocyte-specific loss of DDB1 attenuates hepatic steatosis but
            aggravates liver inflammation and fibrosis in MASH
  JOURNAL   Hepatol Commun 8 (7), e0474 (2024)
   PUBMED   38934719
  REMARK    GeneRIF: Hepatocyte-specific loss of DDB1 attenuates hepatic
            steatosis but aggravates liver inflammation and fibrosis in MASH.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1152)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 1152)
  AUTHORS   Yang,L., Chen,W., Li,L., Xiao,Y., Fan,S., Zhang,Q., Xia,T., Li,M.,
            Hong,Y., Zhao,T., Li,Q., Liu,W.H. and Xiao,N.
  TITLE     Ddb1 Is Essential for the Expansion of CD4+ Helper T Cells by
            Regulating Cell Cycle Progression and Cell Death
  JOURNAL   Front Immunol 12, 722273 (2021)
   PUBMED   34526995
  REMARK    GeneRIF: Ddb1 Is Essential for the Expansion of CD4(+) Helper T
            Cells by Regulating Cell Cycle Progression and Cell Death.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1152)
  AUTHORS   Wang,X., Wang,H.Y., Hu,G.S., Tang,W.S., Weng,L., Zhang,Y., Guo,H.,
            Yao,S.S., Liu,S.Y., Zhang,G.L., Han,Y., Liu,M., Zhang,X.D., Cen,X.,
            Shen,H.F., Xiao,N., Liu,C.Q., Wang,H.R., Huang,J., Liu,W., Li,P.
            and Zhao,T.J.
  TITLE     DDB1 binds histone reader BRWD3 to activate the transcriptional
            cascade in adipogenesis and promote onset of obesity
  JOURNAL   Cell Rep 35 (12), 109281 (2021)
   PUBMED   34161765
  REMARK    GeneRIF: DDB1 binds histone reader BRWD3 to activate the
            transcriptional cascade in adipogenesis and promote onset of
            obesity.
REFERENCE   5  (residues 1 to 1152)
  AUTHORS   Wu,Y., Dong,J., Feng,S., Zhao,Q., Duan,P., Xiong,M., Wen,Y., Lv,C.,
            Wang,X. and Yuan,S.
  TITLE     Maternal UHRF1 Is Essential for Transcription Landscapes and
            Repression of Repetitive Elements During the Maternal-to-Zygotic
            Transition
  JOURNAL   Front Cell Dev Biol 8, 610773 (2021)
   PUBMED   33634103
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1152)
  AUTHORS   Cang,Y., Zhang,J., Nicholas,S.A., Bastien,J., Li,B., Zhou,P. and
            Goff,S.P.
  TITLE     Deletion of DDB1 in mouse brain and lens leads to p53-dependent
            elimination of proliferating cells
  JOURNAL   Cell 127 (5), 929-940 (2006)
   PUBMED   17129780
  REMARK    GeneRIF: These results indicate that DDB1 plays an essential role
            in maintaining viability and genomic integrity of dividing cells.
REFERENCE   7  (residues 1 to 1152)
  AUTHORS   Higa,L.A., Wu,M., Ye,T., Kobayashi,R., Sun,H. and Zhang,H.
  TITLE     CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat
            proteins and regulates histone methylation
  JOURNAL   Nat Cell Biol 8 (11), 1277-1283 (2006)
   PUBMED   17041588
REFERENCE   8  (residues 1 to 1152)
  AUTHORS   Zolezzi,F. and Linn,S.
  TITLE     Studies of the murine DDB1 and DDB2 genes
  JOURNAL   Gene 245 (1), 151-159 (2000)
   PUBMED   10713455
REFERENCE   9  (residues 1 to 1152)
  AUTHORS   Seki,N., Hayashi,A., Hattori,A., Kozuma,S., Sasaki,M., Suzuki,Y.,
            Sugano,S., Muramatsu,M. and Saito,T.
  TITLE     cDNA cloning, tissue expression, and chromosomal assignment of a
            mouse gene, encoding a 127 kDa UV-damaged DNA binding protein which
            is defective in XPE cells
  JOURNAL   DNA Res 6 (5), 319-322 (1999)
   PUBMED   10574459
REFERENCE   10 (residues 1 to 1152)
  AUTHORS   Fernandes,M., Poirier,C., Lespinasse,F. and Carle,G.F.
  TITLE     The mouse homologs of human GIF, DDB1, and CFL1 genes are located
            on chromosome 19
  JOURNAL   Mamm Genome 9 (4), 339 (1998)
   PUBMED   9530637
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125093.4 and AC132247.3.
            
            On Aug 1, 2022 this sequence version replaced XP_006526702.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.1351.1,
                                           SRR13422597.374287.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1152
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 6.66 cM"
     Protein         1..1152
                     /product="DNA damage-binding protein 1 isoform 1"
                     /note="DNA damage-binding protein 1; damaged-DNA
                     recognition protein 1; DDB p127 subunit; UV-damaged
                     DNA-binding factor; damage-specific DNA-binding protein,
                     DNA repair"
                     /calculated_mol_wt=127966
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:Q16531; propagated from
                     UniProtKB/Swiss-Prot (Q3U1J4.2)"
     Region          75..555
                     /region_name="MMS1_N"
                     /note="Mono-functional DNA-alkylating methyl
                     methanesulfonate N-term; pfam10433"
                     /db_xref="CDD:463091"
     Region          403..720
                     /region_name="WD repeat beta-propeller B, Interaction with
                     CUL4A. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U1J4.2)"
     Region          721..1055
                     /region_name="WD repeat beta-propeller C.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U1J4.2)"
     Region          783..1152
                     /region_name="Interaction with CDT1 and CUL4A.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U1J4.2)"
     Region          801..1111
                     /region_name="CPSF_A"
                     /note="CPSF A subunit region; pfam03178"
                     /db_xref="CDD:427182"
     Site            1079
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q16531; propagated from
                     UniProtKB/Swiss-Prot (Q3U1J4.2)"
     Site            1137
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9ESW0; propagated from
                     UniProtKB/Swiss-Prot (Q3U1J4.2)"
     CDS             1..1152
                     /gene="Ddb1"
                     /gene_synonym="127kDa; p127-Ddb1"
                     /coded_by="NM_001410219.1:110..3568"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:13194"
                     /db_xref="MGI:MGI:1202384"
ORIGIN      
        1 msynyvvtaq kptavngcvt ghftsaedln lliakntrle iyvvtaeglr pvkevgmygk
       61 iavmelfrpk geskdllfil takynacile ykqsgesidi itrahgnvqd rigrpsetgi
      121 igiidpecrm iglrlydglf kvipldrdnk elkafnirle elhvidvkfl ygcqapticf
      181 vyqplkgdfg spktddpqgr hvktyevslr ekefnkgpwk qenveaeasm viavpepfgg
      241 aiiigqesit yhngdkylai appiikqsti vchnrvdpng sryllgdmeg rlfmllleke
      301 eqmdgtvtlk dlrvellget siaecltyld ngvvfvgsrl gdsqlvklnv dsneqgsyvv
      361 ametftnlgp ivdmcvvdle rqgqgqlvtc sgafkegslr iirngigihe hasidlpgik
      421 glwplrsdpg retddtlvls fvgqtrvlml ngeeveetel mgfvddqqtf fcgnvahqql
      481 iqitsasvrl vsqepkalvs ewkepqgkni svascnssqv vvavgralyy lqihpqelrq
      541 ishtemehev aclditplgd snglsplcai glwtdisari lklpsfellh kemlggeiip
      601 rsilmttfes shyllcalgd galfyfglni etgllsdrkk vtlgtqptvl rtfrslsttn
      661 vfacsdrptv iyssnhklvf snvnlkevny mcplnsdgyp dslalannst ltigtideiq
      721 klhirtvply esprkicyqe vsqcfgvlss rievqdssgg ttalrpsast qalsssvsss
      781 klfssstaph etsfgeevev hnlliidqht fevlhahqfl qneyalslvs cklgkdpnty
      841 fivgtamvyp eeaepkqgri vvfqysdgkl qtvaekevkg avysmvefng kllasinstv
      901 rlyewtteke lrtecnhynn imalylktkg dfilvgdlmr svlllaykpm egnfeeiard
      961 fnpnwmsave ildddnflga enafnlfvcq kdsaattdee rqhlqevglf hlgefvnvfc
     1021 hgslvmqnlg eastptqgsv lfgtvngmig lvtslseswy nllldmqnrl nkviksvgki
     1081 ehsfwrsfht erktepatgf idgdliesfl disrpkmqev vanlqyddgs gmkreatadd
     1141 likvveeltr ih
//
